Detailed information for compound 759551

Basic information

Technical information
  • TDR Targets ID: 759551
  • Name: N-(2,5-dimethylphenyl)-3-[4-(2-methoxyphenyl) piperazin-1-yl]propanamide
  • MW: 367.485 | Formula: C22H29N3O2
  • H donors: 1 H acceptors: 1 LogP: 3.36 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)CCC(=O)Nc1cc(C)ccc1C
  • InChi: 1S/C22H29N3O2/c1-17-8-9-18(2)19(16-17)23-22(26)10-11-24-12-14-25(15-13-24)20-6-4-5-7-21(20)27-3/h4-9,16H,10-15H2,1-3H3,(H,23,26)
  • InChiKey: KHUBTVNYEOAZNJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,5-dimethylphenyl)-3-[4-(2-methoxyphenyl)-1-piperazinyl]propanamide
  • N-(2,5-dimethylphenyl)-3-[4-(2-methoxyphenyl)piperazin-1-yl]propionamide
  • N-(2,5-Dimethyl-phenyl)-3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propionamide
  • Oprea1_588606
  • STK146093
  • Oprea1_004973
  • BAS 03086423

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0101 0.0637 0.1813
Schistosoma mansoni protein kinase 0.0101 0.0637 0.2654
Echinococcus multilocularis General substrate transporter 0.0283 0.1952 0.5813
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0175 0.0409
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0532 0.3751 0.3725
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Onchocerca volvulus 0.0046 0.0243 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0329 0.2287 0.683
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Chlamydia trachomatis proline--tRNA ligase 0.0035 0.0161 0.2978
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Onchocerca volvulus 0.0046 0.0243 1
Echinococcus multilocularis neuropeptide s receptor 0.0474 0.3329 1
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Entamoeba histolytica hypothetical protein 0.0073 0.044 0.6689
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0073 0.044 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0175 0.0655
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0329 0.2287 0.683
Leishmania major hypothetical protein, conserved 0.0016 0.0027 0.0368
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0027 0.0368
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0027 0.0368
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Brugia malayi beta-lactamase family protein 0.0037 0.0175 0.0767
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0175 0.0409
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0243 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0243 0.0956
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0019 0.0043 0.0089
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0101 0.0637 0.1813
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0115 0.0741 1
Onchocerca volvulus 0.0046 0.0243 1
Brugia malayi Major Facilitator Superfamily protein 0.0046 0.0243 0.1064
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Plasmodium vivax calcium-dependent protein kinase, putative 0.0101 0.0637 0.0599
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0019 0.0043 0.0578
Plasmodium falciparum protein kinase 7 0.093 0.6626 0.6613
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0019 0.0043 0.0187
Schistosoma mansoni glucose transport protein 0.0329 0.2287 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0041 0.0061
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0175 0.0935
Trichomonas vaginalis glucose transporter, putative 0.0046 0.0243 0.0956
Brugia malayi glycyl-tRNA synthetase 0.0019 0.0043 0.0187
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0019 0.0043 0.0262
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0175 0.0935
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0175 0.2488
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0101 0.0637 0.0599
Loa Loa (eye worm) sugar transporter 0.0046 0.0243 0.1064
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0073 0.044 0.6932
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Schistosoma mansoni protein kinase 0.0101 0.0637 0.2654
Plasmodium falciparum mitogen-activated protein kinase 2 0.0532 0.3751 0.3725
Plasmodium vivax glycine--tRNA ligase, putative 0.0019 0.0043 0.0002
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Schistosoma mansoni protein kinase 0.0101 0.0637 0.2654
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0115 0.0741 1
Trypanosoma brucei glucose transporter, putative 0.0102 0.0646 0.8729
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0027 0.0368
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0101 0.0637 0.2786
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0041 0.0932
Brugia malayi beta-lactamase 0.0037 0.0175 0.0767
Schistosoma mansoni hypothetical protein 0.0173 0.1155 0.496
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Schistosoma mansoni lysyl-tRNA synthetase 0.0073 0.044 0.1776
