Detailed information for compound 808132

Basic information

Technical information
  • TDR Targets ID: 808132
  • Name: (4Z)-2-(2-bromophenyl)-4-(thiophen-2-ylmethyl idene)-1,3-oxazol-5-one
  • MW: 334.188 | Formula: C14H8BrNO2S
  • H donors: 0 H acceptors: 1 LogP: 3.97 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OC(=NC1=Cc1cccs1)c1ccccc1Br
  • InChi: 1S/C14H8BrNO2S/c15-11-6-2-1-5-10(11)13-16-12(14(17)18-13)8-9-4-3-7-19-9/h1-8H/b12-8-
  • InChiKey: ZRTHJWZDMLTDLA-WQLSENKSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-bromophenyl)-4-(thiophen-2-ylmethylidene)-1,3-oxazol-5-one
  • (4Z)-2-(2-bromophenyl)-4-(2-thienylmethylene)oxazol-5-one
  • 2-(2-bromophenyl)-4-(2-thienylmethylene)oxazol-5-one
  • (4Z)-2-(2-bromophenyl)-4-(2-thienylmethylene)-5-oxazolone
  • 2-(2-bromophenyl)-4-(2-thienylmethylene)-5-oxazolone
  • ZINC04589113
  • ZINC00055425
  • STOCK2S-30179
  • BIM-0013074.P001
  • CBMicro_013070

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptides capa receptor 0.0089 0.191 0.191
Onchocerca volvulus 0.0053 0.0907 0.2893
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.191 0.191
Schistosoma mansoni neuropeptide receptor 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Brugia malayi putative neuropeptide receptor 0.0089 0.191 0.191
Echinococcus granulosus 7TM GPCR rhodopsin 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus granulosus g-protein coupled receptor 0.0089 0.191 0.191
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0089 0.191 0.191
Echinococcus granulosus neuropeptide Y receptor 0.0089 0.191 0.191
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.1238 0.1238
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0089 0.191 0.191
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0152 0.3689 1
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.6467 0.6467
Brugia malayi hypothetical protein 0.0089 0.191 0.191
Brugia malayi neuropeptide F receptor 0.0089 0.191 0.191
Schistosoma mansoni amine GPCR 0.0089 0.191 0.191
Echinococcus granulosus tm gpcr rhodopsin 0.0089 0.191 0.191
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0152 0.3689 1
Onchocerca volvulus 0.0089 0.191 0.6094
Schistosoma mansoni high-affinity choline transporter 0.0376 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.191 0.191
Echinococcus multilocularis allatostatin A receptor 0.0089 0.191 0.191
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0152 0.3689 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.191 0.191
Echinococcus multilocularis somatostatin receptor 0.0089 0.191 0.191
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0089 0.191 0.191
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0089 0.191 0.191
Loa Loa (eye worm) TYRA-2 protein 0.0089 0.191 0.191
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0152 0.3689 1
Echinococcus multilocularis solute carrier family 5 0.0041 0.0568 0.0568
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0089 0.191 0.191
Brugia malayi hypothetical protein 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus granulosus neuropeptides capa receptor 0.0089 0.191 0.191
Echinococcus multilocularis serotonin receptor 0.0089 0.191 0.191
Brugia malayi Dopamine receptor protein 1 0.0089 0.191 0.191
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0152 0.3689 0.3689
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Brugia malayi G protein-coupled receptor F59B2.13 0.0089 0.191 0.191
Brugia malayi putative neuropeptide receptor NPR1 0.0089 0.191 0.191
Onchocerca volvulus 0.0089 0.191 0.6094
Echinococcus granulosus lamin 0.0029 0.0221 0.0221
Onchocerca volvulus 0.0089 0.191 0.6094
Brugia malayi RE15519p 0.0089 0.191 0.191
Schistosoma mansoni lamin 0.0029 0.0221 0.0221
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0089 0.191 0.191
Schistosoma mansoni amine GPCR 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0089 0.191 0.191
Schistosoma mansoni alpha-1 adrenergic receptor 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0152 0.3689 1
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.6467 0.6467
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus multilocularis g protein coupled receptor 0.0089 0.191 0.191
Echinococcus multilocularis orexin receptor type 2 0.0089 0.191 0.191
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.191 0.191
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.1634 0.1634
Echinococcus granulosus dro:myosuppressin receptor 0.0089 0.191 0.191
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.191 0.191
Schistosoma mansoni biogenic amine receptor 0.0089 0.191 0.191
Brugia malayi follicle stimulating hormone receptor 0.0089 0.191 0.191
