Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0667 | 0.0667 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0254 | 0.2565 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0169 | 0.1586 | 0.2516 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0254 | 0.2565 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0089 | 0.0667 | 0.1058 |
Schistosoma mansoni | hypothetical protein | 0.0213 | 0.2086 | 0.331 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.004 | 0.0096 | 0.0152 |
Brugia malayi | ecdysone receptor | 0.008 | 0.0556 | 0.0556 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.008 | 0.0556 | 0.0883 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.0189 | 0.0189 |
Brugia malayi | hypothetical protein | 0.0089 | 0.0667 | 0.0667 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0667 | 0.0667 |
Echinococcus multilocularis | serotonin receptor | 0.0415 | 0.4424 | 0.7018 |
Brugia malayi | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.0401 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0899 | 1 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.008 | 0.0556 | 0.0556 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.0308 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0415 | 0.4424 | 0.4424 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0169 | 0.1586 | 0.1586 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0169 | 0.1586 | 0.1586 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.1559 | 0.5923 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1586 | 0.1586 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0076 | 0.0517 | 0.082 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0058 | 0.0302 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0238 | 0.2376 | 0.3769 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0071 | 0.0113 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0169 | 0.1586 | 0.1586 |
Leishmania major | trypanothione reductase | 0.0048 | 0.0189 | 0.0883 |
Schistosoma mansoni | hypothetical protein | 0.0351 | 0.3687 | 0.5849 |
Onchocerca volvulus | 0.008 | 0.0556 | 0.0556 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.0308 | 0.0859 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0058 | 0.0308 | 0.2 |
Brugia malayi | Nuclear hormone receptor E75 | 0.008 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0064 | 0.0371 | 0.0371 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.0293 | 0.0293 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0058 | 0.0308 | 0.2 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.0308 | 0.0859 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0169 | 0.1586 | 0.3584 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.0401 | 0.0637 |
Brugia malayi | Trypsin family protein | 0.0099 | 0.0774 | 0.0774 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0064 | 0.0371 | 0.2598 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0086 | 0.0136 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0169 | 0.1586 | 0.2516 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.0189 | 0.0428 |
Schistosoma mansoni | hypothetical protein | 0.0353 | 0.3709 | 0.5885 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.0189 | 0.6053 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.1559 | 0.5923 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0064 | 0.0371 | 0.0371 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0169 | 0.1586 | 0.1586 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0238 | 0.2376 | 0.5371 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0072 | 0.0072 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0089 | 0.0667 | 0.0667 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0071 | 0.0113 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0169 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0086 | 0.0086 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0058 | 0.0302 | 0.2501 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0169 | 0.1586 | 0.3584 |
Brugia malayi | Cytochrome P450 family protein | 0.0065 | 0.0382 | 0.0382 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.008 | 0.0556 | 0.0883 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0401 | 0.0637 |
Brugia malayi | nuclear receptor NHR-88 | 0.0169 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0169 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.0899 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0169 | 0.1586 | 0.1586 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0132 | 0.1156 | 0.1834 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0132 | 0.1156 | 0.1156 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1586 | 0.1586 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.008 | 0.0556 | 0.1258 |
Schistosoma mansoni | nuclear hormone receptor | 0.008 | 0.0556 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0774 | 0.0774 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0121 | 0.1037 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0169 | 0.1586 | 0.1586 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0401 | 0.0637 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0254 | 0.2565 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0169 | 0.1586 | 0.3584 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0415 | 0.4424 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.008 | 0.0556 | 0.0556 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0031 | 0.000000021017 | 0.000000047506 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.008 | 0.0556 | 0.1258 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0774 | 0.0774 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0169 | 0.1586 | 0.3584 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.2568 | 0.2568 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0238 | 0.2376 | 0.3769 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.0189 | 0.6053 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.0189 | 0.0189 |
Brugia malayi | nuclear receptor RXR | 0.0089 | 0.0667 | 0.0667 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.0189 | 0.0189 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0169 | 0.1586 | 0.2516 |
Loa Loa (eye worm) | hypothetical protein | 0.0415 | 0.4424 | 0.4424 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1586 | 0.1586 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.0293 | 0.0293 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.1662 | 0.6342 |
