Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.1531 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0121 | 0.0622 | 0.2306 |
Echinococcus granulosus | phenylalanyl tRNA synthetase | 0.0234 | 0.1369 | 0.4068 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0356 | 0.218 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0155 | 0.023 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase mitochondrial | 0.0234 | 0.1369 | 0.5996 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0121 | 0.0622 | 0.1706 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.021 | 0.121 | 0.3565 |
Brugia malayi | Bromodomain containing protein | 0.0084 | 0.0372 | 0.1705 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0121 | 0.0622 | 0.2742 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0134 | 0.0707 | 0.3136 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0134 | 0.0707 | 0.2725 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0061 | 0.0218 | 0.0431 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0356 | 0.218 | 1 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0356 | 0.218 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0061 | 0.0218 | 0.1 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0356 | 0.218 | 0.663 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.0622 | 0.2742 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0061 | 0.0218 | 0.0431 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.0099 | 0.0456 |
Brugia malayi | phenylalanyl-tRNA synthetase, mitochondrial precursor, putative | 0.0234 | 0.1369 | 0.628 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0121 | 0.0622 | 0.0567 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0121 | 0.0622 | 0.2509 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0067 | 0.0258 | 0.0557 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0134 | 0.0707 | 0.3136 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0121 | 0.0622 | 0.1706 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0061 | 0.0218 | 0.0431 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0134 | 0.0707 | 0.3136 |
Loa Loa (eye worm) | MBCTL1 | 0.0061 | 0.0218 | 0.0568 |
Loa Loa (eye worm) | phenylalanyl-tRNA synthetase | 0.0234 | 0.1369 | 0.6101 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0356 | 0.218 | 1 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0356 | 0.218 | 0.663 |
Giardia lamblia | Phenylalanyl-tRNA synthetase alpha chain | 0.0356 | 0.218 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0155 | 0.023 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0053 | 0.0169 | 0.0072 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0516 | 0.3247 | 1 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase | 0.0234 | 0.1369 | 0.4068 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0155 | 0.023 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0053 | 0.0169 | 0.0276 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0171 | 0.095 | 0.4269 |
Schistosoma mansoni | bromodomain containing protein | 0.0071 | 0.0285 | 0.0643 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.0622 | 0.2742 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0132 | 0.0153 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0121 | 0.0622 | 0.2509 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0121 | 0.0622 | 0.2306 |
Onchocerca volvulus | 0.0053 | 0.0169 | 0.5 | |
Echinococcus granulosus | neuropeptide s receptor | 0.0516 | 0.3247 | 1 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0356 | 0.218 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0061 | 0.0218 | 0.0314 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0121 | 0.0622 | 0.0567 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.0169 | 0.0776 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0516 | 0.3247 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0053 | 0.0169 | 0.0333 |
Brugia malayi | phosphofructokinase | 0.0121 | 0.0622 | 0.2852 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 0.218 | 1 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0356 | 0.218 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0117 | 0.0084 |
Chlamydia trachomatis | phenylalanine--tRNA ligase subunit beta | 0.0037 | 0.0058 | 0.0025 |
Schistosoma mansoni | hypothetical protein | 0.0324 | 0.1967 | 0.8947 |
Entamoeba histolytica | phenylalanyl-tRNA synthetase alpha subunit, putative | 0.0356 | 0.218 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.0622 | 0.2742 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0121 | 0.0622 | 0.2742 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0061 | 0.0218 | 0.0431 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0053 | 0.0169 | 0.5 |
Treponema pallidum | phenylalanyl-tRNA synthetase subunit alpha | 0.0356 | 0.218 | 1 |
Mycobacterium leprae | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0222 | 0.1289 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0169 | 0.0333 |
Trichomonas vaginalis | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0356 | 0.218 | 1 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.1531 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.034 | 0.1154 |
Plasmodium vivax | phenylalanine--tRNA ligase, putative | 0.0234 | 0.1369 | 0.6222 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.0169 | 0.0072 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0356 | 0.218 | 1 |
Loa Loa (eye worm) | phosphofructokinase | 0.0121 | 0.0622 | 0.2509 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.021 | 0.121 | 0.3565 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.0155 | 0.0263 |
Toxoplasma gondii | Ferredoxin-fold anticodon binding domain-containing protein | 0.0234 | 0.1369 | 0.6222 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0053 | 0.0169 | 0.0276 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.1531 | 1 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0053 | 0.0169 | 0.0276 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0121 | 0.0622 | 0.2742 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.0169 | 0.0072 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0516 | 0.3247 | 1 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.0169 | 0.0776 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0067 | 0.0258 | 0.0557 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0218 | 0.0568 |
Plasmodium falciparum | phenylalanine--tRNA ligase | 0.0234 | 0.1369 | 0.6222 |
Brugia malayi | 6-phosphofructokinase | 0.0121 | 0.0622 | 0.2852 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0356 | 0.218 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0053 | 0.0169 | 0.0276 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0155 | 0.023 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0121 | 0.0622 | 0.2742 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.0155 | 0.0709 |
Brugia malayi | 6-phosphofructokinase | 0.0121 | 0.0622 | 0.2852 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0121 | 0.0622 | 0.2742 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.