TDR Targets

Basic information

Technical information

TDR Targets ID: 738249
Name: 2-(1,3-dimethyl-2,6-dioxopurin-9-yl)-N-(2-nap hthalen-1-yl-1,3-benzoxazol-5-yl)acetamide
MW: 480.475 | Formula: C26H20N6O4
H donors: 1 H acceptors: 5 LogP: 3.33 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cn1cnc2c1n(C)c(=O)n(c2=O)C)Nc1ccc2c(c1)nc(o2)c1cccc2c1cccc2
InChi: 1S/C26H20N6O4/c1-30-24-22(25(34)31(2)26(30)35)27-14-32(24)13-21(33)28-16-10-11-20-19(12-16)29-23(36-20)18-9-5-7-15-6-3-4-8-17(15)18/h3-12,14H,13H2,1-2H3,(H,28,33)
InChiKey: UNPSSGSTPFRYEI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(1,3-dimethyl-2,6-dioxo-purin-9-yl)-N-[2-(1-naphthyl)-1,3-benzoxazol-5-yl]acetamide
2-(1,3-dimethyl-2,6-dioxo-9-purinyl)-N-[2-(1-naphthyl)-1,3-benzoxazol-5-yl]acetamide
2-(2,6-diketo-1,3-dimethyl-purin-9-yl)-N-[2-(1-naphthyl)-1,3-benzoxazol-5-yl]acetamide
2-(1,3-dimethyl-2,6-dioxo-purin-9-yl)-N-(2-naphthalen-1-yl-1,3-benzoxazol-5-yl)ethanamide
ZINC02857821
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-9H-purin-9-yl)-N-[2-(1-naphthyl)-1,3-benzoxazol-5-yl]acetamide
MLS000050083
SMR000077113

