TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 481.01 | Formula: C25H25ClN4O2S
H donors: 1 H acceptors: 3 LogP: 5.03 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)n1c(nnc1SCc1cccc(c1)Cl)CN(Cc1ccc(cc1)O)C
InChi: 1S/C25H25ClN4O2S/c1-29(15-18-9-11-22(31)12-10-18)16-24-27-28-25(33-17-19-5-3-6-20(26)13-19)30(24)21-7-4-8-23(14-21)32-2/h3-14,31H,15-17H2,1-2H3
InChiKey: ODWWCDJQNFCEJP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	histidinol dehydrogenase	1.6725	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.002	0.0145
Schistosoma mansoni	ap endonuclease	0.0027	0.0009	0.0063
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.002	0.0145
Onchocerca volvulus		0.0021	0.0005	0.0442
Brugia malayi	intermediate filament protein	0.0043	0.0019	0.0628
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.002	0.008
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0046	0.002	0.0145
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0036	0.0014	0.0056
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.002	0.0145
Schistosoma mansoni	hypothetical protein	0.0046	0.002	0.0145
Trichomonas vaginalis	ap endonuclease, putative	0.0027	0.0009	0.0953
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0016	0.0002	0.0028
Brugia malayi	hypothetical protein	0.0016	0.0002	0.0079
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.0028	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.0028	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.002	0.008
Brugia malayi	hypothetical protein	0.0046	0.002	0.0691
Brugia malayi	follicle stimulating hormone receptor	0.0171	0.0095	0.3215
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0002	0.0215
Onchocerca volvulus		0.0016	0.0002	0.0093
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.002	0.008
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Schistosoma mansoni	amine GPCR	0.0367	0.0212	0.1524
Echinococcus granulosus	neuropeptide FF receptor 2	0.0046	0.002	0.008
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0016	0.0002	0.0106
Schistosoma mansoni	biogenic amine receptor	0.0046	0.002	0.0145
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0002	0.0201
Onchocerca volvulus		0.0046	0.002	0.2115
Echinococcus multilocularis	cysteine protease	0.0016	0.0002	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Plasmodium vivax	vivapain-2	0.0016	0.0002	0.0544
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.2338	0.1391	0.5551
Echinococcus granulosus	lamin dm0	0.0043	0.0019	0.0072
Echinococcus multilocularis	serotonin receptor	0.0046	0.002	0.008
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.002	0.008
Onchocerca volvulus		0.0046	0.002	0.2115
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0002	0.0007
Echinococcus granulosus	neuropeptide receptor A26	0.0046	0.002	0.008
Brugia malayi	putative neuropeptide receptor	0.0046	0.002	0.0691
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0046	0.002	0.2148
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0046	0.002	0.0145
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0016	0.0002	0.0008
Echinococcus multilocularis	lamin dm0	0.0043	0.0019	0.0073
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0002	0.0201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0002	0.0201
Onchocerca volvulus		0.0046	0.002	0.2115
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.002	0.008
Loa Loa (eye worm)	hypothetical protein	0.006	0.0028	0.2991
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0021	0.0005	0.002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0002	0.0201
Schistosoma mansoni	myosin xvIII	0.0046	0.002	0.0145
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0025	0.0008	0.0029
Schistosoma mansoni	histamine h1 receptor	0.0046	0.002	0.0145
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0021	0.0005	0.0036
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0027	0.0009	0.0034
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0016	0.0002	0.0008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0002	0.0201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.0028	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.2338	0.1391	1
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0016	0.0002	0.0008
Schistosoma mansoni	hypothetical protein	0.0018	0.0004	0.0025
Echinococcus multilocularis	G protein coupled receptor 139	0.0046	0.002	0.008
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.002	0.008
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0027	0.0009	0.03
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Echinococcus multilocularis	sex peptide receptor	0.0046	0.002	0.008
Echinococcus granulosus	sex peptide receptor	0.0046	0.002	0.008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0002	0.0201
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0025	0.0008	0.0053
Onchocerca volvulus		0.0046	0.002	0.2115
Onchocerca volvulus		0.0046	0.002	0.2115
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0002	0.0007
Brugia malayi	Bloom's syndrome protein homolog	0.0075	0.0037	0.1268
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0002	0.0201
Onchocerca volvulus		0.0046	0.002	0.2115
Loa Loa (eye worm)	ctsf protein	0.0016	0.0002	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0025	0.0008	0.0053
