TDR Targets

Basic information

Technical information

TDR Targets ID: 771610
Name: 4-[[3-(carboxymethylsulfanyl)-4-hydroxynaphth alen-1-yl]sulfamoyl]benzoic acid
MW: 433.455 | Formula: C19H15NO7S2
H donors: 4 H acceptors: 7 LogP: 2.97 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CSc1cc(NS(=O)(=O)c2ccc(cc2)C(=O)O)c2c(c1O)cccc2
InChi: 1S/C19H15NO7S2/c21-17(22)10-28-16-9-15(13-3-1-2-4-14(13)18(16)23)20-29(26,27)12-7-5-11(6-8-12)19(24)25/h1-9,20,23H,10H2,(H,21,22)(H,24,25)
InChiKey: CIERPRDYPKVDJO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[[3-(carboxymethylsulfanyl)-4-hydroxy-1-naphthyl]sulfamoyl]benzoic acid
4-[[3-(carboxymethylthio)-4-hydroxy-1-naphthyl]sulfamoyl]benzoic acid
4-[[3-(carboxymethylsulfanyl)-4-hydroxy-naphthalen-1-yl]sulfamoyl]benzoic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Saccharomyces cerevisiae	histone acetyltransferase GCN5	Starlite/ChEMBL	References
Saccharomyces cerevisiae	Rtt109p	Starlite/ChEMBL	References
Homo sapiens	E1A binding protein p300	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium vivax	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Brugia malayi	TAZ zinc finger family protein	Get druggable targets OG5_129174	All targets in OG5_129174
Schistosoma japonicum	CREB-binding protein, putative	Get druggable targets OG5_129174	All targets in OG5_129174
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	CREB-binding protein 1 (SmCBP1)	Get druggable targets OG5_129174	All targets in OG5_129174
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129174	All targets in OG5_129174
Echinococcus multilocularis	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium yoelii	histone acetyltransferase GCN5-related	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Schistosoma japonicum	ko:K06062 p300/CBP-associated factor, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Babesia bovis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium falciparum	histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Schistosoma japonicum	Protein cbp-1, putative	Get druggable targets OG5_129174	All targets in OG5_129174
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	CBP-B	Get druggable targets OG5_129174	All targets in OG5_129174
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129174	All targets in OG5_129174
Giardia lamblia	Histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	CREB-binding protein 2	Get druggable targets OG5_129174	All targets in OG5_129174
Candida albicans	Regulation of mitochondrial network	Get druggable targets OG5_136567	All targets in OG5_136567
Cryptosporidium hominis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	hypothetical protein	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium knowlesi	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K04498 E1A/CREB-binding protein, putative	Get druggable targets OG5_129174	All targets in OG5_129174
Echinococcus granulosus	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Brugia malayi	acetyltransferase, GNAT family protein	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium parvum	GCN5 like acetylase + bromodomain	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	Bromodomain containing protein, related	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium berghei	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	IPR011071,Polysaccharide lyase family 8-like, C-terminal,domain-containing	Get druggable targets OG5_129174	All targets in OG5_129174
Theileria parva	histone acetyltransferase Gcn5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	CREB binding protein	Get druggable targets OG5_129174	All targets in OG5_129174
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Entamoeba histolytica	acetyltransferase, GNAT family	Get druggable targets OG5_127781	All targets in OG5_127781

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0213	0.3885	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0273	0.544
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0379	0.7122	1
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0209	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0213	0.3885	0.8964
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0098	0.1654	0.2282
Schistosoma mansoni	glucose transport protein	0.0107	0.1827	0.4171
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0382	0.0404
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.039	0.8107
Loa Loa (eye worm)	acetylcholine receptor protein	0.0098	0.1654	0.1654
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0273	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0315	0.0315
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0209	0.1846
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0071	0.1122	0.282
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0097	0.1383
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0213	0.3885	0.5431
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Plasmodium vivax	hexose transporter	0.0107	0.1827	0.2094
Echinococcus multilocularis	CREB binding protein	0.002	0.0134	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0862	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.039	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0115	0.1974	0.2735
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0071	0.1128	0.1128
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1974	0.1974
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0369	0.0774
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0213	0.3885	0.5431
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0028	0.0291	0.5843
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0098	0.1654	0.4203
Schistosoma mansoni	nAChR subunit	0.0098	0.1654	0.3767
Brugia malayi	TAZ zinc finger family protein	0.0235	0.4329	0.6059
