Detailed information for compound 763660

Basic information

Technical information
  • TDR Targets ID: 763660
  • Name: (E)-2-(4-chlorophenyl)sulfonyl-3-[2-(4-methyl phenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]pro p-2-enenitrile
  • MW: 477.92 | Formula: C24H16ClN3O4S
  • H donors: 0 H acceptors: 4 LogP: 4.01 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1c(Oc2ccc(cc2)C)nc2n(c1=O)cccc2)S(=O)(=O)c1ccc(cc1)Cl
  • InChi: 1S/C24H16ClN3O4S/c1-16-5-9-18(10-6-16)32-23-21(24(29)28-13-3-2-4-22(28)27-23)14-20(15-26)33(30,31)19-11-7-17(25)8-12-19/h2-14H,1H3/b20-14+
  • InChiKey: NQRFCGIZISTXQR-XSFVSMFZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-chlorophenyl)sulfonyl-3-[2-(4-methylphenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile
  • 2-(4-chlorophenyl)sulfonyl-3-[2-(4-methylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile
  • (E)-2-(4-chlorophenyl)sulfonyl-3-[2-(4-methylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile
  • 2-(4-chlorophenyl)sulfonyl-3-[2-(4-methylphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]prop-2-enenitrile
  • (E)-2-(4-chlorophenyl)sulfonyl-3-[2-(4-methylphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]prop-2-enenitrile
  • 2-(4-chlorophenyl)sulfonyl-3-[4-keto-2-(4-methylphenoxy)pyrido[1,2-a]pyrimidin-3-yl]acrylonitrile
  • (E)-2-(4-chlorophenyl)sulfonyl-3-[4-keto-2-(4-methylphenoxy)pyrido[1,2-a]pyrimidin-3-yl]acrylonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0164 0.0715
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Brugia malayi Major Facilitator Superfamily protein 0.0049 0.0249 0.1087
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Echinococcus granulosus neuropeptide receptor A26 0.0469 0.3111 1
Trypanosoma brucei glucose transporter, putative 0.0108 0.0652 0.8739
Toxoplasma gondii glycyl-tRNA synthetase 0.002 0.0049 0.0024
Plasmodium falciparum calcium-dependent protein kinase 3 0.0107 0.0643 0.0605
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.002 0.0049 0.0653
Loa Loa (eye worm) hypothetical protein 0.0037 0.0164 0.0715
Trypanosoma brucei glucose transporter 2A 0.0108 0.0652 0.8739
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Echinococcus granulosus calcium dependent protein kinase 0.01 0.0598 0.1816
Treponema pallidum threonyl-tRNA synthetase 0.002 0.0049 0.0675
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0349 0.2291 0.7331
Loa Loa (eye worm) beta-lactamase 0.0037 0.0164 0.0715
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0164 0.2196
Plasmodium falciparum hexose transporter 0.0349 0.2291 0.226
Mycobacterium ulcerans beta-lactamase 0.0037 0.0164 0.3678
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Echinococcus granulosus Threonyl tRNA synthetase C 0.002 0.0049 0.0028
Onchocerca volvulus 0.0049 0.0249 1
Brugia malayi hypothetical protein 0.0049 0.0249 0.1087
Giardia lamblia Prolyl-tRNA synthetase 0.0105 0.0628 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0078 0.0445 0.1826
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0066 0.0365 0.2258
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.004 0.0031
Brugia malayi hypothetical protein 0.0049 0.0249 0.1087
Onchocerca volvulus 0.0049 0.0249 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0164 0.3678
Loa Loa (eye worm) threonyl-tRNA synthetase 0.002 0.0049 0.0212
Schistosoma mansoni hypothetical protein 0.0171 0.108 0.4617
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Plasmodium falciparum calcium-dependent protein kinase 2 0.0107 0.0643 0.0605
Leishmania major protein kinase, putative 0.0107 0.0643 0.8614
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.002 0.0049 0.0212
Leishmania major glucose transporter/membrane transporter D2, putative 0.0108 0.0652 0.8739
Plasmodium falciparum threonine--tRNA ligase 0.002 0.0049 0.0009
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0349 0.2291 0.7331
Toxoplasma gondii exonuclease III APE 0.0018 0.004 0.0011
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0107 0.0643 0.1962
Loa Loa (eye worm) hypothetical protein 0.0105 0.0628 0.274
Entamoeba histolytica protein kinase, putative 0.0107 0.0643 1
Leishmania major hypothetical protein, conserved 0.0037 0.0164 0.2196
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0105 0.0628 0.274
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0643 0.2676
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0107 0.0643 0.1962
Trypanosoma cruzi hexose transporter, putative 0.0108 0.0652 0.8739
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.1505 1
Plasmodium vivax proline--tRNA ligase, putative 0.0122 0.0746 0.0709
Loa Loa (eye worm) hypothetical protein 0.0037 0.0164 0.0715
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0652 0.274
Plasmodium vivax hexose transporter 0.0349 0.2291 0.226
