TDR Targets

Basic information

Technical information

TDR Targets ID: 801519
Name: 3-[(2-fluorophenyl)amino]-2-pyridin-3-yl-3H-i soindol-1-one
MW: 319.332 | Formula: C19H14FN3O
H donors: 1 H acceptors: 2 LogP: 3.35 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1c2ccccc2C(N1c1cccnc1)Nc1ccccc1F
InChi: 1S/C19H14FN3O/c20-16-9-3-4-10-17(16)22-18-14-7-1-2-8-15(14)19(24)23(18)13-6-5-11-21-12-13/h1-12,18,22H
InChiKey: WOFGYLUMAHHYBF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[(2-fluorophenyl)amino]-2-(3-pyridyl)isoindolin-1-one
3-[(2-fluorophenyl)amino]-2-(3-pyridyl)-1-isoindolinone
MLS000116983
SMR000093937

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	hypothetical protein, conserved	0.0233	0.1782	0.177
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0258	0.0243
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0296	0.2322	0.231
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0258	0.0243
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0373	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0115	0.0072
Loa Loa (eye worm)	transcriptional regulator	0.1193	1	1
Toxoplasma gondii	thioredoxin reductase	0.0098	0.0628	0.1431
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.038	0.0305
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0648	0.5334	0.5327
Plasmodium falciparum	glutathione reductase	0.0098	0.0628	0.1431
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0258	0.0215
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.0484	0.3926	0.3879
Echinococcus granulosus	chromobox protein 1	0.0069	0.0373	0.0359
Mycobacterium ulcerans	Sir2-like regulatory protein	0.0296	0.2322	0.5897
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0034	0.0078	0.0062
Trypanosoma brucei	polo-like protein kinase	0.0197	0.1469	0.1403
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0373	0.0359
Loa Loa (eye worm)	sirtuin 4	0.0296	0.2322	0.2288
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0484	0.3926	0.3917
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0197	0.1469	1
Toxoplasma gondii	histone deacetylase SIR2-like	0.0296	0.2322	0.5831
Schistosoma mansoni	serine/threonine protein kinase	0.0197	0.1469	0.1403
Trichomonas vaginalis	CAMK family protein kinase	0.0197	0.1469	0.1456
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0225	0.1708	0.4329
Schistosoma mansoni	chromobox protein	0.0069	0.0373	0.0298
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.038	0.0305
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0296	0.2322	0.231
Mycobacterium tuberculosis	Probable reductase	0.0225	0.1708	0.4329
Leishmania major	sir2-family protein-like protein	0.0296	0.2322	0.231
Schistosoma mansoni	kinase	0.01	0.0641	0.0568
Loa Loa (eye worm)	thioredoxin reductase	0.0098	0.0628	0.0587
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0225	0.1708	0.4329
Trypanosoma brucei	hypothetical protein, conserved	0.0233	0.1782	0.1718
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.1193	1	1
Leishmania major	hypothetical protein, conserved	0.0233	0.1782	0.177
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0034	0.0078	0.0062
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.038	0.0305
Mycobacterium ulcerans	NAD-dependent deacetylase	0.0484	0.3926	1
Giardia lamblia	Transcriptional regulator, Sir2 family	0.0484	0.3926	0.3879
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.0078	0.5
Echinococcus granulosus	thioredoxin glutathione reductase	0.0098	0.0628	0.0614
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0484	0.3926	0.3917
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.014	0.0675
Echinococcus multilocularis	tar DNA binding protein	0.0069	0.038	0.0365
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0484	0.3926	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0225	0.1708	0.4329
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0484	0.3926	0.3917
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.1193	1	1
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.1193	1	1
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0197	0.1469	0.1456
Plasmodium vivax	glutathione reductase, putative	0.0098	0.0628	0.1431
Trichomonas vaginalis	CAMK family protein kinase	0.0197	0.1469	0.1456
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.014	0.0125
Brugia malayi	glutathione reductase	0.0098	0.0628	0.0628
Leishmania major	trypanothione reductase	0.0098	0.0628	0.0614
Echinococcus granulosus	tar DNA binding protein	0.0069	0.038	0.0365
Schistosoma mansoni	chromatin regulatory protein sir2	0.0484	0.3926	0.3879
Trichomonas vaginalis	CAMK family protein kinase	0.0197	0.1469	0.1456
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0296	0.2322	0.2322
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0373	0.0359
Brugia malayi	Thioredoxin reductase	0.0098	0.0628	0.0628
Trypanosoma cruzi	trypanothione reductase, putative	0.0098	0.0628	0.0614
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0034	0.0078	0.0078
Brugia malayi	chromobox protein homolog 3	0.0039	0.0115	0.0115
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0078	0.0062
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0034	0.0078	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0258	0.0243
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.0078	0.0062
Trichomonas vaginalis	CAMK family protein kinase	0.0197	0.1469	0.1456
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0484	0.3926	0.288
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0258	0.0182
Brugia malayi	RNA binding protein	0.0069	0.038	0.038
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0225	0.1708	0.4329
Brugia malayi	Heterochromatin protein 1	0.0069	0.0373	0.0373
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.1193	1	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0648	0.5334	0.5327
Giardia lamblia	Kinase, PLK	0.0197	0.1469	0.1403
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0225	0.1708	0.4329
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.0078	0.0062
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0296	0.2322	0.231
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0296	0.2322	0.231
Loa Loa (eye worm)	TAR-binding protein	0.0069	0.038	0.0338
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0069	0.038	0.0338
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0648	0.5334	0.5327
Schistosoma mansoni	chromatin regulatory protein sir2	0.1193	1	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0078	0.0062
Schistosoma mansoni	chromatin regulatory protein sir2	0.0648	0.5334	0.5298
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.1193	1	1
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0648	0.5334	0.5298
Loa Loa (eye worm)	RNA binding protein	0.0069	0.038	0.0338
Brugia malayi	MH2 domain containing protein	0.0144	0.1019	0.1019
