Detailed information for compound 755655

Basic information

Technical information
  • TDR Targets ID: 755655
  • Name: 1-(1-tert-butyl-1,3,4,9-tetrahydropyrido[3,4- b]indol-2-yl)-3-methoxypropan-1-one
  • MW: 314.422 | Formula: C19H26N2O2
  • H donors: 1 H acceptors: 1 LogP: 2.96 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCC(=O)N1CCc2c(C1C(C)(C)C)[nH]c1c2cccc1
  • InChi: 1S/C19H26N2O2/c1-19(2,3)18-17-14(13-7-5-6-8-15(13)20-17)9-11-21(18)16(22)10-12-23-4/h5-8,18,20H,9-12H2,1-4H3
  • InChiKey: ZBFXNXCJZRWKDH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(1-tert-butyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)-3-methoxy-propan-1-one
  • 1-(1-tert-butyl-1,3,4,9-tetrahydro-$b-carbolin-2-yl)-3-methoxy-propan-1-one
  • MLS000734790
  • SMR000319537
  • 1-tert-butyl-2-(3-methoxypropanoyl)-2,3,4,9-tetrahydro-1H-beta-carboline

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0195 0.268 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0031 0.0123
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0184 0.0606
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0076 0.0559
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0186 0.2558 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1726 0.6396
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0758 0.075
Schistosoma mansoni ap endonuclease 0.0019 0.0184 0.0176
Brugia malayi hypothetical protein 0.0012 0.0076 0.0169
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0076 0.2928
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0085 0.0076
Echinococcus granulosus Chromo domain 0.0012 0.0076 0.0067
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.132 0.4866
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0076 0.082
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0524 0.5644
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0169
Onchocerca volvulus 0.0012 0.0085 0.1087
Schistosoma mansoni hypothetical protein 0.0031 0.0356 0.0347
Giardia lamblia Ribonuclease H 0.0026 0.0274 0.3109
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0076 0.082
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0076 0.082
Entamoeba histolytica hypothetical protein 0.0012 0.0076 0.1017
Echinococcus multilocularis ribonuclease H1 0.0026 0.0274 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0125 0.1344
Echinococcus multilocularis chromobox protein 2 0.0012 0.0076 0.0067
Schistosoma mansoni hypothetical protein 0.0031 0.0356 0.0347
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0472 0.0464
Schistosoma mansoni smad1 5 8 and 0.0009 0.0033 0.0024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0356 0.0347
Echinococcus multilocularis cpg binding protein 0.003 0.0332 0.0324
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0472 0.0464
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0076 0.0067
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0833 0.0825
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0472 0.0464
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0076 0.2928
Trichomonas vaginalis antibiotic synthetase, putative 0.0009 0.0031 0.0337
Leishmania major ribonuclease H1, putative 0.0026 0.0274 0.107
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0356 0.0347
Brugia malayi RNase H family protein 0.0026 0.0274 0.0915
Trichomonas vaginalis ribonuclease H1, putative 0.0026 0.0274 0.295
Trypanosoma cruzi ribonuclease H1, putative 0.0026 0.0274 0.1056
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0099 0.009
Leishmania major 4-coumarate:coa ligase-like protein 0.0009 0.0031 0.0123
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0472 0.182
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0472 0.5085
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0033 0.0024
Brugia malayi Protein cec-1. 0.0012 0.0076 0.0169
Brugia malayi MH1 domain containing protein 0.0009 0.0033 0.0007
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0184 0.0176
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0472 1
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0076 0.082
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0184 0.0578
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0184 0.1987
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0169
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0125 0.1344
Brugia malayi CHD4 protein 0.0013 0.0099 0.0255
Echinococcus multilocularis microtubule associated protein 2 0.0708 1 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0009 0.0031 0.0023
Loa Loa (eye worm) hypothetical protein 0.0099 0.132 0.4866
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0076 0.082
Brugia malayi Smad1 0.0009 0.0033 0.0007
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0833 0.3257
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0472 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.132 0.4866
Brugia malayi SET domain containing protein 0.0012 0.0085 0.0202
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0472 0.1663
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0076 0.2928
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0184 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0167 0.1796
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0076 0.1017
Schistosoma mansoni hypothetical protein 0.0031 0.0356 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0076 0.082
Entamoeba histolytica hypothetical protein 0.0012 0.0076 0.1017
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0076 0.0169
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0833 0.0825
Echinococcus granulosus cpg binding protein 0.003 0.0332 0.0324
Schistosoma mansoni cpg binding protein 0.003 0.0332 0.0324
Leishmania major 4-coumarate:coa ligase-like protein 0.0009 0.0031 0.0123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0167 0.1796
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0667 0.793