Onchocerca volvulus | 0.0099 | 0.0774 | 0.0774 | |
Schistosoma mansoni | zinc finger protein | 0.008 | 0.0556 | 0.0883 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0058 | 0.0302 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.008 | 0.0556 | 0.0556 |
Onchocerca volvulus | 0.0899 | 1 | 1 | |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0089 | 0.0667 | 0.1058 |
Schistosoma mansoni | hypothetical protein | 0.0353 | 0.3709 | 0.5885 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Echinococcus granulosus | tumor protein p63 | 0.0372 | 0.3926 | 0.8875 |
Onchocerca volvulus | 0.0092 | 0.07 | 0.07 | |
Brugia malayi | MAP kinase sur-1 | 0.0058 | 0.0308 | 0.0308 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.0436 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0169 | 0.1586 | 0.2516 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0238 | 0.2376 | 0.3769 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.0896 | 0.8507 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0161 | 0.1494 | 0.3378 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0401 | 0.0637 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0099 | 0.0774 | 0.1228 |
Echinococcus multilocularis | Protein lozenge | 0.0113 | 0.0937 | 0.1487 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0058 | 0.0308 | 0.2 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.0189 | 0.0883 |
Echinococcus multilocularis | serotonin receptor | 0.0415 | 0.4424 | 0.7018 |
Echinococcus granulosus | snurportin 1 | 0.0351 | 0.3687 | 0.8333 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0169 | 0.1586 | 0.3584 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.0293 | 0.0293 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0071 | 0.0113 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.008 | 0.0556 | 0.0556 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0058 | 0.0308 | 0.2 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0099 | 0.0774 | 0.1228 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0003 | 0.0003 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.008 | 0.0556 | 0.0556 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0579 | 0.6304 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0089 | 0.0667 | 0.1058 |
Schistosoma mansoni | lozenge | 0.0113 | 0.0937 | 0.1487 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0169 | 0.1586 | 0.2516 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0254 | 0.2565 | 0.2565 |
Brugia malayi | RNA, U transporter 1 | 0.0094 | 0.0716 | 0.0716 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0066 | 0.0066 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.1662 | 0.6342 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0089 | 0.0667 | 0.0667 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.0436 | 0.0692 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0121 | 0.1037 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0033 | 0.0017 | 0.0027 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0089 | 0.0667 | 0.1507 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.0401 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0667 | 0.0667 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0409 | 0.4355 | 0.6909 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0169 | 0.1586 | 0.1586 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0169 | 0.1586 | 0.1586 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0169 | 0.1586 | 0.2516 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0169 | 0.1586 | 0.2516 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0254 | 0.2565 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0401 | 0.0637 |
Brugia malayi | nuclear receptor NHR-88 | 0.008 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0132 | 0.1156 | 0.1156 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Schistosoma mansoni | nuclear hormone receptor | 0.008 | 0.0556 | 0.0883 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0238 | 0.2376 | 0.5371 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0058 | 0.0308 | 0.0696 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0058 | 0.0302 | 0.1943 |
Schistosoma mansoni | importin beta-1 | 0.0033 | 0.0017 | 0.0027 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.008 | 0.0556 | 0.0883 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0169 | 0.1586 | 0.1586 |
Brugia malayi | nuclear hormone receptor | 0.0169 | 0.1586 | 0.1586 |
Onchocerca volvulus | 0.008 | 0.0556 | 0.0556 | |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0069 | 0.0436 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.004 | 0.0096 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0667 | 0.0667 |
Echinococcus multilocularis | jun protein | 0.0262 | 0.2651 | 0.4205 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.1559 | 0.5923 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.008 | 0.0556 | 0.0883 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0254 | 0.2565 | 1 |
Loa Loa (eye worm) | DR-78 | 0.008 | 0.0556 | 0.0556 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0058 | 0.0302 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0089 | 0.0667 | 0.0667 |
Brugia malayi | nuclear receptor RXR | 0.008 | 0.0556 | 0.0556 |
Echinococcus multilocularis | snurportin 1 | 0.0351 | 0.3687 | 0.5849 |
Brugia malayi | RNA binding protein | 0.0066 | 0.0401 | 0.0401 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.004 | 0.0096 | 0.0096 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0169 | 0.1586 | 0.1586 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0169 | 0.1586 | 0.1586 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0071 | 0.0161 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.008 | 0.0556 | 0.1258 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0169 | 0.1586 | 0.2516 |
Brugia malayi | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0265 | 0.0265 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0238 | 0.2376 | 0.3769 |
Onchocerca volvulus | 0.0054 | 0.0265 | 0.0265 | |
Leishmania major | cytochrome p450-like protein | 0.0064 | 0.0371 | 0.2598 |
Schistosoma mansoni | thyroid hormone receptor | 0.0579 | 0.6304 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0409 | 0.4355 | 0.9845 |