Loa Loa (eye worm)	glutathione reductase	0.0098	0.0628	0.0587
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.0619	0.0605
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0034	0.0078	0.0159
Plasmodium vivax	hypothetical protein, conserved	0.0296	0.2322	0.5831
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.1193	1	1
Schistosoma mansoni	chromatin regulatory protein sir2	0.0296	0.2322	0.2262
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0197	0.1469	0.1456
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0484	0.3926	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0098	0.0628	0.1567
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0225	0.1708	0.5973
Trichomonas vaginalis	CAMK family protein kinase	0.0197	0.1469	0.1456
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0648	0.5334	0.5334
Trypanosoma cruzi	polo-like protein kinase, putative	0.0197	0.1469	0.1456
Brugia malayi	TAR-binding protein	0.0069	0.038	0.038
Echinococcus granulosus	chromobox protein 1	0.0069	0.0373	0.0359
Trichomonas vaginalis	CAMK family protein kinase	0.0197	0.1469	0.1456
Loa Loa (eye worm)	hypothetical protein	0.0648	0.5334	0.5314
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.0078	0.0062
Schistosoma mansoni	chromatin regulatory protein sir2	0.1193	1	1
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0034	0.0078	0.0159
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.014	0.0125
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.1193	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0233	0.1782	0.177
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.025	0.1923	0.4877
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0115	0.01
Toxoplasma gondii	histone deacetylase SIR2	0.0484	0.3926	1
Brugia malayi	RNA recognition motif domain containing protein	0.0069	0.038	0.038
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0648	0.5334	0.5327
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.0619	0.0605
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0258	0.0258
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0034	0.0078	0.0062
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0034	0.0078	0.0159
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.1193	1	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.1193	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1019	0.098
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.0296	0.2322	0.0999
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.025	0.1923	1
Trichomonas vaginalis	CAMK family protein kinase	0.0197	0.1469	0.1456
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.0078	0.0062
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.038	0.0305
Schistosoma mansoni	chromatin regulatory protein sir2	0.0296	0.2322	0.2262
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0078	0.0062
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0258	0.0182
Trypanosoma cruzi	trypanothione reductase, putative	0.0034	0.0078	0.0062
Schistosoma mansoni	chromatin regulatory protein sir2	0.1193	1	1
Plasmodium vivax	thioredoxin reductase, putative	0.0098	0.0628	0.1431
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0484	0.3926	0.3917
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0034	0.0078	0.0159
Schistosoma mansoni	chromobox protein	0.0069	0.0373	0.0298
Trypanosoma cruzi	polo-like protein kinase, putative	0.0197	0.1469	0.1456
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.0296	0.2322	0.5831
Giardia lamblia	Sirtuin type 2	0.0296	0.2322	0.2262
Echinococcus multilocularis	chromatin regulatory protein sir2	0.1193	1	1
Loa Loa (eye worm)	transcriptional regulator	0.0296	0.2322	0.2288
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.0484	0.3926	0.3917
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0258	0.0243
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0258	0.0182
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0034	0.0078	0.0062
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0373	0.0359
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0296	0.2322	0.231
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0197	0.1469	0.1432
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0098	0.0628	0.0614
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0296	0.2322	0.231
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1019	0.098
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0078	0.0062
Trichomonas vaginalis	glutathione reductase, putative	0.0034	0.0078	0.0062
Echinococcus granulosus	chromatin regulatory protein sir2	0.1193	1	1
Entamoeba histolytica	hypothetical protein, conserved	0.0296	0.2322	0.0999
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0484	0.3926	0.3917
Leishmania major	silent information regulator 2, putative	0.1193	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.025	0.1923	0.4877
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0648	0.5334	0.5327
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0078	0.0062
Mycobacterium tuberculosis	Transcriptional regulatory protein	0.0484	0.3926	1
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0115	0.01
Loa Loa (eye worm)	heterochromatin protein 1	0.0069	0.0373	0.0331
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0078	0.0062
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0197	0.1469	0.1456
Plasmodium falciparum	thioredoxin reductase	0.0098	0.0628	0.1431
Trypanosoma brucei	SIR2-like protein 4, putative	0.0296	0.2322	0.2262
Trypanosoma brucei	trypanothione reductase	0.0098	0.0628	0.0555
Treponema pallidum	NADH oxidase	0.0034	0.0078	0.5
Giardia lamblia	Hypothetical protein	0.1193	1	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.0078	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0019	0.0003
Trichomonas vaginalis	mercuric reductase, putative	0.0034	0.0078	0.0062
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0648	0.5334	0.5327
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0019	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0352	0.2798	0.2767
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0296	0.2322	0.2322
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.025	0.1923	0.4877
Brugia malayi	serine/threonine-protein kinase plk-2	0.0197	0.1469	0.1469
Loa Loa (eye worm)	transcriptional regulator	0.0296	0.2322	0.2288
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.038	0.0305
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0115	0.05

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.2387 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.6964 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1726045
Search by Saint Jude

Bibliographic References

No literature references available for this target.

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Detailed information for compound 801519