Detailed information for compound 738028

Basic information

Technical information
  • TDR Targets ID: 738028
  • Name: 2-[[5-(4-methoxyphenyl)-1H-1,2,4-triazol-3-yl ]sulfanyl]-N-naphthalen-2-ylacetamide
  • MW: 390.458 | Formula: C21H18N4O2S
  • H donors: 2 H acceptors: 3 LogP: 3.93 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1n[nH]c(n1)SCC(=O)Nc1ccc2c(c1)cccc2
  • InChi: 1S/C21H18N4O2S/c1-27-18-10-7-15(8-11-18)20-23-21(25-24-20)28-13-19(26)22-17-9-6-14-4-2-3-5-16(14)12-17/h2-12H,13H2,1H3,(H,22,26)(H,23,24,25)
  • InChiKey: SAKBFDGUPRGNJI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5-(4-methoxyphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-N-(2-naphthyl)acetamide
  • 2-[[5-(4-methoxyphenyl)-1H-1,2,4-triazol-3-yl]thio]-N-(2-naphthyl)acetamide
  • 2-[[5-(4-methoxyphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-N-naphthalen-2-yl-ethanamide
  • ZINC04682014
  • STK140166
  • CBKinase1_020062
  • CBKinase1_007662

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0132 0.0577 0.0866
Trichomonas vaginalis glucose transporter, putative 0.006 0.018 0.0634
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0973 0.4335
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0158
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Brugia malayi Sugar transporter family protein 0.006 0.018 0.0782
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Plasmodium vivax proline--tRNA ligase, putative 0.015 0.0681 0.0675
Trypanosoma cruzi hexose transporter, putative 0.0133 0.0586 0.8519
Schistosoma mansoni hypothetical protein 0.0035 0.0041 0.0045
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0096 0.0378 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.015 0.0681 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0096 0.0378 0.5266
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.0467 0.2069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0158
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0053 0.0139 0.0595
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Schistosoma mansoni protein kinase 0.0132 0.0577 0.0723
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0158
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.043 0.2237 0.283
Loa Loa (eye worm) hypothetical protein 0.0077 0.027 0.1184
Echinococcus granulosus microtubule associated protein 2 0.1447 0.7903 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0132 0.0577 0.073
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.015 0.0681 0.1023
Trypanosoma brucei glucose transporter, putative 0.0133 0.0586 0.8519
Plasmodium vivax sugar transporter, putative 0.006 0.018 0.0175
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0096 0.0378 0.5266
Trichomonas vaginalis myo-inositol transporter, putative 0.006 0.018 0.0634
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0577 0.0723
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0577 0.0723
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0158
Schistosoma mansoni microtubule-associated protein tau 0.1447 0.7903 1
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.0577 0.2439
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.015 0.0681 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0081 0.0298 0.241
Brugia malayi major facilitator superfamily protein 0.006 0.018 0.0782
Onchocerca volvulus 0.006 0.018 0.1554
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Trichomonas vaginalis conserved hypothetical protein 0.043 0.2237 1
Onchocerca volvulus 0.006 0.018 0.1554
Plasmodium vivax hexose transporter 0.043 0.2237 0.2232
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0158
Onchocerca volvulus 0.0231 0.1129 1
Toxoplasma gondii protein kinase, putative 0.1214 0.6605 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0577 0.0723
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0132 0.0577 0.2558
Onchocerca volvulus 0.006 0.018 0.1554
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0081 0.0298 0.241
Echinococcus multilocularis solute carrier family 22 0.006 0.018 0.0221
Schistosoma mansoni glucose transport protein 0.043 0.2237 0.2825
Brugia malayi beta-lactamase family protein 0.0035 0.0041 0.0158
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Giardia lamblia Lysyl-tRNA synthetase 0.0096 0.0378 0.5182
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Brugia malayi beta-lactamase 0.0035 0.0041 0.0158
Leishmania major lysyl-tRNA synthetase, putative 0.0096 0.0378 0.5266
Echinococcus multilocularis solute carrier family 22 0.006 0.018 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.006 0.018 0.0634
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Loa Loa (eye worm) major facilitator superfamily transporter 0.006 0.018 0.0782
Brugia malayi lysyl-tRNA synthetase 0.0096 0.0378 0.1668
Trypanosoma brucei THT1 - hexose transporter, putative 0.0133 0.0586 0.8519
Schistosoma mansoni protein kinase 0.0132 0.0577 0.0723
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0129 0.0562 0.0704
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0041 0.0045
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0096 0.0378 0.647
