Detailed information for compound 763579

Basic information

Technical information
  • TDR Targets ID: 763579
  • Name: 2-cyano-3-[2-(4-fluorophenoxy)-4-oxopyrido[1, 2-a]pyrimidin-3-yl]-N-(oxolan-2-ylmethyl)prop -2-enamide
  • MW: 434.42 | Formula: C23H19FN4O4
  • H donors: 1 H acceptors: 3 LogP: 2.01 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1c(Oc2ccc(cc2)F)nc2n(c1=O)cccc2)C(=O)NCC1CCCO1
  • InChi: 1S/C23H19FN4O4/c24-16-6-8-17(9-7-16)32-22-19(23(30)28-10-2-1-5-20(28)27-22)12-15(13-25)21(29)26-14-18-4-3-11-31-18/h1-2,5-10,12,18H,3-4,11,14H2,(H,26,29)/b15-12+
  • InChiKey: ZXBUQVSHQVKAHT-NTCAYCPXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-2-cyano-3-[2-(4-fluorophenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]-N-(oxolan-2-ylmethyl)prop-2-enamide
  • 2-cyano-3-[2-(4-fluorophenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(tetrahydrofuran-2-ylmethyl)prop-2-enamide
  • (E)-2-cyano-3-[2-(4-fluorophenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(tetrahydrofuran-2-ylmethyl)prop-2-enamide
  • 2-cyano-3-[2-(4-fluorophenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-N-(2-tetrahydrofuranylmethyl)prop-2-enamide
  • (E)-2-cyano-3-[2-(4-fluorophenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-N-(2-tetrahydrofuranylmethyl)prop-2-enamide
  • 2-cyano-3-[2-(4-fluorophenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]-N-(tetrahydrofurfuryl)acrylamide
  • (E)-2-cyano-3-[2-(4-fluorophenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]-N-(tetrahydrofurfuryl)acrylamide
  • 2-cyano-3-[2-(4-fluorophenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(oxolan-2-ylmethyl)prop-2-enamide
  • (E)-2-cyano-3-[2-(4-fluorophenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(oxolan-2-ylmethyl)prop-2-enamide
  • STOCK4S-42503

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0448 0.1952
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0448 0.0625
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0448 0.0399
Giardia lamblia Sugar-proton symporter 0.0029 0.0251 0.346
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.063 0.9752
Brugia malayi hypothetical protein 0.0029 0.0251 0.1096
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0434 0.1894
Loa Loa (eye worm) hypothetical protein 0.0063 0.063 0.2748
Echinococcus multilocularis solute carrier family 22 0.0029 0.0251 0.1096
Entamoeba histolytica protein kinase, putative 0.0064 0.0645 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.063 0.2748
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.063 0.2748
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0251 0.303
Trypanosoma cruzi hexose transporter, putative 0.0035 0.032 0.3994
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0368 1
Toxoplasma gondii sugar transporter ST1 0.0029 0.0251 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0645 0.2812
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0645 0.0597
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2293 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0251 0.0956
Leishmania major glucose transporter, lmgt3 0.0065 0.0654 0.868
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0251 0.0201
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0654 0.274
Brugia malayi Sugar transporter family protein 0.0029 0.0251 0.1096
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0251 0.0327
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.063 0.2748
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0051 0.0218
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0448 0.1952
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0051 0.0218
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0448 0.1826
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0169 0.2978
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0748 0.0701
Brugia malayi Sugar transporter family protein 0.0029 0.0251 0.1096
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0448 0.5783
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0654 0.274
Plasmodium vivax sugar transporter, putative 0.0029 0.0251 0.0201
Echinococcus multilocularis solute carrier family 22 0.0029 0.0251 0.1096
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0051 0.0222
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Loa Loa (eye worm) hypothetical protein 0.0051 0.0496 0.2165
Trypanosoma brucei glucose transporter, putative 0.0065 0.0654 0.868
Toxoplasma gondii sugar transporter ST2 0.0029 0.0251 0.0327
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0645 0.0597
Echinococcus granulosus solute carrier family 22 0.0029 0.0251 0.1096
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0448 0.6932
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0251 0.303
Schistosoma mansoni protein kinase 0.0064 0.0645 0.2812
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0654 0.274
Plasmodium falciparum hexose transporter 0.0209 0.2293 0.2253
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096
Trypanosoma brucei glucose transporter 1E 0.0065 0.0654 0.868
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.063 0.2748
Trypanosoma brucei glucose transporter 2A 0.0065 0.0654 0.868
Echinococcus multilocularis solute carrier family 22 0.0029 0.0251 0.1096
Leishmania major glucose transporter, lmgt2 0.0065 0.0654 0.868
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0051 0.0222
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0251 0.6499
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0051 0.0222
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0448 0.0399
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0251 0.5239
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0051 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0654 0.868
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0251 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0051 0.0377
