TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 335.443 | Formula: C21H25N3O
H donors: 1 H acceptors: 1 LogP: 3.89 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)CNC(c1cnn(c1C)c1ccccc1)C
InChi: 1S/C21H25N3O/c1-4-25-20-12-10-18(11-13-20)14-22-16(2)21-15-23-24(17(21)3)19-8-6-5-7-9-19/h5-13,15-16,22H,4,14H2,1-3H3
InChiKey: QOXAGLXDLLSOLC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Threonyl-tRNA synthetase	0.0018	0.0043	0.0001
Giardia lamblia	Lysyl-tRNA synthetase	0.0072	0.044	0.6849
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0175	0.2368
Giardia lamblia	Sugar-proton symporter	0.0045	0.0243	0.3461
Echinococcus granulosus	lysyl tRNA synthetase	0.0072	0.044	0.1208
Brugia malayi	beta-lactamase family protein	0.0036	0.0175	0.0767
Schistosoma mansoni	hypothetical protein	0.0169	0.1155	0.4959
Schistosoma mansoni	sugar transporter	0.0045	0.0243	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0175	0.0767
Brugia malayi	major facilitator superfamily protein	0.0045	0.0243	0.1064
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0113	0.074	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0489	0.2137
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0243	0.061
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0043	0.0069
Echinococcus granulosus	solute carrier family 22	0.0045	0.0243	0.061
Trypanosoma brucei	glucose transporter, putative	0.01	0.0646	0.8729
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Leishmania major	glucose transporter/membrane transporter D2, putative	0.01	0.0646	0.8729
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0097	0.0622	0.2722
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Plasmodium falciparum	lysine--tRNA ligase	0.0072	0.044	0.0399
Schistosoma mansoni	sugar transporter	0.0045	0.0243	0.0894
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0099	0.0637	0.2786
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0243	0.0956
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0018	0.0043	0.0001
Trichomonas vaginalis	myo-inositol transporter, putative	0.0045	0.0243	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0175	0.0767
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0097	0.0622	1
Trypanosoma brucei	glucose transporter, putative	0.01	0.0646	0.8729
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Trypanosoma brucei	glucose transporter, putative	0.01	0.0646	0.8729
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0027	0.0367
Schistosoma mansoni	hypothetical protein	0.0323	0.2287	1
Plasmodium falciparum	proline--tRNA ligase	0.0113	0.074	0.0701
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0045	0.0243	0.061
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0175	0.249
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0175	0.0936
Brugia malayi	beta-lactamase family protein	0.0036	0.0175	0.0767
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Brugia malayi	hypothetical protein	0.0045	0.0243	0.1064
Trypanosoma brucei	glucose transporter 1E	0.01	0.0646	0.8729
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Trypanosoma brucei	glucose transporter, putative	0.01	0.0646	0.8729
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Onchocerca volvulus		0.0045	0.0243	1
Brugia malayi	beta-lactamase	0.0036	0.0175	0.0767
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Toxoplasma gondii	lysine-tRNA ligase	0.0072	0.044	0.0625
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0072	0.044	0.1826
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0072	0.044	1
Trypanosoma brucei	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0027	0.0367
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0043	0.0577
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0099	0.0637	0.0597
Leishmania major	myo-inositol/proton symporter (MIT)	0.0045	0.0243	0.3286
Brugia malayi	Major Facilitator Superfamily protein	0.0045	0.0243	0.1064
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0175	0.0403
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0175	0.0656
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0072	0.044	0.5938
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0622	0.2722
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0061	0.036	0.21
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0175	0.0936
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0097	0.0622	0.9752
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0099	0.0637	0.1808
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Plasmodium vivax	sugar transporter, putative	0.0045	0.0243	0.0201
Onchocerca volvulus		0.0045	0.0243	1
Onchocerca volvulus		0.0045	0.0243	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Leishmania major	protein kinase, putative	0.0099	0.0637	0.8603
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0175	0.0767
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0175	0.249
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0323	0.2287	0.6826
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0099	0.0637	0.0597
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0099	0.0637	0.0597
Brugia malayi	Major Facilitator Superfamily protein	0.0045	0.0243	0.1064
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.01	0.0646	0.274
Onchocerca volvulus		0.0045	0.0243	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0018	0.0043	0.0577
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0034	0.0161	0.3661
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0045	0.0243	0.1365
Trypanosoma cruzi	hexose transporter, putative	0.01	0.0646	0.8729