Giardia lamblia Lysyl-tRNA synthetase 0.0073 0.044 0.6859
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0041 0.0553
Giardia lamblia Threonyl-tRNA synthetase 0.0019 0.0043 0.0031
Trypanosoma cruzi hexose transporter, putative 0.0102 0.0646 0.8729
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0115 0.0741 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0115 0.0741 1
Chlamydia trachomatis lysine--tRNA ligase 0.0073 0.044 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0175 0.0767
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Trypanosoma cruzi hexose transporter, putative 0.0046 0.0243 0.3286
Schistosoma mansoni sugar transporter 0.0046 0.0243 0.0901
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Brugia malayi hypothetical protein 0.0046 0.0243 0.1064
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0019 0.0043 0.0187
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0329 0.2287 0.683
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0019 0.0043 0.0973
Leishmania major hypothetical protein, conserved 0.0016 0.0027 0.0368
Leishmania major lysyl-tRNA synthetase, putative 0.0073 0.044 0.5938
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0099 0.0622 0.1768
Plasmodium vivax CDK-related protein kinase 6, putative 0.1397 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0243 0.0956
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Echinococcus granulosus General substrate transporter 0.0283 0.1952 0.5813
Loa Loa (eye worm) major facilitator superfamily transporter 0.0046 0.0243 0.1064
Toxoplasma gondii facilitative glucose transporter GT1 0.0329 0.2287 0.3424
Brugia malayi Sugar transporter family protein 0.0046 0.0243 0.1064
Echinococcus granulosus solute carrier family 22 0.0046 0.0243 0.0615
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0175 0.0598
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0329 0.2287 0.683
Trypanosoma cruzi hexose transporter 0.0102 0.0646 0.8729
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0046 0.0243 0.5534
Echinococcus granulosus solute carrier family 22 0.0046 0.0243 0.0615
Trypanosoma brucei glucose transporter, putative 0.0102 0.0646 0.8729
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0019 0.0043 0.0098
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0101 0.0637 0.2786
Brugia malayi beta-lactamase family protein 0.0037 0.0175 0.0767
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0101 0.0637 0.2786
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0101 0.0637 0.0599
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0175 0.0655
Loa Loa (eye worm) hypothetical protein 0.0037 0.0175 0.0767
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Brugia malayi major facilitator superfamily protein 0.0046 0.0243 0.1064
Loa Loa (eye worm) hypothetical protein 0.0037 0.0175 0.0767
Loa Loa (eye worm) sugar transporter 0.0329 0.2287 1
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0175 0.0655
Echinococcus multilocularis solute carrier family 22 0.0046 0.0243 0.0615
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Loa Loa (eye worm) hypothetical protein 0.0037 0.0175 0.0767
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0041 0.0553
Echinococcus granulosus glycyl tRNA synthetase 0.0019 0.0043 0.0006
Onchocerca volvulus 0.0046 0.0243 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0041 0.0553
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0046 0.0243 0.0901
Trypanosoma cruzi hexose transporter, putative 0.0056 0.0312 0.4214
Echinococcus granulosus solute carrier family 22 0.0046 0.0243 0.0615
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0532 0.3751 0.5643
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0041 0.0179
Onchocerca volvulus 0.0046 0.0243 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0637 0.2786
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0041 0.0087
Mycobacterium ulcerans beta-lactamase 0.0037 0.0175 0.3986
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0329 0.2287 0.683
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0046 0.0243 0.5534
Echinococcus granulosus synaptic vesicle 2 protein 0.0046 0.0243 0.0615
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0041 0.0202 0.0883
Brugia malayi Cam kinase protein 1 0.0101 0.0637 0.2786
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Echinococcus multilocularis solute carrier family 22 0.0046 0.0243 0.0615
Toxoplasma gondii lysine-tRNA ligase 0.0073 0.044 0.0625
Trichomonas vaginalis conserved hypothetical protein 0.0329 0.2287 1
Mycobacterium ulcerans sugar transporter 0.0046 0.0243 0.5534
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0101 0.0637 0.1813
