Detailed information for compound 806433

Basic information

Technical information
  • TDR Targets ID: 806433
  • Name: 2-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl-(4- propan-2-ylphenyl)amino]-N-[4-(trifluoromethy l)phenyl]acetamide
  • MW: 494.53 | Formula: C23H25F3N4O3S
  • H donors: 2 H acceptors: 4 LogP: 4.64 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(cc1)C(C)C)Nc1ccc(cc1)C(F)(F)F
  • InChi: 1S/C23H25F3N4O3S/c1-14(2)17-5-11-20(12-6-17)30(34(32,33)22-15(3)28-29-16(22)4)13-21(31)27-19-9-7-18(8-10-19)23(24,25)26/h5-12,14H,13H2,1-4H3,(H,27,31)(H,28,29)
  • InChiKey: OWFZJVMOWFLXOC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl-(4-isopropylphenyl)amino]-N-[4-(trifluoromethyl)phenyl]acetamide
  • 2-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl-(4-propan-2-ylphenyl)amino]-N-[4-(trifluoromethyl)phenyl]ethanamide
  • C517-3414
  • NCGC00109147-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni axis inhibition protein axin 0.002 0.0005 0.0009
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0081 0.0431 0.357
Trichomonas vaginalis malate dehydrogenase, putative 0.0193 0.1206 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0169 0.03
Trypanosoma cruzi malate dehydrogenase, putative 0.0081 0.0431 0.357
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0085 0.0459 0.0814
Echinococcus granulosus cytosolic malate dehydrogenase 0.0193 0.1206 0.2138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.009 0.0733
Brugia malayi RNase H family protein 0.0022 0.0022 0.0184
Schistosoma mansoni regulator of G protein signaling 0.002 0.0005 0.0009
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0005 0.004
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0021
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0005 0.004
Brugia malayi hypothetical protein 0.002 0.0005 0.004
Echinococcus multilocularis malate dehydrogenase 0.0081 0.0431 0.0763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0167 0.1369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0071 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0148 0.1208
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0005 0.004
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0005 0.0009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0285 0.2364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0071 0.0571
Trichomonas vaginalis malate dehydrogenase, putative 0.0193 0.1206 1
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0005 0.0009
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0005 0.0009
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0035 0.0291
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0024 0.0035 0.0291
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0244 0.2023
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0024 0.0199
Toxoplasma gondii lactate dehydrogenase LDH2 0.0081 0.0431 0.0431
Echinococcus granulosus cytosolic malate dehydrogenase 0.0193 0.1206 0.2138
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0193 0.1206 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0244 0.2022
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0081 0.0431 0.357
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5643 1
Giardia lamblia Malate dehydrogenase 0.0193 0.1206 1
Leishmania major malate dehydrogenase, putative 0.0081 0.0431 0.357
Schistosoma mansoni phosphoglucomutase 0.0022 0.0022 0.0039
Plasmodium falciparum malate dehydrogenase 0.0081 0.0431 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0071 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0093 0.0751
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0081 0.0431 0.357
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0081 0.0431 0.0431
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.004
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0193 0.1206 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0244 0.0433
Onchocerca volvulus 0.006 0.0282 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0002 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0021
Giardia lamblia Ribonuclease H 0.0022 0.0022 0.0165
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0005 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0167 0.1369
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0169 0.03
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0005 0.0009
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0005 0.0009
Echinococcus granulosus malate dehydrogenase 0.0081 0.0431 0.0763
Giardia lamblia GTOR 0.0054 0.0244 0.2008
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.0035 0.0291
Trichomonas vaginalis ribonuclease H1, putative 0.0022 0.0022 0.0165
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0244 0.2022
Trichomonas vaginalis malate dehydrogenase, putative 0.0151 0.0918 0.7603
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0148 0.1208
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.004
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.1462 1 1
Loa Loa (eye worm) RGS-3 protein 0.002 0.0005 0.004
Trypanosoma brucei cytosolic malate dehydrogenase 0.0193 0.1206 1
Schistosoma mansoni axis inhibition protein axin 0.002 0.0005 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0021
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0193 0.1206 1
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5643 1
Brugia malayi hypothetical protein 0.002 0.0005 0.004
Loa Loa (eye worm) hypothetical protein 0.0081 0.0431 0.3571
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0193 0.1206 0.2138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0189 0.1552
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0005 0.0009
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0244 0.2022
Toxoplasma gondii ribonuclease HI protein 0.0022 0.0022 0.0022
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0002 0.0017
Leishmania major malate dehydrogenase, putative 0.0081 0.0431 0.357
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.004
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0022 0.0022 0.002
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0002 0.0009
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0867 0.7188
Trichomonas vaginalis malate dehydrogenase, putative 0.0193 0.1206 1
Brugia malayi isocitrate dehydrogenase 0.0019 0 0.0002
Brugia malayi PXA domain containing protein 0.002 0.0005 0.004
Brugia malayi Isocitrate dehydrogenase 0.0019 0 0.0002
