Detailed information for compound 798210

Basic information

Technical information
  • TDR Targets ID: 798210
  • Name: 2-chloro-5-fluoro-4-(4-propanoylpiperazin-1-y l)benzonitrile
  • MW: 295.74 | Formula: C14H15ClFN3O
  • H donors: 0 H acceptors: 2 LogP: 2.23 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)N1CCN(CC1)c1cc(Cl)c(cc1F)C#N
  • InChi: 1S/C14H15ClFN3O/c1-2-14(20)19-5-3-18(4-6-19)13-8-11(15)10(9-17)7-12(13)16/h7-8H,2-6H2,1H3
  • InChiKey: YYEYCHOPWTWCEK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-5-fluoro-4-[4-(1-oxopropyl)-1-piperazinyl]benzonitrile
  • 2-chloro-5-fluoro-4-(4-propionylpiperazin-1-yl)benzonitrile
  • ZINC00092898
  • BAS 03569576
  • 2-Chloro-5-fluoro-4-(4-propionyl-piperazin-1-yl)-benzonitrile
  • A2794/0118067
  • Oprea1_672763

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0243 0.0823
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Onchocerca volvulus 0.0026 0.0045 0.0095
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.1158 0.1632
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.0017 0.0058
Echinococcus granulosus g protein coupled receptor 0.0022 0.0017 0.0058
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0045 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Brugia malayi Dopamine receptor 0.0022 0.0017 0.0024
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni hypothetical protein 0.0067 0.0289 0.0977
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Schistosoma mansoni opsin-like receptor 0.0022 0.0017 0.0058
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0062 0.0087
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.0017 0.0058
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.0017 0.0024
Onchocerca volvulus 0.0029 0.0062 0.0153
Schistosoma mansoni Replicative DNA helicase 0.0376 0.2158 0.7297
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Schistosoma mansoni hypothetical protein 0.0022 0.0017 0.0058
Brugia malayi hypothetical protein 0.0022 0.0017 0.0024
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Plasmodium vivax SET domain protein, putative 0.0029 0.0062 0.5
Echinococcus multilocularis somatostatin receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0062 0.021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni hypothetical protein 0.0022 0.0017 0.0058
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.0017 0.0024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0243 0.1128
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.0017 0.0024
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.0017 0.0024
Schistosoma mansoni hypothetical protein 0.0067 0.0289 0.0977
Schistosoma mansoni intermediate filament proteins 0.0026 0.0045 0.0152
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Echinococcus granulosus serotonin receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0289 0.0977
Brugia malayi follicle stimulating hormone receptor 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0017 0.0058
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Brugia malayi putative neuropeptide receptor 0.0022 0.0017 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0017 0.0058
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.0017 0.0024
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Brugia malayi neuropeptide F receptor 0.0022 0.0017 0.0024
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1192 0.7095 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0062 0.0087
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0017 0.0058
Trichomonas vaginalis set domain proteins, putative 0.023 0.1279 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0376 0.2158 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0289 0.0407
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0045 0.0064
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0017 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0062 0.021
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.0017 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Schistosoma mansoni neuropeptide receptor 0.0022 0.0017 0.0058
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.0017 0.0058
Brugia malayi neuropeptide F receptor 0.0022 0.0017 0.0024
Schistosoma mansoni lamin 0.0026 0.0045 0.0152
Brugia malayi GnHR receptor homolog 0.0022 0.0017 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Brugia malayi G-protein coupled receptor 0.0022 0.0017 0.0024
Schistosoma mansoni hypothetical protein 0.0022 0.0017 0.0058
Schistosoma mansoni myosin xvIII 0.0022 0.0017 0.0058
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.0017 0.0058
Brugia malayi intermediate filament protein 0.0026 0.0045 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.0017 0.0024
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1192 0.7095 1
Brugia malayi hypothetical protein 0.0022 0.0017 0.0024
Brugia malayi G-protein coupled receptor 0.0022 0.0017 0.0024
Schistosoma mansoni histamine h1 receptor 0.0022 0.0017 0.0058
Echinococcus granulosus fmrfamide receptor 0.0022 0.0017 0.0058
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0017 0.0058
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.0017 0.0058
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis musashi 0.0026 0.0045 0.0152
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.0407
Echinococcus granulosus orexin receptor type 2 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Brugia malayi Serotonin receptor 0.0022 0.0017 0.0024
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0289 0.0407
Loa Loa (eye worm) hypothetical protein 0.0026 0.0042 0.0059
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.0017 0.0058
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0017 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0243 0.1128