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0175 0.0598
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0637 0.2699
Plasmodium falciparum calcium-dependent protein kinase 4 0.0101 0.0637 0.0599
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0099 0.0622 0.9753
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0099 0.0622 0.1768
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0101 0.0637 0.1813
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0175 0.2367
Onchocerca volvulus 0.0046 0.0243 1
Trichomonas vaginalis myo-inositol transporter, putative 0.0046 0.0243 0.0956
Echinococcus granulosus Sugar transporter ERD6 protein 0.0046 0.0243 0.0615
Trypanosoma cruzi hexose transporter, putative 0.0102 0.0646 0.8729
Schistosoma mansoni lysyl-tRNA synthetase 0.0073 0.044 0.1776
Onchocerca volvulus 0.0046 0.0243 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0175 0.0935
Leishmania major glucose transporter, lmgt1 0.0102 0.0646 0.8729
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0046 0.0243 0.1365
Trypanosoma brucei glucose transporter, putative 0.0102 0.0646 0.8729
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0175 0.0135
Trichomonas vaginalis sugar transporter, putative 0.0102 0.0646 0.274
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Mycobacterium ulcerans hypothetical protein 0.0016 0.0027 0.0619
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0019 0.0043 0.0069
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0064 0.0374 0.1536
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0019 0.0043 0.0973
Giardia lamblia Sugar-proton symporter 0.0046 0.0243 0.3481
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0099 0.0622 0.2722
Onchocerca volvulus 0.0046 0.0243 1
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0035 0.0161 0.3661
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Schistosoma mansoni glycyl-tRNA synthetase 0.0019 0.0043 0.0008
Echinococcus multilocularis solute carrier family 22 0.0046 0.0243 0.0615
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0019 0.0043 0.003
Leishmania major glucose transporter, lmgt3 0.0102 0.0646 0.8729
Trypanosoma brucei glucose transporter 1E 0.0102 0.0646 0.8729
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0646 0.274
Toxoplasma gondii protein kinase, putative 0.093 0.6626 1
Echinococcus granulosus neuropeptide s receptor 0.0474 0.3329 1
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0019 0.0043 0.0578
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0019 0.0043 0.0187
Toxoplasma gondii sugar transporter ST1 0.0046 0.0243 0.0327
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0115 0.0741 1
Onchocerca volvulus 0.0046 0.0243 1
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Leishmania major hypothetical protein, conserved 0.0037 0.0175 0.2367
Echinococcus multilocularis neuropeptide receptor A26 0.0474 0.3329 1
Plasmodium vivax hexose transporter 0.0329 0.2287 0.2255
Plasmodium vivax proline--tRNA ligase, putative 0.0115 0.0741 0.0702
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0646 0.274
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0175 0.0655
Onchocerca volvulus 0.0046 0.0243 1
Treponema pallidum threonyl-tRNA synthetase 0.0019 0.0043 0.0151
Brugia malayi Major Facilitator Superfamily protein 0.0046 0.0243 0.1064
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0175 0.0935
Trypanosoma cruzi glucose transporter, putative 0.0046 0.0243 0.3286
Echinococcus multilocularis geminin 0.0173 0.1155 0.3388
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0041 0.0179
Plasmodium vivax lysine--tRNA ligase, putative 0.0073 0.044 0.04
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0329 0.2287 0.683
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0099 0.0622 0.2634
Trichomonas vaginalis glucose transporter, putative 0.0102 0.0646 0.274
Leishmania major threonyl-tRNA synthetase, putative 0.0019 0.0043 0.0578
Plasmodium falciparum calcium-dependent protein kinase 1 0.0101 0.0637 0.0599
Trypanosoma brucei THT1 - hexose transporter, putative 0.0102 0.0646 0.8729
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0062 0.036 0.5587
Schistosoma mansoni glucose transport protein 0.0329 0.2287 1
Leishmania major glucose transporter, lmgt2 0.0102 0.0646 0.8729
Onchocerca volvulus 0.0046 0.0243 1
Giardia lamblia Hexose transporter 0.0046 0.0243 0.3481
Echinococcus granulosus lysyl tRNA synthetase 0.0073 0.044 0.1213
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0046 0.0243 0.0615
Trypanosoma brucei sugar transporter, putative 0.0046 0.0243 0.3286
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0101 0.0637 0.0925
Mycobacterium tuberculosis Conserved protein 0.0037 0.0175 0.0935
