Detailed information for compound 78334

Basic information

Technical information
  • TDR Targets ID: 78334
  • Name: N-(3-bromophenyl)-7-fluoropyrido[4,3-d]pyrimi din-4-amine
  • MW: 319.132 | Formula: C13H8BrFN4
  • H donors: 1 H acceptors: 3 LogP: 3.47 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cccc(c1)Nc1ncnc2c1cnc(c2)F
  • InChi: 1S/C13H8BrFN4/c14-8-2-1-3-9(4-8)19-13-10-6-16-12(15)5-11(10)17-7-18-13/h1-7H,(H,17,18,19)
  • InChiKey: ZSEDCGVJIAHLRN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-bromophenyl)-7-fluoro-pyrido[4,3-d]pyrimidin-4-amine
  • N-(3-bromophenyl)-7-fluoro-4-pyrido[4,3-d]pyrimidinamine
  • (3-bromophenyl)-(7-fluoropyrido[4,3-d]pyrimidin-4-yl)amine
  • N-(3-bromophenyl)-7-fluoropyrido[5,4-e]pyrimidin-4-amine
  • N-(3-bromophenyl)-7-fluoro-pyrido[5,4-e]pyrimidin-4-amine
  • N-(3-bromophenyl)-7-fluoro-4-pyrido[5,4-e]pyrimidinamine
  • (3-bromophenyl)-(7-fluoropyrido[5,4-e]pyrimidin-4-yl)amine
  • Pyrido[4,3-d]pyrimidine 5e

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni transient receptor potential channel 0.0063 0.124 0.3095
Schistosoma mansoni hypothetical protein 0.0102 0.2171 0.5417
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2171 0.5396
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0602 0.0894
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0506 0.0752
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.034 0.034
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0589 0.1469
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0036 0.0597 1
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.124 0.3062
Brugia malayi Probable DNA topoisomerase II 0.0137 0.2985 0.7386
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0506 0.1416
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0497 0.0497
Toxoplasma gondii sugar transporter ST1 0.0014 0.0097 0.0148
Echinococcus granulosus solute carrier family 22 0.0014 0.0097 0.0196
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0192 0.0243
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0014 0.004
Entamoeba histolytica protein kinase, putative 0.0031 0.0497 0.0401
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0538 0.0799
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.3007 0.7491
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0215 0.0354
Chlamydia trachomatis DNA gyrase subunit A 0.0029 0.0452 0.2696
Echinococcus granulosus dna polymerase kappa 0.0059 0.1152 0.284
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0497 0.0756
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.1152 0.3357
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0497 0.124
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0359 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1152 0.1711
Loa Loa (eye worm) hypothetical protein 0.0032 0.0517 0.1168
Schistosoma mansoni glucose transporter 0.0014 0.0097 0.0243
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0497 0.1384
Brugia malayi CHE-14 protein 0.0041 0.0734 0.1627
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.0752
Leishmania major DNA topoisomerase ii 0.0129 0.2811 0.4176
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0506 0.0752
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0734 0.1791
Brugia malayi MH2 domain containing protein 0.0117 0.2515 0.6182
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0506 0.1416
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0497 0.0497
Brugia malayi isocitrate dehydrogenase 0.0015 0.0123 0.0065
Schistosoma mansoni sugar transporter 0.0014 0.0097 0.0243
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0497 0.0497
Schistosoma mansoni hypothetical protein 0.0035 0.0589 0.1469
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0497 0.1118
Trichomonas vaginalis DNA topoisomerase II, putative 0.0137 0.2985 1
Trypanosoma brucei DNA topoisomerase ii 0.0154 0.3381 0.5022
Entamoeba histolytica hypothetical protein 0.0023 0.0297 0.0137
Trypanosoma cruzi DNA topoisomerase II, putative 0.0129 0.2811 0.4176
Schistosoma mansoni hypothetical protein 0.004 0.0698 0.1743
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.2515 0.6223
Mycobacterium ulcerans DNA gyrase subunit B 0.008 0.164 0.478
Schistosoma mansoni protein kinase 0.0031 0.0497 0.124
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0097 0.0144
Entamoeba histolytica hypothetical protein 0.0035 0.0589 0.0522
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0497 0.1198
Plasmodium vivax sugar transporter, putative 0.0014 0.0097 0.0097
Echinococcus multilocularis protein dispatched 1 0.0047 0.0871 0.2137
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0739 0.1097
Leishmania major hypothetical protein, conserved 0.0025 0.034 0.0505
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0538 0.1127
Schistosoma mansoni tyrosine kinase 0.0097 0.2041 0.5093
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.1152 0.1711
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0058 0.1116 0.275
Loa Loa (eye worm) hypothetical protein 0.0093 0.1942 0.4774
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.069 0.1025
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0123 0.0182
Giardia lamblia Sugar-proton symporter 0.0014 0.0097 0.0125
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.008 0.164 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0497 0.0738
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0192 0.0434
Plasmodium vivax DNA gyrase subunit B, putative 0.008 0.164 0.164
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.1152 0.1711
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0123 0.0187
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0029 0.0452 0.1064
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.1152 0.3357
Schistosoma mansoni protein kinase 0.0031 0.0497 0.124
Schistosoma mansoni hypothetical protein 0.0015 0.0122 0.0305
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0506 0.0752
Loa Loa (eye worm) hypothetical protein 0.0033 0.0538 0.1221
Echinococcus multilocularis General substrate transporter 0.0088 0.1832 0.4545
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0152 0.0232
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0359 0.0769
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0122 0.0259
Loa Loa (eye worm) hypothetical protein 0.0019 0.0202 0.037
