TDR Targets

Basic information

Technical information

TDR Targets ID: 786383
Name: 3,4-dimethoxy-N-(4-methylphenyl)benzenesulfon amide
MW: 307.365 | Formula: C15H17NO4S
H donors: 1 H acceptors: 2 LogP: 2.75 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC)S(=O)(=O)Nc1ccc(cc1)C
InChi: 1S/C15H17NO4S/c1-11-4-6-12(7-5-11)16-21(17,18)13-8-9-14(19-2)15(10-13)20-3/h4-10,16H,1-3H3
InChiKey: VVPQLKNZJPDFGL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ZINC00249141
MLS000044935
SMR000023042

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	K(lysine) acetyltransferase 2A	Starlite/ChEMBL	No references
Bacillus anthracis	Anthrax lethal factor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Theileria parva	histone acetyltransferase Gcn5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	Get druggable targets OG5_127781	All targets in OG5_127781
Babesia bovis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	hypothetical protein	Get druggable targets OG5_127781	All targets in OG5_127781
Giardia lamblia	Histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium yoelii	histone acetyltransferase GCN5-related	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium hominis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium knowlesi	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium falciparum	histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium vivax	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium berghei	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	Bromodomain containing protein, related	Get druggable targets OG5_127781	All targets in OG5_127781
Entamoeba histolytica	acetyltransferase, GNAT family	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K06062 p300/CBP-associated factor, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Brugia malayi	acetyltransferase, GNAT family protein	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium parvum	GCN5 like acetylase + bromodomain	Get druggable targets OG5_127781	All targets in OG5_127781