Echinococcus granulosus	dro:myosuppressin receptor	0.0046	0.002	0.008
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.002	0.2148
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0171	0.0095	1
Brugia malayi	Pre-SET motif family protein	0.0145	0.008	0.2705
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.002	0.008
Brugia malayi	hypothetical protein	0.0046	0.002	0.0691
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0002	0.0201
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0025	0.0008	0.0029
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0027	0.0009	0.484
Plasmodium vivax	SET domain protein, putative	0.0021	0.0005	0.1479
Onchocerca volvulus		0.0046	0.002	0.2115
Mycobacterium ulcerans	epimerase	0.0018	0.0004	0.0004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0002	0.0201
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.002	0.0145
Loa Loa (eye worm)	hypothetical protein	0.002	0.0005	0.0496
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.004	0.0017	0.5502
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0043	0.0019	0.1954
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.002	0.0145
Schistosoma mansoni	DNA helicase recq5	0.0031	0.0011	0.0079
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0046	0.002	0.008
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.002	0.0145
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.002	0.008
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.004	0.0017	0.555
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0034	0.3587
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0027	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Schistosoma mansoni	opsin-like receptor	0.0046	0.002	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0002	0.0069
Brugia malayi	larval opioid receptor	0.0046	0.002	0.0691
Echinococcus granulosus	bloom syndrome protein	0.0075	0.0037	0.0147
Loa Loa (eye worm)	TYRA-2 protein	0.0046	0.002	0.2148
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0046	0.002	0.0145
Echinococcus granulosus	allatostatin A receptor	0.0046	0.002	0.008
Brugia malayi	hypothetical protein	0.0046	0.002	0.0691
Trichomonas vaginalis	set domain proteins, putative	0.0165	0.0092	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0027	0.0009	0.2552
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.002	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.002	0.008
Echinococcus multilocularis	lamin	0.0043	0.0019	0.0073
Schistosoma mansoni	hypothetical protein	0.0014	0.0001	0.0007
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.002	0.008
Onchocerca volvulus		0.0046	0.002	0.2115
Mycobacterium leprae	conserved hypothetical protein	0.0018	0.0004	0.0004
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.0028	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.002	0.008
Brugia malayi	G-protein coupled receptor	0.0046	0.002	0.0691
Schistosoma mansoni	hypothetical protein	0.0046	0.002	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Echinococcus multilocularis	allatostatin A receptor	0.0046	0.002	0.008
Loa Loa (eye worm)	matrixin family protein	0.0022	0.0006	0.0631
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0025	0.0008	0.0053
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0046	0.002	0.0145
Mycobacterium ulcerans	endonuclease IV	0.0069	0.0034	0.0034
Trichomonas vaginalis	DNA helicase recq1, putative	0.0075	0.0037	0.406
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0046	0.002	0.008
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0027	0.0009	0.263
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0046	0.002	0.008
Brugia malayi	cytoplasmic intermediate filament protein	0.0023	0.0007	0.0222
Plasmodium vivax	apurinic/apyrimidinic endonuclease Apn1, putative	0.0069	0.0034	1
Trichomonas vaginalis	DNA helicase recq, putative	0.0075	0.0037	0.406
Trypanosoma cruzi	major cysteine proteinase, putative	0.0047	0.0021	0.7098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.0028	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0046	0.002	0.008
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.002	0.008
Echinococcus granulosus	G protein coupled receptor 139	0.0046	0.002	0.008
Brugia malayi	Intermediate filament tail domain containing protein	0.0043	0.0019	0.0628
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.002	0.0145
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0016	0.0002	0.0008
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0046	0.002	0.008
Entamoeba histolytica	recQ family helicase, putative	0.004	0.0017	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.002	0.008
Brugia malayi	hypothetical protein	0.0046	0.002	0.0691
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.002	0.008
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0046	0.002	0.0145
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.0002	0.0544
Plasmodium vivax	vivapain-2	0.0016	0.0002	0.0544
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0016	0.0002	0.0008
Onchocerca volvulus		0.0046	0.002	0.2115
Toxoplasma gondii	cathepsin CPL	0.0016	0.0002	0.0544
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.002	0.008
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0046	0.002	0.2115
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0025	0.0008	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0046	0.002	0.008