Echinococcus granulosus | Ankyrin | 0.0032 | 0.0003 | 0.0007 |
Trypanosoma brucei | protein kinase, putative | 0.0058 | 0.0308 | 0.2554 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.0189 | 0.1514 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.0401 | 0.0401 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.0436 | 0.0692 |
Brugia malayi | Cytochrome P450 family protein | 0.0064 | 0.0371 | 0.0371 |
Onchocerca volvulus | 0.0169 | 0.1586 | 0.1586 | |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.008 | 0.0556 | 0.0883 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0169 | 0.1586 | 0.1586 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0262 | 0.2651 | 0.5992 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0169 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0799 | 0.8842 | 0.8842 |
Schistosoma mansoni | hypothetical protein | 0.0409 | 0.4355 | 0.6909 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0238 | 0.2376 | 0.2376 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.008 | 0.0556 | 0.1258 |
Brugia malayi | hypothetical protein | 0.0205 | 0.2004 | 0.2004 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0169 | 0.1586 | 0.2516 |
Brugia malayi | conserved hypotetical protein | 0.008 | 0.0556 | 0.0556 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0069 | 0.0436 | 0.0986 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.008 | 0.0556 | 0.0883 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0132 | 0.1156 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.0189 | 0.6053 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.008 | 0.0556 | 0.1258 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0169 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0401 | 0.0637 |
Brugia malayi | Uncoordinated protein 44 | 0.0031 | 0.000000021017 | 0.000000021017 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0169 | 0.1586 | 0.2516 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0667 | 0.0667 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0169 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0017 | 0.0017 |
Brugia malayi | follicle stimulating hormone receptor | 0.0799 | 0.8842 | 0.8842 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.008 | 0.0556 | 0.0556 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.0189 | 0.6053 |
Schistosoma mansoni | nuclear receptor | 0.008 | 0.0556 | 0.0883 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0254 | 0.2565 | 0.2565 |
Brugia malayi | steroid hormone receptor | 0.0169 | 0.1586 | 0.1586 |
Trypanosoma brucei | cytochrome P450, putative | 0.0064 | 0.0371 | 0.311 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.0896 | 0.8507 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.008 | 0.0556 | 0.0556 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0058 | 0.0308 | 0.2 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0064 | 0.0371 | 0.809 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0058 | 0.0308 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0064 | 0.0371 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0169 | 0.1586 | 0.1586 |
Echinococcus multilocularis | tumor protein p63 | 0.0372 | 0.3926 | 0.6229 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0032 | 0.0003 | 0.0005 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.1559 | 0.5923 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0058 | 0.0308 | 0.0308 |
Loa Loa (eye worm) | runx1 | 0.0113 | 0.0937 | 0.0937 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0058 | 0.0308 | 0.0488 |
Brugia malayi | tailless protein | 0.008 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0169 | 0.1586 | 0.1586 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0169 | 0.1586 | 0.2516 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0069 | 0.0436 | 0.3211 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0121 | 0.1037 | 1 |
Brugia malayi | hypothetical protein | 0.0089 | 0.0667 | 0.0667 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.0896 | 0.8507 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0161 | 0.1494 | 0.237 |
Brugia malayi | Nuclear hormone receptor E75 | 0.008 | 0.0556 | 0.0556 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0169 | 0.1586 | 0.1586 |
Brugia malayi | nuclear hormone receptor | 0.008 | 0.0556 | 0.0556 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.008 | 0.0556 | 0.0883 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0169 | 0.1586 | 0.3584 |
Brugia malayi | bZIP transcription factor family protein | 0.0262 | 0.2651 | 0.2651 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0254 | 0.2565 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0058 | 0.0302 | 0.6793 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.008 | 0.0556 | 0.0556 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0169 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1586 | 0.1586 |
Echinococcus granulosus | jun protein | 0.0262 | 0.2651 | 0.5992 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0169 | 0.1586 | 0.1586 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0132 | 0.1156 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.004 | 0.0096 | 0.0096 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0064 | 0.0371 | 0.2598 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.008 | 0.0556 | 0.0556 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0169 | 0.1586 | 0.3584 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.008 | 0.0556 | 0.0883 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0169 | 0.1586 | 0.2516 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0238 | 0.2376 | 0.3769 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0169 | 0.1586 | 0.2516 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1586 | 0.1586 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.004 | 0.0096 | 0.2768 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0031 | 0.000000021017 | 0.000000033342 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0058 | 0.0308 | 0.2 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0169 | 0.1586 | 0.2516 |
Brugia malayi | Cytochrome P450 family protein | 0.0064 | 0.0371 | 0.0371 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0169 | 0.1586 | 0.3584 |
Schistosoma mansoni | ap endonuclease | 0.004 | 0.0096 | 0.0152 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0169 | 0.1586 | 0.1586 |
