Detailed information for compound 765563

Basic information

Technical information
  • TDR Targets ID: 765563
  • Name: 5-(diaminomethylideneamino)-2-[[2-[(4-methylp henyl)sulfonylamino]-3-phenylpropanoyl]amino] pentanoic acid
  • MW: 475.561 | Formula: C22H29N5O5S
  • H donors: 4 H acceptors: 5 LogP: 2.41 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(NS(=O)(=O)c1ccc(cc1)C)Cc1ccccc1)NC(C(=O)[O-])CCCNC(=[NH2+])N
  • InChi: 1S/C22H29N5O5S/c1-15-9-11-17(12-10-15)33(31,32)27-19(14-16-6-3-2-4-7-16)20(28)26-18(21(29)30)8-5-13-25-22(23)24/h2-4,6-7,9-12,18-19,27H,5,8,13-14H2,1H3,(H,26,28)(H,29,30)(H4,23,24,25)
  • InChiKey: GTDYZKRTCCRNKB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-guanidino-2-[[2-[(4-methylphenyl)sulfonylamino]-3-phenyl-propanoyl]amino]pentanoic acid
  • 5-guanidino-2-[[2-[(4-methylphenyl)sulfonylamino]-1-oxo-3-phenylpropyl]amino]pentanoic acid
  • 5-guanidino-2-[[2-[(4-methylphenyl)sulfonylamino]-3-phenyl-propanoyl]amino]valeric acid
  • 5-(diaminomethylideneamino)-2-[[2-[(4-methylphenyl)sulfonylamino]-3-phenyl-propanoyl]amino]pentanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0032 0.0207 0.1328
Onchocerca volvulus 0.0076 0.0809 0.6379
Echinococcus multilocularis c4b binding protein beta chain 0.0076 0.0809 0.0809
Loa Loa (eye worm) DPY-31 protein 0.0032 0.0207 0.0768
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0105 0.1201 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0301 0.6922
Schistosoma mansoni hypothetical protein 0.002 0.0049 0.0049
Brugia malayi hypothetical protein 0.0076 0.0809 0.6522
Echinococcus granulosus Mastin 0.002 0.0049 0.0049
Trypanosoma brucei trypanothione reductase 0.0041 0.034 0.7818
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0435 1
Brugia malayi Sushi domain 0.0076 0.0809 0.6522
Onchocerca volvulus 0.0029 0.018 0.1098
Echinococcus multilocularis Tolloid protein 1 0.0139 0.1667 0.1667
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0052 0.1204
Schistosoma mansoni microtubule-associated protein tau 0.0755 1 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0718 0.0718
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0639
Echinococcus granulosus lamin 0.0029 0.018 0.018
Schistosoma mansoni hypothetical protein 0.0138 0.1645 0.1645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0268 0.6145
Echinococcus multilocularis thyroid hormone receptor alpha 0.0149 0.1794 0.1794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0134 0.3078
Loa Loa (eye worm) hypothetical protein 0.0032 0.0207 0.0768
Brugia malayi Trypsin family protein 0.002 0.0049 0.0394
Loa Loa (eye worm) hypothetical protein 0.0076 0.0809 0.3001
Brugia malayi Nematode astacin protease protein 30 0.0032 0.0207 0.167
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0032 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0032 0.0207 0.0768
Onchocerca volvulus 0.0076 0.0809 0.6379
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0435 1
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0032 0.0207 0.0207
Echinococcus granulosus laminin 0.0108 0.124 0.124
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0435 1
Echinococcus granulosus tar DNA binding protein 0.0069 0.0718 0.0718
Echinococcus granulosus glycoprotein Antigen 5 0.002 0.0049 0.0049
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0049 0.0049
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0105 0.1201 1
Giardia lamblia GTOR 0.0048 0.0435 0.5
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.034 0.1263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0134 0.3078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0268 0.6145
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0049 0.0049
Brugia malayi hypothetical protein 0.0076 0.0809 0.6522
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0049 0.0049
Brugia malayi CUB domain containing protein 0.0032 0.0207 0.167
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0718 0.0718
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0105 0.1201 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0207 0.0768
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0049 0.0049
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0139 0.1667 0.1667
Loa Loa (eye worm) hypothetical protein 0.0029 0.018 0.0667
Loa Loa (eye worm) CUB domain-containing protein 0.0032 0.0207 0.0768
Leishmania major trypanothione reductase 0.0041 0.034 0.7818
Brugia malayi pregnancy-associated plasma protein-A 0.0076 0.0809 0.6522
Loa Loa (eye worm) hypothetical protein 0.0032 0.0207 0.0768
Loa Loa (eye worm) hypothetical protein 0.0108 0.124 0.4601
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0181