Trichomonas vaginalis malate dehydrogenase, putative 0.0193 0.1206 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0005 0.004
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.1462 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0002 0.0019
Toxoplasma gondii exonuclease III APE 0.0019 0.0002 0.0002
Loa Loa (eye worm) apoptosis regulator protein 0.0085 0.0459 0.3808
Echinococcus multilocularis lactate dehydrogenase a 0.0081 0.0431 0.0763
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0005 0.0009
Leishmania major ribonuclease H1, putative 0.0022 0.0022 0.0182
Schistosoma mansoni regulator of G protein signaling 0.002 0.0005 0.0009
Brugia malayi lactate dehydrogenase. 0.0081 0.0431 0.3571
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0 0.0002
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0022 0.0182
Echinococcus multilocularis malate dehydrogenase 0.0081 0.0431 0.0763
Trypanosoma brucei RNA helicase, putative 0.0083 0.0446 0.3697
Entamoeba histolytica hypothetical protein 0.0043 0.0169 0.1385
Loa Loa (eye worm) malate dehydrogenase 0.0081 0.0431 0.3571
Echinococcus multilocularis lactate dehydrogenase a 0.0081 0.0431 0.0763
Plasmodium falciparum L-lactate dehydrogenase 0.0081 0.0431 0.0431
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0244 0.2022
Brugia malayi PXA domain containing protein 0.002 0.0005 0.004
Schistosoma mansoni hypothetical protein 0.0083 0.0446 0.0791
Trichomonas vaginalis malate dehydrogenase, putative 0.0193 0.1206 1
Echinococcus multilocularis tumor protein p63 0.0408 0.2696 0.4777
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0193 0.1206 1
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1462 1 1
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0005 0.0009
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0081 0.0431 0.0763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.009 0.0733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0071 0.0571
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0005 0.0009
Echinococcus multilocularis expressed protein 0.0385 0.2533 0.4489
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0005 0.0009
Entamoeba histolytica hypothetical protein 0.002 0.0005 0.0021
Entamoeba histolytica malate dehydrogenase, putative 0.0081 0.0431 0.3559
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0002 0.0017
Leishmania major malate dehydrogenase 0.0081 0.0431 0.357
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0022 0.0182
Trypanosoma brucei ribonuclease H1 0.0022 0.0022 0.0182
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0867 0.7188
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1462 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0244 0.2008
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0244 0.0433
Plasmodium vivax lactate dehydrogenase 0.0081 0.0431 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0148 0.1208
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0085 0.0459 0.0814
Loa Loa (eye worm) hypothetical protein 0.006 0.0285 0.2364
Toxoplasma gondii lactate dehydrogenase LDH1 0.0081 0.0431 0.0431
Loa Loa (eye worm) malate dehydrogenase 0.0193 0.1206 1
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0005 0.0009
Brugia malayi RNase H family protein 0.0022 0.0022 0.0184
Schistosoma mansoni hypothetical protein 0.0085 0.0459 0.0814
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0085 0.0459 0.3808
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0352 0.2305 1
Entamoeba histolytica hypothetical protein 0.0043 0.0169 0.1385
Plasmodium vivax malate dehydrogenase, putative 0.0081 0.0431 0.0431
Schistosoma mansoni regulator of G protein signaling 0.002 0.0005 0.0009
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0193 0.1206 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0002 0.0004
Trichomonas vaginalis malate dehydrogenase, putative 0.0193 0.1206 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0002 0.0017
Schistosoma mansoni malate dehydrogenase 0.0081 0.0431 0.0763
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0005 0.0009
Schistosoma mansoni ap endonuclease 0.0019 0.0002 0.0004
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0193 0.1206 0.2138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0167 0.1369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0167 0.1369
Leishmania major glycosomal malate dehydrogenase 0.0081 0.0431 0.357
Echinococcus granulosus malate dehydrogenase 0.0081 0.0431 0.0763
Entamoeba histolytica malate dehydrogenase, putative 0.0193 0.1206 1
Schistosoma mansoni hypothetical protein 0.0041 0.0153 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.004
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0005 0.0009
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0167 0.1387
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0005 0.0009
Schistosoma mansoni phosphoglucomutase 0.0022 0.0022 0.0039
Leishmania major mitochondrial malate dehydrogenase 0.0081 0.0431 0.357
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0005 0.004
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0005 0.004
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0148 0.0148
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0169 0.03
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0081 0.0431 0.0429
Schistosoma mansoni hypothetical protein 0.0043 0.0169 0.03
Echinococcus granulosus axis inhibition protein axin 0.002 0.0005 0.0009
Brugia malayi MH2 domain containing protein 0.0144 0.0867 0.7188
Loa Loa (eye worm) hypothetical protein 0.0085 0.0459 0.3808
Leishmania major cytosolic malate dehydrogenase 0.0193 0.1206 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0005 0.004
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0167 0.1387
Trichomonas vaginalis malate dehydrogenase, putative 0.0193 0.1206 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0193 0.1206 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0002 0.0019
Entamoeba histolytica hypothetical protein 0.0043 0.0169 0.1385
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0085 0.0459 0.0814
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0285 0.2364
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0244 0.2008
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5643 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0244 0.2022
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0005 0.0009