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0123 0.0306
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1152 0.1711
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1152 0.1711
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0538 0.0799
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0614 0.0912
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0192 0.0286
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0123 0.0187
Echinococcus granulosus expressed conserved protein 0.009 0.1893 0.4699
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0482 0.1161
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0097 0.0097
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0123 0.0065
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2171 0.5396
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.0752
Echinococcus multilocularis 0.0056 0.1073 0.2643
Brugia malayi Flap endonuclease-1 0.0025 0.0359 0.067
Plasmodium falciparum DNA gyrase subunit A 0.0029 0.0452 0.0452
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0506 0.0752
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0137 0.2985 0.7437
Loa Loa (eye worm) hypothetical protein 0.0041 0.0734 0.1716
Loa Loa (eye worm) hypothetical protein 0.0049 0.0909 0.216
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0506 0.1416
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Entamoeba histolytica hypothetical protein 0.0097 0.2042 0.2436
Loa Loa (eye worm) hypothetical protein 0.0096 0.2031 0.5
Echinococcus granulosus geminin 0.0166 0.3671 0.9155
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0482 0.1203
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0123 0.0123
Echinococcus multilocularis expressed conserved protein 0.009 0.1893 0.4699
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0497 0.0497
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0122 0.0259
Brugia malayi polk-prov protein 0.0036 0.0614 0.1321
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0097 0.0107
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0589 0.1428
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0058 0.1116 0.275
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Echinococcus granulosus insulin receptor 0.0058 0.1116 0.275
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0538 0.1127
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0097 0.0283
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.069 0.1025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.034 0.034
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0497 0.0756
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.3007 0.7491
Trypanosoma brucei unspecified product 0.0023 0.0296 0.0439
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.1152 0.1711
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0497 0.0497
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0538 0.1301
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0122 0.0259
Leishmania major glucose transporter, lmgt2 0.0032 0.0506 0.0752
Schistosoma mansoni flap endonuclease-1 0.0023 0.0302 0.0752
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2171 0.5396
Schistosoma mansoni sugar transporter 0.0014 0.0097 0.0243
Plasmodium falciparum DNA gyrase subunit B 0.008 0.164 0.164
Echinococcus granulosus epidermal growth factor receptor 0.018 0.4008 1
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0592 0.1264
Entamoeba histolytica hypothetical protein 0.0035 0.0589 0.0522
Echinococcus granulosus flap endonuclease 1 0.0025 0.0359 0.0853
Schistosoma mansoni DNA topoisomerase II 0.0137 0.2985 0.7449
Toxoplasma gondii sugar transporter ST3 0.0014 0.0097 0.0148
Toxoplasma gondii protein kinase, putative 0.0289 0.6576 1
Giardia lamblia DNA repair protein RAD52 0.034 0.7785 1
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0359 0.022
Loa Loa (eye worm) sugar transporter 0.0014 0.0097 0.0107
Plasmodium falciparum DNA topoisomerase 2 0.0137 0.2985 0.2985
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0123 0.0182
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.2515 0.6223
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0297 0.0441
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0497 0.1198
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0359 0.0907
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3657 0.3657
Plasmodium falciparum protein kinase 7 0.0289 0.6576 0.6576
Plasmodium vivax DNA topoisomerase II, putative 0.0137 0.2985 0.2985
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0448 0.0666
Plasmodium vivax hexose transporter 0.0102 0.2171 0.2171
Trypanosoma cruzi hexose transporter 0.0032 0.0506 0.0752
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0602 0.0894
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0137 0.2985 0.7386
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0029 0.0452 0.2696
Mycobacterium ulcerans sugar transporter 0.0014 0.0097 0.0283
Loa Loa (eye worm) hypothetical protein 0.0031 0.0482 0.108
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0097 0.2042 0.2436
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0123 0.0182
Leishmania major DNA polymerase eta, putative 0.0033 0.0538 0.0799
Loa Loa (eye worm) hypothetical protein 0.0056 0.1071 0.257
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.0752
Echinococcus granulosus dna polymerase eta 0.0033 0.0538 0.1301
Trypanosoma brucei DNA polymerase IV, putative 0.0053 0.0999 0.1485
Schistosoma mansoni transient receptor potential channel 0.0063 0.124 0.3095
Brugia malayi Sugar transporter family protein 0.0102 0.2171 0.5303
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.4008 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2171 0.5396
Giardia lamblia Hexose transporter 0.0014 0.0097 0.0125
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0123 0.026
Loa Loa (eye worm) hypothetical protein 0.0025 0.0346 0.0736
Schistosoma mansoni glucose transport protein 0.0102 0.2171 0.5417
Schistosoma mansoni ap endonuclease 0.0018 0.0192 0.048
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0123 0.026
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0092 0.1939 0.5847
Leishmania major glucose transporter, lmgt1 0.0032 0.0506 0.0752
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0192 0.0329
Loa Loa (eye worm) hypothetical protein 0.0051 0.0953 0.2272
