Detailed information for compound 797438

Basic information

Technical information
  • TDR Targets ID: 797438
  • Name: 3-(1,3-benzothiazol-2-ylsulfanyl)-1-(4-methyl phenyl)pyrrolidine-2,5-dione
  • MW: 354.446 | Formula: C18H14N2O2S2
  • H donors: 0 H acceptors: 3 LogP: 4.2 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)N1C(=O)CC(C1=O)Sc1nc2c(s1)cccc2
  • InChi: 1S/C18H14N2O2S2/c1-11-6-8-12(9-7-11)20-16(21)10-15(17(20)22)24-18-19-13-4-2-3-5-14(13)23-18/h2-9,15H,10H2,1H3
  • InChiKey: KTSGGFREOYZZAP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(1,3-benzothiazol-2-ylthio)-1-(4-methylphenyl)pyrrolidine-2,5-dione
  • 3-(1,3-benzothiazol-2-ylthio)-1-(4-methylphenyl)pyrrolidine-2,5-quinone
  • Oprea1_658676
  • A2158/0090682
  • BIM-0039660.P001
  • 3-(Benzothiazol-2-ylsulfanyl)-1-p-tolyl-pyrrolidine-2,5-dione
  • BAS 01306704
  • CBMicro_039480

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0053 0.1276 0.3391
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0018 0.0116 0.0554
Loa Loa (eye worm) Plcb4 protein 0.0018 0.0116 0.0308
Onchocerca volvulus 0.0014 0.0002 0.0009
Trichomonas vaginalis casein kinase II beta chain, putative 0.0023 0.0283 0.0529
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.1112 0.532
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0308
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0014 0.0002 0.0009
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0002 0.0009
Brugia malayi PAN domain containing protein 0.0035 0.0662 0.1759
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.065 0.1212
Loa Loa (eye worm) hypothetical protein 0.0053 0.1276 0.3391
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0714 0.1332
Loa Loa (eye worm) hypothetical protein 0.0036 0.0714 0.1898
Brugia malayi Variant SH3 domain containing protein 0.013 0.3763 1
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0019 0.0151 0.072
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.1112 0.532
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Onchocerca volvulus 0.0035 0.0662 0.3166
Toxoplasma gondii hypothetical protein 0.0035 0.0662 0.0662
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0079 0.209 0.209
Toxoplasma gondii hypothetical protein 0.0035 0.0662 0.0662
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0002 0.0009
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0662 0.1759
Schistosoma mansoni casein kinase II beta subunit 0.0079 0.209 1
Toxoplasma gondii ck2 beta subunit 0.0079 0.209 0.209
Loa Loa (eye worm) hypothetical protein 0.0036 0.0714 0.1898
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0019 0.0151 0.0151
Onchocerca volvulus 0.0035 0.0662 0.3166
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.0151 0.04
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0014 0.0002 0.0009
Onchocerca volvulus 0.0014 0.0002 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0048 0.1112 0.2956
Brugia malayi PAN domain containing protein 0.0035 0.0662 0.1759
Trichomonas vaginalis casein kinase II beta chain, putative 0.0023 0.0283 0.0529
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.1112 0.2075
Trichomonas vaginalis casein kinase II beta chain, putative 0.0023 0.0283 0.0529
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.1112 0.2075
Onchocerca volvulus 0.0014 0.0002 0.0009
Schistosoma mansoni hypothetical protein 0.0053 0.1276 0.6105
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0662 0.0662
Loa Loa (eye worm) hypothetical protein 0.0035 0.0662 0.1759
Plasmodium vivax casein kinase II beta chain, putative 0.0079 0.209 0.39
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.065 0.1212
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0023 0.0283 0.0529
Onchocerca volvulus 0.0035 0.0662 0.3166
Trichomonas vaginalis casein kinase II beta chain, putative 0.0023 0.0283 0.0529
Loa Loa (eye worm) variant SH3 domain-containing protein 0.013 0.3763 1
Toxoplasma gondii microneme protein MIC17A 0.0035 0.0662 0.0662
Loa Loa (eye worm) hypothetical protein 0.0035 0.0662 0.1759
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0018 0.0116 0.0216
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0002 0.0009
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0662 0.0662
Loa Loa (eye worm) hypothetical protein 0.0036 0.0714 0.1898
Trichomonas vaginalis casein kinase II beta chain, putative 0.0023 0.0283 0.0529
Trichomonas vaginalis casein kinase II beta chain, putative 0.0023 0.0283 0.0529
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.1112 0.532
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0662 0.1759
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0662 0.0662
Plasmodium falciparum casein kinase II beta chain 0.0079 0.209 0.39
Loa Loa (eye worm) hypothetical protein 0.0048 0.1112 0.2956
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0002 0.0009
Echinococcus granulosus enteropeptidase 0.0014 0.0002 0.0009
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0002 0.0009
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.1112 0.2075
Leishmania major hypothetical protein, conserved 0.0053 0.1276 0.6105
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0002 0.0009
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0079 0.209 1