Loa Loa (eye worm)	cysteine protease	0.0016	0.0002	0.0215
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.002	0.008
Brugia malayi	hypothetical protein	0.0046	0.002	0.0691
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.0028	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.0028	1
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.004	0.0017	0.555
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0002	0.0069
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0046	0.002	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.0002	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.005	0.0023	0.6721
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Onchocerca volvulus		0.0046	0.002	0.2115
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0046	0.002	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0002	0.0191
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0002	0.0201
Echinococcus granulosus	fmrfamide receptor	0.0046	0.002	0.008
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.002	0.008
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.002	0.008
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0002	0.0215
Schistosoma mansoni	cathepsin D (A01 family)	0.0037	0.0015	0.0105
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0002	0.0069
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0046	0.002	0.0691
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0031	0.0011	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0021	0.0005	0.002
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0031	0.0011	0.3241
Trypanosoma cruzi	cruzipain precursor, putative	0.0059	0.0028	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0037	0.0015	0.0105
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0016	0.0002	0.0008
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0046	0.002	0.008
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0016	0.0002	0.0231
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0046	0.002	0.008
Echinococcus granulosus	aminopeptidase N	0.0054	0.0025	0.0099
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0031	0.0011	0.0044
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.0028	1
Schistosoma mansoni	hypothetical protein	0.0046	0.002	0.0145
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0027	0.0009	0.0933
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.0028	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0002	0.0215
Brugia malayi	AKH receptor	0.0046	0.002	0.0691
Schistosoma mansoni	blooms syndrome DNA helicase	0.0016	0.0002	0.0014
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0066	0.0032	0.9396
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0002	0.0566
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0002	0.0201
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.002	0.2148
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.002	0.008
Echinococcus multilocularis	aminopeptidase N	0.0054	0.0025	0.01
Schistosoma mansoni	biogenic amine receptor	0.0046	0.002	0.0145
Trichomonas vaginalis	DNA helicase recq, putative	0.004	0.0017	0.1789
Mycobacterium ulcerans	aminopeptidase N PepN	0.0016	0.0002	0.0002
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.002	0.008
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0046	0.002	0.0691
Echinococcus granulosus	biogenic amine 5HT receptor	0.2338	0.1391	0.5491
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0046	0.002	0.2115
Echinococcus granulosus	intermediate filament protein	0.0043	0.0019	0.0072
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.002	0.008
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0002	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0016	0.166
Brugia malayi	Hemopexin family protein	0.0014	0.0001	0.0041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0002	0.0201
Brugia malayi	G protein-coupled receptor F59B2.13	0.0046	0.002	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0009	0.0933
Schistosoma mansoni	amine GPCR	0.0046	0.002	0.0145
Brugia malayi	Dopamine receptor	0.0046	0.002	0.0691
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0002	0.0013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.002	0.0145
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0002	0.0093
Schistosoma mansoni	growth hormone secretagogue receptor	0.0046	0.002	0.0145
Chlamydia trachomatis	endonuclease IV	0.0069	0.0034	0.5
Loa Loa (eye worm)	RecQ helicase	0.0075	0.0037	0.3944
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0025	0.0008	0.0793
Brugia malayi	Matrixin family protein	0.0024	0.0007	0.0243
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.0028	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0019	0.1954
Brugia malayi	Serotonin receptor	0.0505	0.0295	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0002	0.0007
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0031	0.0011	0.1177
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0145	0.008	0.8414
Echinococcus granulosus	hypothetical protein	0.4247	0.2534	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Onchocerca volvulus		0.0046	0.002	0.2115
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0046	0.002	0.008