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0045	0.0243	0.0201
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0099	0.0637	0.1808
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0175	0.0767
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0113	0.074	1
Trichomonas vaginalis	esterase, putative	0.0036	0.0175	0.0656
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0113	0.074	1
Trypanosoma cruzi	hexose transporter, putative	0.01	0.0646	0.8729
Echinococcus granulosus	neuropeptide receptor A26	0.0465	0.333	1
Brugia malayi	Sugar transporter family protein	0.0323	0.2287	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0018	0.0043	0.0024
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0018	0.0043	0.0187
Trypanosoma brucei	glucose transporter, putative	0.01	0.0646	0.8729
Trypanosoma brucei	THT1 - hexose transporter, putative	0.01	0.0646	0.8729
Treponema pallidum	threonyl-tRNA synthetase	0.0018	0.0043	0.0003
Plasmodium falciparum	protein kinase 7	0.0913	0.6626	0.6612
Echinococcus multilocularis	neuropeptide receptor A26	0.0465	0.333	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.01	0.0646	0.8729
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0243	0.061
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0043	0.0069
Onchocerca volvulus		0.0045	0.0243	1
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0097	0.0622	0.1763
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0323	0.2287	0.6826
Leishmania major	glucose transporter, lmgt1	0.01	0.0646	0.8729
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0018	0.0043	0.0187
Echinococcus granulosus	solute carrier family 22	0.0045	0.0243	0.061
Schistosoma mansoni	sugar transporter	0.0045	0.0243	0.0894
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0175	0.0936
Leishmania major	lysyl-tRNA synthetase, putative	0.0072	0.044	0.5938
Schistosoma mansoni	hypothetical protein	0.0169	0.1155	0.4959
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0027	0.0367
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0018	0.0043	0.0577
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0045	0.0243	0.1365
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Brugia malayi	lysyl-tRNA synthetase	0.0072	0.044	0.1923
Echinococcus granulosus	solute carrier family 22	0.0045	0.0243	0.061
Trypanosoma brucei	glucose transporter, putative	0.01	0.0646	0.8729
Loa Loa (eye worm)	sugar transporter	0.0045	0.0243	0.1064
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0061	0.036	0.21
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0323	0.2287	0.6826
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0099	0.0637	0.1808
Leishmania major	glucose transporter, lmgt3	0.01	0.0646	0.8729
Plasmodium falciparum	threonine--tRNA ligase	0.0018	0.0043	0.0000039782
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0099	0.0637	0.0597
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0323	0.2287	0.6826
Leishmania major	glucose transporter, lmgt2	0.01	0.0646	0.8729
Echinococcus multilocularis	calcium dependent protein kinase	0.0093	0.0592	0.1671
Mycobacterium ulcerans	sugar transporter	0.0045	0.0243	0.5534
Brugia malayi	Sugar transporter family protein	0.0045	0.0243	0.1064
Echinococcus granulosus	synaptic vesicle 2 protein	0.0045	0.0243	0.061
Mycobacterium ulcerans	integral membrane transport protein	0.0045	0.0243	0.5534
Trichomonas vaginalis	sugar transport protein, putative	0.0045	0.0243	0.0956
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0637	0.2699
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0175	0.0403
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0175	0.3988
Toxoplasma gondii	sugar transporter ST2	0.0045	0.0243	0.0327
Onchocerca volvulus		0.0045	0.0243	1
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0243	0.0956
Brugia malayi	glycyl-tRNA synthetase	0.0018	0.0043	0.0187
Wolbachia endosymbiont of Brugia malayi	prolyl-tRNA synthetase	0.0018	0.0043	0.0002
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0099	0.0637	0.8603
Echinococcus granulosus	neuropeptide s receptor	0.0465	0.333	1
Trypanosoma brucei	glucose transporter 2A	0.01	0.0646	0.8729
Trypanosoma cruzi	hexose transporter, putative	0.01	0.0646	0.8729
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Echinococcus granulosus	calcium dependent protein kinase	0.0093	0.0592	0.1671
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0175	0.0767
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0175	0.0133
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0175	0.0936
Loa Loa (eye worm)	sugar transporter	0.0323	0.2287	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0175	0.0936
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0043	0.0577
Schistosoma mansoni	glucose transport protein	0.0323	0.2287	1
Brugia malayi	major facilitator superfamily protein	0.0045	0.0243	0.1064
Giardia lamblia	Hexose transporter	0.0045	0.0243	0.3461
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0018	0.0043	0.0001
Schistosoma mansoni	lysyl-tRNA synthetase	0.0072	0.044	0.1769
Giardia lamblia	Prolyl-tRNA synthetase	0.0097	0.0622	1
Brugia malayi	Major Facilitator Superfamily protein	0.0045	0.0243	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0061	0.036	0.5587
Plasmodium vivax	glycine--tRNA ligase, putative	0.0018	0.0043	0.0000039782
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0175	0.0936
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0045	0.0243	0.5534
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0018	0.0043	0.0262
Echinococcus granulosus	geminin	0.0169	0.1155	0.3385
