TDR Targets

Basic information

Technical information

TDR Targets ID: 820326
Name: 2-(thiophene-2-carbonylamino)benzoic acid
MW: 247.27 | Formula: C12H9NO3S
H donors: 2 H acceptors: 3 LogP: 2.85 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cccs1)Nc1ccccc1C(=O)O
InChi: 1S/C12H9NO3S/c14-11(10-6-3-7-17-10)13-9-5-2-1-4-8(9)12(15)16/h1-7H,(H,13,14)(H,15,16)
InChiKey: OGUBBDMPILZTQG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[[oxo-(2-thienyl)methyl]amino]benzoic acid
2-(thiophen-2-ylcarbonylamino)benzoic acid
SR-01000421877-2
2-[(Thiophene-2-carbonyl)-amino]-benzoic acid
BAS 00458269
Oprea1_498077
benzoic acid, 2-[(2-thienylcarbonyl)amino]-
CBMicro_016046
BIM-0016086.P001
IVK/6197205
2-[(2-thienylcarbonyl)amino]benzoic acid
InChI=1/C12H9NO3S/c14-11(10-6-3-7-17-10)13-9-5-2-1-4-8(9)12(15)16/h1-7H,(H,13,14)(H,15,16
Oprea1_349294

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	cathepsin B-like cysteine proteinase	0.0169	0.4703	0.4703
Plasmodium vivax	vivapain-2	0.0057	0.1091	0.4737
Echinococcus granulosus	cysteine protease	0.0032	0.0283	0.0602
Onchocerca volvulus		0.0057	0.1091	0.0582
Loa Loa (eye worm)	hypothetical protein	0.004	0.054	0.054
Schistosoma mansoni	cathepsin F (C01 family)	0.0057	0.1091	0.2319
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0057	0.1091	0.4737
Plasmodium vivax	vivapain-3	0.0032	0.0283	0.1229
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0062	0.1258	0.8416
Leishmania major	cathepsin L-like protease	0.0057	0.1091	0.7296
Loa Loa (eye worm)	hypothetical protein	0.0169	0.4703	0.4703
Brugia malayi	Cathepsin L-like precursor	0.0057	0.1091	0.1091
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0169	0.4703	1
Onchocerca volvulus		0.0057	0.1091	0.0582
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0057	0.1094	0.2326
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0283	0.0283
Echinococcus multilocularis	cathepsin b	0.0169	0.4703	1
Toxoplasma gondii	cathepsin B	0.0062	0.127	0.5513
Leishmania major	cathepsin L-like protease	0.0057	0.1091	0.7296
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.1091	0.8593
Brugia malayi	Cathepsin L-like precursor	0.0057	0.1091	0.1091
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0062	0.127	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0094	0.2303	1
Brugia malayi	Probable ClpP-like protease	0.0094	0.2303	0.2303
Trypanosoma cruzi	cysteine proteinase, putative	0.0032	0.0283	0.0602
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0057	0.1094	0.1094
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0169	0.4703	1
Onchocerca volvulus	Cathepsin L homolog	0.0057	0.1091	0.0582
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0057	0.1091	0.8593
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0069	0.1495	0.3179
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0283	0.2594
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0283	0.2594
Echinococcus multilocularis	cathepsin L cysteine protease	0.0057	0.1091	0.2319
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.1091	0.8593
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2303	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0033	0.0315	0.137
Entamoeba histolytica	cysteine proteinase 1, putative	0.0032	0.0283	0.2594
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.1091	0.8593
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0069	0.1495	1
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0057	0.1094	0.8616
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0071	0.1551	0.3298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.1091	0.8593
Onchocerca volvulus	Huntingtin homolog	0.0148	0.4021	0.368
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0283	0.2594
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0283	0.2594
Loa Loa (eye worm)	hypothetical protein	0.004	0.054	0.054
Plasmodium vivax	vivapain-2	0.0057	0.1091	0.4737
Brugia malayi	jmjC domain containing protein	0.0071	0.1551	0.1551
Echinococcus granulosus	cathepsin L cysteine protease	0.0032	0.0283	0.0602
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0062	0.1258	0.4744
Toxoplasma gondii	cathepsin CPL	0.0057	0.1091	0.4737
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.1091	0.8593
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0283	0.2594
Giardia lamblia	Cathepsin B precursor	0.0062	0.127	1
Loa Loa (eye worm)	ctsf protein	0.0057	0.1091	0.1091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.1091	0.8593
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.1091	0.8593
Entamoeba histolytica	cysteine proteinase, putative	0.0057	0.1091	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0057	0.1091	0.2319
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0283	0.2594
Echinococcus granulosus	cathepsin L	0.0032	0.0283	0.0602
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.1091	0.8593
Plasmodium vivax	aspartyl proteinase, putative	0.0057	0.1094	0.475
Brugia malayi	Cathepsin L-like precursor	0.0057	0.1091	0.1091
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0169	0.4703	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.1091	0.8593
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0283	0.0602
Loa Loa (eye worm)	cathepsin B	0.0062	0.127	0.127
Plasmodium vivax	vivapain-1	0.0032	0.0283	0.1229
Entamoeba histolytica	cysteine proteinase, putative	0.0057	0.1091	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0057	0.1091	0.8593