Echinococcus multilocularis | Ankyrin | 0.0032 | 0.0003 | 0.0005 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0169 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.0401 | 0.0401 |
Schistosoma mansoni | nuclear hormone receptor | 0.0169 | 0.1586 | 0.2516 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0415 | 0.4424 | 0.7018 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.0896 | 0.8507 |
Schistosoma mansoni | thyroid hormone receptor | 0.0579 | 0.6304 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0086 | 0.0086 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0132 | 0.1156 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0132 | 0.1156 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.0401 | 0.0401 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0058 | 0.0308 | 0.0488 |
Echinococcus granulosus | importin subunit beta 1 | 0.0033 | 0.0017 | 0.0038 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0121 | 0.1037 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0048 | 0.0189 | 0.0995 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0076 | 0.0517 | 0.1168 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0169 | 0.1586 | 0.3584 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0069 | 0.0436 | 0.3619 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0058 | 0.0308 | 0.6937 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0058 | 0.0308 | 0.2554 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.008 | 0.0556 | 0.0883 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0058 | 0.0302 | 0.1943 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.004 | 0.0096 | 0.0692 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0058 | 0.0308 | 0.0696 |
Leishmania major | hypothetical protein, conserved | 0.0058 | 0.0302 | 0.1943 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0031 | 0.000000021017 | 0.000000033342 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.008 | 0.0556 | 0.1258 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.0896 | 0.8507 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0132 | 0.1156 | 0.1834 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.1559 | 0.5923 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.0896 | 0.8507 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.004 | 0.0096 | 0.5 |
Echinococcus granulosus | geminin | 0.0353 | 0.3709 | 0.8385 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.004 | 0.0096 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1586 | 0.1586 |
Brugia malayi | hypothetical protein | 0.0058 | 0.0302 | 0.0302 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.004 | 0.0096 | 0.2768 |
Brugia malayi | Protein kinase domain containing protein | 0.0032 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0351 | 0.3687 | 0.3687 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0169 | 0.1586 | 0.2516 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.0436 | 1 |
Echinococcus multilocularis | geminin | 0.0353 | 0.3709 | 0.5885 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.008 | 0.0556 | 0.0556 |
Brugia malayi | Death domain containing protein | 0.0031 | 0.000000021017 | 0.000000021017 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0069 | 0.0436 | 0.0692 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.1559 | 0.5923 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.0189 | 0.4112 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.0308 | 0.0859 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0167 | 0.1559 | 0.1559 |
Schistosoma mansoni | ap endonuclease | 0.004 | 0.0096 | 0.0152 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.0189 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0293 | 0.0293 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0238 | 0.2376 | 0.2376 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0262 | 0.2651 | 0.4205 |
Schistosoma mansoni | nuclear receptor | 0.008 | 0.0556 | 0.0883 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0132 | 0.1156 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0169 | 0.1586 | 0.1586 |
Brugia malayi | glutathione reductase | 0.0048 | 0.0189 | 0.0189 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.0401 | 0.0907 |
Schistosoma mansoni | coup transcription factor | 0.0169 | 0.1586 | 0.2516 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.1559 | 0.5923 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0169 | 0.1586 | 0.1586 |
Schistosoma mansoni | jun-related protein | 0.0213 | 0.2086 | 0.331 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0169 | 0.1586 | 0.1586 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0054 | 0.0265 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0556 | 0.0556 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.004 | 0.0096 | 0.0216 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0071 | 0.0071 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0132 | 0.1156 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.0436 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0169 | 0.1586 | 0.2516 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0058 | 0.0308 | 0.0488 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0169 | 0.1586 | 0.2516 |
Onchocerca volvulus | 0.0205 | 0.2004 | 0.2004 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0169 | 0.1586 | 0.1586 |
Toxoplasma gondii | exonuclease III APE | 0.004 | 0.0096 | 0.188 |
Brugia malayi | Importin beta-1 subunit | 0.0033 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0065 | 0.0382 | 0.0382 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Glycaemia evolution (functional) | = -7 % | Percent glycaemia evolution at 200 mg/kg at 2 hr after the last administration for 4 days chronictreatment (J4) in Wistar rats | ChEMBL. | 10969979 |
Glycaemia evolution (functional) | = -6 % | Percent glycaemia evolution at 20 mg/kg at 2 hr after the last administration for 4 days chronictreatment (J4) in Wistar rats | ChEMBL. | 10969979 |
Glycaemia evolution (functional) | = -4 % | Percent glycaemia evolution at 200 mg/kg at 2 hr after a sharp administration (J1) in Wistar rats | ChEMBL. | 10969979 |
Glycaemia evolution (functional) | = 1 % | Percent glycaemia evolution at 20 mg/kg at 2 hr after a sharp administration (J1) in Wistar rats | ChEMBL. | 10969979 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.