Leishmania major hypothetical protein, conserved 0.006 0.018 0.2176
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0129 0.0562 0.2492
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.006 0.018 0.0221
Trypanosoma brucei THT1 - hexose transporter, putative 0.0133 0.0586 0.8519
Onchocerca volvulus 0.006 0.018 0.1554
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.027 0.1184
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0039 0.0042
Loa Loa (eye worm) sugar transporter 0.006 0.018 0.0782
Trypanosoma brucei glucose transporter, putative 0.0133 0.0586 0.8519
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Onchocerca volvulus 0.0035 0.0041 0.0315
Trypanosoma brucei glucose transporter, putative 0.0133 0.0586 0.8519
Echinococcus multilocularis General substrate transporter 0.0369 0.19 0.2399
Plasmodium vivax lysine--tRNA ligase, putative 0.0096 0.0378 0.0372
Brugia malayi Sugar transporter family protein 0.006 0.018 0.0782
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.043 0.2237 0.2825
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0158
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Plasmodium falciparum calcium-dependent protein kinase 5 0.0132 0.0577 0.0404
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Onchocerca volvulus 0.006 0.018 0.1554
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0132 0.0577 0.073
Echinococcus granulosus solute carrier family 22 0.006 0.018 0.0228
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Onchocerca volvulus 0.006 0.018 0.1554
Onchocerca volvulus 0.0035 0.0041 0.0315
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0129 0.0562 0.2371
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0132 0.0577 0.073
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0132 0.0577 0.2558
Brugia malayi hypothetical protein 0.006 0.018 0.0782
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0132 0.0577 0.0866
Toxoplasma gondii sugar transporter ST3 0.006 0.018 0.0264
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0041 0.0045
Onchocerca volvulus Putative transporter 0.006 0.018 0.1554
Toxoplasma gondii facilitative glucose transporter GT1 0.043 0.2237 0.3381
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0041 0.0052
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0041 0.0035
Leishmania major protein kinase, putative 0.0132 0.0577 0.8372
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0132 0.0577 0.073
Trypanosoma cruzi hexose transporter, putative 0.0133 0.0586 0.8519
Brugia malayi major facilitator superfamily protein 0.006 0.018 0.0782
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Schistosoma mansoni protein kinase 0.0132 0.0577 0.0723
Echinococcus granulosus GPCR family 2 0.0035 0.0041 0.0052
Brugia malayi beta-lactamase family protein 0.0035 0.0041 0.0158
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0081 0.0298 0.4923
Plasmodium falciparum protein kinase 7 0.1214 0.6605 0.6542
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0039 0.0049
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Mycobacterium ulcerans sugar transporter 0.006 0.018 0.4131
Schistosoma mansoni sugar transporter 0.006 0.018 0.0221
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Loa Loa (eye worm) hypothetical protein 0.0129 0.0562 0.2492
Chlamydia trachomatis lysine--tRNA ligase 0.0096 0.0378 1
Echinococcus granulosus synaptic vesicle 2 protein 0.006 0.018 0.0228
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Trichomonas vaginalis conserved hypothetical protein 0.006 0.018 0.0634
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Echinococcus multilocularis synaptic vesicle 2 protein 0.006 0.018 0.0221
Loa Loa (eye worm) sugar transporter 0.043 0.2237 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.006 0.018 0.0221
Trypanosoma brucei glucose transporter, putative 0.0133 0.0586 0.8519
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.043 0.2237 0.2825
Echinococcus granulosus General substrate transporter 0.0369 0.19 0.2405
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Trichomonas vaginalis conserved hypothetical protein 0.006 0.018 0.0634
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Plasmodium vivax CDK-related protein kinase 6, putative 0.1823 1 1
Onchocerca volvulus 0.0035 0.0041 0.0315
Toxoplasma gondii sugar transporter ST2 0.006 0.018 0.0264
Brugia malayi Major Facilitator Superfamily protein 0.006 0.018 0.0782
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.043 0.2237 0.2825
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0041 0.0045
Echinococcus granulosus solute carrier family 22 0.006 0.018 0.0228
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1105 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0084 0.0312 0.1234
Schistosoma mansoni sugar transporter 0.006 0.018 0.0221
Onchocerca volvulus 0.006 0.018 0.1554
Trichomonas vaginalis glucose transporter, putative 0.0133 0.0586 0.2481
Plasmodium falciparum hexose transporter 0.043 0.2237 0.2094
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0132 0.0577 0.2558