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4021	0.4021
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.1091	0.8593
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0283	0.2594
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0283	0.2594
Entamoeba histolytica	cysteine proteinase, putative	0.004	0.054	0.495
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.1091	0.8593
Echinococcus multilocularis	cathepsin L cysteine protease	0.0057	0.1091	0.2319
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0169	0.4703	1
Echinococcus granulosus	cathepsin l1	0.004	0.054	0.1148
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.1091	0.8593
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0057	0.1091	0.1091
Plasmodium falciparum	plasmepsin I	0.0057	0.1094	0.475
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0057	0.1091	0.2319
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0057	0.1094	0.2326
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0069	0.1495	0.3179
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0283	0.2594
Onchocerca volvulus		0.0057	0.1091	0.0582
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0062	0.127	0.2699
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0283	0.2594
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.1091	0.8593
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.1091	0.8593
Echinococcus granulosus	peptidase Clp S14 family	0.0062	0.1258	0.2675
Echinococcus multilocularis	cysteine protease	0.0057	0.1091	0.2319
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0057	0.1091	0.2319
Trypanosoma cruzi	cysteine protease, putative	0.0032	0.0283	0.0602
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0069	0.1495	0.1495
Echinococcus granulosus	cathepsin b	0.0169	0.4703	1
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0057	0.1094	0.475
Plasmodium falciparum	plasmepsin VI	0.0057	0.1094	0.475
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2303	0.5
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0094	0.2303	0.4896
Plasmodium falciparum	plasmepsin II	0.0057	0.1094	0.475
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0283	0.2594
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0283	0.2594
Schistosoma mansoni	cathepsin D (A01 family)	0.0167	0.4646	0.9878
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2303	1
Plasmodium falciparum	plasmepsin IV	0.0057	0.1094	0.475
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0062	0.127	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0057	0.1091	0.2319
Echinococcus granulosus	lysine specific demethylase 5A	0.0071	0.1551	0.3298
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.1091	0.8593
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0069	0.1495	0.6492
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.1091	0.8593
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.1091	0.8593
Echinococcus multilocularis	cathepsin b	0.0169	0.4703	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2303	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.1091	0.8593
Brugia malayi	Cathepsin L-like precursor	0.0057	0.1091	0.1091
Onchocerca volvulus		0.0057	0.1091	0.0582
Brugia malayi	hypothetical protein	0.0148	0.4021	0.4021
Leishmania major	cysteine peptidase A (CPA)	0.0057	0.1091	0.7296
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.1091	0.8593
Brugia malayi	jmjC domain containing protein	0.0071	0.1551	0.1551
Trypanosoma cruzi	cysteine peptidase, putative	0.0057	0.1091	0.2319
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.1551	0.3298
Leishmania major	cathepsin L-like protease	0.0057	0.1091	0.7296
Schistosoma mansoni	peptidase Clp (S14 family)	0.0094	0.2303	0.4896
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0057	0.1091	0.2319
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.1091	0.8593
Loa Loa (eye worm)	hypothetical protein	0.004	0.054	0.054
Toxoplasma gondii	aspartyl protease ASP1	0.0057	0.1094	0.475
Echinococcus granulosus	cathepsin b	0.0169	0.4703	1
Onchocerca volvulus		0.0334	1	1
Brugia malayi	Cathepsin L-like precursor	0.0057	0.1091	0.1091
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2303	1
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0283	0.2594
Loa Loa (eye worm)	hypothetical protein	0.0334	1	1
Echinococcus multilocularis	cathepsin L	0.0032	0.0283	0.0602
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0283	0.0602
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.054	0.4253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.1091	0.8593
Loa Loa (eye worm)	hypothetical protein	0.0334	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0057	0.1091	0.1091
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.1091	0.8593
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1094	0.1094
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.1091	0.8593
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0283	0.2229
Brugia malayi	cathepsin L-like precursor	0.004	0.054	0.054
Schistosoma mansoni	cathepsin D (A01 family)	0.0167	0.4646	0.9878
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0283	0.2594
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0094	0.2303	0.4896
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.1091	0.8593
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2303	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.1091	0.8593
