Detailed information for compound 765066

Basic information

Technical information
  • TDR Targets ID: 765066
  • Name: 2,3-dimethylquinoxalin-6-amine
  • MW: 173.214 | Formula: C10H11N3
  • H donors: 1 H acceptors: 2 LogP: 1.33 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc2c(c1)nc(c(n2)C)C
  • InChi: 1S/C10H11N3/c1-6-7(2)13-10-5-8(11)3-4-9(10)12-6/h3-5H,11H2,1-2H3
  • InChiKey: QBZGAULXCVZXFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,3-Dimethyl-6-quinoxalinamine
  • (2,3-dimethylquinoxalin-6-yl)amine
  • 7576-88-7
  • ZINC00169546
  • Oprea1_733303
  • 2,3-Dimethyl-quinoxalin-6-ylamine
  • BAS 01914825
  • 5-25-11-00200 (Beilstein Handbook Reference)
  • 6-Amino-2,3-dimethylquinoxaline
  • 6-Quinoxalinamine, 2,3-dimethyl-
  • BRN 0126666
  • Oprea1_734848
  • ST5257480

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0427
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0324 0.0565
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.1006 0.1754
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.03 0.077
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.03 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0617 0.0987
Echinococcus granulosus jumonji domain containing protein 0.004 0.0367 0.0546
Onchocerca volvulus 0.0035 0.03 0.0132
Schistosoma mansoni hypothetical protein 0.0016 0.0057 0.01
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0817 0.1426
Brugia malayi hypothetical protein 0.0017 0.0064 0.0111
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0097 0.0071
Loa Loa (eye worm) hypothetical protein 0.0049 0.0487 0.0757
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0037 0.0327 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.03 1
Entamoeba histolytica hypothetical protein 0.0037 0.0324 0.9877
Brugia malayi MH2 domain containing protein 0.0116 0.1344 0.2344
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.03 0.0244
Schistosoma mansoni hypothetical protein 0.0029 0.0221 0.0386
Onchocerca volvulus 0.0488 0.6167 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.03 0.077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0645 0.1126
Echinococcus multilocularis geminin 0.0173 0.2085 0.2039
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.03 0.0523
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.1006 0.0954
Echinococcus multilocularis thyroid hormone receptor alpha 0.0137 0.1615 0.1567
Onchocerca volvulus 0.0062 0.0645 0.0713
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.1006 0.1671
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0645 0.1126
Schistosoma mansoni hypothetical protein 0.0173 0.2085 0.3637
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0299 0.0427
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0221 0.0289
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0685 0.1195
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0685 0.1195
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0645 0.1036
Schistosoma mansoni thyroid hormone receptor 0.0137 0.1615 0.2817
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0645 1
Mycobacterium ulcerans lipase LipD 0.0035 0.03 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0645 0.1126
Brugia malayi Pre-SET motif family protein 0.0062 0.0645 0.1126
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0645 0.0591
Echinococcus multilocularis sodium bile acid cotransporter 0.0455 0.5732 0.5708
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.0426
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.03 0.883
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0182 0.3681
Brugia malayi beta-lactamase 0.0035 0.03 0.0523
Mycobacterium leprae Probable lipase LipE 0.0035 0.03 0.5
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0057 0.01
Brugia malayi hypothetical protein 0.0026 0.0182 0.0317
Mycobacterium ulcerans hypothetical protein 0.0035 0.03 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.03 0.0427
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0221 0.2262
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0097 0.017
Schistosoma mansoni hypothetical protein 0.0126 0.1484 0.2588
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0221 0.0165
Echinococcus multilocularis peregrin 0.0029 0.0221 0.0165
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0685 0.1195
Schistosoma mansoni ap endonuclease 0.0019 0.0097 0.017
Schistosoma mansoni hypothetical protein 0.0016 0.0057 0.01
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0327 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1344 0.2267
Schistosoma mansoni sodium-bile acid cotransporter related 0.0455 0.5732 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.03 0.883
Echinococcus granulosus peregrin 0.0029 0.0221 0.0289
Echinococcus granulosus geminin 0.0173 0.2085 0.3573
Schistosoma mansoni hypothetical protein 0.0173 0.2085 0.3637
Mycobacterium tuberculosis Conserved protein 0.0035 0.03 0.077
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0037 0.0327 0.057
Leishmania major hypothetical protein, conserved 0.0035 0.03 0.883
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0685 0.1106
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0327 0.0378
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0327 0.0475
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1068 0.1016
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0221 0.2262
Mycobacterium tuberculosis Conserved protein 0.0035 0.03 0.077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0645 0.1126
Loa Loa (eye worm) RNA binding protein 0.0065 0.0685 0.1106
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0037 0.0327 0.4185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.1006 0.1754
Schistosoma mansoni thyroid hormone receptor 0.0137 0.1615 0.2817
Loa Loa (eye worm) hypothetical protein 0.0455 0.5732 1
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0037 0.0327 0.0271
Echinococcus granulosus sodium bile acid cotransporter 0.0455 0.5732 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.1006 0.1671
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0685 0.1195
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0645 0.0591
Schistosoma mansoni hypothetical protein 0.0037 0.0324 0.0565
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0097 0.0071
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0037 0.0327 0.057
Onchocerca volvulus 0.0455 0.5732 0.9269
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0299 0.0427
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.03 0.0523
Brugia malayi Bromodomain containing protein 0.0029 0.0221 0.0386
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2729 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0645 0.1036