Schistosoma mansoni intermediate filament proteins 0.0029 0.018 0.018
Plasmodium vivax apical sushi protein, putative 0.0076 0.0809 1
Brugia malayi CUB domain containing protein 0.0032 0.0207 0.167
Toxoplasma gondii thioredoxin reductase 0.0041 0.034 0.075
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0051 0.0476 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0268 0.6145
Brugia malayi hypothetical protein 0.0032 0.0207 0.167
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0435 1
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0032 0.0207 0.167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0134 0.3078
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.002 0.0049 0.0049
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0348 0.0348
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0718 0.0718
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0313 0.0313
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0435 0.0435
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0032 0.0207 0.4755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0301 0.6922
Mycobacterium ulcerans hypothetical protein 0.002 0.0049 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0181
Brugia malayi Nematode astacin protease protein 30 0.0032 0.0207 0.167
Echinococcus granulosus intermediate filament protein 0.0029 0.018 0.018
Brugia malayi hypothetical protein 0.0076 0.0809 0.6522
Loa Loa (eye worm) hypothetical protein 0.0076 0.0809 0.3001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.034 0.78
Brugia malayi CUB domain containing protein 0.0032 0.0207 0.167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0268 0.6145
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0032 0.0207 0.167
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0138 0.1645 0.1645
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0049 0.0049
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.1201 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.018 0.0667
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0168 0.3855
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.018 0.1449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0134 0.3066
Brugia malayi Kelch motif family protein 0.0032 0.0207 0.167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0172 0.3945
Echinococcus granulosus transmembrane protease serine 3 0.002 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0039 0.0313 0.0313
Brugia malayi hypothetical protein 0.002 0.0049 0.0394
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0172 0.3945
Brugia malayi CUB domain containing protein 0.0032 0.0207 0.167
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0181
Echinococcus multilocularis glycoprotein Antigen 5 0.002 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0032 0.0207 0.0768
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0718 0.0718
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0181
Brugia malayi Trypsin family protein 0.002 0.0049 0.0394
Echinococcus multilocularis microtubule associated protein 2 0.0755 1 1
Echinococcus multilocularis lamin 0.0029 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0076 0.0809 0.3001
Loa Loa (eye worm) glutathione reductase 0.0041 0.034 0.1263
Brugia malayi hypothetical protein 0.0076 0.0809 0.6522
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0094 0.1058 0.8342
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0181
Loa Loa (eye worm) hypothetical protein 0.0139 0.1667 0.6184
Brugia malayi hypothetical protein 0.0076 0.0809 0.6522
Brugia malayi Trypsin family protein 0.002 0.0049 0.0394
Brugia malayi hypothetical protein 0.0076 0.0809 0.6522
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0032 0.0207 0.4755
Loa Loa (eye worm) trypsin family protein 0.002 0.0049 0.0181
Schistosoma mansoni egf-like domain protein 0.0108 0.124 0.124
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0049 0.0049
Echinococcus granulosus Tolloid protein 1 0.0139 0.1667 0.1667
Schistosoma mansoni lamin 0.0029 0.018 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.022 0.5047
Schistosoma mansoni thyroid hormone receptor 0.0149 0.1794 0.1794
Brugia malayi intermediate filament protein 0.0029 0.018 0.1449
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.002 0.0049 0.0049
Onchocerca volvulus 0.0076 0.0809 0.6379
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0108 0.124 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0268 0.6145
Loa Loa (eye worm) hypothetical protein 0.0108 0.124 0.4601
Echinococcus multilocularis enteropeptidase 0.002 0.0049 0.0049