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0017 0.0058
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.0017 0.0058
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0243 0.0823
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.0017 0.0058
Echinococcus multilocularis allatostatin A receptor 0.0022 0.0017 0.0058
Brugia malayi latrophilin 2 splice variant baaae 0.0144 0.0756 0.1065
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Loa Loa (eye worm) twinkle helicase 0.0107 0.0535 0.0755
Brugia malayi Dopamine receptor protein 2 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.0017 0.0058
Echinococcus granulosus intermediate filament protein 0.0026 0.0045 0.0152
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0017 0.0024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0017 0.0058
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis neuropeptide s receptor 0.0469 0.2721 0.9201
Echinococcus multilocularis neuropeptide receptor A26 0.0469 0.2721 0.9201
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni hypothetical protein 0.0022 0.0017 0.0058
Echinococcus granulosus neuropeptide receptor A26 0.0469 0.2721 0.9201
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0017 0.0058
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0017 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0062 0.021
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0017 0.0058
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0017 0.0058
Echinococcus granulosus lamin dm0 0.0026 0.0045 0.0152
Schistosoma mansoni opsin-like receptor 0.0022 0.0017 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0243 0.1128
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni hypothetical protein 0.0144 0.0756 0.2555
Schistosoma mansoni vesicular acetylcholine transporter 0.0508 0.2957 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0017 0.0058
Onchocerca volvulus 0.023 0.1279 0.4291
Echinococcus granulosus g protein coupled receptor 0.0022 0.0017 0.0058
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.0017 0.0024
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0017 0.0058
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.1158 0.1632
Leishmania major C-8 sterol isomerase-like protein 0.1192 0.7095 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis lamin dm0 0.0026 0.0045 0.0152
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.111 0.1564
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Brugia malayi Melatonin receptor type 1A 0.0022 0.0017 0.0024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0289 0.0977
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.0017 0.0058
Echinococcus granulosus neuropeptide receptor 0.0022 0.0017 0.0058
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0062 0.021
Schistosoma mansoni hypothetical protein 0.0165 0.0882 0.2984
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0017 0.0058
Schistosoma mansoni biogenic amine receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0017 0.0058
Brugia malayi vesicular acetylcholine transporter unc-17 0.0508 0.2957 0.4168
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Brugia malayi larval opioid receptor 0.0022 0.0017 0.0024
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.0017 0.0058
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.0017 0.0058
Echinococcus granulosus GPCR family 2 0.0067 0.0289 0.0977
Echinococcus multilocularis GPCR, family 2 0.0067 0.0289 0.0977
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.0017 0.0058
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.1158 0.1632
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0017 0.0058
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0045 0.0064
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0017 0.0024
Brugia malayi sulfakinin receptor protein 0.0022 0.0017 0.0024
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0062 0.021
Brugia malayi G protein-coupled receptor 0.0022 0.0017 0.0024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0017 0.0058
Echinococcus multilocularis geminin 0.0165 0.0882 0.2984
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.0017 0.0058
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0045 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0017 0.0058
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0017 0.0058
Echinococcus granulosus neuropeptide receptor 0.0022 0.0017 0.0058
Brugia malayi hypothetical protein 0.0022 0.0017 0.0024
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.0017 0.0024
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.0017 0.0058
Echinococcus multilocularis sex peptide receptor 0.0022 0.0017 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Brugia malayi RE15519p 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.0017 0.0058
Schistosoma mansoni hypothetical protein 0.0067 0.0289 0.0977
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0017 0.0058
Schistosoma mansoni neuropeptide receptor 0.0022 0.0017 0.0058
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0508 0.2957 0.4168
Echinococcus granulosus somatostatin receptor 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni biogenic amine receptor 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.1192 0.7095 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.0017 0.0058
Echinococcus granulosus lamin 0.0026 0.0045 0.0152
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Brugia malayi hypothetical protein 0.0022 0.0017 0.0024
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0289 0.0977
Schistosoma mansoni hypothetical protein 0.0165 0.0882 0.2984
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0243 0.0823