Echinococcus granulosus allatostatin A receptor 0.0089 0.191 0.191
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0152 0.3689 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0206 0.0206
Schistosoma mansoni intermediate filament proteins 0.0029 0.0221 0.0221
Echinococcus granulosus intermediate filament protein 0.0029 0.0221 0.0221
Echinococcus multilocularis neuropeptide receptor 0.0089 0.191 0.191
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0152 0.3689 0.5
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0152 0.3689 0.3689
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus multilocularis tar DNA binding protein 0.0065 0.1238 0.1238
Brugia malayi neuropeptide F receptor 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus multilocularis fmrfamide receptor 0.0089 0.191 0.191
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0041 0.0568 0.0568
Echinococcus multilocularis neuropeptide s receptor 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Brugia malayi sulfakinin receptor protein 0.0089 0.191 0.191
Onchocerca volvulus 0.0089 0.191 0.6094
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0152 0.3689 1
Loa Loa (eye worm) G-protein coupled receptor 0.0089 0.191 0.191
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0089 0.191 0.191
Onchocerca volvulus 0.0089 0.191 0.6094
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Brugia malayi hypothetical protein 0.0089 0.191 0.191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.191 0.191
Loa Loa (eye worm) RNA binding protein 0.0065 0.1238 0.1238
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0089 0.191 0.191
Schistosoma mansoni opsin-like receptor 0.0089 0.191 0.191
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0089 0.191 0.191
Echinococcus multilocularis neuropeptides capa receptor 0.0089 0.191 0.191
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.01 0.2209 0.4737
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0152 0.3689 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Schistosoma mansoni sodium/solute symporter 0.0041 0.0568 0.0568
Onchocerca volvulus Huntingtin homolog 0.0132 0.3135 1
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0105 0.236 0.236
Echinococcus multilocularis neuropeptide Y receptor 0.0089 0.191 0.191
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0221 0.0221
Brugia malayi hypothetical protein 0.0089 0.191 0.191
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0152 0.3689 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Brugia malayi Melatonin receptor type 1A 0.0089 0.191 0.191
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0152 0.3689 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Onchocerca volvulus Neuropeptide F receptor homolog 0.0089 0.191 0.6094
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0089 0.191 0.191
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0152 0.3689 0.5
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus multilocularis neuropeptide Y receptor 0.0089 0.191 0.191
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0089 0.191 0.191
Echinococcus granulosus sodium:glucose cotransporter 2 0.0041 0.0568 0.0568
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1238 0.1238
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.01 0.2209 0.2209
Echinococcus granulosus tm gpcr rhodopsin 0.0089 0.191 0.191
Schistosoma mansoni hypothetical protein 0.0089 0.191 0.191
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0089 0.191 0.191
Echinococcus granulosus neuropeptide receptor 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus granulosus orexin receptor type 2 0.0089 0.191 0.191
Brugia malayi hypothetical protein 0.0089 0.191 0.191
Echinococcus granulosus high affinity choline transporter 1 0.0376 1 1
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0041 0.0568 0.0568
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0152 0.3689 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0089 0.191 0.191
Schistosoma mansoni hypothetical protein 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Schistosoma mansoni biogenic amine receptor 0.0089 0.191 0.191
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0089 0.191 0.191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0053 0.0907 0.0907
Brugia malayi MH2 domain containing protein 0.025 0.6467 0.6467
Schistosoma mansoni neuropeptide F-like receptor 0.0089 0.191 0.191
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0152 0.3689 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.191 0.191
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0089 0.191 0.191