Echinococcus multilocularis fibrillin 1 0.0108 0.124 0.124
Schistosoma mansoni hypothetical protein 0.002 0.0049 0.0049
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0051 0.0476 0.0476
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.002 0.0049 0.0049
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0094 0.1058 0.8342
Toxoplasma gondii rhoptry neck protein RON1 0.0076 0.0809 0.5565
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0435 1
Schistosoma mansoni thyroid hormone receptor 0.0149 0.1794 0.1794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0435 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0207 0.0768
Brugia malayi Fibulin-1 precursor 0.0108 0.124 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0435 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0809 0.3001
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0108 0.124 0.4601
Echinococcus granulosus cubilin 0.0032 0.0207 0.0207
Schistosoma mansoni c4b-binding protein beta chain 0.0076 0.0809 0.0809
Onchocerca volvulus 0.0032 0.0207 0.1328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0134 0.3066
Echinococcus multilocularis tumor protein p63 0.0364 0.4707 0.4707
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0049 0.0049
Echinococcus multilocularis Mastin 0.002 0.0049 0.0049
Onchocerca volvulus 0.0076 0.0809 0.6379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0134 0.3066
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.018 0.0667
Onchocerca volvulus Putative cubilin 0.0032 0.0207 0.1328
Echinococcus multilocularis lamin dm0 0.0029 0.018 0.018
Brugia malayi Thioredoxin reductase 0.0041 0.034 0.2746
Loa Loa (eye worm) RNA binding protein 0.0069 0.0718 0.2665
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0313 0.0313
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.002 0.0049 0.0049
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0049 0.0049
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0049 0.0049
Echinococcus multilocularis cubilin 0.0032 0.0207 0.0207
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0049 0.0049
Echinococcus granulosus tumor protein p63 0.0364 0.4707 0.4707
Brugia malayi CUB domain containing protein 0.0032 0.0207 0.167
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0718 0.0718
Echinococcus multilocularis transmembrane protease serine 3 0.002 0.0049 0.0049
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.009 0.207
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0501 0.0501
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0049 0.0049
Onchocerca volvulus 0.0076 0.0809 0.6379
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0435 1
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0718 0.2665
Brugia malayi Calcium binding EGF domain containing protein 0.0032 0.0207 0.167
Loa Loa (eye worm) hypothetical protein 0.0053 0.0501 0.186
Plasmodium falciparum apical sushi protein 0.0076 0.0809 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0435 0.3512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0435 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0181
Brugia malayi Lectin C-type domain containing protein 0.0032 0.0207 0.167
Loa Loa (eye worm) hypothetical protein 0.0076 0.0809 0.3001
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0032 0.0207 0.0768
Onchocerca volvulus Arrow homolog 0.0108 0.124 1
Onchocerca volvulus 0.0053 0.0501 0.3799
Onchocerca volvulus 0.0076 0.0809 0.6379
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0435 0.0435
Echinococcus multilocularis CUB 0.0032 0.0207 0.0207
Echinococcus granulosus enteropeptidase 0.002 0.0049 0.0049
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0435 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0049 0.0049
Onchocerca volvulus 0.0076 0.0809 0.6379
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.002 0.0049 0.0394
Brugia malayi RNA binding protein 0.0069 0.0718 0.5793
Echinococcus granulosus c4b binding protein beta chain 0.0076 0.0809 0.0809
Brugia malayi glutathione reductase 0.0041 0.034 0.2746
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0301 0.6922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0168 0.3855
Loa Loa (eye worm) hypothetical protein 0.0076 0.0809 0.3001
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.0207
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0032 0.0207 0.167
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0435 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0108 0.124 1
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0076 0.0809 0.3001
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0302 0.6934