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0057	0.1091	0.4737
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.1091	0.8593
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0283	0.2229
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.1091	0.8593
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0065	0.1345	0.1345
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.1091	0.8593
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1091	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4021	0.4021
Leishmania major	cathepsin L-like protease	0.0057	0.1091	0.7296
Brugia malayi	Cathepsin L-like precursor	0.0057	0.1091	0.1091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.1091	0.8593
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0057	0.1091	0.4737
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0033	0.0315	0.137
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.054	0.4253
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0062	0.1258	0.2675
Brugia malayi	Cathepsin L-like cysteine proteinase	0.004	0.054	0.054
Trypanosoma cruzi	cysteine peptidase, putative	0.0057	0.1091	0.2319
Echinococcus multilocularis	cysteine protease	0.0057	0.1091	0.2319
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.1551	0.3298
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0283	0.2594
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0057	0.1091	0.2319
Loa Loa (eye worm)	jmjC domain-containing protein	0.0071	0.1551	0.1551
Schistosoma mansoni	cathepsin F (C01 family)	0.004	0.054	0.1148
Schistosoma mansoni	jumonji domain containing protein	0.0071	0.1551	0.3298
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0069	0.1495	0.3179
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.1091	0.8593
Onchocerca volvulus		0.0057	0.1091	0.0582
Onchocerca volvulus		0.0057	0.1091	0.0582
Echinococcus multilocularis	lysine specific demethylase 5A	0.0071	0.1551	0.3298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.1091	0.8593
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0283	0.2594
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0032	0.0283	0.1229
Giardia lamblia	Cathepsin B precursor	0.0062	0.127	1
Onchocerca volvulus	Cathepsin L homolog	0.0057	0.1091	0.0582
Entamoeba histolytica	cysteine protease, putative	0.0057	0.1091	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0057	0.1091	0.2319
Loa Loa (eye worm)	fibroinase	0.0057	0.1091	0.1091
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0057	0.1091	0.1091
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0283	0.0602
Onchocerca volvulus		0.0057	0.1091	0.0582
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.2303	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.1091	0.8593
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0032	0.0283	0.0602
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2303	1
Onchocerca volvulus	Cathepsin F homolog	0.0057	0.1091	0.0582
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.127	0.2699
Plasmodium vivax	unspecified product	0.0032	0.0283	0.1229
Brugia malayi	Cathepsin L-like precursor	0.004	0.054	0.054
Loa Loa (eye worm)	hypothetical protein	0.0094	0.2303	0.2303
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0283	0.2594
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0283	0.0283
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.004	0.054	0.1148
Plasmodium vivax	plasmepsin IV, putative	0.0057	0.1094	0.475
Leishmania major	cathepsin L-like protease	0.0057	0.1091	0.7296
Echinococcus granulosus	cathepsin l1	0.0057	0.1091	0.2319
Entamoeba histolytica	cysteine proteinase 2	0.0032	0.0283	0.2594
Trypanosoma cruzi	cysteine proteinase, putative	0.0032	0.0283	0.0602
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.1091	0.8593
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0071	0.1551	0.3298
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0062	0.1258	0.8416
Leishmania major	cathepsin L-like protease	0.0057	0.1091	0.7296
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.2303	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0062	0.127	0.8492
Giardia lamblia	Cathepsin B precursor	0.0062	0.127	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0069	0.1495	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.1091	0.8593
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0169	0.4703	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0094	0.2303	1
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0057	0.1094	0.2326
Brugia malayi	Cathepsin L-like precursor	0.004	0.054	0.054
Leishmania major	cathepsin L-like protease	0.0057	0.1091	0.7296
Schistosoma mansoni	cathepsin F (C01 family)	0.0057	0.1091	0.2319
Toxoplasma gondii	hypothetical protein	0.0033	0.0315	0.137
Leishmania major	cathepsin L-like protease	0.0057	0.1091	0.7296
Loa Loa (eye worm)	cysteine protease	0.0057	0.1091	0.1091
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0283	0.2229
Onchocerca volvulus	Huntingtin homolog	0.0148	0.4021	0.368
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0033	0.0315	0.137
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0069	0.1495	0.6492
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0283	0.0602
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0283	0.2229

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 820326