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0213	0.3885	0.5431
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.039	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0213	0.3885	1
Toxoplasma gondii	protein kinase, putative	0.0302	0.5631	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0098	0.1654	0.3767
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0382	0.0404
Schistosoma mansoni	nAChR subunit	0.0213	0.3885	0.8964
Loa Loa (eye worm)	ACC-1 protein	0.0213	0.3885	0.3885
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0213	0.3885	0.8964
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.1827	0.4171
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0381	0.0804
Loa Loa (eye worm)	GABA receptor subunit	0.0115	0.1974	0.1974
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0115	0.1974	0.4514
Echinococcus granulosus	CREB binding protein	0.002	0.0134	0.0228
Echinococcus granulosus	flap endonuclease 1	0.0028	0.0291	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0209	0.395
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0382	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Schistosoma mansoni	protein kinase	0.0033	0.0381	0.0804
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0036	0.5
Brugia malayi	acetyltransferase, GNAT family protein	0.0071	0.1122	0.1532
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0098	0.1654	0.1654
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Loa Loa (eye worm)	hypothetical protein	0.0379	0.7122	0.7122
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0273	0.0277
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0071	0.1122	0.2528
Echinococcus granulosus	glycine receptor subunit beta	0.0213	0.3885	0.8964
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0213	0.3885	0.8964
Onchocerca volvulus	Putative nachr subunit	0.0213	0.3885	1
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.039	0.8107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.1827	0.4171
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0098	0.1654	0.4203
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0213	0.3885	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.039	0.8107
Brugia malayi	hypothetical protein	0.0027	0.0273	0.0335
Trypanosoma brucei	glucose transporter 1E	0.0033	0.039	0.8107
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0213	0.3885	0.5431
Entamoeba histolytica	hypothetical protein	0.0039	0.05	0.165
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0209	0.0201
Trypanosoma brucei	glucose transporter, putative	0.0033	0.039	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0209	0.395
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.1827	0.4654
Plasmodium falciparum	protein kinase 7	0.0302	0.5631	0.6542
Schistosoma mansoni	hypothetical protein	0.0039	0.05	0.108
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0209	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0071	0.1122	0.194
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0098	0.1654	0.1654
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0342	0.0712
Leishmania major	hypothetical protein, conserved	0.0027	0.0273	0.544
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0151	0.0641
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0209	0.0209
Plasmodium falciparum	histone acetyltransferase GCN5	0.0063	0.0969	0.109
Entamoeba histolytica	hypothetical protein	0.0039	0.05	0.165
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0472	1
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0315	0.0393
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0213	0.3885	0.3885
Plasmodium falciparum	flap endonuclease 1	0.0028	0.0291	0.0298
Schistosoma mansoni	acetylcholine receptor-related	0.0098	0.1654	0.3767
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0381	0.0381
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0209	0.0401
Onchocerca volvulus		0.0213	0.3885	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0213	0.3885	0.5431
Trypanosoma brucei	glucose transporter, putative	0.0033	0.039	0.8107
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0369	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0369	0.0369
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0213	0.3885	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0213	0.3885	0.3885
Schistosoma mansoni	nAChR subunit	0.0213	0.3885	0.8964
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0071	0.1122	0.606
Plasmodium falciparum	protein kinase 6	0.0454	0.8588	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0062	0.0952	0.2134
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0213	0.3885	0.5431
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0071	0.1122	0.2528
Loa Loa (eye worm)	ACC-1 protein	0.0213	0.3885	0.3885
Trypanosoma cruzi	hexose transporter	0.0033	0.039	0.8107
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0472	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.039	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1974	0.1974
Echinococcus granulosus	CREB binding protein	0.0189	0.3416	0.7872
Loa Loa (eye worm)	sugar transporter	0.0015	0.0036	0.0036
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.039	0.8107
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0071	0.1122	0.194
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0381	0.7919
Schistosoma mansoni	protein kinase	0.0033	0.0381	0.0804
Leishmania major	protein kinase, putative	0.0033	0.0381	0.7919
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0209	0.0243
Schistosoma mansoni	CREB-binding protein 2	0.0235	0.4329	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0209	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0209	0.0401
Echinococcus multilocularis	CREB binding protein	0.002	0.0134	0.0254