Echinococcus multilocularis neuropeptide receptor A26 0.0469 0.3111 1
Trichomonas vaginalis esterase, putative 0.0037 0.0164 0.0579
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Onchocerca volvulus 0.0049 0.0249 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0122 0.0746 1
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.002 0.0049 0.0212
Toxoplasma gondii sugar transporter ST1 0.0049 0.0249 0.0327
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.002 0.0049 0.0653
Toxoplasma gondii protein kinase, putative 0.0985 0.6628 1
Echinococcus granulosus neuropeptide s receptor 0.0469 0.3111 1
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0652 0.274
Trypanosoma brucei glucose transporter 1E 0.0108 0.0652 0.8739
Leishmania major glucose transporter, lmgt3 0.0108 0.0652 0.8739
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.002 0.0049 0.0262
Echinococcus multilocularis solute carrier family 22 0.0049 0.0249 0.0681
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.002 0.0049 0.0409
Trichomonas vaginalis glucose transporter, putative 0.0108 0.0652 0.274
Leishmania major threonyl-tRNA synthetase, putative 0.002 0.0049 0.0653
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0349 0.2291 0.7331
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0105 0.0628 0.2634
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Plasmodium vivax lysine--tRNA ligase, putative 0.0078 0.0445 0.0407
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.004 0.0175
Echinococcus multilocularis geminin 0.0171 0.108 0.3385
Schistosoma mansoni glucose transporter 0.0049 0.0249 0.0928
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0164 0.0888
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0249 0.0956
Giardia lamblia Glycyl-tRNA synthetase 0.002 0.0049 0.0146
Onchocerca volvulus 0.0049 0.0249 1
Echinococcus granulosus lysyl tRNA synthetase 0.0078 0.0445 0.132
Onchocerca volvulus 0.0049 0.0249 1
Giardia lamblia Hexose transporter 0.0049 0.0249 0.3556
Leishmania major glucose transporter, lmgt2 0.0108 0.0652 0.8739
Schistosoma mansoni glucose transport protein 0.0349 0.2291 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0066 0.0365 0.5587
Leishmania major hypothetical protein, conserved 0.0049 0.0249 0.3339
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.0108 0.0652 0.8739
Plasmodium falciparum calcium-dependent protein kinase 1 0.0107 0.0643 0.0605
Plasmodium vivax threonine--tRNA ligase, putative 0.002 0.0049 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0108 0.0652 0.274
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0107 0.0643 0.0925
Brugia malayi Sugar transporter family protein 0.0349 0.2291 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0049 0.0249 0.1087
Echinococcus granulosus solute carrier family 22 0.0049 0.0249 0.0681
Brugia malayi Major Facilitator Superfamily protein 0.0049 0.0249 0.1087
Echinococcus multilocularis calcium dependent protein kinase 0.01 0.0598 0.1816
Mycobacterium tuberculosis Conserved protein 0.0037 0.0164 0.0888
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0107 0.0643 0.0925
Trypanosoma brucei sugar transporter, putative 0.0049 0.0249 0.3339
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0049 0.0249 0.0681
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0017 0.0033 0.0444
Echinococcus multilocularis lysyl tRNA synthetase 0.0078 0.0445 0.132
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0078 0.0445 0.597
Giardia lamblia Threonyl-tRNA synthetase 0.002 0.0049 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0107 0.0643 0.8614
Brugia malayi major facilitator superfamily protein 0.0049 0.0249 0.1087
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0078 0.0445 0.597
Loa Loa (eye worm) hypothetical protein 0.0037 0.0164 0.0715
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0164 0.0579
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0066 0.0365 0.2258
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0105 0.0628 0.2611
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0164 0.0888
Loa Loa (eye worm) hypothetical protein 0.0105 0.0628 0.274
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0107 0.0643 0.1962
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0049 0.0249 0.021
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0049 0.0249 0.3339
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Echinococcus granulosus solute carrier family 22 0.0049 0.0249 0.0681
Onchocerca volvulus 0.0049 0.0249 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0164 0.0888
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0107 0.0643 0.1962
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0164 0.3678
Schistosoma mansoni sugar transporter 0.0049 0.0249 0.0928