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0132 0.0577 0.8372
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0129 0.0562 0.0711
Brugia malayi Cam kinase protein 1 0.0132 0.0577 0.2558
Plasmodium falciparum calcium-dependent protein kinase 4 0.0132 0.0577 0.0404
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0129 0.0562 0.9724
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0132 0.0577 0.0866
Entamoeba histolytica protein kinase, putative 0.0132 0.0577 1
Trichomonas vaginalis sugar transporter, putative 0.0133 0.0586 0.2481
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1129 0.4955
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0039 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.006 0.018 0.0634
Echinococcus multilocularis solute carrier family 22 0.006 0.018 0.0221
Schistosoma mansoni hypothetical protein 0.0035 0.0041 0.0045
Plasmodium falciparum mitogen-activated protein kinase 2 0.0694 0.3711 0.3595
Trypanosoma brucei glucose transporter 2A 0.0133 0.0586 0.8519
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0132 0.0577 0.0572
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Schistosoma mansoni glucose transport protein 0.043 0.2237 0.2825
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0041 0.0158
Schistosoma mansoni hypothetical protein 0.0035 0.0039 0.0042
Schistosoma mansoni hypothetical protein 0.0035 0.0041 0.0045
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.043 0.2237 0.2825
Brugia malayi hypothetical protein 0.0035 0.0039 0.0149
Trypanosoma brucei THT1 - hexose transporter, putative 0.0133 0.0586 0.8519
Trypanosoma brucei sugar transporter, putative 0.006 0.018 0.2176
Echinococcus granulosus calcium dependent protein kinase 0.0123 0.0531 0.0672
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0129 0.0562 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.0467 0.2069
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Onchocerca volvulus 0.006 0.018 0.1554
Brugia malayi hypothetical protein 0.006 0.018 0.0782
Schistosoma mansoni hypothetical protein 0.043 0.2237 0.2825
Schistosoma mansoni lysyl-tRNA synthetase 0.0096 0.0378 0.0471
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0096 0.0378 1
Toxoplasma gondii sugar transporter ST1 0.006 0.018 0.0264
Trichomonas vaginalis sugar transporter, putative 0.0133 0.0586 0.2481
Echinococcus multilocularis solute carrier family 22 0.006 0.018 0.0221
Leishmania major glucose transporter, lmgt3 0.0133 0.0586 0.8519
Plasmodium falciparum calcium-dependent protein kinase 3 0.0132 0.0577 0.0404
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Leishmania major glucose transporter, lmgt2 0.0133 0.0586 0.8519
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.0577 0.0723
Brugia malayi Sugar transporter family protein 0.043 0.2237 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0132 0.0577 0.0572
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0041 0.0045
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Brugia malayi Major Facilitator Superfamily protein 0.006 0.018 0.0782
Trypanosoma cruzi hexose transporter, putative 0.006 0.018 0.2176
Schistosoma mansoni sugar transporter 0.006 0.018 0.0221
Schistosoma mansoni glucose transporter 0.006 0.018 0.0221
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.0467 0.2069
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0158
Leishmania major glucose transporter/membrane transporter D2, putative 0.0133 0.0586 0.8519
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.015 0.0681 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0694 0.3711 0.3707
Schistosoma mansoni glucose transport protein 0.043 0.2237 0.2825
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0041 0.0158
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.006 0.018 0.1309
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.015 0.0681 1
Leishmania major myo-inositol/proton symporter (MIT) 0.006 0.018 0.2176
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.006 0.018 0.1309
Echinococcus multilocularis microtubule associated protein 2 0.1447 0.7903 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0694 0.3711 0.5614
Trypanosoma brucei glucose transporter, putative 0.0133 0.0586 0.8519
Trichomonas vaginalis sugar transporter, putative 0.0133 0.0586 0.2481
Trypanosoma brucei glucose transporter 1E 0.0133 0.0586 0.8519
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0586 0.2481
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0129 0.0562 0.0704
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.043 0.2237 0.283
Trichomonas vaginalis sugar transport protein, putative 0.006 0.018 0.0634
Onchocerca volvulus 0.006 0.018 0.1554
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0096 0.0378 0.1534
Brugia malayi Pre-SET motif family protein 0.0203 0.0973 0.4335
Echinococcus granulosus solute carrier family 22 0.006 0.018 0.0228
Treponema pallidum prolyl-tRNA synthetase 0.0046 0.0098 0.5
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0132 0.0577 0.0572
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0041 0.0052