Echinococcus multilocularis calcium dependent protein kinase 0.0095 0.0592 0.1676
Echinococcus granulosus solute carrier family 22 0.0046 0.0243 0.0615
Brugia malayi Major Facilitator Superfamily protein 0.0046 0.0243 0.1064
Loa Loa (eye worm) major facilitator superfamily transporter 0.0046 0.0243 0.1064
Brugia malayi Sugar transporter family protein 0.0329 0.2287 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0101 0.0637 0.0925
Trichomonas vaginalis sugar transporter, putative 0.0102 0.0646 0.274
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0019 0.0043 0.003
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0019 0.0043 0.0578
Plasmodium falciparum calcium-dependent protein kinase 3 0.0101 0.0637 0.0599
Toxoplasma gondii glycyl-tRNA synthetase 0.0019 0.0043 0.0024
Trypanosoma brucei glucose transporter, putative 0.0102 0.0646 0.8729
Echinococcus granulosus neuropeptide receptor A26 0.0474 0.3329 1
Toxoplasma gondii sugar transporter ST2 0.0046 0.0243 0.0327
Brugia malayi Sugar transporter family protein 0.0046 0.0243 0.1064
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0175 0.0767
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0073 0.044 0.1826
Giardia lamblia Prolyl-tRNA synthetase 0.0099 0.0622 1
Brugia malayi major facilitator superfamily protein 0.0046 0.0243 0.1064
Echinococcus granulosus Threonyl tRNA synthetase C 0.0019 0.0043 0.0006
Onchocerca volvulus 0.0046 0.0243 1
Schistosoma mansoni sugar transporter 0.0046 0.0243 0.0901
Plasmodium falciparum hexose transporter 0.0329 0.2287 0.2255
Mycobacterium ulcerans hypothetical protein 0.0037 0.0175 0.3986
Mycobacterium tuberculosis Conserved protein 0.0037 0.0175 0.0935
Loa Loa (eye worm) beta-lactamase 0.0037 0.0175 0.0767
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0329 0.2287 0.683
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0019 0.0043 0.0578
Echinococcus granulosus calcium dependent protein kinase 0.0095 0.0592 0.1676
Trypanosoma brucei glucose transporter 2A 0.0102 0.0646 0.8729
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0175 0.0935
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0329 0.2287 0.683
Toxoplasma gondii exonuclease III APE 0.0018 0.0041 0.0021
Leishmania major glucose transporter/membrane transporter D2, putative 0.0102 0.0646 0.8729
Giardia lamblia Glycyl-tRNA synthetase 0.0019 0.0043 0.0031
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0019 0.0043 0.0187
Leishmania major protein kinase, putative 0.0101 0.0637 0.8603
Plasmodium falciparum calcium-dependent protein kinase 2 0.0101 0.0637 0.0599
Schistosoma mansoni hypothetical protein 0.0173 0.1155 0.496
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0019 0.0043 0.0024
Mycobacterium tuberculosis Conserved protein 0.0037 0.0175 0.0935
Onchocerca volvulus 0.0046 0.0243 1
Schistosoma mansoni sugar transporter 0.0046 0.0243 0.0901
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0041 0.0061
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0062 0.036 0.2101
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.161 1
Trypanosoma cruzi hexose transporter, putative 0.0102 0.0646 0.8729
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0637 0.2654
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0101 0.0637 0.1813
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0099 0.0622 0.2722
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0175 0.0655
Entamoeba histolytica protein kinase, putative 0.0101 0.0637 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0622 0.2722
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0101 0.0637 0.1813
Echinococcus granulosus geminin 0.0173 0.1155 0.3388
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Plasmodium vivax sugar transporter, putative 0.0046 0.0243 0.0203
Loa Loa (eye worm) hypothetical protein 0.0073 0.044 0.1923
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0175 0.2367
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0027 0.0368
Plasmodium falciparum threonine--tRNA ligase 0.0019 0.0043 0.0002
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0073 0.044 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.0175 0.2488
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0099 0.0622 1
Trichomonas vaginalis glucose transporter, putative 0.0102 0.0646 0.274
Onchocerca volvulus 0.0046 0.0243 1
Trypanosoma brucei glucose transporter, putative 0.0102 0.0646 0.8729
Echinococcus multilocularis synaptic vesicle 2 protein 0.0046 0.0243 0.0615
Onchocerca volvulus Putative transporter 0.0046 0.0243 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0489 0.2137
Plasmodium falciparum proline--tRNA ligase 0.0115 0.0741 0.0702
Trypanosoma cruzi sugar transporter, putative 0.0046 0.0243 0.3286
