Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0152 | 0.0165 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.0119 | 0.0491 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0324 | 0.2084 | 0.6253 |
Schistosoma mansoni | hypothetical protein | 0.0316 | 0.2026 | 0.9723 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0324 | 0.2084 | 0.6253 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0324 | 0.2084 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0052 | 0.0191 | 0.0572 |
Brugia malayi | Bromodomain containing protein | 0.0082 | 0.0397 | 0.1837 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0118 | 0.0653 | 0.2958 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0059 | 0.0241 | 0.0722 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0176 | 0.0764 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.016 | 0.0943 | 0.4385 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0324 | 0.2084 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.0281 | 0.0845 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0324 | 0.2084 | 1 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.1461 | 1 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0052 | 0.0191 | 0.5 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0118 | 0.0653 | 0.2713 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0052 | 0.0191 | 0.0572 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0503 | 0.3332 | 1 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0324 | 0.2084 | 1 |
Onchocerca volvulus | 0.0052 | 0.0191 | 0.5 | |
Echinococcus granulosus | neuropeptide s receptor | 0.0503 | 0.3332 | 1 |
Brugia malayi | phosphofructokinase | 0.0118 | 0.0653 | 0.3073 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0052 | 0.0191 | 0.0915 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0052 | 0.0191 | 0.0572 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0059 | 0.0241 | 0.0722 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0503 | 0.3332 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0176 | 0.0527 |
Brugia malayi | 6-phosphofructokinase | 0.0118 | 0.0653 | 0.3073 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0059 | 0.0241 | 0.0722 |
Brugia malayi | phenylalanyl-tRNA synthetase, mitochondrial precursor, putative | 0.016 | 0.0943 | 0.4477 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0118 | 0.0653 | 0.2958 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0052 | 0.0191 | 0.0572 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0176 | 0.0527 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0324 | 0.2084 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0118 | 0.0653 | 0.3073 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.011 | 0.0592 | 0.2657 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0176 | 0.0527 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0205 | 0.1253 | 0.3761 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | 0.016 | 0.0943 | 0.2829 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0118 | 0.0653 | 0.3132 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0191 | 0.036 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0324 | 0.2084 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0191 | 0.0915 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.1461 | 1 | 1 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0118 | 0.0653 | 0.1959 |
Echinococcus granulosus | phenylalanyl tRNA synthetase | 0.016 | 0.0943 | 0.2829 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0176 | 0.0284 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0191 | 0.0915 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0324 | 0.2084 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0118 | 0.0653 | 0.2713 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0324 | 0.2084 | 1 |
Loa Loa (eye worm) | MBCTL1 | 0.0059 | 0.0241 | 0.0615 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0059 | 0.0241 | 0.0722 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0101 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0365 | 0.1248 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0059 | 0.0241 | 0.1078 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0138 | 0.0091 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.016 | 0.0943 | 0.4385 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.011 | 0.0592 | 0.2657 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.1461 | 1 | 0.5 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0205 | 0.1253 | 0.3761 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0324 | 0.2084 | 1 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.011 | 0.0592 | 0.2839 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0214 | 0.1321 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0176 | 0.0843 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0118 | 0.0653 | 0.1959 |
Toxoplasma gondii | Ferredoxin-fold anticodon binding domain-containing protein | 0.016 | 0.0943 | 0.4385 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0324 | 0.2084 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0241 | 0.0615 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0118 | 0.0653 | 0.2958 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.0309 | 0.1481 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0118 | 0.0653 | 0.2958 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0118 | 0.0653 | 0.2958 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0324 | 0.2084 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0101 | 0.0304 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0052 | 0.0191 | 0.036 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0503 | 0.3332 | 1 |
Loa Loa (eye worm) | phenylalanyl-tRNA synthetase | 0.016 | 0.0943 | 0.419 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0324 | 0.2084 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0176 | 0.0843 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0128 | 0.072 | 0.3291 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.0281 | 0.0845 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0176 | 0.0843 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0191 | 0.0836 |
Loa Loa (eye worm) | phosphofructokinase | 0.0118 | 0.0653 | 0.2713 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0118 | 0.0653 | 0.2958 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0118 | 0.0653 | 0.3132 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0176 | 0.0527 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0191 | 0.0836 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0118 | 0.0653 | 0.2958 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.011 | 0.0592 | 0.2657 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0118 | 0.0653 | 0.2958 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0059 | 0.0241 | 0.1155 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase mitochondrial | 0.016 | 0.0943 | 0.4525 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.2084 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.