Detailed information for compound 765066

Basic information

Technical information
  • TDR Targets ID: 765066
  • Name: 2,3-dimethylquinoxalin-6-amine
  • MW: 173.214 | Formula: C10H11N3
  • H donors: 1 H acceptors: 2 LogP: 1.33 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc2c(c1)nc(c(n2)C)C
  • InChi: 1S/C10H11N3/c1-6-7(2)13-10-5-8(11)3-4-9(10)12-6/h3-5H,11H2,1-2H3
  • InChiKey: QBZGAULXCVZXFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,3-Dimethyl-6-quinoxalinamine
  • (2,3-dimethylquinoxalin-6-yl)amine
  • 7576-88-7
  • ZINC00169546
  • Oprea1_733303
  • 2,3-Dimethyl-quinoxalin-6-ylamine
  • BAS 01914825
  • 5-25-11-00200 (Beilstein Handbook Reference)
  • 6-Amino-2,3-dimethylquinoxaline
  • 6-Quinoxalinamine, 2,3-dimethyl-
  • BRN 0126666
  • Oprea1_734848
  • ST5257480

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0037 0.0327 1
Schistosoma mansoni hypothetical protein 0.0126 0.1484 0.2588
Leishmania major hypothetical protein, conserved 0.0035 0.03 0.883
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.03 0.077
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.03 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.03 0.077
Loa Loa (eye worm) hypothetical protein 0.0026 0.0182 0.0219
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0327 0.0378
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.03 0.077
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.03 0.0427
Echinococcus multilocularis sodium bile acid cotransporter 0.0455 0.5732 0.5708
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.03 0.0334
Plasmodium vivax SET domain protein, putative 0.0062 0.0645 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0097 0.0071
Brugia malayi RNA binding protein 0.0065 0.0685 0.1195
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0427
Giardia lamblia PHD finger protein 15 0.0029 0.0221 1
Schistosoma mansoni hypothetical protein 0.0173 0.2085 0.3637
Echinococcus multilocularis peregrin 0.0029 0.0221 0.0165
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1344 0.2267
Onchocerca volvulus 0.0455 0.5732 0.9269
Schistosoma mansoni hypothetical protein 0.0016 0.0057 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.03 0.883
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.03 0.0427
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0327 0.0475
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0057 0.01
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0685 0.1195
Echinococcus granulosus sodium bile acid cotransporter 0.0455 0.5732 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.1006 0.1754
Loa Loa (eye worm) hypothetical protein 0.0062 0.0645 0.1036
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0182 0.3681
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0685 0.1195
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.03 0.077
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0685 0.1195
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0427
Schistosoma mansoni hypothetical protein 0.0016 0.0057 0.01
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0037 0.0327 0.0475
Onchocerca volvulus 0.0488 0.6167 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0507 0.0884
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0616 0.0985
Mycobacterium ulcerans beta-lactamase 0.0035 0.03 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.1484 0.2514
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0327 0.0475
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0685 0.1195
Brugia malayi MH2 domain containing protein 0.0116 0.1344 0.2344
Brugia malayi hypothetical protein 0.0017 0.0064 0.0111
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0327 0.0378
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0182 0.3681
Mycobacterium tuberculosis Conserved protein 0.0035 0.03 0.077
Loa Loa (eye worm) hypothetical protein 0.0029 0.0221 0.0289
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.03 0.0334
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0037 0.0327 0.057
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.03 0.077
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0221 0.0289
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0097 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 0.0507 0.0792
Loa Loa (eye worm) hypothetical protein 0.0049 0.0487 0.0757
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0299 0.0522
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0182 0.3681
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0817 0.1426
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.1006 0.1754
Trichomonas vaginalis set domain proteins, putative 0.0488 0.6167 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0617 0.0987
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0037 0.0327 0.0271
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0037 0.0327 0.057
Loa Loa (eye worm) hypothetical protein 0.0455 0.5732 1
Plasmodium falciparum phd finger protein, putative 0.0029 0.0221 0.5404
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.03 0.0523
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0685 0.1106
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.03 0.077
Echinococcus multilocularis sodium bile acid cotransporter 0.0455 0.5732 0.5708
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0645 0.1126
Echinococcus granulosus sodium bile acid cotransporter 0.0455 0.5732 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0427
Brugia malayi PHD-finger family protein 0.0029 0.0221 0.0386
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0645 0.1036
Mycobacterium leprae conserved hypothetical protein 0.0035 0.03 0.5
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0037 0.0327 0.4185
Onchocerca volvulus 0.0035 0.03 0.0132
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0299 0.0244
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0429 0.54 0.9415
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0097 0.017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.1006 0.1671
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.1006 0.1671
Loa Loa (eye worm) RNA binding protein 0.0065 0.0685 0.1106
Schistosoma mansoni hypothetical protein 0.0037 0.0324 0.0565
Brugia malayi Bromodomain containing protein 0.0029 0.0221 0.0386
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1068 0.1016
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0057 0.01
Brugia malayi TAR-binding protein 0.0065 0.0685 0.1195
Entamoeba histolytica hypothetical protein 0.0037 0.0324 0.9877
Brugia malayi Pre-SET motif family protein 0.0429 0.54 0.9421
Echinococcus multilocularis thyroid hormone receptor alpha 0.0137 0.1615 0.1567
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0221 0.0165