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0166 0.3671 0.9159
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1152 0.1711
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0123 0.0182
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0192 0.0247
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0602 0.0894
Trypanosoma brucei glucose transporter 2A 0.0032 0.0506 0.0752
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2171 0.5396
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1152 0.1711
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.008 0.164 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1166 0.281
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0359 0.0534
Toxoplasma gondii exonuclease III APE 0.0018 0.0192 0.0292
Leishmania major DNA polymerase kappa, putative 0.004 0.069 0.1025
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0192 0.0434
Entamoeba histolytica protein kinase, putative 0.0031 0.0497 0.0401
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0506 0.1416
Echinococcus granulosus GPCR family 2 0.0015 0.0122 0.0259
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3657 0.3657
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0359 0.0853
Mycobacterium ulcerans hypothetical protein 0.0156 0.3431 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0497 0.1118
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0497 0.0497
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0451 0.1084
Chlamydia trachomatis DNA gyrase subunit A 0.0029 0.0452 0.2696
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.124 0.3062
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0129 0.2811 0.4176
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0909 0.2076
Loa Loa (eye worm) TOPoisomerase family member 0.0137 0.2985 0.7414
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.6732 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0297 0.074
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.1924 0.4777
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0297 0.074
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.0752
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0122 0.0064
Leishmania major glucose transporter, lmgt3 0.0032 0.0506 0.0752
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0734 0.2203
Brugia malayi Cam kinase protein 1 0.0031 0.0497 0.1022
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.2041 0.507
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0092 0.1939 0.5847
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.124 0.3062
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0097 0.0196
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.3058 0.4543
Schistosoma mansoni glucose transport protein 0.0102 0.2171 0.5417
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0451 0.1084
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0097 0.0196
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.008 0.164 0.2494
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0192 0.0286
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.1924 0.4777
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0092 0.1939 0.5847
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0297 0.174
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.3431 1
Loa Loa (eye worm) sugar transporter 0.0102 0.2171 0.5353
Loa Loa (eye worm) hypothetical protein 0.0025 0.034 0.0721
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0123 0.026
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0192 0.0615
Schistosoma mansoni tyrosine kinase 0.0096 0.2017 0.5033
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.034 0.034
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.1999 0.4988
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0123 0.026
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.034 0.0517
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.3058 0.4543
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0538 0.1321
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0497 0.0497
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.1152 0.3651
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0097 0.0144
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0297 0.0441
Leishmania major hypothetical protein, conserved 0.0014 0.0097 0.0144
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.069 0.1778
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0506 0.1416
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0538 0.1221
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0589 0.1428
Brugia malayi hypothetical protein 0.0148 0.3247 0.8055
Brugia malayi hypothetical protein 0.0016 0.0134 0.0093
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0097 0.0243
Plasmodium vivax CDK-related protein kinase 6, putative 0.0434 1 1
Schistosoma mansoni patched 1 0.0041 0.0734 0.183
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0497 0.1198
Schistosoma mansoni tyrosine kinase 0.018 0.4008 1
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0506 0.1416
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0122 0.0259
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0506 0.0752
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2171 0.5396
Leishmania major mitochondrial DNA topoisomerase II 0.0154 0.3381 0.5022
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0592 0.1435
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0192 0.1098
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0097 0.0196
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0482 0.0382
Echinococcus multilocularis solute carrier family 22 0.0014 0.0097 0.0196
Loa Loa (eye worm) hypothetical protein 0.0023 0.0297 0.0611
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.0752
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0497 0.0756
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.0752
Entamoeba histolytica hypothetical protein 0.0035 0.0589 0.0522
Loa Loa (eye worm) hypothetical protein 0.0019 0.0202 0.037
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0297 0.0696
Loa Loa (eye worm) TK/EGFR protein kinase 0.018 0.4008 1
Toxoplasma gondii sugar transporter ST2 0.0014 0.0097 0.0148
Echinococcus granulosus General substrate transporter 0.0088 0.1832 0.4545