Onchocerca volvulus 0.006 0.018 0.1554
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Schistosoma mansoni hypothetical protein 0.0077 0.027 0.0335
Trypanosoma cruzi hexose transporter, putative 0.0073 0.025 0.3258
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.006 0.018 0.4131
Toxoplasma gondii transporter, major facilitator family protein 0.006 0.018 0.0264
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.043 0.2237 0.283
Loa Loa (eye worm) hypothetical protein 0.0132 0.0577 0.2558
Entamoeba histolytica protein kinase, putative 0.0132 0.0577 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0041 0.0158
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Trichomonas vaginalis glucose transporter, putative 0.0133 0.0586 0.2481
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0006 0.0008
Loa Loa (eye worm) major facilitator superfamily transporter 0.006 0.018 0.0782
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Trypanosoma cruzi hexose transporter 0.0133 0.0586 0.8519
Trypanosoma cruzi sugar transporter, putative 0.006 0.018 0.2176
Echinococcus granulosus Sugar transporter ERD6 protein 0.006 0.018 0.0228
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Plasmodium vivax calcium-dependent protein kinase, putative 0.0132 0.0577 0.0572
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Echinococcus granulosus lysyl tRNA synthetase 0.0096 0.0378 0.0478
Loa Loa (eye worm) hypothetical protein 0.0105 0.0427 0.1888
Toxoplasma gondii lysine-tRNA ligase 0.0096 0.0378 0.0564
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0041 0.0158
Loa Loa (eye worm) beta-lactamase 0.0035 0.0041 0.0158
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Giardia lamblia Prolyl-tRNA synthetase 0.0129 0.0562 1
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Plasmodium falciparum lysine--tRNA ligase 0.0096 0.0378 0.0201
Loa Loa (eye worm) hypothetical protein 0.0129 0.0562 0.2492
Onchocerca volvulus 0.006 0.018 0.1554
Plasmodium falciparum calcium-dependent protein kinase 1 0.0132 0.0577 0.0404
Schistosoma mansoni hypothetical protein 0.0035 0.0041 0.0045
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0129 0.0562 0.2492
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.006 0.018 0.2176
Trypanosoma cruzi glucose transporter, putative 0.006 0.018 0.2176
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0782
Schistosoma mansoni lysyl-tRNA synthetase 0.0096 0.0378 0.0471
Echinococcus granulosus solute carrier family 22 0.006 0.018 0.0228
Plasmodium falciparum calcium-dependent protein kinase 2 0.0132 0.0577 0.0404
Trypanosoma brucei glucose transporter, putative 0.0133 0.0586 0.8519
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.043 0.2237 0.283
Onchocerca volvulus 0.006 0.018 0.1554
Trypanosoma brucei glucose transporter, putative 0.0133 0.0586 0.8519
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0041 0.0045
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0129 0.0562 0.0704
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0586 0.2481
Schistosoma mansoni sugar transporter 0.006 0.018 0.0221
Trypanosoma brucei glucose transporter, putative 0.0133 0.0586 0.8519
Onchocerca volvulus 0.006 0.018 0.1554
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Onchocerca volvulus 0.006 0.018 0.1554
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0041 0.0052
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0041 0.0158
Brugia malayi hypothetical protein 0.006 0.018 0.0782
Entamoeba histolytica hypothetical protein 0.0096 0.0378 0.6306
Onchocerca volvulus 0.006 0.018 0.1554
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Trypanosoma cruzi hexose transporter, putative 0.0133 0.0586 0.8519
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.006 0.018 0.5
Echinococcus multilocularis GPCR, family 2 0.0035 0.0041 0.0045
Echinococcus multilocularis lysyl tRNA synthetase 0.0096 0.0378 0.0471
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Loa Loa (eye worm) hypothetical protein 0.0096 0.0378 0.1668
Toxoplasma gondii ABC1 family protein 0.0035 0.0041 0.0054
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Trichomonas vaginalis sugar transporter, putative 0.006 0.018 0.0634
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.015 0.0681 1
Trichomonas vaginalis conserved hypothetical protein 0.006 0.018 0.0634
Loa Loa (eye worm) hypothetical protein 0.0112 0.0467 0.2069
Plasmodium falciparum proline--tRNA ligase 0.015 0.0681 0.051
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.006 0.018 0.4131
Onchocerca volvulus 0.006 0.018 0.1554
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0046 0.0098 0.1671
Brugia malayi Major Facilitator Superfamily protein 0.006 0.018 0.0782
Echinococcus multilocularis calcium dependent protein kinase 0.0123 0.0531 0.0665
Leishmania major glucose transporter, lmgt1 0.0133 0.0586 0.8519
Mycobacterium ulcerans integral membrane transport protein 0.006 0.018 0.4131
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0577 0.0723

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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