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0005	0.0036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0002	0.0201
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.002	0.008
Plasmodium falciparum	apurinic/apyrimidinic endonuclease Apn1, putative	0.0069	0.0034	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.002	0.008
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Toxoplasma gondii	exonuclease III APE	0.0027	0.0009	0.2583
Schistosoma mansoni	lamin	0.0043	0.0019	0.0132
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0016	0.0002	0.0106
Onchocerca volvulus		0.0054	0.0025	0.2664
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0046	0.002	0.2148
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0002	0.0069
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0027	0.0009	0.0009
Brugia malayi	DNA-(Apurinic or apyrimidinic site) lyase	0.0069	0.0034	0.1153
Brugia malayi	neuropeptide F receptor	0.0046	0.002	0.0691
Echinococcus granulosus	7tm_1 domain containing protein	0.0046	0.002	0.008
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0549
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.002	0.008
Schistosoma mansoni	opsin-like receptor	0.0046	0.002	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0022	0.2316
Onchocerca volvulus		0.0043	0.0019	0.1913
Echinococcus granulosus	neuropeptide receptor	0.0046	0.002	0.008
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0002	0.0201
Onchocerca volvulus	Matrilysin homolog	0.0022	0.0006	0.0528
Loa Loa (eye worm)	fibroinase	0.0016	0.0002	0.0215
Brugia malayi	neuropeptide F receptor	0.0046	0.002	0.0691
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0016	0.0002	0.0231
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0031	0.0011	0.0378
Onchocerca volvulus		0.0016	0.0002	0.0093
Schistosoma mansoni	amine GPCR	0.0046	0.002	0.0145
Echinococcus multilocularis	dro:myosuppressin receptor	0.0046	0.002	0.008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0002	0.0201
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0016	0.0002	0.0008
Brugia malayi	hypothetical protein	0.0046	0.002	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Echinococcus granulosus	biogenic amine 5HT receptor	0.0046	0.002	0.008
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0027	0.0009	0.03
Plasmodium vivax	ATP-dependent DNA helicase Q1, putative	0.0015	0.0002	0.046
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0002	0.0201
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0027	0.0009	0.263
Onchocerca volvulus		0.0046	0.002	0.2115
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.002	0.2148
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0016	0.0002	0.0015
Echinococcus granulosus	somatostatin receptor	0.0046	0.002	0.008
Schistosoma mansoni	opsin-like receptor	0.0046	0.002	0.0145
Brugia malayi	Pre-SET motif family protein	0.0021	0.0005	0.0176
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0005	0.0036
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.002	0.008
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.002	0.008
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.002	0.008
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0031	0.0011	0.0043
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0046	0.002	0.008
Schistosoma mansoni	neuropeptide receptor	0.0046	0.002	0.0145
Trypanosoma cruzi	aminopeptidase, putative	0.0016	0.0002	0.0106
Brugia malayi	G-protein coupled receptor	0.0046	0.002	0.0691
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.002	0.008
Schistosoma mansoni	biogenic amine receptor	0.0046	0.002	0.0145
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0016	0.0002	0.0008
Onchocerca volvulus		0.0046	0.002	0.2115
Schistosoma mansoni	ap endonuclease	0.0027	0.0009	0.0063
Onchocerca volvulus		0.0046	0.002	0.2115
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0036	0.0014	0.0057
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.0002	0.0544
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0016	0.0002	0.0008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.002	0.008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0002	0.0201
Onchocerca volvulus		0.0016	0.0002	0.0093
Onchocerca volvulus		0.0046	0.002	0.2115
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0046	0.002	0.008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.0028	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.002	0.008
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0027	0.0009	0.263
Leishmania major	cathepsin L-like protease	0.0059	0.0028	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0002	0.0007
Brugia malayi	Peptidase family M1 containing protein	0.0016	0.0002	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0545
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0002	0.0191
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.002	0.008
Brugia malayi	Peptidase family M1 containing protein	0.0054	0.0025	0.0859
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.0028	1
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0044	0.0019	0.2016
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0046	0.002	0.008
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0002	0.0223
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0046	0.002	0.0691
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0002	0.0013