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.1152 0.1711
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0097 0.0144
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0192 0.0192
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0909 0.216
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0953 0.1416
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0448 0.0666
Echinococcus multilocularis solute carrier family 22 0.0014 0.0097 0.0196
Loa Loa (eye worm) hypothetical protein 0.0035 0.0592 0.1357
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0123 0.026
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0545 0.1145
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0297 0.0297
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.034 0.0505
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0538 0.0455
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0297 0.0864
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0097 0.0283
Schistosoma mansoni tyrosine kinase 0.0058 0.1116 0.2785
Trypanosoma brucei sugar transporter, putative 0.0014 0.0097 0.0144
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0297 0.069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.6732 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0538 0.1301
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.2041 0.507
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0297 0.0864
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0482 0.0619
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.1999 0.4964
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0506 0.0752
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2171 0.3302
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0122 0.017
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0192 0.0285
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0739 0.1097
Leishmania major protein kinase, putative 0.0031 0.0497 0.0738
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0029 0.0452 0.23
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.2041 0.507
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.0752
Giardia lamblia DINP protein human, muc B family 0.004 0.069 0.0886
Mycobacterium ulcerans DNA gyrase subunit A 0.0029 0.0452 0.1318
Plasmodium vivax DNA gyrase subunit A, putative 0.0029 0.0452 0.0452
Schistosoma mansoni hypothetical protein 0.0166 0.3671 0.9159
Loa Loa (eye worm) hypothetical protein 0.0095 0.1999 0.4918
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0538 0.1342
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0497 0.1198
Schistosoma mansoni hypothetical protein 0.004 0.0698 0.1743
Echinococcus multilocularis GPCR, family 2 0.0015 0.0122 0.0259
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.008 0.164 0.4627
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.2031 0.2422
Schistosoma mansoni tyrosine kinase 0.0096 0.2017 0.5033
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0497 0.1198
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0154 0.3381 0.5022
Loa Loa (eye worm) hypothetical protein 0.0033 0.0545 0.1239
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0614 0.0912
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.1999 0.4964
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0297 0.0381
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0739 0.1097
Echinococcus granulosus solute carrier family 22 0.0014 0.0097 0.0196
Schistosoma mansoni hypothetical protein 0.004 0.0698 0.1743
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.2031 0.4946
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0497 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0506 0.1416
Onchocerca volvulus 0.0148 0.3247 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0123 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1152 0.1711
Schistosoma mansoni hypothetical protein 0.0015 0.0122 0.0305
Echinococcus granulosus solute carrier family 22 0.0014 0.0097 0.0196
Plasmodium falciparum hexose transporter 0.0102 0.2171 0.2171
Loa Loa (eye worm) hypothetical protein 0.0036 0.0614 0.1414
Schistosoma mansoni tyrosine kinase 0.0058 0.1116 0.2785
Schistosoma mansoni ap endonuclease 0.0018 0.0192 0.048
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0602 0.0915
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0482 0.1161
Loa Loa (eye worm) hypothetical protein 0.0031 0.0482 0.108
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0734 0.1716
Giardia lamblia DNA topoisomerase II 0.013 0.2817 0.3619
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0129 0.2811 0.4176
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0123 0.0076
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.1152 0.3651
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0097 0.0144
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.023 0.046
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0297 0.213
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Plasmodium falciparum flap endonuclease 1 0.0025 0.0359 0.0359
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0359 0.0461
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.0752
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0602 0.0602
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.124 0.3062
Chlamydia trachomatis DNA gyrase subunit B 0.008 0.164 1
Schistosoma mansoni tyrosine kinase 0.0096 0.2017 0.5033
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0192 0.0347
Loa Loa (eye worm) hypothetical protein 0.0031 0.0497 0.1118
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0123 0.026
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0734 0.1791
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Schistosoma mansoni DNA polymerase eta 0.0033 0.0538 0.1342
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.1152 0.1711
Schistosoma mansoni hypothetical protein 0.0015 0.0122 0.0305
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0097 0.0107
Schistosoma mansoni glucose transport protein 0.0102 0.2171 0.5417
Schistosoma mansoni sugar transporter 0.0014 0.0097 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1152 0.1711
Trypanosoma brucei unspecified product 0.0053 0.0999 0.1485
Schistosoma mansoni protein kinase 0.0031 0.0497 0.124
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0167 0.0248
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0123 0.0182