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0394	0.5184	0.5174
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0059	0.0538	0.2105
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0205	0.2555	1
Leishmania major	hypothetical protein, conserved	0.0081	0.0843	1
Schistosoma mansoni	tyrosine kinase	0.0237	0.3003	0.2989
Schistosoma mansoni	aldehyde dehydrogenase	0.0044	0.0321	0.0302
Plasmodium vivax	thioredoxin reductase, putative	0.0029	0.0126	0.0495
Mycobacterium tuberculosis	Probable lipase LipE	0.0081	0.0843	0.1056
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0033	0.0178	0.0158
Echinococcus multilocularis	inositol monophosphatase 1	0.0054	0.0472	0.0453
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.2145	0.213
Mycobacterium tuberculosis	Probable hydrolase	0.0081	0.0843	0.1056
Schistosoma mansoni	aldehyde dehydrogenase	0.0044	0.0321	0.0302
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0059	0.0538	0.097
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0059	0.0538	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0843	0.0824
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0059	0.0538	0.6384
Mycobacterium leprae	conserved hypothetical protein	0.0081	0.0843	0.3297
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0033	0.0178	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0843	0.0824
Trichomonas vaginalis	penicillin-binding protein, putative	0.0081	0.0843	0.1846
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0212	0.266	1
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0054	0.0472	0.0439
Toxoplasma gondii	aldehyde dehydrogenase	0.0044	0.0321	0.3812
Schistosoma mansoni	inositol monophosphatase	0.0054	0.0472	0.0453
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0431	0.0412
Onchocerca volvulus		0.0081	0.0843	0.5
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0081	0.0843	0.0824
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0081	0.0843	0.0824
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0212	0.266	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0033	0.0178	0.0158
Onchocerca volvulus		0.0081	0.0843	0.5
Schistosoma mansoni	lipoxygenase	0.0059	0.0537	0.0518
Mycobacterium leprae	Probable lipase LipE	0.0081	0.0843	0.3297
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0538	0.0519
Mycobacterium ulcerans	esterase/lipase LipP	0.0081	0.0843	0.2334
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0054	0.0472	0.4828
Echinococcus multilocularis	snurportin 1	0.0233	0.2947	0.2933
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0056	0.0036
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0205	0.2555	0.3582
Trypanosoma brucei	trypanothione reductase	0.0029	0.0126	0.1295
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.2145	0.213
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0843	0.0824
Echinococcus granulosus	microtubule associated protein 2	0.0495	0.658	0.6574
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0081	0.0843	0.1056
Plasmodium falciparum	importin beta, putative	0.0022	0.002	0.0078
Toxoplasma gondii	thioredoxin reductase	0.0029	0.0126	0.15
Mycobacterium tuberculosis	Conserved protein	0.0081	0.0843	0.1056
Schistosoma mansoni	tyrosine kinase	0.0394	0.5184	0.5174
Brugia malayi	Inositol-1	0.0054	0.0472	0.0453
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0205	0.2555	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0036	0.0213	0.0194
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0039	0.0255	0.019
Schistosoma mansoni	tyrosine kinase	0.0398	0.5242	0.5233
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0059	0.0538	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0033	0.0178	0.0158
Treponema pallidum	fructose-bisphosphate aldolase	0.0212	0.266	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0081	0.0843	0.1056
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0044	0.0321	0.0287
Trichomonas vaginalis	penicillin-binding protein, putative	0.0081	0.0843	0.1846
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0081	0.0843	0.0824
Brugia malayi	beta-lactamase family protein	0.0081	0.0843	0.0824
Giardia lamblia	Fructose-bisphosphate aldolase	0.0212	0.266	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0059	0.0538	0.5
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0067	0.0651	0.0773
Schistosoma mansoni	inositol monophosphatase	0.0054	0.0472	0.0453
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0431	0.5119
Echinococcus multilocularis	insulin receptor	0.0237	0.3003	0.2989
Onchocerca volvulus		0.0081	0.0843	0.5
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0054	0.0472	0.5498
Loa Loa (eye worm)	acetyltransferase	0.0175	0.2145	0.213
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0843	0.0824
Plasmodium falciparum	thioredoxin reductase	0.0029	0.0126	0.0495
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0033	0.0178	0.0158
Brugia malayi	beta-lactamase	0.0081	0.0843	0.0824
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0067	0.0651	0.0773
Loa Loa (eye worm)	inositol-1	0.0054	0.0472	0.0453
Brugia malayi	beta-lactamase family protein	0.0081	0.0843	0.0824
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0059	0.0538	0.5
Schistosoma mansoni	tyrosine kinase	0.0398	0.5242	0.5233
Mycobacterium tuberculosis	Conserved protein	0.0081	0.0843	0.1056
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.2145	0.213
Echinococcus granulosus	inositol monophosphatase 1	0.0054	0.0472	0.0453
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0039	0.0255	0.0999
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0036	0.0213	0.0194
Brugia malayi	Thioredoxin reductase	0.0029	0.0126	0.0107
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0033	0.0178	0.0158
Schistosoma mansoni	hypothetical protein	0.0024	0.0056	0.0036
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0059	0.0538	0.2105
Trypanosoma cruzi	hypothetical protein, conserved	0.0081	0.0843	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0213	0.0194
Echinococcus granulosus	epidermal growth factor receptor	0.0398	0.5242	0.5233
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0081	0.0843	0.0824
Mycobacterium ulcerans	beta-lactamase	0.0081	0.0843	0.2334
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0843	0.0824
Plasmodium falciparum	glutathione reductase	0.0029	0.0126	0.0495
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0039	0.0255	0.019
Schistosoma mansoni	hypothetical protein	0.0123	0.1423	0.1406
Plasmodium vivax	importin-beta 2, putative	0.0022	0.002	0.0078
Schistosoma mansoni	hypothetical protein	0.0233	0.2947	0.2933
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0081	0.0843	0.0824
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0081	0.0843	0.1056
Mycobacterium tuberculosis	Probable reductase	0.0067	0.0651	0.0773
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0237	0.3003	0.2989
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0398	0.5242	0.5233
Plasmodium vivax	hypothetical protein, conserved	0.0081	0.0843	0.3297
Mycobacterium tuberculosis	Conserved protein	0.0081	0.0843	0.1056
Echinococcus multilocularis	microtubule associated protein 2	0.0495	0.658	0.6574
