Detailed information for compound 777378

Basic information

Technical information
  • TDR Targets ID: 777378
  • Name: 3,5-dimethyl-6-propylpyrano[5,6-f][1]benzoxol -7-one
  • MW: 256.296 | Formula: C16H16O3
  • H donors: 0 H acceptors: 1 LogP: 3.94 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1c(=O)oc2c(c1C)cc1c(c2)occ1C
  • InChi: 1S/C16H16O3/c1-4-5-11-10(3)13-6-12-9(2)8-18-14(12)7-15(13)19-16(11)17/h6-8H,4-5H2,1-3H3
  • InChiKey: WYJIAHORHOZJHY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3,5-dimethyl-6-propyl-pyrano[5,6-f]benzofuran-7-one
  • 3,5-dimethyl-6-propyl-7-pyrano[5,6-f]benzofuranone
  • 3,5-dimethyl-6-propyl-pyrano[5,6-f][1]benzoxol-7-one
  • EU-0014609
  • ST5451181
  • ZINC00095243

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0039 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0273 0.0286
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0039 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.5
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0101 0.0106
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.1224 0.9531 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.5
Schistosoma mansoni beta-mannosidase 0.0416 0.3164 0.9195
Trichomonas vaginalis conserved hypothetical protein 0.1284 1 1
Brugia malayi intermediate filament protein 0.0028 0.0101 0.0106
Schistosoma mansoni lamin 0.0028 0.0101 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.5
Giardia lamblia DINP protein human, muc B family 0.002 0.0039 0.5
Brugia malayi Beta-glucuronidase precursor 0.119 0.9258 0.9713
Loa Loa (eye worm) hypothetical protein 0.0027 0.0097 0.0102
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0039 0.5
Leishmania major DNA polymerase eta, putative 0.002 0.0039 0.5
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0039 0.5
Entamoeba histolytica beta-galactosidase, putative 0.0868 0.6719 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0101 0.0106
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0039 0.5
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0039 0.5
Echinococcus granulosus lamin dm0 0.0028 0.0101 0.0353
Schistosoma mansoni hypothetical protein 0.0049 0.0273 0.0688
Trichomonas vaginalis beta-mannosidase, putative 0.0416 0.3164 0.3137
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0039 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0106
Schistosoma mansoni survival motor neuron protein 0.0049 0.0273 0.0688
Leishmania major DNA polymerase kappa, putative 0.002 0.0039 0.5
Echinococcus multilocularis lamin 0.0028 0.0101 0.0353
Schistosoma mansoni intermediate filament proteins 0.0028 0.0101 0.0182
Schistosoma mansoni lamin 0.0028 0.0101 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.5
Loa Loa (eye worm) hypothetical protein 0.0773 0.5977 0.6271
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.1794 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0039 0.5
Brugia malayi manba-prov protein 0.0416 0.3164 0.332
Onchocerca volvulus 0.0049 0.0273 1
Echinococcus multilocularis lamin dm0 0.0028 0.0101 0.0353
Loa Loa (eye worm) glycosyl hydrolase family 2 0.1224 0.9531 1
Echinococcus multilocularis musashi 0.0028 0.0101 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0039 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0041
Schistosoma mansoni hypothetical protein 0.0451 0.3438 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.5
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.1794 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0039 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.5
Brugia malayi hypothetical protein 0.0242 0.1794 0.1882
Echinococcus granulosus intermediate filament protein 0.0028 0.0101 0.0353
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0039 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0039 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.5
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0039 0.0041
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0101 0.0106
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0039 0.5
Loa Loa (eye worm) beta-glucuronidase 0.119 0.9258 0.9713
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0039 0.5
Trichomonas vaginalis beta-galactosidase, putative 0.1284 1 1
Echinococcus granulosus lamin 0.0028 0.0101 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0039 0.5
Loa Loa (eye worm) hypothetical protein 0.0242 0.1794 0.1882
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0039 0.5
Trypanosoma brucei unspecified product 0.002 0.0039 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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