Detailed information for compound 820052

Basic information

Technical information
  • TDR Targets ID: 820052
  • Name: N-[2-chloro-5-(trifluoromethyl)phenyl]-2-nitr obenzamide
  • MW: 344.673 | Formula: C14H8ClF3N2O3
  • H donors: 1 H acceptors: 3 LogP: 4.1 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1NC(=O)c1ccccc1[N+](=O)[O-])C(F)(F)F
  • InChi: 1S/C14H8ClF3N2O3/c15-10-6-5-8(14(16,17)18)7-11(10)19-13(21)9-3-1-2-4-12(9)20(22)23/h1-7H,(H,19,21)
  • InChiKey: FQQFRROFIDZWHY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-chloro-5-(trifluoromethyl)phenyl]-2-nitro-benzamide
  • BIM-0011240.P001
  • ZINC00271917
  • STK097716
  • CBMicro_011215

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ankyrin 23/unc44 0.0062 0.0499 0.0679
Trypanosoma brucei PAB1-binding protein , putative 0.0048 0.0329 1
Echinococcus multilocularis jun protein 0.0264 0.3001 0.3001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0069 0.0585 0.0585
Echinococcus granulosus Ankyrin 0.0062 0.0504 0.0675
Plasmodium vivax ataxin-2 like protein, putative 0.0048 0.0329 1
Brugia malayi hypothetical protein 0.0069 0.0585 0.162
Brugia malayi MH2 domain containing protein 0.0122 0.1244 0.3905
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0151 0.5
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0062 0.0504 0.0686
Schistosoma mansoni microtubule-associated protein tau 0.0616 0.7348 1
Schistosoma mansoni inositol monophosphatase 0.0038 0.02 0.0272
Brugia malayi Death domain containing protein 0.0062 0.0499 0.1323
Echinococcus granulosus jun protein 0.0264 0.3001 0.4018
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.004 0.0225 0.1909
Loa Loa (eye worm) hepatopoietin HPO2 0.004 0.0225 0.0091
Trypanosoma cruzi PAB1-binding protein , putative 0.0048 0.0329 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0499 0.1104
Schistosoma mansoni jun-related protein 0.0215 0.2389 0.3251
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0151 0.5
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0048 0.0329 0.0478
Loa Loa (eye worm) hypothetical protein 0.0211 0.2342 0.7899
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0625 0.7469 0.7469
Echinococcus multilocularis neuropeptide receptor A26 0.0475 0.5608 0.5608
Echinococcus granulosus neuropeptide s receptor 0.0475 0.5608 0.7508
Brugia malayi follicle stimulating hormone receptor 0.024 0.2695 0.8938
Plasmodium falciparum ataxin-2 like protein, putative 0.0048 0.0329 1
Echinococcus multilocularis neuropeptide s receptor 0.0475 0.5608 0.5608
Echinococcus multilocularis netrin receptor unc 5 0.0062 0.0499 0.0499
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0264 0.3001 0.4018
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1244 0.385
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.004 0.0225 0.1909
Brugia malayi hypothetical protein 0.0048 0.0329 0.0734
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0062 0.0499 0.0499
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.004 0.0225 0.1909
Brugia malayi Augmenter of liver regeneration 0.004 0.0225 0.037
Entamoeba histolytica hypothetical protein 0.0069 0.0585 1
Brugia malayi bZIP transcription factor family protein 0.0264 0.3001 1
Brugia malayi hypothetical protein 0.0208 0.2299 0.7565
Plasmodium falciparum ataxin-2 like protein, putative 0.0048 0.0329 1
Brugia malayi Uncoordinated protein 44 0.0062 0.0499 0.1323
Schistosoma mansoni hypothetical protein 0.0043 0.0264 0.036
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.004 0.0225 0.1909
Echinococcus granulosus netrin receptor unc 5 0.0062 0.0499 0.0668
Echinococcus granulosus microtubule associated protein 2 0.0616 0.7348 0.9837
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.2695 0.9201
Trypanosoma cruzi PAB1-binding protein , putative 0.0048 0.0329 1
Leishmania major hypothetical protein, conserved 0.004 0.0225 0.1909
Echinococcus granulosus neuropeptide receptor A26 0.0475 0.5608 0.7508
Loa Loa (eye worm) hypothetical protein 0.0062 0.0504 0.1121
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.02 0.5
Brugia malayi Protein kinase domain containing protein 0.0062 0.0499 0.1323
Echinococcus multilocularis survival motor neuron protein 1 0.0211 0.2342 0.2342
Brugia malayi hypothetical protein 0.0211 0.2342 0.7713
Echinococcus multilocularis microtubule associated protein 2 0.0616 0.7348 0.7348
Loa Loa (eye worm) hypothetical protein 0.0257 0.2911 1
Onchocerca volvulus Netrin receptor homolog 0.0062 0.0499 0.1154
Onchocerca volvulus 0.0208 0.2299 1
Toxoplasma gondii Erv1 / Alr family protein 0.004 0.0225 0.1909
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.0499 0.1323
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.004 0.0225 0.0225
Leishmania major hypothetical protein, conserved 0.0048 0.0329 1
Echinococcus granulosus survival motor neuron protein 1 0.0211 0.2342 0.3135
Entamoeba histolytica hypothetical protein 0.0069 0.0585 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.02 0.5
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.02 0.5
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.02 0.5
Echinococcus granulosus nuclear factor of activated T cells 5 0.0625 0.7469 1
Schistosoma mansoni hypothetical protein 0.0215 0.2389 0.3251
Echinococcus granulosus death domain containing protein 0.0062 0.0499 0.0668
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0069 0.0585 0.0783
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0062 0.0499 0.0668
Schistosoma mansoni inositol monophosphatase 0.0038 0.02 0.0272
Toxoplasma gondii LsmAD domain-containing protein 0.0048 0.0329 1
Brugia malayi Inositol-1 0.0038 0.02 0.0285
Schistosoma mansoni netrin receptor unc5 0.0062 0.0499 0.0679
Toxoplasma gondii Erv1 / Alr family protein 0.004 0.0225 0.1909
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0043 0.0264 0.0509
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0062 0.0499 0.1104
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1244 0.385
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.02 0.0267
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0264 0.3001 0.3001
Schistosoma mansoni transcription factor LCR-F1 0.0069 0.0585 0.0796
Entamoeba histolytica hypothetical protein 0.0069 0.0585 1
Schistosoma mansoni survival motor neuron protein 0.0043 0.0264 0.036
Schistosoma mansoni hypothetical protein 0.0062 0.0499 0.0679
Schistosoma mansoni hypothetical protein 0.0069 0.0585 0.0796
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.02 0.5
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.004 0.0225 0.0301
Entamoeba histolytica hypothetical protein 0.0069 0.0585 1
Echinococcus multilocularis Ankyrin 0.0062 0.0504 0.0504

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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