Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.7967 | 0.861 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.4881 | 0.5275 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0199 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0199 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.7967 | 0.861 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3186 | 0.3845 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0199 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0199 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.7967 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.9254 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.4881 | 0.6027 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0518 | 0.041 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.3599 | 0.3469 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0199 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0199 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0851 | 0.0839 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0851 | 0.0839 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0199 | 0.0215 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.7967 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3611 | 0.3902 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0199 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4357 | 0.4709 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.7956 | 0.9985 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0333 | 0.0173 |
Brugia malayi | RNA binding protein | 0.0062 | 0.7967 | 0.7926 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0199 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.7332 | 0.9182 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0199 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0851 | 0.0839 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0199 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0199 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.7967 | 0.7926 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.7967 | 0.861 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.4881 | 0.6027 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.7967 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.4881 | 0.6027 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4024 | 0.4348 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.7967 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.4881 | 0.6027 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3186 | 0.3845 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0333 | 0.0173 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0199 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.7967 | 0.7926 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0333 | 0.0173 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.4881 | 0.6027 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.7967 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0518 | 0.0559 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.7967 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.7967 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.4881 | 0.6027 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.4881 | 0.4777 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.7332 | 0.9182 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0199 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.1264 | 0.1086 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.4881 | 0.6027 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0199 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0199 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.