Brugia malayi	Probable ClpP-like protease	0.0059	0.0538	0.0519
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0075	0.0755	0.0927
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0049	0.0393	0.0393
Schistosoma mansoni	tyrosine kinase	0.0394	0.5184	0.5174
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0104	0.1155	0.1516
Toxoplasma gondii	HEAT repeat-containing protein	0.0022	0.002	0.0236
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0372	0.1455
Echinococcus multilocularis	epidermal growth factor receptor	0.0741	1	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0741	1	1
Schistosoma mansoni	microtubule-associated protein tau	0.0495	0.658	0.6574
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0075	0.0755	0.0927
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0054	0.0472	0.0183
Brugia malayi	latrophilin 2 splice variant baaae	0.0024	0.0056	0.0036
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0081	0.0843	0.2334
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0233	0.2947	0.2933
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0044	0.0321	0.272
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0054	0.0472	0.5604
Echinococcus granulosus	geminin	0.0123	0.1423	0.1406
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0212	0.266	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0081	0.0843	0.1846
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0212	0.266	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0237	0.3003	0.2989
Schistosoma mansoni	tyrosine kinase	0.0741	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0081	0.0843	0.1846
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0632	0.8487	0.8484
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0212	0.266	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0212	0.266	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0104	0.1155	0.373
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0081	0.0843	0.1056
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0033	0.0178	0.0158
Echinococcus granulosus	insulin receptor	0.0237	0.3003	0.2989
Echinococcus multilocularis	epidermal growth factor receptor	0.0398	0.5242	0.5233
Plasmodium vivax	glutathione reductase, putative	0.0029	0.0126	0.0495
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0059	0.0538	0.2023
Echinococcus multilocularis	neuropeptide receptor A26	0.0336	0.4372	0.4361
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0049	0.0393	0.1538
Echinococcus granulosus	neuropeptide receptor A26	0.0336	0.4372	0.4361
Mycobacterium ulcerans	hypothetical protein	0.0081	0.0843	0.2334
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0054	0.0472	0.0676
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0059	0.0538	0.2105
Echinococcus granulosus	beta LACTamase domain containing family member	0.0081	0.0843	0.0824
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0205	0.2555	1
Loa Loa (eye worm)	thioredoxin reductase	0.0029	0.0126	0.0107
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0036	0.0213	0.0194
Mycobacterium tuberculosis	Probable dehydrogenase	0.0067	0.0651	0.0773
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0075	0.0755	0.2953
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0044	0.0321	0.0302
Schistosoma mansoni	tyrosine kinase	0.0237	0.3003	0.2989
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0033	0.0178	0.0158
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0431	0.1688
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0431	0.5119
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0205	0.2555	1
Loa Loa (eye worm)	glutathione reductase	0.0029	0.0126	0.0107
Echinococcus multilocularis	thioredoxin glutathione reductase	0.003	0.0132	0.0112
Trichomonas vaginalis	D-aminoacylase, putative	0.0081	0.0843	0.1846
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0085	0.089	0.0872
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0067	0.0651	0.0773
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.2077	0.2061
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0104	0.1155	0.4518
Schistosoma mansoni	hypothetical protein	0.0123	0.1423	0.1406
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0518	0.6907	1
Brugia malayi	RNA, U transporter 1	0.0062	0.0578	0.0559
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0059	0.0538	0.6384
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0039	0.0255	0.0236
Schistosoma mansoni	peptidase Clp (S14 family)	0.0059	0.0538	0.0519
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0054	0.0472	0.0183
Echinococcus granulosus	epidermal growth factor receptor	0.0741	1	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0054	0.0472	0.0183
Echinococcus multilocularis	geminin	0.0123	0.1423	0.1406
Loa Loa (eye worm)	TK/INSR protein kinase	0.0237	0.3003	0.2989
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0059	0.0538	0.0519
Echinococcus multilocularis	neuropeptide s receptor	0.0336	0.4372	0.4361
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0212	0.266	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0085	0.089	0.0872
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0212	0.266	1
Schistosoma mansoni	lipoxygenase	0.0085	0.089	0.0872
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0054	0.0472	0.4828
Echinococcus granulosus	neuropeptide s receptor	0.0336	0.4372	0.4361
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0212	0.266	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0044	0.0321	0.0302
Treponema pallidum	hypothetical protein	0.0205	0.2555	0.9608
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0843	0.0824
Brugia malayi	Protein kinase domain containing protein	0.0237	0.3003	0.2989
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0212	0.266	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.003	0.0132	0.0112
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0033	0.0178	0.0158
Trichomonas vaginalis	esterase, putative	0.0081	0.0843	0.1846
Trypanosoma brucei	hypothetical protein, conserved	0.0081	0.0843	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0075	0.0755	0.0927
Mycobacterium ulcerans	lipase LipD	0.0081	0.0843	0.2334
Trypanosoma cruzi	hypothetical protein, conserved	0.0081	0.0843	1
Echinococcus granulosus	peptidase Clp S14 family	0.0039	0.0255	0.0236
Echinococcus granulosus	snurportin 1	0.0233	0.2947	0.2933
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0067	0.0651	0.2546
Toxoplasma gondii	ABC1 family protein	0.0081	0.0843	1
Echinococcus multilocularis		0.0229	0.29	0.2886
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0054	0.0472	0.4828
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0067	0.0651	0.0773
Mycobacterium tuberculosis	Probable lipase LipD	0.0081	0.0843	0.1056
Loa Loa (eye worm)	beta-lactamase	0.0081	0.0843	0.0824
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0059	0.0538	0.097
Brugia malayi	glutathione reductase	0.0029	0.0126	0.0107

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.4716 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1507940
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 786383