TDR Targets

Basic information

Technical information

TDR Targets ID: 788996
Name: N-(4-ethoxyphenyl)-3,5-dimethyl-1,2-oxazole-4 -sulfonamide
MW: 296.342 | Formula: C13H16N2O4S
H donors: 1 H acceptors: 3 LogP: 2.03 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)NS(=O)(=O)c1c(C)noc1C
InChi: 1S/C13H16N2O4S/c1-4-18-12-7-5-11(6-8-12)15-20(16,17)13-9(2)14-19-10(13)3/h5-8,15H,4H2,1-3H3
InChiKey: WOFTWEPYTKABOV-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-(4-ethoxyphenyl)-3,5-dimethyl-isoxazole-4-sulfonamide
N-(4-ethoxyphenyl)-3,5-dimethyl-4-isoxazolesulfonamide
EU-0058956
ZINC00428641

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0195	0.4625	0.4568
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.0548	0.0554
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0171	0.3954	1
Brugia malayi	follicle stimulating hormone receptor	0.0236	0.5778	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.011	0.2243	0.3154
Echinococcus granulosus	geminin	0.0173	0.4003	0.394
Trypanosoma cruzi	cytochrome P450, putative	0.0044	0.0407	0.7936
Brugia malayi	Cytochrome P450 family protein	0.0044	0.0407	0.0704
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0513	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0304	0.0225
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0154	0.3477	0.3409
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0548	0.0949
Mycobacterium ulcerans	hypothetical protein	0.0171	0.3954	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.011	0.2243	0.5314
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0513	0.034
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0748	0.1295
Loa Loa (eye worm)	hepatopoietin HPO2	0.0034	0.0103	0.0179
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0154	0.3477	0.4483
Brugia malayi	mbt repeat family protein	0.0049	0.0548	0.0949
Schistosoma mansoni	cellular tumor antigen P53	0.0057	0.0748	0.0822
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0513	1
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0034	0.0103	0.2014
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0056	0.074	0.0811
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0304	0.5918
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0034	0.0103	0.2014
Loa Loa (eye worm)	cytochrome P450 family protein	0.0107	0.2148	0.3718
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.011	0.2243	0.3154
Trypanosoma cruzi	cytochrome P450, putative	0.0044	0.0407	0.7936
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0056	0.074	0.0644
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0513	1
Leishmania major	hypothetical protein, conserved	0.0034	0.0103	0.2014
Mycobacterium tuberculosis	Probable aminotransferase	0.0171	0.3954	0.5935
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0304	0.0525
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0304	0.5918
Schistosoma mansoni	hypothetical protein	0.0173	0.4003	0.5189
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0236	0.5778	1
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.0548	0.0554
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0513	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.026	0.6454	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0154	0.3477	0.4483
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0304	0.0525
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0586	0.1014
Plasmodium falciparum	glutathione reductase	0.0048	0.0513	1
Schistosoma mansoni	hypothetical protein	0.0301	0.7589	1
Brugia malayi	mbt repeat family protein	0.0049	0.0548	0.0949
Brugia malayi	Cytochrome P450 family protein	0.0044	0.0407	0.0704
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0049	0.0548	0.5501
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0136	0.0235
Leishmania major	cytochrome p450-like protein	0.0044	0.0407	0.7936
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0513	0.0888
Loa Loa (eye worm)	mbt repeat family protein	0.0049	0.0548	0.0949
Brugia malayi	Cytochrome P450 family protein	0.0107	0.2148	0.3718
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0056	0.074	0.0644
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0513	0.0414
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0154	0.3477	0.3409
Echinococcus granulosus	SAM and MBT domain containing protein	0.0049	0.0548	0.045
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0304	0.0525
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.011	0.2243	0.3154
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0304	0.5918
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0049	0.0548	0.0554
Toxoplasma gondii	Erv1 / Alr family protein	0.0034	0.0103	0.2014
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0154	0.3477	0.6018
Loa Loa (eye worm)	MBCTL1	0.0056	0.074	0.1281
Leishmania major	hypothetical protein, conserved	0.0041	0.0304	0.5918
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0122	0.2587	0.3713
Trypanosoma brucei	cytochrome P450, putative	0.0044	0.0407	0.7936
Trypanosoma brucei	trypanothione reductase	0.0048	0.0513	1
Loa Loa (eye worm)	CYP4Cod1	0.0044	0.0407	0.0704
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0171	0.3954	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0122	0.2587	0.6256
Toxoplasma gondii	ABC1 family protein	0.0041	0.0304	0.5918
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0034	0.0103	0.2014
Mycobacterium tuberculosis	Probable oxidoreductase	0.0122	0.2587	0.3713
Loa Loa (eye worm)	cytochrome P450 family protein	0.0044	0.0407	0.0704
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0154	0.3477	0.3409
Brugia malayi	Thioredoxin reductase	0.0048	0.0513	0.0888
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0136	0.0235
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0304	0.5918
Loa Loa (eye worm)	cytochrome P450 family protein	0.0044	0.0407	0.0704
Leishmania major	trypanothione reductase	0.0048	0.0513	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0586	0.1014
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0034	0.0103	0.2014
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0513	0.0414
Brugia malayi	glutathione reductase	0.0048	0.0513	0.0888
Echinococcus multilocularis	tumor protein p63	0.0387	1	1
Mycobacterium tuberculosis	Probable reductase	0.011	0.2243	0.3154
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0154	0.3477	0.4483
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0056	0.074	0.0644
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0056	0.074	0.1281
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0049	0.0548	0.045
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0586	0.1014
Onchocerca volvulus		0.0057	0.0748	1
Plasmodium falciparum	thioredoxin reductase	0.0048	0.0513	1
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0195	0.4625	0.4568
Loa Loa (eye worm)	hypothetical protein	0.0056	0.074	0.1281
Mycobacterium tuberculosis	Probable dehydrogenase	0.011	0.2243	0.3154
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0171	0.3954	0.5935
Echinococcus multilocularis	polycomb protein SCMH1	0.0049	0.0548	0.045
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0304	0.0202
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0304	0.0202
Echinococcus granulosus	histone acetyltransferase MYST2	0.0056	0.074	0.0644
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0122	0.2587	0.3713
Echinococcus multilocularis	geminin	0.0173	0.4003	0.394
Brugia malayi	Augmenter of liver regeneration	0.0034	0.0103	0.0179
Brugia malayi	beta-lactamase	0.0041	0.0304	0.0525
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0154	0.3477	0.6018
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.011	0.2243	0.3154
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0044	0.0407	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0304	0.0525
Onchocerca volvulus		0.0049	0.0548	0.5501
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0304	0.0225
Echinococcus granulosus	polycomb protein SCMH1	0.0049	0.0548	0.045
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0171	0.3954	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0586	0.1014
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0304	0.0525
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0304	0.0525
Schistosoma mansoni	hypothetical protein	0.0173	0.4003	0.5189
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0304	0.0525
Brugia malayi	beta-lactamase family protein	0.0041	0.0304	0.0525
Toxoplasma gondii	Erv1 / Alr family protein	0.0034	0.0103	0.2014
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0304	0.0525
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0513	0.0888
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0154	0.3477	0.3409
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0304	0.0525
Brugia malayi	beta-lactamase family protein	0.0041	0.0304	0.0525
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0034	0.0103	0.2014
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0034	0.0103	0.2014

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 788996