TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 492.563 | Formula: C28H32N2O6
H donors: 1 H acceptors: 3 LogP: 3.6 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: C=CCOc1ccc(c(c1)C)C(=O)C1=C(O)C(=O)N(C1c1ccc(cc1)OC)CCN1CCOCC1
InChi: 1S/C28H32N2O6/c1-4-15-36-22-9-10-23(19(2)18-22)26(31)24-25(20-5-7-21(34-3)8-6-20)30(28(33)27(24)32)12-11-29-13-16-35-17-14-29/h4-10,18,25,32H,1,11-17H2,2-3H3
InChiKey: QWORQHUWGGTCDD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0115	0.5
Leishmania major	glycerol uptake protein, putative	0.0066	0.0775	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0017	0.0129	0.0129
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0066	0.0775	0.0775
Schistosoma mansoni	hypothetical protein	0.0015	0.0107	0.0107
Echinococcus multilocularis	cpg binding protein	0.0059	0.0681	0.0681
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0115	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.113	0.113
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0107	0.0107
Brugia malayi	CXXC zinc finger family protein	0.0056	0.064	0.064
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0066	0.0775	0.0775
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0118	0.1463	0.1463
Loa Loa (eye worm)	cytochrome P450 family protein	0.0046	0.0512	0.0512
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0115	0.0115
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.0115	1
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0066	0.0775	0.0775
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0066	0.0775	0.0775
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0107	0.1382
Leishmania major	glycerol uptake protein, putative	0.0066	0.0775	1
Brugia malayi	hypothetical protein	0.0035	0.0365	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0775	0.0775
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.0115	0.5
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0066	0.0775	0.0775
Schistosoma mansoni	hypothetical protein	0.0035	0.0365	0.0365
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.051	0.6027
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0341	0.0341
Trypanosoma cruzi	GUP1, putative	0.0066	0.0775	1
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0107	0.0107
Brugia malayi	MBOAT family protein	0.0066	0.0775	0.0775
Leishmania major	glycerol uptake protein, putative	0.0066	0.0775	1
Loa Loa (eye worm)	MBOAT family protein	0.0066	0.0775	0.0775
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0115	0.1479
Trypanosoma brucei	glycerol uptake protein, putative	0.0066	0.0775	1
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0115	0.1479
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.001	0.001
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0066	0.0775	0.0775
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0115	0.0112
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0017	0.0132	0.0132
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0014	0.0088	0.0088
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.1438	1
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0775	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0107	0.0826
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0775	1
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0107	0.0107
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0592	0.7701	0.7701
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0066	0.0775	0.5978
Leishmania major	hypothetical protein, conserved	0.0066	0.0775	1
Brugia malayi	Hhat protein	0.0066	0.0775	0.0775
Schistosoma mansoni	hypothetical protein	0.0015	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0107	0.0107
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.113	0.113
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0115	0.1479
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0014	0.0088	0.0088
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0066	0.0775	0.0775
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0107	0.0107
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0365	0.0365
Brugia malayi	diacylglycerol acyltransferase	0.0066	0.0775	0.0775
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0056	0.064	0.064
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0066	0.0775	0.0775
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0115	0.1479
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0775	1
Entamoeba histolytica	hypothetical protein	0.0066	0.0775	1
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0107	0.0107
Plasmodium vivax	glutathione reductase, putative	0.0046	0.051	0.6027
Loa Loa (eye worm)	hypothetical protein	0.0293	0.377	0.377
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.0115	0.0112
Plasmodium falciparum	thioredoxin reductase	0.0046	0.051	0.6027
Brugia malayi	Muscleblind-like protein	0.0293	0.377	0.377
Trypanosoma cruzi	glycerol uptake protein, putative	0.0066	0.0775	1
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0016	0.0115	0.0797
Leishmania major	trypanothione reductase	0.0046	0.051	0.6576
Schistosoma mansoni	cpg binding protein	0.0056	0.064	0.064
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.0115	0.0112
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0015	0.0107	0.0745
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0107	0.0107
Schistosoma mansoni	sterol O-acyltransferase 1	0.0066	0.0775	0.0775
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0066	0.0775	0.0775
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0066	0.0775	0.0775
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0115	0.0115
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0017	0.0132	0.0132
Mycobacterium tuberculosis	Probable reductase	0.0105	0.1284	0.893
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0115	0.1479
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0341	0.0341
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0066	0.0775	0.0775
Schistosoma mansoni	cpg binding protein	0.0059	0.0681	0.0681
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0115	0.0884
Schistosoma mansoni	cpg binding protein	0.0059	0.0681	0.0681
Loa Loa (eye worm)	histone methyltransferase	0.0017	0.0132	0.0132
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0107	0.1382
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0015	0.0107	0.1382
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0115	0.0884
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0115	0.0613
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0107	0.0107
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.0115	1
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0066	0.0775	1
Trypanosoma cruzi	GUP1, putative	0.0066	0.0775	1
Loa Loa (eye worm)	hypothetical protein	0.0293	0.377	0.377
Trichomonas vaginalis	porcupine, putative	0.0066	0.0775	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.1284	0.893
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0775	0.0775
Toxoplasma gondii	thioredoxin reductase	0.0046	0.051	0.3931
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.113	0.113
Echinococcus granulosus	cpg binding protein	0.0059	0.0681	0.0681
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0107	0.0107
Toxoplasma gondii	hypothetical protein	0.0066	0.0775	0.5978
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0115	0.1479
Trypanosoma brucei	glycerol uptake protein, putative	0.0066	0.0775	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0775	0.0775
Echinococcus multilocularis	muscleblind protein	0.0293	0.377	0.377