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1462 1 1
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1462 1 1
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0041 0.0153 0.127
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0046 0.0378
Entamoeba histolytica hypothetical protein 0.002 0.0005 0.0021
Trichomonas vaginalis malate dehydrogenase, putative 0.0193 0.1206 1
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0081 0.0431 0.3571
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0193 0.1206 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0021
Schistosoma mansoni hypothetical protein 0.0085 0.0459 0.0814
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0005 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0071 0.0569
Entamoeba histolytica hypothetical protein 0.0043 0.0169 0.1385
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0193 0.1206 1
Schistosoma mansoni L-lactate dehydrogenase 0.0081 0.0431 0.0763
Schistosoma mansoni malate dehydrogenase 0.0193 0.1206 0.2138
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0081 0.0431 0.357
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0002 0.0002
Toxoplasma gondii malate dehydrogenase MDH 0.0081 0.0431 0.0431
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0005 0.0009
Entamoeba histolytica hypothetical protein 0.002 0.0005 0.0021
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0005 0.004
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0167 0.1387
Echinococcus granulosus expressed protein 0.0385 0.2533 0.4489
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0005 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0148 0.1208
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0148 0.1208
Trichomonas vaginalis malate dehydrogenase, putative 0.0193 0.1206 1
Trypanosoma cruzi malate dehydrogenase, putative 0.0081 0.0431 0.357
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.1462 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0285 0.2364
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0005 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0071 0.0571
Echinococcus granulosus ribonuclease H1 0.0022 0.0022 0.0039
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0244 0.2022
Trichomonas vaginalis malate dehydrogenase, putative 0.004 0.0142 0.1162
Schistosoma mansoni phosphoglucomutase 0.0022 0.0022 0.0039
Echinococcus multilocularis lactate dehydrogenase a 0.0081 0.0431 0.0763
Mycobacterium ulcerans malate dehydrogenase 0.0193 0.1206 0.1204
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0153 0.127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0112 0.0912
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0093 0.0751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.012 0.098
Schistosoma mansoni apoptosis regulator bax 0.0085 0.0459 0.0814
Plasmodium falciparum lactate dehydrogenase, putative 0.0081 0.0431 0.0431
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0085 0.0459 0.0814
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0167 0.1369
Echinococcus multilocularis lactate dehydrogenase protein 0.0081 0.0431 0.0763
Echinococcus granulosus L lactate dehydrogenase B chain 0.0081 0.0431 0.0763
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0193 0.1206 0.5233
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0005 0.0009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0244 0.2023
Echinococcus multilocularis ribonuclease H1 0.0022 0.0022 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0244 0.2008
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0005 0.0021
Schistosoma mansoni hypothetical protein 0.0085 0.0459 0.0814
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0005 0.0009
Brugia malayi hypothetical protein 0.0043 0.0169 0.1402
Trichomonas vaginalis malate dehydrogenase, putative 0.0081 0.0431 0.3559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0071 0.0569
Schistosoma mansoni ap endonuclease 0.0019 0.0002 0.0004
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0193 0.1206 1
Echinococcus granulosus tumor protein p63 0.0408 0.2696 0.4777
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0085 0.0459 0.0814
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0002 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0244 0.2008
Echinococcus granulosus lactate dehydrogenase protein 0.0081 0.0431 0.0763
Schistosoma mansoni malate dehydrogenase 0.0081 0.0431 0.0763
Trichomonas vaginalis malate dehydrogenase, putative 0.0193 0.1206 1
Schistosoma mansoni L-lactate dehydrogenase 0.0081 0.0431 0.0763
Trypanosoma brucei malate dehydrogenase-related 0.0081 0.0431 0.357
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0282 0.05
Echinococcus granulosus axis inhibition protein axin 0.002 0.0005 0.0009
Echinococcus granulosus lactate dehydrogenase a 0.0081 0.0431 0.0763
Schistosoma mansoni malate dehydrogenase 0.0193 0.1206 0.2138
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0244 0.0433
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.004
Loa Loa (eye worm) hypothetical protein 0.006 0.0282 0.2337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0244 0.2008
Schistosoma mansoni regulator of G protein signaling 0.002 0.0005 0.0009
Echinococcus granulosus lactate dehydrogenase a 0.0081 0.0431 0.0763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0093 0.0751
Trypanosoma brucei glycosomal malate dehydrogenase 0.0081 0.0431 0.357
Schistosoma mansoni regulator of G protein signaling 0.002 0.0005 0.0009
Treponema pallidum ribonuclease H (rnhA) 0.0022 0.0022 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0148 0.1208
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.004
Brugia malayi RNase H family protein 0.0022 0.0022 0.0184
Trypanosoma brucei unspecified product 0.0024 0.0035 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0148 0.1208
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.0035 0.0291
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0005 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0005 0.0009

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.6892 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) 14.6892 uM PubChem BioAssay. Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in WT MEF Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.1216 uM PubChem BioAssay. Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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