Brugia malayi	Sugar transporter family protein	0.0107	0.1827	0.2527
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0209	0.395
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0472	0.051
Entamoeba histolytica	hypothetical protein	0.0115	0.1974	1
Echinococcus multilocularis	tar DNA binding protein	0.0071	0.1128	0.2837
Plasmodium vivax	flap endonuclease 1, putative	0.0028	0.0291	0.0298
Trypanosoma brucei	glucose transporter, putative	0.0033	0.039	0.8107
Brugia malayi	TAR-binding protein	0.0071	0.1128	0.1541
Trichomonas vaginalis	conserved hypothetical protein	0.0107	0.1827	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0213	0.3885	0.8964
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0098	0.1654	0.2282
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0036	0.0036
Echinococcus granulosus	glycine receptor subunit beta	0.0213	0.3885	0.8964
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.039	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0213	0.3885	0.8964
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1128	0.2543
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.05	0.108
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0213	0.3885	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1974	0.1974
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1974	0.1974
Echinococcus multilocularis	nAChR subunit	0.0213	0.3885	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.039	0.1973
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.039	0.1973
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0098	0.1654	0.2282
Echinococcus multilocularis	glycine receptor subunit beta	0.0213	0.3885	1
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0213	0.3885	1
Echinococcus granulosus	nAChR subunit	0.0115	0.1974	0.4514
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0213	0.3885	0.5431
Loa Loa (eye worm)	RNA binding protein	0.0071	0.1128	0.1128
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.1827	0.4171
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0213	0.3885	0.5431
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1128	0.2543
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0213	0.3885	0.5431
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0138	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0381	0.0381
Giardia lamblia	Histone acetyltransferase GCN5	0.0063	0.0969	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0213	0.3885	0.5431
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0382	0.0404
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0382	0.0404
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0098	0.1654	0.4203
Onchocerca volvulus		0.0213	0.3885	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0098	0.1654	0.2282
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0213	0.3885	0.3885
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0213	0.3885	1
Onchocerca volvulus		0.0213	0.3885	1
Giardia lamblia	Flap structure-specific endonuclease	0.0028	0.0291	0.2731
Brugia malayi	RNA binding protein	0.0071	0.1128	0.1541
Schistosoma mansoni	nAChR subunit	0.0098	0.1654	0.3767
Brugia malayi	excitatory GABA receptor EXP-1A	0.0213	0.3885	0.5431
Schistosoma mansoni	protein kinase	0.0033	0.0381	0.0804
Onchocerca volvulus		0.0115	0.1974	0.5036
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0472	0.051
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0382	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Loa Loa (eye worm)	sugar transporter	0.0107	0.1827	0.1827
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0213	0.3885	0.3885
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0472	1
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0213	0.3885	1
Echinococcus multilocularis	General substrate transporter	0.0092	0.1534	0.3892
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0107	0.1827	0.4654
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0213	0.3885	0.3885
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0213	0.3885	0.8964
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Onchocerca volvulus		0.0098	0.1654	0.4203
Leishmania major	glucose transporter, lmgt1	0.0033	0.039	0.8107
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0381	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0173	0.3111	0.5495
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0209	0.0201
Echinococcus granulosus	nAChR subunit	0.0213	0.3885	0.8964
Brugia malayi	hypothetical protein	0.0098	0.1654	0.2282
Loa Loa (eye worm)	flap endonuclease-1	0.0028	0.0291	0.0291
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0381	0.0804
Trypanosoma brucei	glucose transporter, putative	0.0033	0.039	0.8107
Brugia malayi	hypothetical protein	0.0039	0.05	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Echinococcus multilocularis	CREB binding protein	0.002	0.0134	0.0254
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.1827	0.4654
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0209	0.0401
Trypanosoma brucei	glucose transporter 2A	0.0033	0.039	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Echinococcus granulosus	General substrate transporter	0.0092	0.1534	0.3489
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0381	0.0804
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0369	0.0469
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0213	0.3885	0.5431
Echinococcus granulosus	CREB binding protein	0.0235	0.4329	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0369	0.0774
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0213	0.3885	0.8964
Schistosoma mansoni	nAChR subunit	0.0213	0.3885	0.8964
Loa Loa (eye worm)	acetyltransferase	0.0071	0.1122	0.1122
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0273	0.0424
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1128	0.2543
