TDR Targets

Basic information

Technical information

TDR Targets ID: 802024
Name: N-(4-fluorophenyl)-3-(4-methoxyphenyl)-5-meth yl-4-oxopyridazino[5,4-b]indole-1-carboxamide
MW: 442.442 | Formula: C25H19FN4O3
H donors: 1 H acceptors: 2 LogP: 4.18 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)n1nc(C(=O)Nc2ccc(cc2)F)c2c(c1=O)n(C)c1c2cccc1
InChi: 1S/C25H19FN4O3/c1-29-20-6-4-3-5-19(20)21-22(24(31)27-16-9-7-15(26)8-10-16)28-30(25(32)23(21)29)17-11-13-18(33-2)14-12-17/h3-14H,1-2H3,(H,27,31)
InChiKey: DNZGYQRRSDOYKG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-fluorophenyl)-3-(4-methoxyphenyl)-5-methyl-4-oxo-pyridazino[5,4-b]indole-1-carboxamide
N-(4-fluorophenyl)-3-(4-methoxyphenyl)-5-methyl-4-oxo-1-pyridazino[5,4-b]indolecarboxamide
N-(4-fluorophenyl)-4-keto-3-(4-methoxyphenyl)-5-methyl-pyridazino[5,4-b]indole-1-carboxamide
EU-0093076

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	kinase	0.005	0.026	0.094
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0041	0.0145	0.0491
Schistosoma mansoni	hypothetical protein	0.0176	0.181	0.6994
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0041	0.0145	0.0126
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0041	0.0145	0.0491
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0231	0.0827
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0231	0.0212
Schistosoma mansoni	sodium/chloride dependent transporter	0.0041	0.0145	0.0491
Trypanosoma cruzi	polo-like protein kinase, putative	0.0098	0.0853	0.5
Echinococcus granulosus	sodium and chloride dependent glycine	0.0041	0.0145	0.0491
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0041	0.0145	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0038	0.0073
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0283	0.1032
Echinococcus multilocularis	serotonin transporter	0.0239	0.258	0.2566
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0231	0.0827
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0146	0.1707
Brugia malayi	jmjC domain containing protein	0.0037	0.0098	0.0306
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0244	0.286
Toxoplasma gondii	hypothetical protein	0.0041	0.0145	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0231	0.0827
Echinococcus granulosus	chromobox protein 1	0.0072	0.0536	0.202
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0041	0.0145	0.0491
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0099	0.0866	0.0849
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0041	0.0145	0.0491
Onchocerca volvulus		0.0239	0.258	1
Echinococcus multilocularis	geminin	0.0176	0.181	0.1795
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0041	0.0145	0.0491
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0041	0.0145	0.0491
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0041	0.0145	0.0126
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0041	0.0145	0.0491
Brugia malayi	chromobox protein homolog 3	0.0041	0.0146	0.0494
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0041	0.0145	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0145	0.0491
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.0853	1
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0098	0.0853	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0244	0.286
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0041	0.0145	0.0491
Loa Loa (eye worm)	norepinephrine transporter	0.0239	0.258	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0231	0.0827
Echinococcus multilocularis	chromobox protein 1	0.0072	0.0536	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0285	0.1038
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0041	0.0145	0.0491
Onchocerca volvulus		0.0041	0.0145	0.0491
Echinococcus multilocularis	jumonji domain containing protein	0.0042	0.0165	0.0146
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0041	0.0145	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0145	0.0491
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0041	0.0145	0.0491
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.0853	1
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.0536	0.629
Schistosoma mansoni	hypothetical protein	0.0176	0.181	0.6994
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0239	0.258	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.0098	0.0853	0.3256
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0098	0.0853	0.3256
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0231	0.0827
Echinococcus granulosus	chromobox protein 1	0.0072	0.0536	0.202
Toxoplasma gondii	hypothetical protein	0.0041	0.0145	1
Schistosoma mansoni	jumonji domain containing protein	0.0079	0.0615	0.2329
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0145	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0283	0.1032
Brugia malayi	Heterochromatin protein 1	0.0072	0.0536	0.202
Trypanosoma cruzi	polo-like protein kinase, putative	0.0098	0.0853	0.5
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0098	0.0306
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0098	0.0306
Echinococcus granulosus	serotonin transporter	0.0239	0.258	1
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.0536	0.629
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0098	0.0306
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0231	0.0827
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0041	0.0145	0.0126
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0283	0.1032
Loa Loa (eye worm)	heterochromatin protein 1	0.0072	0.0536	0.202
Onchocerca volvulus		0.0041	0.0145	0.0491
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.0416	0.1548
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0041	0.0145	0.0491
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0098	0.0306
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0239	0.258	1
Plasmodium falciparum	transporter, putative	0.0041	0.0145	1
Onchocerca volvulus		0.0032	0.0038	0.0073
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0183	0.0641
Echinococcus granulosus	jumonji domain containing protein	0.0042	0.0165	0.0569
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0098	0.0853	0.5
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.0098	0.0078
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0041	0.0145	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0146	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0082	0.0245
Schistosoma mansoni	chromobox protein	0.0072	0.0536	0.202
Brugia malayi	hypothetical protein	0.0041	0.0145	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0239	0.258	1
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.0853	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0041	0.0145	0.0491
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0041	0.0145	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0145	0.0491
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0146	0.0494
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0283	0.1032
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0231	0.0827
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0041	0.0145	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0145	0.0491
Schistosoma mansoni	chromobox protein	0.0072	0.0536	0.202
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0099	0.0866	0.3307
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.0853	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0041	0.0145	1
Loa Loa (eye worm)	hypothetical protein	0.0239	0.258	1
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.0853	1
Echinococcus granulosus	sodium and chloride dependent glycine	0.0041	0.0145	0.0491
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0183	0.2151
Loa Loa (eye worm)	hypothetical protein	0.0239	0.258	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0041	0.0145	0.0491
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0239	0.258	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0145	0.0491
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0098	0.0853	0.3256
Schistosoma mansoni	sodium/chloride dependent transporter	0.0239	0.258	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0098	0.0853	0.3256
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0041	0.0145	0.0491
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0146	0.1707
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0183	0.2151
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0098	0.0853	0.0835
Plasmodium vivax	amine transporter, putative	0.0041	0.0145	1
Loa Loa (eye worm)	serotonin transporter b	0.0239	0.258	1
Trypanosoma brucei	polo-like protein kinase	0.0098	0.0853	0.5
Schistosoma mansoni	sodium/chloride dependent transporter	0.0041	0.0149	0.0506
Onchocerca volvulus		0.0041	0.0145	0.0491
Echinococcus multilocularis	chromobox protein 1	0.0072	0.0536	0.0518
Giardia lamblia	Kinase, PLK	0.0098	0.0853	1
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.0853	1
Schistosoma mansoni	serine/threonine protein kinase	0.0098	0.0853	0.3256
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0041	0.0145	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0041	0.0145	0.0491
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0082	0.0245
Brugia malayi	jmjC domain containing protein	0.0099	0.0866	0.3307
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0231	0.0212
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0041	0.0145	0.0491
Treponema pallidum	sodium- and chloride- dependent transporter	0.0239	0.258	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0145	1
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.0853	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0041	0.0145	0.0491
Echinococcus granulosus	geminin	0.0176	0.181	0.6994
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0145	0.0491
Schistosoma mansoni	hypothetical protein	0.0035	0.0082	0.0245
Plasmodium falciparum	amino acid transporter, putative	0.0041	0.0145	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 802024