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0019 0.0043 0.0089
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0046 0.0243 1
Toxoplasma gondii ABC1 family protein 0.0037 0.0175 0.0224
Schistosoma mansoni hypothetical protein 0.0329 0.2287 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0041 0.0553
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0115 0.0741 0.1081
Trypanosoma brucei glucose transporter, putative 0.0102 0.0646 0.8729
Loa Loa (eye worm) hypothetical protein 0.0037 0.0175 0.0767
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0099 0.0622 0.2589
Trypanosoma brucei glucose transporter, putative 0.0102 0.0646 0.8729
Echinococcus multilocularis solute carrier family 22 0.0046 0.0243 0.0615
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Schistosoma mansoni glucose transporter 0.0046 0.0243 0.0901
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0101 0.0637 0.0599
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Plasmodium falciparum lysine--tRNA ligase 0.0073 0.044 0.04
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Trichomonas vaginalis sugar transport protein, putative 0.0046 0.0243 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Echinococcus multilocularis glycyl tRNA synthetase 0.0019 0.0043 0.0006
Mycobacterium ulcerans lipase LipD 0.0037 0.0175 0.3986
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Brugia malayi lysyl-tRNA synthetase 0.0073 0.044 0.1923
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0243 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0243 0.0956
Trypanosoma brucei glucose transporter, putative 0.0102 0.0646 0.8729
Brugia malayi hypothetical protein 0.0046 0.0243 0.1064
Trypanosoma brucei THT1 - hexose transporter, putative 0.0102 0.0646 0.8729
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0175 0.0935
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0175 0.2367
Loa Loa (eye worm) hypothetical protein 0.0046 0.0243 0.1064
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0175 0.3986
Loa Loa (eye worm) hypothetical protein 0.0037 0.0175 0.0767
Trichomonas vaginalis esterase, putative 0.0037 0.0175 0.0655
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0073 0.044 0.5938
Brugia malayi hypothetical protein 0.0046 0.0243 0.1064
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0101 0.0637 0.8603
Toxoplasma gondii sugar transporter ST3 0.0046 0.0243 0.0327
Plasmodium vivax threonine--tRNA ligase, putative 0.0019 0.0043 0.0002
Echinococcus multilocularis lysyl tRNA synthetase 0.0073 0.044 0.1213
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0073 0.044 0.5938
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0027 0.0368
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0101 0.0637 0.1813
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Loa Loa (eye worm) hypothetical protein 0.0099 0.0622 0.2722
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0175 0.0935
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0099 0.0622 0.2589
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0062 0.036 0.2101
Plasmodium falciparum calcium-dependent protein kinase 5 0.0101 0.0637 0.0599
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0101 0.0637 0.0925
Schistosoma mansoni glucose transport protein 0.0329 0.2287 1
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Schistosoma mansoni sugar transporter 0.0046 0.0243 0.0901
Loa Loa (eye worm) hypothetical protein 0.0037 0.0175 0.0767
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0175 0.3986
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0101 0.0637 0.1813
Onchocerca volvulus 0.0046 0.0243 1
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0046 0.0243 0.1365
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0046 0.0243 0.3286
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0046 0.0243 0.0203
Onchocerca volvulus 0.0046 0.0243 1
Mycobacterium ulcerans integral membrane transport protein 0.0046 0.0243 0.5534
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Entamoeba histolytica protein kinase, putative 0.0101 0.0637 1
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0243 0.0956
Treponema pallidum prolyl-tRNA synthetase 0.0035 0.0161 1
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0019 0.0043 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0102 0.0646 0.274
Toxoplasma gondii transporter, major facilitator family protein 0.0046 0.0243 0.0327
Leishmania major myo-inositol/proton symporter (MIT) 0.0046 0.0243 0.3286
Trypanosoma brucei THT1 - hexose transporter, putative 0.0102 0.0646 0.8729
Leishmania major hypothetical protein, conserved 0.0046 0.0243 0.3286

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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