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0005	0.0036
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0002	0.0007
Onchocerca volvulus	Putative hydroxypyruvate isomerase	0.0018	0.0004	0.0263
Loa Loa (eye worm)	melatonin receptor type 1A	0.0046	0.002	0.2148
Mycobacterium ulcerans	sugar phosphate isomerases/epimerases	0.0018	0.0004	0.0004
Echinococcus multilocularis	orexin receptor type 2	0.0046	0.002	0.008
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0046	0.002	0.2148
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0023	0.0007	0.069
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0002	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0395
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0016	0.0002	0.0028
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.002	0.008
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0011	0.1177
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.002	0.0145
Echinococcus granulosus	cathepsin l1	0.0016	0.0002	0.0007
Onchocerca volvulus		0.0165	0.0092	1
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.002	0.008
Leishmania major	cathepsin L-like protease	0.0059	0.0028	1
Brugia malayi	Dopamine receptor protein 1	0.0046	0.002	0.0691
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0046	0.002	0.2148
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0002	0.0069
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0046	0.002	0.0691
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0002	0.0201
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0031	0.0011	0.3241
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.002	0.008
Brugia malayi	GnHR receptor homolog	0.0046	0.002	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.002	0.2148
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0027	0.0009	0.5
Echinococcus multilocularis	bloom syndrome protein	0.0075	0.0037	0.0148
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.002	0.008
Brugia malayi	putative neuropeptide receptor NPR1	0.0046	0.002	0.0691
Brugia malayi	hypothetical protein	0.0046	0.002	0.0691
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.002	0.008
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0021	0.0005	0.1479
Echinococcus multilocularis	neuropeptide receptor A26	0.0046	0.002	0.008
Brugia malayi	Melatonin receptor type 1A	0.0046	0.002	0.0691
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0016	0.0002	0.0015
Onchocerca volvulus		0.0043	0.0019	0.1913
Leishmania major	cathepsin L-like protease	0.0059	0.0028	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0021	0.0005	0.002
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0046	0.002	0.0145
Mycobacterium leprae	PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE)	0.0069	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0002	0.0069
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0031	0.0011	0.0378
Echinococcus multilocularis	serotonin receptor	0.0046	0.002	0.008
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0046	0.002	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0002	0.0007
Schistosoma mansoni	neuropeptide receptor	0.0046	0.002	0.0145
Echinococcus granulosus	serotonin receptor	0.0046	0.002	0.008
Echinococcus granulosus	neuropeptide receptor	0.0046	0.002	0.008
Schistosoma mansoni	hypothetical protein	0.0046	0.002	0.0145
Echinococcus granulosus	g protein coupled receptor	0.0046	0.002	0.008
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0046	0.002	0.008
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0018	0.1904
Brugia malayi	sulfakinin receptor protein	0.0046	0.002	0.0691
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.002	0.008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0002	0.0201
Trichomonas vaginalis	ap endonuclease, putative	0.0027	0.0009	0.0953
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Onchocerca volvulus		0.0046	0.002	0.2115
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.002	0.008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0002	0.0201
Loa Loa (eye worm)	hypothetical protein	0.002	0.0005	0.0496
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0022	0.0006	0.0528
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0027	0.0009	0.0942
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.002	0.008
Echinococcus multilocularis	g-protein coupled receptor	0.0046	0.002	0.008
Schistosoma mansoni	adenoreceptor	0.0046	0.002	0.0145
Echinococcus granulosus	g-protein coupled receptor	0.0046	0.002	0.008
Toxoplasma gondii	endonuclease IV APN	0.0069	0.0034	1
Echinococcus granulosus	g protein coupled receptor	0.0046	0.002	0.008
Schistosoma mansoni	neuropeptide receptor	0.0046	0.002	0.0145
Onchocerca volvulus		0.0016	0.0002	0.0093
Brugia malayi	Hypothetical 29.7 kDa protein C05D11.5 in chromosome III	0.0018	0.0004	0.0121
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0046	0.002	0.0691
Echinococcus granulosus	neuropeptide s receptor	0.0046	0.002	0.008
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Onchocerca volvulus		0.0016	0.0002	0.0124
Echinococcus granulosus	orexin receptor type 2	0.0046	0.002	0.008
Entamoeba histolytica	aminopeptidase, putative	0.0016	0.0002	0.0377
Schistosoma mansoni	intermediate filament proteins	0.0043	0.0019	0.0132