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	hydroxysteroid (17-beta) dehydrogenase 10	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	Get druggable targets OG5_129031	All targets in OG5_129031
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	Get druggable targets OG5_129031	All targets in OG5_129031
Cryptosporidium parvum	scully CG7113-PA, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania braziliensis	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania donovani	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania infantum	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Cryptosporidium hominis	scully CG7113-PA	Get druggable targets OG5_129031	All targets in OG5_129031
Schistosoma japonicum	ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative	Get druggable targets OG5_129031	All targets in OG5_129031
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania mexicana	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	hydroxysteroid (17-beta) dehydrogenase 10	252 aa	251 aa	24.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.0621	0.868
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2266	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0067	0.0612	0.0597
Brugia malayi	Sugar transporter family protein	0.0031	0.0217	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Echinococcus multilocularis	calcium dependent protein kinase	0.0063	0.0566	0.2448
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.2648
Giardia lamblia	Hexose transporter	0.0031	0.0217	0.346
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Brugia malayi	hypothetical protein	0.0031	0.0217	0.0894
Trypanosoma cruzi	hexose transporter	0.0068	0.0621	0.868
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0217	0.0894
Brugia malayi	lysyl-tRNA synthetase	0.0049	0.0414	0.1769
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2266	1
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0333	0.5587
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0621	0.274
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0067	0.0612	0.0597
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0068	0.0621	0.868
Brugia malayi	Sugar transporter family protein	0.0218	0.2266	1
Giardia lamblia	Prolyl-tRNA synthetase	0.0066	0.0597	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0715	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0414	0.1769
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Brugia malayi	major facilitator superfamily protein	0.0031	0.0217	0.0894
Onchocerca volvulus		0.0031	0.0217	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Schistosoma mansoni	glucose transport protein	0.0218	0.2266	1
Loa Loa (eye worm)	sugar transporter	0.0218	0.2266	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0069	0.0638	1
Leishmania major	glucose transporter, lmgt3	0.0068	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0069	0.0638	0.2766
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Schistosoma mansoni	glucose transport protein	0.0218	0.2266	1
Toxoplasma gondii	protein kinase, putative	0.0617	0.6617	1
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.0621	0.868
Schistosoma mansoni	sugar transporter	0.0031	0.0217	0.0894
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0031	0.0217	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0067	0.0612	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0597	0.2583
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0067	0.0612	0.0925
Schistosoma mansoni	protein kinase	0.0067	0.0611	0.2648
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0067	0.0612	0.0597
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0066	0.0597	0.2583
Plasmodium falciparum	proline--tRNA ligase	0.0076	0.0715	0.0701
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.0621	0.274
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0041	0.0333	0.5227
Onchocerca volvulus		0.0031	0.0217	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Schistosoma mansoni	sugar transporter	0.0031	0.0217	0.0894
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0715	1
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0012	0.0016	0.0262
Schistosoma mansoni	protein kinase	0.0067	0.0611	0.2648
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.2648
Plasmodium falciparum	hexose transporter	0.0218	0.2266	0.2253
Trypanosoma cruzi	hexose transporter, putative	0.0068	0.0621	0.868
Echinococcus granulosus	calcium dependent protein kinase	0.0063	0.0566	0.2448
Trypanosoma brucei	glucose transporter 1E	0.0068	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0218	0.2266	1
Schistosoma mansoni	glucose transport protein	0.0218	0.2266	1
Leishmania major	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Onchocerca volvulus	Putative transporter	0.0031	0.0217	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0066	0.0597	0.9752
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0414	0.1769
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0012	0.0016	0.0245
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0031	0.0217	0.3397
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2266	1
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0067	0.0612	0.0597
Chlamydia trachomatis	proline--tRNA ligase	0.0023	0.0134	0.2978
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0069
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0031	0.0217	0.0894
Giardia lamblia	Sugar-proton symporter	0.0031	0.0217	0.346
Onchocerca volvulus		0.0031	0.0217	0.5
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0621	0.274
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Toxoplasma gondii	lysine-tRNA ligase	0.0049	0.0414	0.0625
Trichomonas vaginalis	sugar transport protein, putative	0.0031	0.0217	0.0956
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0023	0.0134	0.2103
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0031	0.0217	0.3397
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0217	0.0894
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0031	0.0217	0.0894
Brugia malayi	hypothetical protein	0.0031	0.0217	0.0894
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0049	0.0414	0.5783
Echinococcus granulosus	solute carrier family 22	0.0031	0.0217	0.0894
Trypanosoma brucei	glucose transporter 2A	0.0068	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.0621	0.868
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0066	0.0597	1
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Schistosoma mansoni	hypothetical protein	0.0218	0.2266	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Toxoplasma gondii	glycyl-tRNA synthetase	0.0012	0.0016	0.0024
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Toxoplasma gondii	sugar transporter ST1	0.0031	0.0217	0.0327
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0217	0.0894
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0069	0.0638	0.2766
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0463	0.1987
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.0621	0.274
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0067	0.0611	0.2648
Toxoplasma gondii	transporter, major facilitator family protein	0.0031	0.0217	0.0327
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0065	0.0587	0.2539
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Plasmodium falciparum	lysine--tRNA ligase	0.0049	0.0414	0.0399
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0414	0.6484
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0069	0.0638	0.2766
Leishmania major	hypothetical protein, conserved	0.0031	0.0217	0.303
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0217	0.0894
Leishmania major	glucose transporter, lmgt1	0.0068	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Onchocerca volvulus		0.0031	0.0217	0.5
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0067	0.0612	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0217	0.0894
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0031	0.0217	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Toxoplasma gondii	sugar transporter ST2	0.0031	0.0217	0.0327
