Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.1314 | 0.2921 | 0.5 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.4417 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.365 | 0.825 | 0.8192 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1314 | 0.2921 | 0.2686 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1314 | 0.2921 | 0.2686 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1314 | 0.2921 | 0.2921 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.3103 | 0.7003 | 0.5766 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.1314 | 0.2921 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3103 | 0.7003 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0082 | 0.0112 | 0.0112 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.1314 | 0.2921 | 0.2921 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.4417 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Treponema pallidum | uridine phosphorylase (udp) | 0.365 | 0.825 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0052 | 0.0042 | 0.0042 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.365 | 0.825 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0082 | 0.0112 | 0.0112 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1314 | 0.2921 | 0.2921 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.365 | 0.825 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.1314 | 0.2921 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.365 | 0.825 | 0.5 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0115 | 0.0187 | 0.0187 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Leishmania major | nucleoside phosphorylase-like protein | 0.1314 | 0.2921 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.3103 | 0.7003 | 0.5766 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0082 | 0.0112 | 0.0112 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.365 | 0.825 | 0.5 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.1314 | 0.2921 | 0.2921 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.1314 | 0.2921 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1314 | 0.2921 | 0.2686 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1314 | 0.2921 | 0.2686 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0059 | 0.0058 | 0.0058 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.1314 | 0.2921 | 0.5 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.4417 | 1 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.4417 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.365 | 0.825 | 0.8192 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.365 | 0.825 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Trypanosoma brucei | uridine phosphorylase | 0.1314 | 0.2921 | 0.5 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.3103 | 0.7003 | 0.5766 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1314 | 0.2921 | 0.2686 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0059 | 0.0058 | 0.0058 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.1314 | 0.2921 | 0.5 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.4417 | 1 | 1 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.365 | 0.825 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.1314 | 0.2921 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1314 | 0.2921 | 0.2686 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.1314 | 0.2921 | 0.2921 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.1314 | 0.2921 | 0.2686 |
Chlamydia trachomatis | AMP nucleosidase | 0.1314 | 0.2921 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0059 | 0.0058 | 0.0058 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.4417 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv. | ChEMBL. | 3934384 |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv. | ChEMBL. | 3934384 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity against Mycobacterium kansasii | ChEMBL. | 3934384 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity against Mycobacterium intracellulare. | ChEMBL. | 3934384 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.