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0017 0.0058
Onchocerca volvulus 0.0026 0.0045 0.0095
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0376 0.2158 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Giardia lamblia DINP protein human, muc B family 0.0019 0 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Echinococcus granulosus tachykinin peptides receptor 99D 0.0194 0.1061 0.3588
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis orexin receptor type 2 0.0022 0.0017 0.0058
Brugia malayi hypothetical protein 0.0022 0.0017 0.0024
Brugia malayi Dopamine receptor protein 1 0.0022 0.0017 0.0024
Echinococcus multilocularis vesicular acetylcholine transporter 0.0508 0.2957 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.0017 0.0058
Schistosoma mansoni amine GPCR 0.0022 0.0017 0.0058
Mycobacterium leprae Conserved hypothetical protein 0.0492 0.2863 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0243 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Brugia malayi hypothetical protein 0.0022 0.0017 0.0024
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0017 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0062 0.021
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.0017 0.0058
Brugia malayi Serotonin receptor 0.0022 0.0017 0.0024
Echinococcus granulosus vesicular acetylcholine transporter 0.0508 0.2957 1
Schistosoma mansoni amine GPCR 0.0022 0.0017 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Brugia malayi hypothetical protein 0.0022 0.0017 0.0024
Brugia malayi Pre-SET motif family protein 0.0202 0.111 0.1564
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0017 0.0058
Trypanosoma brucei C-8 sterol isomerase, putative 0.1192 0.7095 1
Schistosoma mansoni neuropeptide receptor 0.0022 0.0017 0.0058
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0017 0.0058
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.0017 0.0024
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0508 0.2957 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0243 0.0823
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0289 0.0977
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Echinococcus granulosus geminin 0.0165 0.0882 0.2984
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.0017 0.0058
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0017 0.0058
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0289 0.0407
Echinococcus granulosus g protein coupled receptor 0.0022 0.0017 0.0058
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0017 0.0058
Schistosoma mansoni adenoreceptor 0.0022 0.0017 0.0058
Chlamydia trachomatis replicative DNA helicase 0.0376 0.2158 0.5
Loa Loa (eye worm) hypothetical protein 0.0144 0.0756 0.1065
Brugia malayi ORL1-like opioid receptor 0.0022 0.0017 0.0024
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0017 0.0058
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0609 0.3571 0.5033
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Echinococcus granulosus sex peptide receptor 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni hypothetical protein 0.0067 0.0289 0.0977
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0017 0.0058
Schistosoma mansoni amine GPCR 0.0022 0.0017 0.0058
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0017 0.0058
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0243 0.0343
Loa Loa (eye worm) hypothetical protein 0.021 0.1158 0.1632
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.0017 0.0024
Schistosoma mansoni opsin-like receptor 0.0022 0.0017 0.0058
Treponema pallidum replicative DNA helicase (dnaB) 0.0376 0.2158 0.5
Schistosoma mansoni amine GPCR 0.0022 0.0017 0.0058
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0017 0.0058
Schistosoma mansoni biogenic amine receptor 0.0022 0.0017 0.0058
Brugia malayi AKH receptor 0.0022 0.0017 0.0024
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0194 0.1061 0.3588
Echinococcus granulosus g-protein coupled receptor 0.0022 0.0017 0.0058
Brugia malayi hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0062 0.021
Schistosoma mansoni lamin 0.0026 0.0045 0.0152
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0017 0.0058
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0 0.5
Echinococcus granulosus neuropeptide s receptor 0.0469 0.2721 0.9201
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.0017 0.0024
Echinococcus granulosus hypothetical protein 0.0022 0.0017 0.0058
Echinococcus multilocularis serotonin receptor 0.0022 0.0017 0.0058
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni amine GPCR 0.0022 0.0017 0.0058
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0056 0.0188
Schistosoma mansoni neuropeptide receptor 0.0022 0.0017 0.0058
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1297 0.7729 0.7729
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Brugia malayi hypothetical protein 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Echinococcus multilocularis lamin 0.0026 0.0045 0.0152
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.0017 0.0024
Echinococcus granulosus allatostatin A receptor 0.0022 0.0017 0.0058
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0017 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0017 0.0058
Brugia malayi hypothetical protein 0.0022 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0024
Echinococcus multilocularis serotonin receptor 0.0022 0.0017 0.0058
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.0017 0.0058
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.0017 0.0058
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.0017 0.0058

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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