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0066	0.0775	1
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0107	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0542	0.0542
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0115	0.1479
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0592	0.7701	0.7701
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0766	1	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0115	0.1479
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0066	0.0775	0.0775
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0107	0.0107
Loa Loa (eye worm)	MBOAT family protein	0.0766	1	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0014	0.0088	0.0088
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0115	0.1479
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.1438	1
Plasmodium falciparum	glutathione reductase	0.0046	0.051	0.6027
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.051	0.3544
Echinococcus granulosus	muscleblind protein	0.0293	0.377	0.377
Trypanosoma cruzi	glycerol uptake protein, putative	0.0066	0.0775	1
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0015	0.0107	0.1382
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0066	0.0775	0.0775
Echinococcus granulosus	sterol O acyltransferase 1	0.0066	0.0775	0.0775
Entamoeba histolytica	vacuolar protein sorting 26	0.0066	0.0775	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.113	0.113
Echinococcus granulosus	zinc finger protein	0.07	0.913	0.913
Trypanosoma cruzi	glycerol uptake protein, putative	0.0066	0.0775	1
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0766	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.113	0.113
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.1284	0.893
Loa Loa (eye worm)	hhat protein	0.0066	0.0775	0.0775
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0066	0.0775	1
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0066	0.0775	0.0775
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0115	0.1479
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.113	0.113
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0115	0.5
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0066	0.0775	0.0775
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0066	0.0775	0.0775
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0066	0.0775	0.0775
Brugia malayi	Thioredoxin reductase	0.0046	0.051	0.051
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0115	0.1479
Brugia malayi	MBOAT family protein	0.0066	0.0775	0.0775
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0106	0.1296	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.1438	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0115	0.1479
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0365	0.0365
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0107	0.0107
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.113	0.113
Echinococcus multilocularis	muscleblind protein 1	0.0293	0.377	0.377
Brugia malayi	MBOAT family protein	0.0066	0.0775	0.0775
Schistosoma mansoni	hypothetical protein	0.0015	0.0107	0.0107
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0107	0.0107
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0066	0.0775	0.0775
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0107	0.0107
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.0115	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0115	0.1479
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0107	0.0826
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.1284	0.893
Plasmodium falciparum	glutathione reductase	0.0016	0.0115	0.0112
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0542	0.0542
Brugia malayi	glutathione reductase	0.0046	0.051	0.051
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0107	0.0107
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0115	0.0112
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0107	0.0107
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0107	0.0107
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0115	0.0112
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0115	0.0115
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0365	0.0365
Trypanosoma brucei	trypanothione reductase	0.0046	0.051	0.6576
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.051	0.6576
Echinococcus multilocularis	zinc finger protein	0.07	0.913	0.913
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0066	0.0775	0.5978
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0066	0.0775	0.0775
Echinococcus granulosus	GPCR family 2	0.0015	0.0107	0.0107
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0066	0.0775	0.0775
Brugia malayi	Cytochrome P450 family protein	0.0046	0.0512	0.0512
Entamoeba histolytica	hypothetical protein, conserved	0.0066	0.0775	1
Leishmania major	glycerol uptake protein, putative	0.0066	0.0775	1
Treponema pallidum	alginate O-acetylation protein (algI)	0.0066	0.0775	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.1284	0.893
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0066	0.0775	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0115	0.1479
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0115	0.1479
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.1438	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.0088	0.0088
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0066	0.0775	0.0775
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0066	0.0775	0.0775
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0014	0.0088	0.0088
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0066	0.0775	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0341	0.0341
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0107	0.0107
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.1284	0.893
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0066	0.0775	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0105	0.1284	0.893
Schistosoma mansoni	hypothetical protein	0.0066	0.0775	0.0775
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0115	0.1479
Schistosoma mansoni	zinc finger protein	0.0766	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.113	0.113
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0115	0.0115
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0542	0.0542
Echinococcus multilocularis	sterol O acyltransferase 1	0.0066	0.0775	0.0775
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0542	0.0542
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0059	0.0059
Loa Loa (eye worm)	hhat protein	0.0066	0.0775	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0775	0.0775
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0115	0.0613
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0107	0.0107
Brugia malayi	MBOAT family protein	0.0066	0.0775	0.0775
Schistosoma mansoni	hypothetical protein	0.0015	0.0107	0.0107
Loa Loa (eye worm)	glutathione reductase	0.0046	0.051	0.051
Leishmania major	glycerol uptake protein, putative	0.0066	0.0775	1
Onchocerca volvulus		0.0066	0.0775	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0059	0.0059
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.051	0.051
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0115	0.1479
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.113	0.113
Loa Loa (eye worm)	MBOAT family protein	0.0066	0.0775	0.0775
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.051	0.051

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 761251