Toxoplasma gondii ribonuclease HI protein 0.0026 0.0274 0.3024
Echinococcus multilocularis chromobox protein 1 0.0072 0.0928 0.092
Echinococcus granulosus chromobox protein 2 0.0012 0.0076 0.0067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0076 0.082
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0309 0.105
Brugia malayi chromobox protein homolog 3 0.004 0.048 0.1696
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0472 0.0464
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0033 0.0007
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0076 0.0067
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0184 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0472 0.5085
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0033 0.0024
Onchocerca volvulus 0.0028 0.0309 0.5645
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0076 0.082
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0099 0.009
Onchocerca volvulus 0.0012 0.0076 0.091
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0033 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.004 0.048 0.5176
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0076 0.0067
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0076 0.2928
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0169
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0076 0.0067
Brugia malayi RNase H family protein 0.0026 0.0274 0.0915
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0188 0.2593 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0076 0.082
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0076 0.2928
Brugia malayi MH2 domain containing protein 0.0009 0.0033 0.0007
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0472 0.0464
Brugia malayi RNase H family protein 0.0026 0.0274 0.0915
Brugia malayi Heterochromatin protein 1 0.0072 0.0928 0.3386
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0356 0.1225
Echinococcus granulosus long chain fatty acid transport protein 4 0.0188 0.2593 0.2587
Trypanosoma brucei ingi protein (ORF1) 0.0031 0.0356 0.0923
Schistosoma mansoni chromobox protein 0.0072 0.0928 0.092
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0188 0.2593 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0184 0.1909
Loa Loa (eye worm) helicase 0.0012 0.0076 0.0169
Schistosoma mansoni chromobox protein 0.0012 0.0076 0.0067
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0833 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0169
Echinococcus granulosus ribonuclease H1 0.0026 0.0274 0.0265
Schistosoma mansoni phosphoglucomutase 0.0026 0.0274 0.0265
Trypanosoma brucei ribonuclease H1 0.0026 0.0274 0.0688
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0874 0.3181
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0167 0.1796
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0169
Schistosoma mansoni chromobox protein 0.0012 0.0076 0.0067
Treponema pallidum ribonuclease H (rnhA) 0.0026 0.0274 1
Echinococcus multilocularis smad 0.0009 0.0033 0.0024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0118 0.1273
Schistosoma mansoni FFA transport protein 0.0188 0.2593 0.2587
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0184 0.0711
Schistosoma mansoni smad1 5 8 and 0.0009 0.0033 0.0024
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0928 1
Schistosoma mansoni Smad4 0.0009 0.0033 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0169
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0009 0.0031 0.0121
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0356 0.1225
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0099 0.009
Trypanosoma brucei unspecified product 0.0031 0.0356 0.0923
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0033 0.0024
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0033 0.0024
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0076 0.082
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0026 0.0274 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0076 0.082
Schistosoma mansoni phosphoglucomutase 0.0026 0.0274 0.0265
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0076 0.0169
Brugia malayi MH1 domain containing protein 0.0009 0.0033 0.0007
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0076 0.0559
Leishmania major acetyl-CoA synthetase, putative 0.0009 0.0031 0.0123
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0033 0.0007
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0009 0.0031 0.0023
Loa Loa (eye worm) Smad1 0.0009 0.0033 0.0007
Schistosoma mansoni cpg binding protein 0.003 0.0332 0.0324
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0195 0.268 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0184 0.0711
Leishmania major fatty acid transporter protein-like protein 0.0186 0.2558 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0169
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0472 0.0464
Schistosoma mansoni hypothetical protein 0.04 0.5606 0.5602
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0195 0.268 1
Echinococcus granulosus smad 0.0009 0.0033 0.0024
Schistosoma mansoni microtubule-associated protein tau 0.0708 1 1
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0076 0.082
Echinococcus granulosus chromobox protein 1 0.0072 0.0928 0.092
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0099 0.0255
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0833 0.3027
Echinococcus granulosus dnaJ subfamily B 0.04 0.5606 0.5602
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0928 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.132 0.4866
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0356 0.0347
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0833 0.3027
Schistosoma mansoni hypothetical protein 0.0068 0.0874 0.0866
Echinococcus multilocularis dnaJ subfamily B 0.04 0.5606 0.5602
