Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glycosyl hydrolases family 38 protein | 0.0044 | 0.1032 | 1 |
Onchocerca volvulus | 0.0044 | 0.1032 | 0.5 | |
Schistosoma mansoni | beta-galactosidase | 0.0155 | 0.5521 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0 | 0.5 |
Mycobacterium ulcerans | alpha-mannosidase | 0.0044 | 0.1032 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0059 | 0.164 | 1 |
Schistosoma mansoni | lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) | 0.0044 | 0.1032 | 0.187 |
Brugia malayi | Glycosyl hydrolases family 38 protein | 0.0044 | 0.1032 | 1 |
Echinococcus granulosus | beta galactosidase | 0.0155 | 0.5521 | 1 |
Trichomonas vaginalis | alpha-mannosidase 2c1, putative | 0.0044 | 0.1032 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | beta galactosidase | 0.0155 | 0.5521 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5521 | 0.5521 |
Schistosoma mansoni | mannosidase alpha class 2a | 0.0044 | 0.1032 | 0.187 |
Echinococcus granulosus | lysosomal alpha mannosidase | 0.008 | 0.2484 | 0.4499 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.008 | 0.2484 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0059 | 0.164 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0391 | 0.0391 |
Onchocerca volvulus | 0.0044 | 0.1032 | 0.5 | |
Echinococcus multilocularis | lysosomal alpha mannosidase | 0.008 | 0.2484 | 0.4499 |
Schistosoma mansoni | lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) | 0.0028 | 0.0391 | 0.0708 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1842 | 0.1842 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1032 | 0.1032 |
Trichomonas vaginalis | alpha-mannosidase, putative | 0.0044 | 0.1032 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1032 | 0.1032 |
Schistosoma mansoni | lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) | 0.008 | 0.2484 | 0.4499 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | alpha mannosidase 2 | 0.0044 | 0.1032 | 0.187 |
Brugia malayi | lysosomal alpha-mannosidase | 0.0044 | 0.1032 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.0067 | 0.195 | 0.785 |
Brugia malayi | Glycosyl hydrolases family 38 protein | 0.0044 | 0.1032 | 1 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.008 | 0.2484 | 1 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.008 | 0.2484 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 38 protein | 0.0044 | 0.1032 | 0.1032 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 18 uM | In vitro inhibition of collagen induced platelet aggregation of rabbit platelet rich plasma | ChEMBL. | 2342076 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.