Echinococcus granulosus solute carrier family 5 0.0041 0.0568 0.0568
Echinococcus granulosus g protein coupled receptor 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus granulosus serotonin receptor 0.0089 0.191 0.191
Echinococcus multilocularis sex peptide receptor 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Onchocerca volvulus 0.0089 0.191 0.6094
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0152 0.3689 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1238 0.1238
Brugia malayi hypothetical protein 0.0079 0.1634 0.1634
Echinococcus granulosus geminin 0.0183 0.4567 0.4567
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0152 0.3689 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.01 0.2209 0.4737
Schistosoma mansoni amine GPCR 0.0089 0.191 0.191
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0089 0.191 0.191
Schistosoma mansoni lamin 0.0029 0.0221 0.0221
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0221 0.0221
Brugia malayi RNA binding protein 0.0065 0.1238 0.1238
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.01 0.2209 0.2209
Echinococcus granulosus alpha 1A adrenergic receptor 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus granulosus somatostatin receptor 0.0089 0.191 0.191
Schistosoma mansoni biogenic amine receptor 0.0089 0.191 0.191
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0089 0.191 0.191
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0089 0.191 0.191
Schistosoma mansoni biogenic amine (5HT) receptor 0.0089 0.191 0.191
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0047 0.0728 0.0728
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0089 0.191 0.191
Brugia malayi Cytochrome P450 family protein 0.0024 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0089 0.191 0.191
Echinococcus granulosus sex peptide receptor 0.0089 0.191 0.191
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0152 0.3689 1
Echinococcus multilocularis musashi 0.0029 0.0221 0.0221
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0152 0.3689 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0089 0.191 0.191
Echinococcus multilocularis lamin dm0 0.0029 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.01 0.2209 0.2209
Echinococcus granulosus neuropeptide s receptor 0.0089 0.191 0.191
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0089 0.191 0.191
Echinococcus multilocularis high affinity choline transporter 1 0.0376 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.191 0.191
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0152 0.3689 1
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.1238 0.1238
Echinococcus granulosus sodium:myo inositol cotransporter 0.0041 0.0568 0.0568
Echinococcus granulosus g protein coupled receptor 0.0089 0.191 0.191
Brugia malayi Sodium:solute symporter family protein 0.0041 0.0568 0.0568
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.01 0.2209 0.2209
Brugia malayi G-protein coupled receptor 0.0089 0.191 0.191
Echinococcus multilocularis lamin 0.0029 0.0221 0.0221
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0152 0.3689 1
Echinococcus granulosus neuropeptide receptor A26 0.0089 0.191 0.191
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.191 0.191
Schistosoma mansoni neuropeptide receptor 0.0089 0.191 0.191
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0152 0.3689 0.3689
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0089 0.191 0.191
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0099 0.2207 0.4996
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0152 0.3689 0.3689
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Onchocerca volvulus 0.0089 0.191 0.6094
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0089 0.191 0.191
Schistosoma mansoni lipoxygenase 0.006 0.1082 0.1082
Brugia malayi AKH receptor 0.0089 0.191 0.191
Onchocerca volvulus 0.0041 0.0568 0.1811
Echinococcus multilocularis G protein coupled receptor 139 0.0089 0.191 0.191
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0089 0.191 0.191
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0063 0.0063
Schistosoma mansoni amine GPCR 0.0089 0.191 0.191
Echinococcus granulosus arachidonate 5 lipoxygenase 0.006 0.1082 0.1082
Schistosoma mansoni biogenic amine (5HT) receptor 0.0089 0.191 0.191
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0907 0.0907
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0152 0.3689 1
Schistosoma mansoni histamine h1 receptor 0.0089 0.191 0.191
Echinococcus multilocularis g protein coupled receptor 0.0089 0.191 0.191
Echinococcus granulosus tar DNA binding protein 0.0065 0.1238 0.1238