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2293 1
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0654 0.274
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0645 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Toxoplasma gondii facilitative glucose transporter GT1 0.0209 0.2293 0.3424
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0051 0.0222
Schistosoma mansoni glucose transport protein 0.0209 0.2293 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Trypanosoma brucei glucose transporter, putative 0.0065 0.0654 0.868
Entamoeba histolytica hypothetical protein 0.0047 0.0448 0.6679
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.063 0.2748
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0448 0.1952
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0051 0.0468
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0251 0.0956
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0051 0.0222
Loa Loa (eye worm) MH2 domain-containing protein 0.0107 0.1131 0.4934
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0251 0.303
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0434 0.1894
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0645 0.2812
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2293 1
Leishmania major protein kinase, putative 0.0064 0.0645 0.855
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0645 0.2812
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.063 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0645 0.2812
Entamoeba histolytica protein kinase, putative 0.0064 0.0645 1
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.06 0.2616
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0645 0.855
Schistosoma mansoni protein kinase 0.0064 0.0645 0.2812
Trypanosoma cruzi hexose transporter 0.0065 0.0654 0.868
Loa Loa (eye worm) transcription factor SMAD2 0.0107 0.1131 0.4934
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.021 0.0915
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0654 0.274
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0654 0.274
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2293 1
Loa Loa (eye worm) sugar transporter 0.0209 0.2293 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0748 1
Schistosoma mansoni sugar transporter 0.0029 0.0251 0.1096
Schistosoma mansoni glucose transporter 0.0029 0.0251 0.1096
Schistosoma mansoni glucose transport protein 0.0209 0.2293 1
Toxoplasma gondii protein kinase, putative 0.0591 0.6629 1
Trypanosoma brucei glucose transporter, putative 0.0065 0.0654 0.868
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0654 0.274
Trypanosoma brucei glucose transporter, putative 0.0065 0.0654 0.868
Giardia lamblia Hexose transporter 0.0029 0.0251 0.346
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0654 0.868
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.063 0.2634
Schistosoma mansoni hypothetical protein 0.0209 0.2293 1
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0169 0.3243
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0434 0.1894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0748 1
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0251 0.303
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0051 0.0222
Schistosoma mansoni glucose transport protein 0.0209 0.2293 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0434 0.1894
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0448 0.1952
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0251 0.1096
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0645 0.0597
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0654 0.868
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0645 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0251 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0654 0.868
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0645 0.0597
Plasmodium vivax hexose transporter 0.0209 0.2293 0.2253
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0645 0.2812
Brugia malayi major facilitator superfamily protein 0.0029 0.0251 0.1096
Trypanosoma brucei sugar transporter, putative 0.0029 0.0251 0.303
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Echinococcus granulosus solute carrier family 22 0.0029 0.0251 0.1096
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0448 0.5783
Brugia malayi hypothetical protein 0.013 0.1394 0.6078
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0434 0.1894
Brugia malayi major facilitator superfamily protein 0.0029 0.0251 0.1096
Onchocerca volvulus 0.013 0.1394 1
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0051 0.0262
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096
Brugia malayi Cam kinase protein 1 0.0064 0.0645 0.2812
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0251 0.1096
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0645 0.0925
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0051 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0251 0.5239
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.063 0.2748
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0645 0.2812
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0645 0.0597
Brugia malayi hypothetical protein 0.0029 0.0251 0.1096
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0645 0.2699
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0251 0.1096
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0448 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0654 0.868
Loa Loa (eye worm) hypothetical protein 0.0064 0.0645 0.2812
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.063 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0434 0.1894
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0251 1
Echinococcus granulosus calcium dependent protein kinase 0.006 0.06 0.2616
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0251 0.0956