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.002	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0054	0.0025	0.8824
Echinococcus multilocularis	cysteine protease	0.0016	0.0002	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.002	0.0145
Echinococcus granulosus	lamin	0.0043	0.0019	0.0072
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0025	0.0008	0.0029
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0018	0.0004	0.0004
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0016	0.0002	0.0106
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0027	0.0009	1
Brugia malayi	Dopamine receptor protein 2	0.0046	0.002	0.0691
Brugia malayi	hypothetical protein	0.0046	0.002	0.0691
Echinococcus multilocularis	musashi	0.0043	0.0019	0.0073
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0046	0.002	0.008
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.002	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0377
Mycobacterium tuberculosis	Probable histidinol dehydrogenase HisD (HDH)	1.6725	1	1
Onchocerca volvulus		0.0016	0.0002	0.0093
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0013	0	0.0021
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.002	0.0145
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.002	0.008
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Giardia lamblia	Sgs1 DNA helicase, putative	0.0031	0.0011	1
Entamoeba histolytica	recQ family DNA helicase	0.0016	0.0002	0.0241
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0027	0.0009	0.2583
Schistosoma mansoni	amine GPCR	0.0046	0.002	0.0145
Brugia malayi	RE15519p	0.0046	0.002	0.0691
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0016	0.0002	0.0106
Brugia malayi	latrophilin 2 splice variant baaae	0.0018	0.0004	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.002	0.008
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0004	0.0004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.0028	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0002	0.0201
Brugia malayi	ORL1-like opioid receptor	0.0046	0.002	0.0691
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.002	0.0145
Brugia malayi	G protein-coupled receptor	0.0046	0.002	0.0691
Brugia malayi	exodeoxyribonuclease III family protein	0.0027	0.0009	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Schistosoma mansoni	neuropeptide f receptor 76f	0.0046	0.002	0.0145
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.005	0.0023	0.6615
Onchocerca volvulus		0.0016	0.0002	0.0093
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0016	0.0002	0.0008
Loa Loa (eye worm)	aminopeptidase N	0.0016	0.0002	0.0244
Schistosoma mansoni	neuropeptide receptor	0.0046	0.002	0.0145
Echinococcus granulosus	g protein coupled receptor	0.0046	0.002	0.008
Loa Loa (eye worm)	intermediate filament protein	0.0043	0.0019	0.1954
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0002	0.0201
Onchocerca volvulus		0.0016	0.0002	0.0093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.0028	1
Echinococcus multilocularis	somatostatin receptor	0.0046	0.002	0.008
Echinococcus granulosus	histone lysine methyltransferase setb	0.0021	0.0005	0.002
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0025	0.0008	0.0029
Schistosoma mansoni	blooms syndrome DNA helicase	0.0059	0.0028	0.02
Schistosoma mansoni	lamin	0.0043	0.0019	0.0132
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0002	0.0069
Echinococcus multilocularis	neuropeptide s receptor	0.0046	0.002	0.008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0002	0.0201
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0027	0.0009	0.0035
Brugia malayi	hypothetical protein	0.0046	0.002	0.0691
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0031	0.0011	0.3241
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0046	0.002	0.008
Echinococcus multilocularis	conserved hypothetical protein	0.4201	0.2506	1
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0002	0.0093
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0046	0.002	0.0145
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0027	0.0009	0.2583
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0002	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0021	0.0005	0.002
Echinococcus granulosus	7TM GPCR rhodopsin	0.0046	0.002	0.008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0002	0.0201
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0046	0.002	0.0691
Mycobacterium tuberculosis	Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase)	0.0069	0.0034	0.0034
Brugia malayi	Serotonin receptor	0.0046	0.002	0.0691
Loa Loa (eye worm)	matrixin family protein	0.0024	0.0007	0.0757
Brugia malayi	hypothetical protein	0.0046	0.002	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0031	0.0011	0.0044
Schistosoma mansoni	DNA helicase recq1	0.0031	0.0011	0.0079
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.002	0.0005	0.0018
Schistosoma mansoni	amine GPCR	0.0046	0.002	0.0145
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.002	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Loa Loa (eye worm)	hypothetical protein	0.0046	0.002	0.2148
Onchocerca volvulus		0.0046	0.002	0.2115
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.002	0.008
Loa Loa (eye worm)	hypothetical protein	0.0013	0	0.0021

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 821649