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0049 0.0049
Onchocerca volvulus 0.0032 0.0207 0.1328
Brugia malayi hypothetical protein 0.0076 0.0809 0.6522
Onchocerca volvulus 0.0076 0.0809 0.6379
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0718 0.0718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0206 0.4722
Echinococcus multilocularis musashi 0.0029 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0108 0.124 0.4601
Mycobacterium tuberculosis Probable dehydrogenase 0.0094 0.1058 0.8342
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0435 0.1616
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0139 0.1667 0.6184
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0302 0.6934
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0032 0.0207 0.4755
Echinococcus granulosus CUB 0.0032 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0076 0.0809 0.3001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0301 0.6922
Schistosoma mansoni lamin 0.0029 0.018 0.018
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0138 0.1645 0.1645
Onchocerca volvulus 0.0029 0.018 0.1098
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0207 0.4755
Loa Loa (eye worm) hypothetical protein 0.0032 0.0207 0.0768
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0032 0.0207 0.0768
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0313 0.0313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0134 0.3078
Toxoplasma gondii rhoptry neck protein RON9 0.0076 0.0809 0.5565
Brugia malayi Calcium binding EGF domain containing protein 0.0108 0.124 1
Brugia malayi TAR-binding protein 0.0069 0.0718 0.5793
Mycobacterium tuberculosis Probable reductase 0.0094 0.1058 0.8342
Echinococcus multilocularis C type lectin domian containing protein 0.0076 0.0809 0.0809
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0348 0.0348
Brugia malayi astacin protease protein 30 0.0032 0.0207 0.167
Loa Loa (eye worm) hypothetical protein 0.0215 0.2695 1
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0108 0.124 1
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0049 0.0049
Onchocerca volvulus 0.0032 0.0207 0.1328
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.0207
Echinococcus granulosus lamin dm0 0.0029 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0076 0.0809 0.3001
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.034 0.7818
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0718 0.2665
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0032 0.0207 0.0207
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0032 0.0207 0.0768
Onchocerca volvulus 0.0076 0.0809 0.6379
Loa Loa (eye worm) hypothetical protein 0.0032 0.0207 0.0768
Echinococcus granulosus cubilin 0.0032 0.0207 0.0207
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0302 0.6934
Brugia malayi hypothetical protein 0.0039 0.0313 0.2525
Loa Loa (eye worm) hypothetical protein 0.0032 0.0207 0.0768
Brugia malayi Trypsin-like protease protein 5 0.002 0.0049 0.0394
Brugia malayi GCC2 and GCC3 family protein 0.0076 0.0809 0.6522
Echinococcus granulosus C type lectin domian containing protein 0.0076 0.0809 0.0809
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.002 0.0049 0.0049
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0435 0.0435
Loa Loa (eye worm) CUB domain-containing protein 0.0032 0.0207 0.0768
Toxoplasma gondii calcium binding egf domain-containing protein 0.0108 0.124 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0172 0.3945
Echinococcus multilocularis laminin 0.0108 0.124 0.124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0301 0.6922
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0718 0.5793
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.0207
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0049 0.0049
Onchocerca volvulus 0.0076 0.0809 0.6379
Echinococcus multilocularis cubilin 0.0032 0.0207 0.0207
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0094 0.1058 0.8342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0268 0.6145
Brugia malayi Trypsin family protein 0.002 0.0049 0.0394
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0032 0.0207 0.0207
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0094 0.1058 0.8342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0268 0.6145

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 0 % Inhibition of human alphaVbeta3 receptor expressed in african green monkey Vero E6 cells assessed as inhibition of SNV infection in cells at 1 uM by immunofluorescent assay ChEMBL. 20951038

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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