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0213	0.3885	0.8964
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0273	0.0277
Schistosoma mansoni	nAChR subunit	0.0213	0.3885	0.8964
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0213	0.3885	0.8964
Schistosoma mansoni	CREB-binding protein 1 (SmCBP1)	0.0235	0.4329	1
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0454	0.8588	1
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0173	0.3111	0.3595
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0213	0.3885	0.5431
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Schistosoma mansoni	nAChR subunit	0.0213	0.3885	0.8964
Brugia malayi	Cation transporter family protein	0.0213	0.3885	0.5431
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Echinococcus multilocularis	nAChR subunit	0.0115	0.1974	0.5036
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0369	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0209	1
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1128	0.2543
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.039	0.1973
Brugia malayi	hypothetical protein	0.0098	0.1654	0.2282
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0472	0.0779
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0209	0.0447
Schistosoma mansoni	glucose transport protein	0.0107	0.1827	0.4171
Echinococcus granulosus	CREB binding protein	0.002	0.0134	0.0228
Brugia malayi	Cation transporter family protein	0.0213	0.3885	0.5431
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0213	0.3885	1
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0028	0.0291	0.5843
Schistosoma mansoni	flap endonuclease-1	0.0025	0.0238	0.0471
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0213	0.3885	0.5431
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0213	0.3885	1
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0381	0.1927
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0381	0.0897
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0369	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Brugia malayi	Flap endonuclease-1	0.0028	0.0291	0.0359
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0115	0.1974	0.2735
Onchocerca volvulus		0.0098	0.1654	0.4203
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0213	0.3885	0.8964
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0028	0.0291	0.5843
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1974	0.1974
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1974	0.1974
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0381	0.0897
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0273	0.544
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0098	0.1654	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0382	0.0404
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0381	0.0487
Onchocerca volvulus		0.0098	0.1654	0.4203
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.039	0.8107
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0213	0.3885	0.5431
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0209	0.3046
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0209	0.0308
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0213	0.3885	0.8964
Loa Loa (eye worm)	hypothetical protein	0.0281	0.5212	0.5212
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.039	0.8107
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0472	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0098	0.1654	0.3767
Loa Loa (eye worm)	LGC-31 protein	0.0213	0.3885	0.3885
Trypanosoma brucei	glucose transporter, putative	0.0033	0.039	0.8107
Brugia malayi	RNA recognition motif domain containing protein	0.0071	0.1128	0.1541
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0369	0.0906
Trypanosoma brucei	glucose transporter, putative	0.0033	0.039	0.8107
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0098	0.1654	0.3767
Trypanosoma brucei	glucose transporter, putative	0.0033	0.039	0.8107
Plasmodium falciparum	hexose transporter	0.0107	0.1827	0.2094
Leishmania major	glucose transporter, lmgt2	0.0033	0.039	0.8107
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0382	0.0617
Schistosoma mansoni	nAChR subunit	0.0213	0.3885	0.8964
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0382	0.0404
Echinococcus granulosus	tar DNA binding protein	0.0071	0.1128	0.2543
Onchocerca volvulus		0.0213	0.3885	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.05	0.1205
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.1827	0.4654
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0381	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0273	0.544
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0213	0.3885	0.5431
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0138	1
Schistosoma mansoni	nAChR subunit	0.0213	0.3885	0.8964
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0213	0.3885	0.8964
Onchocerca volvulus		0.0115	0.1974	0.5036
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0369	0.3563
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0213	0.3885	0.8964
Brugia malayi	hypothetical protein	0.0098	0.1654	0.2282
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0098	0.1654	0.2282
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0071	0.1122	0.1269
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0213	0.3885	0.8964
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1974	0.1974
Brugia malayi	Cam kinase protein 1	0.0033	0.0381	0.0487
Entamoeba histolytica	Flap nuclease, putative	0.0028	0.0291	0.0467
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0382	0.0404
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.039	0.8107
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0115	0.1974	0.4514
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1128	0.2543