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0107 0.0643 0.0925
Plasmodium falciparum calcium-dependent protein kinase 5 0.0107 0.0643 0.0605
Schistosoma mansoni glucose transport protein 0.0349 0.2291 1
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0249 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.0108 0.0652 0.8739
Leishmania major myo-inositol/proton symporter (MIT) 0.0049 0.0249 0.3339
Toxoplasma gondii sugar transporter ST2 0.0049 0.0249 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0108 0.0652 0.274
Chlamydia trachomatis proline--tRNA ligase 0.0037 0.0167 0.2978
Schistosoma mansoni glycyl-tRNA synthetase 0.002 0.0049 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Entamoeba histolytica protein kinase, putative 0.0107 0.0643 1
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Mycobacterium ulcerans integral membrane transport protein 0.0049 0.0249 0.5593
Onchocerca volvulus 0.0049 0.0249 1
Plasmodium vivax sugar transporter, putative 0.0049 0.0249 0.021
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.002 0.0049 0.0653
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0078 0.0445 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.0164 0.2197
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0033 0.0444
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0164 0.0579
Loa Loa (eye worm) hypothetical protein 0.0078 0.0445 0.1944
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Echinococcus granulosus geminin 0.0171 0.108 0.3385
Brugia malayi Sugar transporter family protein 0.0049 0.0249 0.1087
Toxoplasma gondii ABC1 family protein 0.0037 0.0164 0.0198
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.002 0.0049 0.0142
Trypanosoma cruzi sugar transporter, putative 0.0049 0.0249 0.3339
Loa Loa (eye worm) hypothetical protein 0.0085 0.0494 0.2157
Plasmodium falciparum proline--tRNA ligase 0.0122 0.0746 0.0709
Echinococcus multilocularis synaptic vesicle 2 protein 0.0049 0.0249 0.0681
Onchocerca volvulus Putative transporter 0.0049 0.0249 1
Trypanosoma brucei glucose transporter, putative 0.0108 0.0652 0.8739
Onchocerca volvulus 0.0049 0.0249 1
Trichomonas vaginalis glucose transporter, putative 0.0108 0.0652 0.274
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0105 0.0628 1
Echinococcus multilocularis glycyl tRNA synthetase 0.002 0.0049 0.0028
Trichomonas vaginalis sugar transport protein, putative 0.0049 0.0249 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Plasmodium falciparum lysine--tRNA ligase 0.0078 0.0445 0.0407
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0107 0.0643 0.0605
Brugia malayi hypothetical protein 0.0049 0.0249 0.1087
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Echinococcus multilocularis solute carrier family 22 0.0049 0.0249 0.0681
Trypanosoma brucei glucose transporter, putative 0.0108 0.0652 0.8739
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0164 0.0579
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0105 0.0628 0.2611
Trypanosoma brucei glucose transporter, putative 0.0108 0.0652 0.8739
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0122 0.0746 0.1081
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.004 0.0538
Schistosoma mansoni hypothetical protein 0.0349 0.2291 1
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0164 0.0888
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Loa Loa (eye worm) hypothetical protein 0.0037 0.0164 0.0715
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0164 0.0888
Trypanosoma brucei THT1 - hexose transporter, putative 0.0108 0.0652 0.8739
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Echinococcus granulosus Sugar transporter ERD6 protein 0.0049 0.0249 0.0681
Trypanosoma brucei glucose transporter, putative 0.0108 0.0652 0.8739
Toxoplasma gondii sugar transporter ST3 0.0049 0.0249 0.0327
Toxoplasma gondii transporter, major facilitator family protein 0.0049 0.0249 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Brugia malayi lysyl-tRNA synthetase 0.0078 0.0445 0.1944
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0037 0.0167 0.3745
Loa Loa (eye worm) sugar transporter 0.0049 0.0249 0.1087
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0107 0.0643 0.0605
Brugia malayi beta-lactamase family protein 0.0037 0.0164 0.0715
Mycobacterium tuberculosis Conserved protein 0.0037 0.0164 0.0888
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.002 0.0049 0.0142
Brugia malayi glycyl-tRNA synthetase 0.002 0.0049 0.0212
Trichomonas vaginalis glucose transporter, putative 0.0049 0.0249 0.0956
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.004 0.0031
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0164 0.2197
Schistosoma mansoni glucose transport protein 0.0349 0.2291 1
Trypanosoma brucei glucose transporter, putative 0.0108 0.0652 0.8739