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0052 0.0878 0.0878
Schistosoma mansoni hypothetical protein 0.0183 0.4567 0.4567
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0089 0.191 0.191
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0089 0.191 0.191
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0052 0.088 0.5
Echinococcus granulosus tumor protein p63 0.0365 0.9704 0.9704
Brugia malayi intermediate filament protein 0.0029 0.0221 0.0221
Schistosoma mansoni neuropeptide receptor 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0376 1 1
Schistosoma mansoni neuropeptide receptor 0.0089 0.191 0.191
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0152 0.3689 1
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0041 0.0568 0.0568
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.1634 0.1634
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.191 0.191
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0105 0.236 0.236
Onchocerca volvulus 0.0089 0.191 0.6094
Echinococcus granulosus 7tm_1 domain containing protein 0.0089 0.191 0.191
Onchocerca volvulus 0.0089 0.191 0.6094
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0152 0.3689 0.3689
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0152 0.3689 1
Schistosoma mansoni opsin-like receptor 0.0089 0.191 0.191
Brugia malayi G protein-coupled receptor 0.0089 0.191 0.191
Brugia malayi hypothetical protein 0.0132 0.3135 0.3135
Onchocerca volvulus 0.0029 0.0221 0.0705
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0152 0.3689 1
Brugia malayi larval opioid receptor 0.0089 0.191 0.191
Onchocerca volvulus 0.0089 0.191 0.6094
Brugia malayi hypothetical protein 0.0089 0.191 0.191
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1238 0.1238
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0041 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Schistosoma mansoni myosin xvIII 0.0089 0.191 0.191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.191 0.191
Brugia malayi Dopamine receptor 0.0089 0.191 0.191
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0089 0.191 0.191
Onchocerca volvulus 0.0089 0.191 0.6094
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Onchocerca volvulus 0.0089 0.191 0.6094
Onchocerca volvulus 0.0029 0.0221 0.0705
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0089 0.191 0.191
Schistosoma mansoni neuropeptide F-like receptor 0.0089 0.191 0.191
Loa Loa (eye worm) melatonin receptor type 1A 0.0089 0.191 0.191
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0089 0.191 0.191
Schistosoma mansoni growth hormone secretagogue receptor 0.0089 0.191 0.191
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0152 0.3689 0.3689
Echinococcus multilocularis G-protein coupled receptor, putative 0.0089 0.191 0.191
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0152 0.3689 1
Brugia malayi hypothetical protein 0.0089 0.191 0.191
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus granulosus tm gpcr rhodopsin 0.0089 0.191 0.191
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.191 0.191
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0152 0.3689 0.3689
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0099 0.2207 0.4996
Onchocerca volvulus 0.0089 0.191 0.6094
Onchocerca volvulus 0.0089 0.191 0.6094
Echinococcus multilocularis g protein coupled receptor 0.0089 0.191 0.191
Echinococcus granulosus tachykinin peptides receptor 99D 0.0089 0.191 0.191
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0089 0.191 0.191
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0089 0.191 0.191
Schistosoma mansoni amine GPCR 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0041 0.0568 0.0568
Brugia malayi Serotonin receptor 0.0089 0.191 0.191
Echinococcus granulosus neuropeptide Y receptor 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus multilocularis g-protein coupled receptor 0.0089 0.191 0.191
Brugia malayi GnHR receptor homolog 0.0089 0.191 0.191
Echinococcus granulosus hypothetical protein 0.0089 0.191 0.191
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0089 0.191 0.191
Echinococcus multilocularis neuropeptide receptor 0.0089 0.191 0.191
Brugia malayi hypothetical protein 0.0089 0.191 0.191
Schistosoma mansoni neuropeptide f receptor 76f 0.0089 0.191 0.191
Brugia malayi Tachykinin-like peptides receptor 99D 0.0089 0.191 0.191
Schistosoma mansoni hypothetical protein 0.0079 0.1634 0.1634
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Loa Loa (eye worm) G-protein coupled receptor 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.006 0.1082 0.1082