Brugia malayi PAN domain containing protein 0.0035 0.0662 0.1759
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0662 0.1759
Brugia malayi Trypsin family protein 0.0014 0.0002 0.0005
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0079 0.209 1
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0023 0.0283 0.1356
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.1112 0.532
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0018 0.0116 0.0554
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0053 0.1276 0.2381
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.065 0.1212
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Brugia malayi Trypsin-like protease protein 5 0.0014 0.0002 0.0005
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0002 0.0009
Brugia malayi PAN domain containing protein 0.0035 0.0662 0.1759
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0179 0.536 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Echinococcus granulosus transmembrane protease serine 3 0.0014 0.0002 0.0009
Onchocerca volvulus 0.0014 0.0002 0.0009
Toxoplasma gondii PAN/Apple domain-containing protein 0.0035 0.0662 0.0662
Onchocerca volvulus 0.0019 0.0151 0.072
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Schistosoma mansoni hypothetical protein 0.0014 0.0002 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0002 0.0009
Brugia malayi PAN domain containing protein 0.0035 0.0662 0.1759
Toxoplasma gondii kringle domain-containing protein 0.0053 0.1276 0.1276
Brugia malayi PAN domain containing protein 0.0035 0.0662 0.1759
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0662 0.1759
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0079 0.209 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.1112 0.532
Leishmania major phospholipase c-like protein 0.0019 0.0151 0.072
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.065 0.1212
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.1276 0.6105
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.1112 0.532
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0662 0.1759
Loa Loa (eye worm) hypothetical protein 0.0035 0.0662 0.1759
Plasmodium vivax phospholipase C-like, putative 0.0018 0.0116 0.0216
Mycobacterium ulcerans hypothetical protein 0.0014 0.0002 0.0003
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0662 0.0662
Loa Loa (eye worm) hypothetical protein 0.0035 0.0662 0.1759
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.1112 0.2075
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0079 0.209 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0023 0.0283 0.0529
Onchocerca volvulus 0.0019 0.0151 0.072
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0714 0.1332
Loa Loa (eye worm) hypothetical protein 0.0048 0.1112 0.2956
Schistosoma mansoni phospholipase C beta 0.0018 0.0116 0.0554
Schistosoma mansoni hypothetical protein 0.0014 0.0002 0.0009
Toxoplasma gondii microneme protein, putative 0.0035 0.0662 0.0662
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0079 0.209 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.1112 0.2956
Loa Loa (eye worm) hypothetical protein 0.0019 0.0151 0.04
Onchocerca volvulus 0.0035 0.0662 0.3166
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Brugia malayi Trypsin family protein 0.0014 0.0002 0.0005
Onchocerca volvulus 0.0035 0.0662 0.3166
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0014 0.0002 0.0005
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Onchocerca volvulus 0.0035 0.0662 0.3166
Brugia malayi PAN domain containing protein 0.0035 0.0662 0.1759
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0002 0.0009
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0002 0.0009
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0035 0.0662 0.0662
Toxoplasma gondii microneme protein MIC17B 0.0035 0.0662 0.0662
Trichomonas vaginalis casein kinase II beta chain, putative 0.0023 0.0283 0.0529
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0014 0.0002 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0048 0.1112 0.2956
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.1112 0.2075
Brugia malayi Trypsin family protein 0.0014 0.0002 0.0005
Echinococcus granulosus glycoprotein Antigen 5 0.0014 0.0002 0.0009
Echinococcus multilocularis tissue type plasminogen activator 0.0053 0.1276 0.6105
Brugia malayi Kringle domain containing protein 0.0053 0.1276 0.3391
Mycobacterium ulcerans hypothetical protein 0.0048 0.1112 0.2075
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0002 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.1112 0.2075
Brugia malayi PAN domain containing protein 0.0035 0.0662 0.1759
Toxoplasma gondii microneme protein MIC4 0.0035 0.0662 0.0662
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0116 0.0308
Trichomonas vaginalis casein kinase II beta chain, putative 0.0023 0.0283 0.0529
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0014 0.0002 0.0009
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0179 0.536 1
Brugia malayi PAN domain containing protein 0.0035 0.0662 0.1759
Onchocerca volvulus 0.0035 0.0662 0.3166
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Toxoplasma gondii subtilisin SUB12 0.0035 0.0662 0.0662