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0099	0.0637	0.2786
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0043	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0637	0.2786
Trypanosoma cruzi	hexose transporter	0.01	0.0646	0.8729
Leishmania major	threonyl-tRNA synthetase, putative	0.0018	0.0043	0.0577
Schistosoma mansoni	glucose transport protein	0.0323	0.2287	1
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0027	0.0367
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0099	0.0637	0.1808
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0099	0.0637	0.1808
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0097	0.0622	0.1763
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0175	0.0656
Trichomonas vaginalis	glucose transporter, putative	0.01	0.0646	0.274
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0231	0.1611	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0097	0.0622	0.2583
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0099	0.0637	0.2786
Brugia malayi	Cam kinase protein 1	0.0099	0.0637	0.2786
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0622	0.2722
Loa Loa (eye worm)	hypothetical protein	0.0072	0.044	0.1923
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0323	0.2287	0.6826
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0018	0.0043	0.0187
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Toxoplasma gondii	transporter, major facilitator family protein	0.0045	0.0243	0.0327
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0018	0.0043	0.0002
Toxoplasma gondii	sugar transporter ST3	0.0045	0.0243	0.0327
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0045	0.0243	0.061
Trichomonas vaginalis	sugar transporter, putative	0.01	0.0646	0.274
Plasmodium falciparum	hexose transporter	0.0323	0.2287	0.2253
Toxoplasma gondii	sugar transporter ST1	0.0045	0.0243	0.0327
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0323	0.2287	0.6826
Brugia malayi	hypothetical protein	0.0045	0.0243	0.1064
Leishmania major	hypothetical protein, conserved	0.0036	0.0175	0.2368
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1371	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Echinococcus granulosus	General substrate transporter	0.0278	0.1952	0.5809
Trypanosoma cruzi	hexose transporter, putative	0.0045	0.0243	0.3286
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0323	0.2287	0.6826
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0175	0.0656
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0175	0.0656
Brugia malayi	Sugar transporter family protein	0.0045	0.0243	0.1064
Schistosoma mansoni	protein kinase	0.0099	0.0637	0.2649
Toxoplasma gondii	ABC1 family protein	0.0036	0.0175	0.0225
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0175	0.0591
Onchocerca volvulus		0.0045	0.0243	1
Trypanosoma cruzi	glucose transporter, putative	0.0045	0.0243	0.3286
Trichomonas vaginalis	sugar transporter, putative	0.01	0.0646	0.274
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0099	0.0637	0.1808
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0175	0.3988
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0099	0.0637	0.0925
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0018	0.0043	0.0973
Schistosoma mansoni	glucose transporter	0.0045	0.0243	0.0894
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0522	0.3751	0.5643
Toxoplasma gondii	exonuclease III APE	0.0018	0.0043	0.0024
Trypanosoma cruzi	hexose transporter, putative	0.0055	0.0312	0.4214
Brugia malayi	hypothetical protein	0.0045	0.0243	0.1064
Toxoplasma gondii	glycyl-tRNA synthetase	0.0018	0.0043	0.0024
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0043	0.0577
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0043	0.0577
Echinococcus granulosus	solute carrier family 22	0.0045	0.0243	0.061
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0243	0.061
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0175	0.0767
Trichomonas vaginalis	glucose transporter, putative	0.0045	0.0243	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0072	0.044	0.5938
Plasmodium vivax	hexose transporter	0.0323	0.2287	0.2253
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.004	0.0202	0.0883
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0045	0.0243	1
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0099	0.0637	0.0597
Onchocerca volvulus		0.0045	0.0243	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0027	0.0367
Trypanosoma brucei	sugar transporter, putative	0.0045	0.0243	0.3286
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0099	0.0637	0.1808
Trichomonas vaginalis	conserved hypothetical protein	0.0323	0.2287	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0175	0.2368
Schistosoma mansoni	protein kinase	0.0099	0.0637	0.2649
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0099	0.0637	0.0925
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0097	0.0622	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0175	0.0936
Entamoeba histolytica	protein kinase, putative	0.0099	0.0637	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Trypanosoma brucei	THT1 - hexose transporter, putative	0.01	0.0646	0.8729
Entamoeba histolytica	hypothetical protein	0.0072	0.044	0.6679
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0045	0.0243	0.0894
Onchocerca volvulus		0.0045	0.0243	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0175	0.0936
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0099	0.0637	0.0597
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0097	0.0622	0.2722