Leishmania major acetyl-CoA synthetase, putative 0.0009 0.0031 0.0123
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0076 0.0067
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0356 0.0923
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0032 0.0001
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0076 0.0067
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0928 0.3386
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0314 0.338
Echinococcus multilocularis Smad4 0.0009 0.0033 0.0024
Echinococcus multilocularis chromobox protein 1 0.0072 0.0928 0.092
Echinococcus granulosus Chromobox protein 3 0.0012 0.0076 0.0067
Echinococcus granulosus Smad4 0.0009 0.0033 0.0024
Schistosoma mansoni phosphoglucomutase 0.0026 0.0274 0.0265
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.048 0.912
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0472 0.0464
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0472 0.0464
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0009 0.0031 0.0121
Trypanosoma brucei RNA helicase, putative 0.0256 0.3554 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0184 0.0578
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0033 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.004 0.048 0.5176
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0076 0.1017
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0833 0.0825
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1726 0.6396
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0184 0.1987
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0833 0.0825
Loa Loa (eye worm) hypothetical protein 0.0039 0.0472 0.1663
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0472 0.182
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0833 0.3027
Echinococcus multilocularis Chromo domain 0.0012 0.0076 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0076 0.082
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0167 0.1796
Brugia malayi MH2 domain containing protein 0.0127 0.1726 0.6396
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0356 0.1225
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0167 0.1796
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0314 0.338
Loa Loa (eye worm) hypothetical protein 0.0031 0.0356 0.1225
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0833 0.3173
Schistosoma mansoni acetyl-CoA synthetase 0.0009 0.0031 0.0023
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0184 0.0578
Schistosoma mansoni smad1 5 8 and 0.0009 0.0033 0.0024
Schistosoma mansoni cpg binding protein 0.0028 0.0309 0.0301
Schistosoma mansoni chromobox protein 0.0072 0.0928 0.092
Brugia malayi MH2 domain containing protein 0.0009 0.0033 0.0007
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0031 0.0121
Loa Loa (eye worm) hypothetical protein 0.004 0.048 0.1696
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0472 0.5085
Entamoeba histolytica hypothetical protein 0.0012 0.0076 0.1017
Schistosoma mansoni hypothetical protein 0.0256 0.3554 0.3548
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0186 0.2558 1
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0076 0.0169
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0524 1
Onchocerca volvulus 0.0012 0.0076 0.091
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0076 0.082
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0033 0.0024
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0188 0.2593 0.2587
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0184 0.0721
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0076 0.0559
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0167 0.1796
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0184 0.3474
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0472 0.1845
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0184 0.0435
Schistosoma mansoni hypothetical protein 0.0012 0.0076 0.0067
Schistosoma mansoni smad 0.0009 0.0033 0.0024
Echinococcus multilocularis GPCR, family 2 0.0031 0.0356 0.0347
Loa Loa (eye worm) hypothetical protein 0.0068 0.0874 0.3181
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0472 0.1251
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0167 0.1796
Trichomonas vaginalis hypothetical protein 0.0012 0.0076 0.082
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0184 0.0176
Trichomonas vaginalis antibiotic synthetase, putative 0.0009 0.0031 0.0337
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0031 0.0121
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0076 0.2928
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0033 0.0007
Echinococcus granulosus GPCR family 2 0.0031 0.0356 0.0347
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0031 0.0356 0.0923
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0356 0.0347
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0076 0.1017
Onchocerca volvulus Ribonuclease H1 homolog 0.0026 0.0274 0.4924
Leishmania major 4-coumarate:coa ligase-like protein 0.0009 0.0031 0.0123
Trypanosoma brucei ingi protein (ORF1) 0.0031 0.0356 0.0923
Loa Loa (eye worm) hypothetical protein 0.0031 0.0357 0.123
Schistosoma mansoni ap endonuclease 0.0019 0.0184 0.0176
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0167 0.1796
Schistosoma mansoni hypothetical protein 0.0031 0.0356 0.0347
Echinococcus granulosus chromobox protein 1 0.0072 0.0928 0.092
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0524 0.5644
Onchocerca volvulus 0.0031 0.0357 0.6614
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0076 0.082
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0076 0.0169
Trypanosoma cruzi ribonuclease H1, putative 0.0026 0.0274 0.1056
Brugia malayi CXXC zinc finger family protein 0.0028 0.0309 0.105

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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