Schistosoma mansoni protein kinase 0.0107 0.0643 0.2676
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0122 0.0746 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Plasmodium vivax glycine--tRNA ligase, putative 0.002 0.0049 0.0009
Plasmodium falciparum mitogen-activated protein kinase 2 0.0563 0.3755 0.3729
Schistosoma mansoni protein kinase 0.0107 0.0643 0.2676
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0078 0.0445 0.6932
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0249 0.0956
Schistosoma mansoni hypothetical protein 0.0171 0.108 0.4617
Brugia malayi beta-lactamase 0.0037 0.0164 0.0715
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.004 0.0901
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0107 0.0643 0.2805
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0017 0.0033 0.0444
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0164 0.0715
Chlamydia trachomatis lysine--tRNA ligase 0.0078 0.0445 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0122 0.0746 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0122 0.0746 1
Trypanosoma cruzi hexose transporter, putative 0.0108 0.0652 0.8739
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.002 0.0049 0.0028
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.004 0.0538
Giardia lamblia Lysyl-tRNA synthetase 0.0078 0.0445 0.6895
Schistosoma mansoni lysyl-tRNA synthetase 0.0078 0.0445 0.18
Onchocerca volvulus 0.0049 0.0249 1
Echinococcus multilocularis neuropeptide s receptor 0.0469 0.3111 1
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Loa Loa (eye worm) hypothetical protein 0.0037 0.0164 0.0715
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0349 0.2291 0.7331
Onchocerca volvulus 0.0049 0.0249 1
Trypanosoma cruzi hexose transporter, putative 0.0049 0.0249 0.3339
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0563 0.3755 0.3729
Brugia malayi beta-lactamase family protein 0.0037 0.0164 0.0715
Echinococcus multilocularis General substrate transporter 0.03 0.1957 0.6243
Schistosoma mansoni protein kinase 0.0107 0.0643 0.2676
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0107 0.0643 0.1962
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0164 0.0549
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0017 0.0033 0.0444
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0033 0.0444
Leishmania major hypothetical protein, conserved 0.0017 0.0033 0.0444
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0349 0.2291 0.7331
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0164 0.0579
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0078 0.0445 1
Entamoeba histolytica hypothetical protein 0.0078 0.0445 0.6726
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0107 0.0643 0.1962
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.002 0.0049 0.0409
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0249 0.0956
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0212
Loa Loa (eye worm) hypothetical protein 0.0037 0.0164 0.0715
Plasmodium falciparum protein kinase 7 0.0985 0.6628 0.6615
Mycobacterium ulcerans threonyl-tRNA synthetase 0.002 0.0049 0.1093
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.002 0.0049 0.0653
Plasmodium vivax calcium-dependent protein kinase, putative 0.0107 0.0643 0.0605
Schistosoma mansoni sugar transporter 0.0049 0.0249 0.0928
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Onchocerca volvulus 0.0049 0.0249 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0122 0.0746 1
Trichomonas vaginalis conserved hypothetical protein 0.0349 0.2291 1
Toxoplasma gondii lysine-tRNA ligase 0.0078 0.0445 0.0625
Brugia malayi Cam kinase protein 1 0.0107 0.0643 0.2805
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Echinococcus multilocularis solute carrier family 22 0.0049 0.0249 0.0681
Echinococcus granulosus synaptic vesicle 2 protein 0.0049 0.0249 0.0681
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0043 0.0208 0.0906
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0349 0.2291 0.7331
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0049 0.0249 0.5593
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0164 0.3678
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.004 0.0048
Loa Loa (eye worm) hypothetical protein 0.0107 0.0643 0.2805
Onchocerca volvulus 0.0049 0.0249 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0105 0.0628 0.9756
Plasmodium falciparum calcium-dependent protein kinase 4 0.0107 0.0643 0.0605
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0643 0.2699
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0164 0.0549
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0107 0.0643 0.1962
Mycobacterium ulcerans sugar transporter 0.0049 0.0249 0.5593
Schistosoma mansoni lysyl-tRNA synthetase 0.0078 0.0445 0.18