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0213	0.3885	1
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0213	0.3885	0.8964
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0115	0.1974	0.2735
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0369	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0273	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0381	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1974	0.1974
Entamoeba histolytica	protein kinase, putative	0.0033	0.0381	0.0979
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0213	0.3885	0.3885
Entamoeba histolytica	hypothetical protein	0.0039	0.05	0.165
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0381	0.0804
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0098	0.1654	0.3767
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0028	0.0291	0.0455
Echinococcus multilocularis	flap endonuclease 1	0.0028	0.0291	0.0662
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0213	0.3885	0.8964
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0382	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0213	0.3885	0.8964
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0382	0.0404
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0036	0.0036
Loa Loa (eye worm)	TAR-binding protein	0.0071	0.1128	0.1128
Entamoeba histolytica	acetyltransferase, GNAT family	0.0063	0.0969	0.4304
Entamoeba histolytica	protein kinase, putative	0.0033	0.0381	0.0979
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Loa Loa (eye worm)	CBP-B	0.0198	0.3601	0.3601
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.039	0.1973
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0071	0.1122	0.606
Entamoeba histolytica	hypothetical protein	0.0039	0.05	0.165
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0098	0.1654	0.3767
Schistosoma mansoni	glucose transport protein	0.0107	0.1827	0.4171
Brugia malayi	hypothetical protein	0.0098	0.1654	0.2282
Echinococcus multilocularis	glycine receptor subunit beta	0.0213	0.3885	1
Onchocerca volvulus		0.0213	0.3885	1
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3885	0.3885
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1654	0.1654
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0472	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0369	0.0469
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.1827	0.4171
Schistosoma mansoni	neurotransmitter gated ion channel	0.0115	0.1974	0.4514
Brugia malayi	hypothetical protein	0.0098	0.1654	0.2282
Brugia malayi	Cation transporter family protein	0.0213	0.3885	0.5431
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0036	0.0036
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0173	0.3111	0.3595
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0381	0.0897
Trichomonas vaginalis	flap endonuclease-1, putative	0.0028	0.0291	0.1422
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0115	0.1974	0.2735
Schistosoma mansoni	hypothetical protein	0.0107	0.1827	0.4171
Brugia malayi	hypothetical protein	0.0018	0.0086	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0369	0.0369
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0342	0.0794
Toxoplasma gondii	facilitative glucose transporter GT1	0.0107	0.1827	0.3201
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.05	0.108
Echinococcus multilocularis	CREB binding protein	0.0197	0.358	0.921
Leishmania major	glucose transporter, lmgt3	0.0033	0.039	0.8107

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 assessed as H3K56 acetylated product at 125 uM after 45 mins by Slot bolt inhibiton assay	ChEMBL.	25634295
Activity (binding)		Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting in presence of 1 mM DTT	ChEMBL.	25634295
Activity (binding)		Inhibition of yeast histone acetyltransferase Gcn5-Ada2-Ada3 complex using tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting in presence of 1 mM DTT	ChEMBL.	25634295
Activity (binding)		Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 assessed as H3K27 acetylated product at 125 uM after 45 mins by Slot bolt inhibiton assay	ChEMBL.	25634295
GI50 (functional)	= 4.4 uM	Growth inhibition of human HT-29 cells after 2 days by MTT assay	ChEMBL.	22309208
IC50 (binding)		Inhibition of human Kif5C ATPase activity by pyruvate kinase/lactate dehydrogenase-linked assay	ChEMBL.	22309208
IC50 (binding)		Inhibition of Eg5 ATPase activity by pyruvate kinase/lactate dehydrogenase-linked assay	ChEMBL.	22309208
IC50 (binding)		Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenzyme A production after 45 mins by CoA-based HTS counter screen assay	ChEMBL.	25634295
IC50 (binding)		Inhibition of human Kif5A ATPase activity by pyruvate kinase/lactate dehydrogenase-linked assay	ChEMBL.	22309208
IC50 (binding)		Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenzyme A production after 45 mins by CPM based HTS assay	ChEMBL.	25634295
IC50 (binding)	= 0.15 uM	Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting	ChEMBL.	25634295
IC50 (binding)	= 0.66 uM	Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting	ChEMBL.	25634295
IC50 (binding)	= 1.3 uM	Inhibition of yeast histone acetyltransferase Gcn5-Ada2-Ada3 complex using tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting	ChEMBL.	25634295
IC50 (binding)	= 20 uM	Inhibition of recombinant STAT3 assessed as inhibition of STAT3-phosphododecapeptide interaction by SPR analysis	ChEMBL.	22650325
IC50 (binding)	= 73 uM	Inhibition of IL6-mediated STAT3 phosphorylation in human HepG2 cells preincubated for 1 hr prior to IL6 challenge measured after 30 mins by immunoblot analysis	ChEMBL.	22650325

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2031566
Search by Saint Jude

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 771610