Echinococcus granulosus sodium bile acid cotransporter 0.0455 0.5732 1
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0221 0.0289
Trichomonas vaginalis set domain proteins, putative 0.0488 0.6167 1
Echinococcus multilocularis sodium bile acid cotransporter 0.0455 0.5732 0.5708
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0427
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.03 0.883
Brugia malayi Sodium Bile acid symporter family protein 0.0455 0.5732 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0324 0.047
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0327 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0057 0.01
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0037 0.0327 0.0475
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0182 0.3681
Plasmodium vivax SET domain protein, putative 0.0062 0.0645 1
Trichomonas vaginalis esterase, putative 0.0035 0.03 0.0334
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1068 0.1781
Onchocerca volvulus 0.0035 0.03 0.0132
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0037 0.0327 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.1484 0.1435
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0429 0.54 0.9415
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0324 0.0268
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0507 0.0884
Brugia malayi TAR-binding protein 0.0065 0.0685 0.1195
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.03 0.0334
Leishmania major hypothetical protein, conserved 0.0026 0.0182 0.3681
Loa Loa (eye worm) hypothetical protein 0.0026 0.0182 0.0219
Schistosoma mansoni ap endonuclease 0.0019 0.0097 0.017
Toxoplasma gondii ABC1 family protein 0.0035 0.03 0.3696
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.03 0.077
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0182 0.3681
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.1006 0.1754
Plasmodium vivax hypothetical protein, conserved 0.0035 0.03 0.3696
Mycobacterium tuberculosis Conserved protein 0.0035 0.03 0.077
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.03 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.03 0.077
Brugia malayi PHD-finger family protein 0.0029 0.0221 0.0386
Mycobacterium leprae conserved hypothetical protein 0.0035 0.03 0.5
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.1484 0.2514
Entamoeba histolytica hypothetical protein 0.0037 0.0324 0.9877
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0685 0.1106
Entamoeba histolytica hypothetical protein 0.0037 0.0324 0.9877
Schistosoma mansoni hypothetical protein 0.0016 0.0057 0.01
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0182 0.1541
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.03 0.0334
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.03 0.0427
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.03 0.0427
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0427
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.03 0.0334
Echinococcus multilocularis sodium bile acid cotransporter 0.0455 0.5732 0.5708
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0182 0.3681
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0299 0.0244
Brugia malayi Pre-SET motif family protein 0.0429 0.54 0.9421
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0097 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.1006 0.1754
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0327 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0221 0.0289
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0037 0.0327 1
Onchocerca volvulus 0.0035 0.03 0.0132
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0427
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.03 0.0523
Entamoeba histolytica hypothetical protein 0.0037 0.0324 0.9877
Brugia malayi jmjC domain containing protein 0.0094 0.1068 0.1863
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.03 0.077
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0685 0.1195
Schistosoma mansoni hypothetical protein 0.0016 0.0057 0.01
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0507 0.0792
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0685 0.1195
Echinococcus granulosus sodium bile acid cotransporter 0.0455 0.5732 1
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0327 0.4185
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0327 0.0475
Schistosoma mansoni sodium-bile acid cotransporter related 0.0184 0.2235 0.3898
Brugia malayi beta-lactamase family protein 0.0035 0.03 0.0523
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0182 0.3681
Brugia malayi RNA binding protein 0.0065 0.0685 0.1195
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.03 0.0334
Plasmodium falciparum phd finger protein, putative 0.0029 0.0221 0.5404
Brugia malayi hypothetical protein 0.0037 0.0324 0.0565
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0327 0.0378
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.1006 0.0954
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0097 0.004
Loa Loa (eye worm) hypothetical protein 0.0051 0.0507 0.0792
Brugia malayi jmjC domain containing protein 0.0035 0.0299 0.0522
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0427
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0299 0.0521
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0616 0.0985
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.03 0.077
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0182 0.1541
Brugia malayi beta-lactamase family protein 0.0035 0.03 0.0523
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0367 0.0312
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0037 0.0327 0.057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.1006 0.1671
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0221 0.0386
Schistosoma mansoni hypothetical protein 0.0035 0.0299 0.0521
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0299 0.0522
Schistosoma mansoni sodium-bile acid cotransporter 0.027 0.3347 0.5838
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.03 0.0334
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0685 0.0631
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1344 0.2267
Giardia lamblia PHD finger protein 15 0.0029 0.0221 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.03 0.077
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0097 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0299 0.0522
Echinococcus granulosus tar DNA binding protein 0.0065 0.0685 0.1106
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0507 0.0884
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0221 0.2262

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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