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0368 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096
Trypanosoma brucei glucose transporter, putative 0.0065 0.0654 0.868
Mycobacterium ulcerans sugar transporter 0.0029 0.0251 0.5239
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0051 0.0069
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0251 0.1096
Trypanosoma brucei glucose transporter, putative 0.0065 0.0654 0.868
Trypanosoma brucei glucose transporter, putative 0.0065 0.0654 0.868
Loa Loa (eye worm) hypothetical protein 0.0063 0.063 0.2748
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0448 0.1952
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0169 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0251 0.1096
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0051 0.0222
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0209 0.2293 1
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0251 0.1096
Echinococcus multilocularis General substrate transporter 0.018 0.1959 0.8543
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0654 0.868
Echinococcus granulosus solute carrier family 22 0.0029 0.0251 0.1096
Loa Loa (eye worm) hypothetical protein 0.013 0.1394 0.6078
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0251 0.303
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096
Plasmodium vivax CDK-related protein kinase 6, putative 0.0888 1 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2293 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0251 0.5239
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2293 1
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0051 0.0024
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0645 0.0597
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0645 0.2812
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Leishmania major glucose transporter, lmgt1 0.0065 0.0654 0.868
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0645 0.2812
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0434 0.1894
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0251 0.1096
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0338 0.3756 0.3724
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Schistosoma mansoni sugar transporter 0.0029 0.0251 0.1096
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0251 0.1096
Brugia malayi hypothetical protein 0.0029 0.0251 0.1096
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0051 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0222
Leishmania major hypothetical protein, conserved 0.0029 0.0251 0.303
Schistosoma mansoni protein kinase 0.0064 0.0645 0.2812
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0051 0.0222
Brugia malayi Sugar transporter family protein 0.0209 0.2293 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0368 0.5587
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0338 0.3756 0.5643
Trypanosoma brucei glucose transporter, putative 0.0065 0.0654 0.868
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0748 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0645 0.0925
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0251 0.6499
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0434 0.1894
Echinococcus granulosus solute carrier family 22 0.0029 0.0251 0.1096
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0645 0.2812
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0251 0.1096
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0645 0.0597
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0051 0.0222
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0748 1
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0051 0.0377
Toxoplasma gondii sugar transporter ST3 0.0029 0.0251 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0251 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0748 0.1081
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0654 0.868
Loa Loa (eye worm) hypothetical protein 0.0047 0.0448 0.1952
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0748 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0448 0.5783
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0448 0.6849
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0251 0.0956
Echinococcus granulosus General substrate transporter 0.018 0.1959 0.8543
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2293 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0338 0.3756 0.3724
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0645 0.2812
Brugia malayi MH2 domain containing protein 0.0107 0.1131 0.4934
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0645 0.0597
Echinococcus multilocularis solute carrier family 22 0.0029 0.0251 0.1096
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0051 0.0222
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0382 0.1536
Schistosoma mansoni sugar transporter 0.0029 0.0251 0.1096
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2293 1
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0251 0.1096
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0448 1
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0251 0.0956
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0448 1
Schistosoma mansoni sugar transporter 0.0029 0.0251 0.1096
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0051 0.0218
Loa Loa (eye worm) sugar transporter 0.0029 0.0251 0.1096
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0645 0.2812
Plasmodium falciparum protein kinase 7 0.0591 0.6629 0.6612
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0645 0.2812
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0748 0.0701
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0434 0.1894
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0251 0.0956
Loa Loa (eye worm) hypothetical protein 0.0029 0.0251 0.1096

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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