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0045	0.0243	0.1064
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0097	0.0622	0.2634
Trypanosoma cruzi	sugar transporter, putative	0.0045	0.0243	0.3286
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0018	0.0043	0.0973
Chlamydia trachomatis	proline--tRNA ligase	0.0034	0.0161	0.2978
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0018	0.0043	0.0187
Leishmania major	hypothetical protein, conserved	0.0016	0.0027	0.0367
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0063	0.0374	0.1536
Trypanosoma brucei	glucose transporter, putative	0.01	0.0646	0.8729
Trichomonas vaginalis	sugar transporter, putative	0.01	0.0646	0.274
Onchocerca volvulus		0.0045	0.0243	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0175	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0175	0.0936
Onchocerca volvulus	Putative transporter	0.0045	0.0243	1
Trichomonas vaginalis	glucose transporter, putative	0.01	0.0646	0.274
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0243	0.1064
Echinococcus multilocularis	neuropeptide s receptor	0.0465	0.333	1
Schistosoma mansoni	glucose transport protein	0.0323	0.2287	1
Onchocerca volvulus		0.0045	0.0243	1
Treponema pallidum	prolyl-tRNA synthetase	0.0034	0.0161	1
Onchocerca volvulus		0.0045	0.0243	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0045	0.0243	0.1064
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0243	0.0956
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0099	0.0637	0.1808
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0175	0.0591
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0522	0.3751	0.3724
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0099	0.0637	0.0925
Echinococcus multilocularis	General substrate transporter	0.0278	0.1952	0.5809
Leishmania major	hypothetical protein, conserved	0.0045	0.0243	0.3286
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0175	0.0767
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0243	0.061
Toxoplasma gondii	facilitative glucose transporter GT1	0.0323	0.2287	0.3424
Leishmania major	hypothetical protein, conserved	0.0016	0.0027	0.0367
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Chlamydia trachomatis	lysine--tRNA ligase	0.0072	0.044	1
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0243	0.0956
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0175	0.0656
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0072	0.044	1
Schistosoma mansoni	protein kinase	0.0099	0.0637	0.2649
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0018	0.0043	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0243	0.0956
Onchocerca volvulus		0.0045	0.0243	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0043	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0175	0.0767
Plasmodium vivax	threonine--tRNA ligase, putative	0.0018	0.0043	0.0000039782
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0099	0.0637	0.0597
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0043	0.0187
Toxoplasma gondii	protein kinase, putative	0.0913	0.6626	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0045	0.0243	0.061
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0113	0.074	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0099	0.0637	0.0597
Schistosoma mansoni	sugar transporter	0.0045	0.0243	0.0894
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0175	0.3988
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0175	0.0767
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0018	0.0043	0.0098
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0043	0.0187
Onchocerca volvulus		0.0045	0.0243	1
Mycobacterium ulcerans	lipase LipD	0.0036	0.0175	0.3988
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0018	0.0043	0.0577
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0323	0.2287	0.6826
Schistosoma mansoni	serine/threonine protein kinase	0.0099	0.0637	0.2649
Trypanosoma brucei	glucose transporter, putative	0.01	0.0646	0.8729
Plasmodium vivax	proline--tRNA ligase, putative	0.0113	0.074	0.0701
Onchocerca volvulus		0.0045	0.0243	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0522	0.3751	0.3724
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0043	0.0098
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0099	0.0637	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Plasmodium vivax	lysine--tRNA ligase, putative	0.0072	0.044	0.0399
Echinococcus multilocularis	geminin	0.0169	0.1155	0.3385
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0175	0.3988
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0045	0.0243	0.3286
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0018	0.0043	0.0577
Entamoeba histolytica	protein kinase, putative	0.0099	0.0637	1
Onchocerca volvulus		0.0045	0.0243	1
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0045	0.0243	0.5534
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0243	0.0956
Echinococcus multilocularis	lysyl tRNA synthetase	0.0072	0.044	0.1208
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0113	0.074	0.1081
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0175	0.2368
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0113	0.074	1
Trichomonas vaginalis	conserved hypothetical protein	0.01	0.0646	0.274
Giardia lamblia	Glycyl-tRNA synthetase	0.0018	0.0043	0.0001
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0072	0.044	0.6932
Schistosoma mansoni	lysyl-tRNA synthetase	0.0072	0.044	0.1769
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0027	0.0619

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 763725