Trypanosoma cruzi hexose transporter, putative 0.0108 0.0652 0.8739
Echinococcus granulosus solute carrier family 22 0.0049 0.0249 0.0681
Trichomonas vaginalis myo-inositol transporter, putative 0.0049 0.0249 0.0956
Onchocerca volvulus 0.0049 0.0249 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0164 0.0403
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0107 0.0643 0.1962
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0105 0.0628 0.1914
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0164 0.2196
Onchocerca volvulus 0.0049 0.0249 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0105 0.0628 0.274
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.002 0.0049 0.0024
Giardia lamblia Sugar-proton symporter 0.0049 0.0249 0.3556
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0068 0.038 0.1536
Mycobacterium ulcerans hypothetical protein 0.0017 0.0033 0.0744
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.002 0.0049 0.0069
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0108 0.0652 0.274
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0164 0.0124
Trypanosoma brucei glucose transporter, putative 0.0108 0.0652 0.8739
Leishmania major glucose transporter, lmgt1 0.0108 0.0652 0.8739
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0049 0.0249 0.1468
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Onchocerca volvulus 0.0049 0.0249 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0164 0.0888
Leishmania major lysyl-tRNA synthetase, putative 0.0078 0.0445 0.597
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0105 0.0628 0.1914
Mycobacterium ulcerans glycyl-tRNA synthetase 0.002 0.0049 0.1093
Leishmania major hypothetical protein, conserved 0.0017 0.0033 0.0444
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0349 0.2291 0.7331
Echinococcus granulosus solute carrier family 22 0.0049 0.0249 0.0681
Loa Loa (eye worm) glycyl-tRNA synthetase 0.002 0.0049 0.0212
Brugia malayi Major Facilitator Superfamily protein 0.0049 0.0249 0.1087
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Brugia malayi Sugar transporter family protein 0.0049 0.0249 0.1087
Schistosoma mansoni sugar transporter 0.0049 0.0249 0.0928
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0049 0.0249 0.5593
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0349 0.2291 0.7331
Trypanosoma cruzi hexose transporter 0.0108 0.0652 0.8739
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0164 0.0888
Trypanosoma cruzi glucose transporter, putative 0.0049 0.0249 0.3339
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0049 0.0249 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0349 0.2291 0.3424
Loa Loa (eye worm) major facilitator superfamily transporter 0.0049 0.0249 0.1087
Echinococcus granulosus General substrate transporter 0.03 0.1957 0.6243
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0249 0.0956
Plasmodium vivax CDK-related protein kinase 6, putative 0.148 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0164 0.0403
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Loa Loa (eye worm) sugar transporter 0.0349 0.2291 1
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0164 0.0888
Brugia malayi major facilitator superfamily protein 0.0049 0.0249 0.1087
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0107 0.0643 0.0605
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0164 0.2196
Treponema pallidum prolyl-tRNA synthetase 0.0037 0.0167 1
Mycobacterium ulcerans lipase LipD 0.0037 0.0164 0.3678
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0107 0.0643 0.2805
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.002 0.0049 0.0106
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0107 0.0643 0.2805
Schistosoma mansoni sugar transporter 0.0049 0.0249 0.0928
Trypanosoma brucei glucose transporter, putative 0.0108 0.0652 0.8739
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.004 0.0175
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0049 0.0249 0.1468
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0563 0.3755 0.5643
Trypanosoma cruzi hexose transporter, putative 0.0059 0.0318 0.426
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0049 0.0249 0.0928
Onchocerca volvulus 0.0049 0.0249 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.004 0.0538
Echinococcus granulosus glycyl tRNA synthetase 0.002 0.0049 0.0028
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.004 0.0538
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0164 0.0579
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0249 0.0956
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.1087
Echinococcus multilocularis solute carrier family 22 0.0049 0.0249 0.0681

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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