Brugia malayi ORL1-like opioid receptor 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0052 0.088 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0089 0.191 0.191
Echinococcus granulosus neuropeptide FF receptor 2 0.0089 0.191 0.191
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1238 0.1238
Loa Loa (eye worm) hypothetical protein 0.0132 0.3135 0.3135
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0152 0.3689 1
Schistosoma mansoni hypothetical protein 0.0183 0.4567 0.4567
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.191 0.191
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.191 0.191
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0152 0.3689 0.3689
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0089 0.191 0.191
Echinococcus granulosus neuropeptide receptor 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0152 0.3689 1
Schistosoma mansoni opsin-like receptor 0.0089 0.191 0.191
Schistosoma mansoni hypothetical protein 0.0089 0.191 0.191
Schistosoma mansoni inositol transporter 0.0041 0.0568 0.0568
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.191 0.191
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0089 0.191 0.191
Echinococcus granulosus peptide allatostatin:somatostatin 0.0089 0.191 0.191
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.191 0.191
Loa Loa (eye worm) neuropeptide F receptor 0.0089 0.191 0.191
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0152 0.3689 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus granulosus fmrfamide receptor 0.0089 0.191 0.191
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0089 0.191 0.191
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0089 0.191 0.191
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0089 0.191 0.6094
Brugia malayi G-protein coupled receptor 0.0089 0.191 0.191
Onchocerca volvulus Huntingtin homolog 0.0132 0.3135 1
Echinococcus granulosus neuropeptides capa receptor 0.0089 0.191 0.191
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0089 0.191 0.191
Brugia malayi Serotonin receptor 0.0089 0.191 0.191
Echinococcus multilocularis neuropeptide FF receptor 2 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Schistosoma mansoni inositol transporter 0.0041 0.0568 0.0568
Schistosoma mansoni adenoreceptor 0.0089 0.191 0.191
Onchocerca volvulus 0.0089 0.191 0.6094
Loa Loa (eye worm) hypothetical protein 0.0132 0.3135 0.3135
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.01 0.2209 0.2209
Echinococcus granulosus G protein coupled receptor 139 0.0089 0.191 0.191
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0089 0.191 0.191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.191 0.191
Echinococcus granulosus g protein coupled receptor 0.0089 0.191 0.191
Echinococcus multilocularis serotonin receptor 0.0089 0.191 0.191
Loa Loa (eye worm) TAR-binding protein 0.0065 0.1238 0.1238
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.191 0.191
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0089 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Echinococcus granulosus lamin dm0 0.0029 0.0221 0.0221
Echinococcus granulosus biogenic amine 5HT receptor 0.0089 0.191 0.191
Onchocerca volvulus 0.0089 0.191 0.6094
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0152 0.3689 0.5
Echinococcus granulosus sodium:glucose cotransporter 0.0041 0.0568 0.0568
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0152 0.3689 0.3689
Loa Loa (eye worm) hypothetical protein 0.0029 0.0221 0.0221
Echinococcus multilocularis fmrfamide receptor 0.0089 0.191 0.191
Loa Loa (eye worm) neuropeptide F receptor 0.0089 0.191 0.191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.191 0.191
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0089 0.191 0.191
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1238 0.1238
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0089 0.191 0.191
Echinococcus multilocularis neuropeptide receptor A26 0.0089 0.191 0.191
Brugia malayi hypothetical protein 0.0089 0.191 0.191
Brugia malayi Dopamine receptor protein 2 0.0089 0.191 0.191
Echinococcus multilocularis tumor protein p63 0.0365 0.9704 0.9704
Brugia malayi TAR-binding protein 0.0065 0.1238 0.1238
Loa Loa (eye worm) hypothetical protein 0.0089 0.191 0.191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.191 0.191
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.1634 0.1634
Brugia malayi hypothetical protein 0.0089 0.191 0.191
Echinococcus multilocularis geminin 0.0183 0.4567 0.4567
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0089 0.191 0.191
Onchocerca volvulus 0.0089 0.191 0.6094

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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