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0221 0.0386
Entamoeba histolytica hypothetical protein 0.0037 0.0324 0.9877
Echinococcus granulosus sodium bile acid cotransporter 0.0455 0.5732 1
Brugia malayi jmjC domain containing protein 0.0035 0.0299 0.0522
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0221 0.0289
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1068 0.1781
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.03 0.0334
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0324 0.047
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0299 0.0427
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.03 0.077
Brugia malayi beta-lactamase family protein 0.0035 0.03 0.0523
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0427
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0299 0.0521
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0097 0.0071
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0221 0.2262
Toxoplasma gondii ABC1 family protein 0.0035 0.03 0.3696
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.03 0.0334
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0324 0.0268
Brugia malayi Sodium Bile acid symporter family protein 0.0455 0.5732 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0645 0.1126
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0182 0.1541
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0327 1
Brugia malayi jmjC domain containing protein 0.0094 0.1068 0.1863
Mycobacterium leprae Probable lipase LipE 0.0035 0.03 0.5
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0037 0.0327 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.03 1
Trichomonas vaginalis esterase, putative 0.0035 0.03 0.0334
Schistosoma mansoni hypothetical protein 0.0016 0.0057 0.01
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0327 0.4185
Schistosoma mansoni ap endonuclease 0.0019 0.0097 0.017
Brugia malayi beta-lactamase 0.0035 0.03 0.0523
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0685 0.0631
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2729 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.1006 0.1754
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0645 0.0591
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.1006 0.0954
Echinococcus granulosus jumonji domain containing protein 0.004 0.0367 0.0546
Schistosoma mansoni hypothetical protein 0.0173 0.2085 0.3637
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.03 0.883
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0685 0.1195
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0685 0.1106
Onchocerca volvulus 0.0035 0.03 0.0132
Brugia malayi beta-lactamase family protein 0.0035 0.03 0.0523
Schistosoma mansoni thyroid hormone receptor 0.0137 0.1615 0.2817
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0327 1
Brugia malayi hypothetical protein 0.0037 0.0324 0.0565
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0507 0.0792
Plasmodium vivax hypothetical protein, conserved 0.0035 0.03 0.3696
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0037 0.0327 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1344 0.2267
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0037 0.0327 0.057
Onchocerca volvulus 0.0035 0.03 0.0132
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0221 0.2262
Schistosoma mansoni sodium-bile acid cotransporter related 0.0184 0.2235 0.3898
Schistosoma mansoni hypothetical protein 0.0016 0.0057 0.01
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.03 0.077
Entamoeba histolytica hypothetical protein 0.0037 0.0324 0.9877
Schistosoma mansoni ap endonuclease 0.0019 0.0097 0.017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.1006 0.1671
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0645 0.0591
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0427
Echinococcus granulosus geminin 0.0173 0.2085 0.3573
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0427
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.1484 0.1435
Schistosoma mansoni hypothetical protein 0.0035 0.0299 0.0521
Leishmania major hypothetical protein, conserved 0.0026 0.0182 0.3681
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0645 0.1126
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0097 0.004
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0299 0.0427
Echinococcus granulosus peregrin 0.0029 0.0221 0.0289
Brugia malayi Pre-SET motif family protein 0.0062 0.0645 0.1126
Onchocerca volvulus 0.0062 0.0645 0.0713
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.03 0.0244
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0645 0.1126
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0182 0.3681
Schistosoma mansoni thyroid hormone receptor 0.0137 0.1615 0.2817
Entamoeba histolytica hypothetical protein 0.0037 0.0324 0.9877
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.03 0.0334
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.0426
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0685 0.1195
Mycobacterium tuberculosis Conserved protein 0.0035 0.03 0.077
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0221 0.2262
Mycobacterium ulcerans lipase LipD 0.0035 0.03 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.03 0.883
Schistosoma mansoni hypothetical protein 0.0029 0.0221 0.0386
Loa Loa (eye worm) beta-lactamase 0.0035 0.03 0.0427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.1006 0.0954
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0645 1
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0367 0.0312
Mycobacterium ulcerans hypothetical protein 0.0035 0.03 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0182 0.3681
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.1006 0.1754
Echinococcus multilocularis geminin 0.0173 0.2085 0.2039
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0097 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0324 0.0565
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0182 0.1541
Schistosoma mansoni sodium-bile acid cotransporter related 0.0455 0.5732 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0507 0.0884
Brugia malayi hypothetical protein 0.0026 0.0182 0.0317
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0327 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.03 0.0523
Schistosoma mansoni sodium-bile acid cotransporter 0.027 0.3347 0.5838
Echinococcus granulosus tar DNA binding protein 0.0065 0.0685 0.1106
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0299 0.0522
Echinococcus multilocularis sodium bile acid cotransporter 0.0455 0.5732 0.5708
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.03 0.0523

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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