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0002 0.0009
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Plasmodium falciparum casein kinase II beta chain 0.0079 0.209 0.39
Loa Loa (eye worm) trypsin family protein 0.0014 0.0002 0.0005
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.1112 0.2075
Loa Loa (eye worm) casein kinase II 0.0023 0.0283 0.0753
Toxoplasma gondii PAN domain-containing protein 0.0322 1 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0053 0.1276 0.3391
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0019 0.0151 0.072
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0079 0.209 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0023 0.0283 0.1356
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0048 0.1112 0.2956
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Echinococcus granulosus casein kinase ii subunit beta 0.0079 0.209 1
Onchocerca volvulus 0.0048 0.1112 0.532
Echinococcus multilocularis enteropeptidase 0.0014 0.0002 0.0009
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0019 0.0151 0.04
Brugia malayi hypothetical protein 0.0014 0.0002 0.0005
Loa Loa (eye worm) Csnk2b protein 0.0079 0.209 0.5555
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Echinococcus granulosus Mastin 0.0014 0.0002 0.0009
Trichomonas vaginalis hypothetical protein 0.0179 0.536 1
Toxoplasma gondii microneme protein MIC17C 0.0035 0.0662 0.0662
Onchocerca volvulus 0.0014 0.0002 0.0009
Echinococcus granulosus tissue type plasminogen activator 0.0053 0.1276 0.6105
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.1112 0.2075
Onchocerca volvulus 0.0035 0.0662 0.3166
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0023 0.0283 0.0529
Loa Loa (eye worm) hypothetical protein 0.0036 0.0714 0.1898
Giardia lamblia Casein kinase II beta chain 0.0079 0.209 1
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0018 0.0116 0.0308
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Onchocerca volvulus 0.0035 0.0662 0.3166
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0019 0.0151 0.072
Onchocerca volvulus 0.0035 0.0662 0.3166
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0002 0.0009
Echinococcus multilocularis glycoprotein Antigen 5 0.0014 0.0002 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0002 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0002 0.0009
Echinococcus multilocularis transmembrane protease serine 3 0.0014 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0714 0.1898
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0002 0.0009
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Brugia malayi Trypsin family protein 0.0014 0.0002 0.0005
Plasmodium falciparum cysteine repeat modular protein 1 0.0053 0.1276 0.2381
Trichomonas vaginalis casein kinase II beta chain, putative 0.0023 0.0283 0.0529
Trichomonas vaginalis casein kinase II beta chain, putative 0.0023 0.0283 0.0529
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Trichomonas vaginalis casein kinase II beta chain, putative 0.0023 0.0283 0.0529
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0079 0.209 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0662 0.1759
Plasmodium falciparum enoyl-acyl carrier reductase 0.0179 0.536 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0662 0.1759
Onchocerca volvulus 0.0035 0.0662 0.3166
Loa Loa (eye worm) hypothetical protein 0.0035 0.0662 0.1759
Trichomonas vaginalis casein kinase II beta chain, putative 0.0023 0.0283 0.0529
Onchocerca volvulus 0.0014 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0151 0.04
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0002 0.0009
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0179 0.536 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.1112 0.2075
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0179 0.536 0.5
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0179 0.536 1
Brugia malayi Csnk2b protein 0.0079 0.209 0.5555
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0179 0.536 1
Plasmodium vivax casein kinase II beta chain, putative 0.0079 0.209 0.39
Trichomonas vaginalis casein kinase II beta chain, putative 0.0079 0.209 0.39
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0714 0.1332
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0079 0.209 1
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0019 0.0151 0.072
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.1112 0.2075
Onchocerca volvulus 0.0053 0.1276 0.6105
Brugia malayi casein kinase II, putaitve 0.0023 0.0283 0.0753
Brugia malayi PAN domain containing protein 0.0035 0.0662 0.1759
Echinococcus multilocularis Mastin 0.0014 0.0002 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.1112 0.2075
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0002 0.0009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0714 0.1332
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0179 0.536 0.536
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0079 0.209 1
Echinococcus multilocularis casein kinase ii subunit beta 0.0079 0.209 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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