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0031	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0031	0.0217	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0067	0.0612	0.0925
Trypanosoma brucei	sugar transporter, putative	0.0031	0.0217	0.303
Brugia malayi	hypothetical protein	0.0031	0.0217	0.0894
Trichomonas vaginalis	CAMK family protein kinase	0.0067	0.0611	0.2699
Entamoeba histolytica	protein kinase, putative	0.0067	0.0611	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2266	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0066	0.0597	0.2583
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0333	0.5227
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0066	0.0597	0.2583
Onchocerca volvulus		0.0031	0.0217	0.5
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.2648
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0414	0.1769
Entamoeba histolytica	hypothetical protein	0.0049	0.0414	0.6679
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0217	0.303
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0066	0.0597	0.2583
Plasmodium vivax	lysine--tRNA ligase, putative	0.0049	0.0414	0.0399
Plasmodium falciparum	protein kinase 7	0.0617	0.6617	0.6612
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0067	0.0611	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Onchocerca volvulus		0.0031	0.0217	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0069	0.0638	0.8919
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0067	0.0612	0.0597
Onchocerca volvulus		0.0031	0.0217	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0031	0.0217	0.303
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2266	1
Schistosoma mansoni	glucose transporter	0.0031	0.0217	0.0894
Giardia lamblia	Lysyl-tRNA synthetase	0.0049	0.0414	0.6849
Schistosoma mansoni	sugar transporter	0.0031	0.0217	0.0894
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0049	0.0414	0.6932
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2266	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Echinococcus multilocularis	General substrate transporter	0.0188	0.193	0.851
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0715	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0611	0.2648
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0353	0.3734	0.3724
Leishmania major	protein kinase, putative	0.0067	0.0611	0.855
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0069	0.0638	1
Echinococcus granulosus	lysyl tRNA synthetase	0.0049	0.0414	0.1769
Trichomonas vaginalis	glucose transporter, putative	0.0068	0.0621	0.274
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0069	0.0638	0.2766
Leishmania major	lysyl-tRNA synthetase, putative	0.0049	0.0414	0.5783
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0049	0.0414	0.5783
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0076	0.0715	0.1081
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0067	0.0611	0.2648
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0217	0.0894
Echinococcus granulosus	solute carrier family 22	0.0031	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Echinococcus granulosus	solute carrier family 22	0.0031	0.0217	0.0894
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.0621	0.868
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0069	0.0638	1
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0611	0.2648
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0353	0.3734	0.5643
Entamoeba histolytica	protein kinase, putative	0.0067	0.0611	1
Mycobacterium ulcerans	integral membrane transport protein	0.0031	0.0217	0.3397
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0414	0.6484
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Leishmania major	myo-inositol/proton symporter (MIT)	0.0031	0.0217	0.303
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.2648
Treponema pallidum	prolyl-tRNA synthetase	0.0023	0.0134	1
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Plasmodium vivax	hexose transporter	0.0218	0.2266	0.2253
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0012	0.0016	0.0024
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0353	0.3734	0.3724
Trypanosoma cruzi	glucose transporter, putative	0.0031	0.0217	0.303
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.0286	0.3994
Brugia malayi	major facilitator superfamily protein	0.0031	0.0217	0.0894
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0031	0.0217	0.3397
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Plasmodium vivax	sugar transporter, putative	0.0031	0.0217	0.0201
Onchocerca volvulus		0.0031	0.0217	0.5
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2266	1
Trichomonas vaginalis	myo-inositol transporter, putative	0.0031	0.0217	0.0956
Onchocerca volvulus		0.0031	0.0217	0.5
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0067	0.0611	0.2648
Schistosoma mansoni	protein kinase	0.0067	0.0611	0.2648
Brugia malayi	Cam kinase protein 1	0.0067	0.0611	0.2648
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0012	0.0016	0.0245
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0068	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0068	0.0621	0.274
Echinococcus granulosus	General substrate transporter	0.0188	0.193	0.851
Schistosoma mansoni	sugar transporter	0.0031	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Toxoplasma gondii	facilitative glucose transporter GT1	0.0218	0.2266	0.3424
Brugia malayi	Sugar transporter family protein	0.0031	0.0217	0.0894
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0031	0.0217	0.3397
Echinococcus granulosus	solute carrier family 22	0.0031	0.0217	0.0894
Plasmodium vivax	proline--tRNA ligase, putative	0.0076	0.0715	0.0701
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0927	1	1
Onchocerca volvulus		0.0031	0.0217	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0597	0.2583
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0049	0.0414	0.1826
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0218	0.2266	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0217	0.0956
Echinococcus granulosus	synaptic vesicle 2 protein	0.0031	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0217	0.0894
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0066	0.0597	0.2634
Mycobacterium ulcerans	sugar transporter	0.0031	0.0217	0.3397
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0043	0.0348	0.1536
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Onchocerca volvulus		0.0031	0.0217	0.5
Trypanosoma brucei	glucose transporter, putative	0.0068	0.0621	0.868
Onchocerca volvulus		0.0031	0.0217	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Trichomonas vaginalis	glucose transporter, putative	0.0068	0.0621	0.274
Loa Loa (eye worm)	sugar transporter	0.0031	0.0217	0.0894
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Chlamydia trachomatis	lysine--tRNA ligase	0.0049	0.0414	1
Leishmania major	glucose transporter, lmgt2	0.0068	0.0621	0.868
Onchocerca volvulus		0.0031	0.0217	0.5
Onchocerca volvulus		0.0031	0.0217	0.5
Trypanosoma cruzi	sugar transporter, putative	0.0031	0.0217	0.303
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0066	0.0597	0.2583
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0067	0.0612	0.0925
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0066	0.0597	0.2583
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0067	0.0612	0.0597
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.2648
Onchocerca volvulus		0.0031	0.0217	0.5
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0067	0.0611	0.855
Toxoplasma gondii	sugar transporter ST3	0.0031	0.0217	0.0327
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0715	1
Echinococcus multilocularis	lysyl tRNA synthetase	0.0049	0.0414	0.1769
Onchocerca volvulus		0.0031	0.0217	0.5
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0067	0.0612	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0027	0.0175	0.0709
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0012	0.0016	0.0245
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0217	0.0894
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0715	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.2648

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 738249