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.1152 0.1711
Entamoeba histolytica hypothetical protein 0.0035 0.0589 0.0522
Loa Loa (eye worm) hypothetical protein 0.0019 0.0202 0.037
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.1116 0.2684
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0297 0.0696
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0592 0.1435
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3657 0.5562
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0215 0.0354
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0192 0.0192
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0497 0.1198
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0122 0.0064
Schistosoma mansoni hypothetical protein 0.0033 0.0545 0.136
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2171 0.5396
Loa Loa (eye worm) hypothetical protein 0.0148 0.3247 0.8076
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.6732 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0093 0.1942 0.4774
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0602 0.0894
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0482 0.6992
Toxoplasma gondii hypothetical protein 0.0048 0.0883 0.1342
Loa Loa (eye worm) hypothetical protein 0.0056 0.1071 0.257
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0448 0.0666
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0154 0.3381 0.5022
Brugia malayi Furin-like cysteine rich region family protein 0.018 0.4008 1
Schistosoma mansoni hypothetical protein 0.004 0.0698 0.1743
Echinococcus multilocularis solute carrier family 22 0.0014 0.0097 0.0196
Toxoplasma gondii DNA topoisomerase 2, putative 0.0137 0.2985 0.454
Echinococcus granulosus solute carrier family 22 0.0014 0.0097 0.0196
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0097 0.0196
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Echinococcus multilocularis insulin receptor 0.0058 0.1116 0.275
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0506 0.0752
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0602 0.0894
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.034 0.7785 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.034 0.0505
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.2031 0.5045
Brugia malayi hypothetical protein 0.0025 0.034 0.0621
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0097 0.0283
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0029 0.0452 0.0688
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0297 0.0297
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0192 0.0286
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0734 0.1791
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0482 0.0984
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.034 0.0505
Schistosoma mansoni sugar transporter 0.0014 0.0097 0.0243
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.2066 0.5156
Schistosoma mansoni hypothetical protein 0.0011 0.0019 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1152 0.1711
Trypanosoma brucei glucose transporter 1E 0.0032 0.0506 0.0752
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2171 0.718
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0192 0.0286
Echinococcus multilocularis protein patched 0.0041 0.0734 0.1791
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0359 0.0359
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.6732 1
Brugia malayi hypothetical protein 0.0035 0.0589 0.1257
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.2031 0.5045
Entamoeba histolytica DNA topoisomerase II, putative 0.0137 0.2985 0.3679
Trypanosoma cruzi DNA topoisomerase II, putative 0.0129 0.2811 0.4176
Echinococcus multilocularis geminin 0.0166 0.3671 0.9155
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0497 0.1198
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0297 0.0451
Brugia malayi Protein kinase domain containing protein 0.0058 0.1116 0.2605
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0297 0.051
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0482 0.1332
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0359 0.0534
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0107
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0482 0.0984
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0538 0.1342
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0097 0.0144
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0097 0.0148
Schistosoma mansoni tyrosine kinase 0.0097 0.2041 0.5093
Schistosoma mansoni hypothetical protein 0.0015 0.0122 0.0305
Trypanosoma brucei unspecified product 0.0023 0.0296 0.0439
Chlamydia trachomatis DNA gyrase subunit B 0.0063 0.1245 0.7571
Echinococcus multilocularis dna polymerase kappa 0.0059 0.1152 0.284
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0359 0.0534
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2171 0.5396
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0137 0.2985 0.7386
Echinococcus multilocularis solute carrier family 22 0.0014 0.0097 0.0196
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0482 0.1203
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0137 0.2985 0.7437
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.1152 0.1711
Loa Loa (eye worm) hypothetical protein 0.0015 0.0122 0.017
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0739 0.1097
Echinococcus multilocularis dna polymerase eta 0.0033 0.0538 0.1301
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0192 0.056
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0909 0.2076
Schistosoma mansoni transient receptor potential channel 0.0095 0.1999 0.4988
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0297 0.0441
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0192 0.0329
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0497 0.1198
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0497 0.1022
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.3058 0.4543

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 13 nM Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells ChEMBL. 8627606
IC50 (binding) = 13 nM Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells ChEMBL. 8627606

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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