Detailed information for compound 824072

Basic information

Technical information
  • TDR Targets ID: 824072
  • Name: 3-[4-(4-methoxyphenyl)-2-(prop-2-enylamino)-1 ,3-thiazol-5-yl]propanoic acid
  • MW: 318.391 | Formula: C16H18N2O3S
  • H donors: 2 H acceptors: 3 LogP: 3.34 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCNc1sc(c(n1)c1ccc(cc1)OC)CCC(=O)O
  • InChi: 1S/C16H18N2O3S/c1-3-10-17-16-18-15(13(22-16)8-9-14(19)20)11-4-6-12(21-2)7-5-11/h3-7H,1,8-10H2,2H3,(H,17,18)(H,19,20)
  • InChiKey: DQCWUWZOSBWFQA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[2-(allylamino)-4-(4-methoxyphenyl)thiazol-5-yl]propanoic acid
  • 3-[2-(allylamino)-4-(4-methoxyphenyl)-5-thiazolyl]propanoic acid
  • 3-[2-(allylamino)-4-(4-methoxyphenyl)thiazol-5-yl]propionic acid
  • Oprea1_005405

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus survival motor neuron protein 1 0.0283 0.3637 0.679
Schistosoma mansoni intermediate filament proteins 0.0032 0.0086 0.0161
Echinococcus multilocularis thyroid hormone receptor alpha 0.02 0.2465 0.4602
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0331 0.0619
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0062 0.0505 0.0452
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0086 0.0237
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0242 0.3059 0.7986
Brugia malayi nuclear receptor NHR-88 0.005 0.0331 0.0911
Mycobacterium tuberculosis Probable dehydrogenase 0.0242 0.3059 0.7986
Schistosoma mansoni hypothetical protein 0.0058 0.0447 0.0834
Trypanosoma brucei Nitroreductase family, putative 0.0064 0.0542 0.0489
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0505 0.0452
Schistosoma mansoni hypothetical protein 0.0151 0.1763 0.3292
Mycobacterium ulcerans nitroreductase 0.0064 0.0542 1
Echinococcus granulosus FTZ F1 alpha 0.005 0.0331 0.0619
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0911
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0331 0.0911
Brugia malayi ecdysteroid receptor 0.005 0.0331 0.0911
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0062 0.0505 0.2137
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0331 0.0619
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0062 0.0505 0.0944
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0331 0.0619
Echinococcus granulosus geminin 0.0203 0.2501 0.467
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0331 0.0911
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0331 0.0911
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0331 0.0911
Loa Loa (eye worm) hypothetical protein 0.0147 0.1711 0.4705
Echinococcus granulosus intermediate filament protein 0.0032 0.0086 0.0161
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0331 0.0619
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0331 0.0911
Mycobacterium tuberculosis Probable F420 biosynthesis protein FbiB 0.0064 0.0542 0.0115
Brugia malayi intermediate filament protein 0.0032 0.0086 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0542 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0287 0.3703 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0155
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0086 0.0237
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0062 0.0505 0.0452
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0062 0.0505 0.0944
Loa Loa (eye worm) fli-1 protein 0.0263 0.3356 0.9226
Brugia malayi nuclear hormone receptor 0.005 0.0331 0.0911
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0331 0.0911
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0856 0.1599
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0331 0.0911
Echinococcus granulosus tumor protein p63 0.0404 0.5356 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0331 0.0911
Trypanosoma brucei nitroreductase 0.0731 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0287 0.3703 1
Onchocerca volvulus 0.0059 0.0467 0.8355
Treponema pallidum NADH oxidase 0.0062 0.0505 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0331 0.0619
Mycobacterium ulcerans nitroreductase 0.0064 0.0542 1
Plasmodium falciparum thioredoxin reductase 0.0178 0.2158 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0331 0.0911
Echinococcus granulosus nuclear factor of activated T cells 5 0.0088 0.0877 0.1638
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0911
Trypanosoma cruzi trypanothione reductase, putative 0.0178 0.2158 0.2114
Mycobacterium tuberculosis Possible oxidoreductase 0.0064 0.0542 0.0115
Plasmodium vivax glutathione reductase, putative 0.0178 0.2158 1
Schistosoma mansoni hypothetical protein 0.0203 0.2501 0.467
Trypanosoma cruzi nitroreductase 0.0731 1 1
Mycobacterium tuberculosis Putative oxidoreductase 0.0064 0.0542 0.0115
Echinococcus multilocularis thioredoxin glutathione reductase 0.0178 0.2158 0.4029
Echinococcus multilocularis tumor protein p63 0.0404 0.5356 1
Trypanosoma brucei trypanothione reductase 0.0178 0.2158 0.2114
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0856 0.1599
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0542 1
Echinococcus granulosus lamin 0.0032 0.0086 0.0161
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0331 0.0619
Brugia malayi glutathione reductase 0.0178 0.2158 0.5934
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0331 0.0911
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0331 0.0619
Brugia malayi jmjC domain containing protein 0.007 0.0626 0.1721
Entamoeba histolytica nitroreductase family protein 0.0064 0.0542 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0239 0.0446
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0045 0.0273 0.075
Giardia lamblia Nitroreductase family protein 0.0064 0.0542 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0542 0.1491
Giardia lamblia Nitroreductase family protein fused to ferredoxin domain Fd-NR1 0.0064 0.0542 1
Schistosoma mansoni thyroid hormone receptor 0.02 0.2465 0.4603
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0331 0.0619
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0062 0.0505 0.5
Mycobacterium ulcerans hypothetical protein 0.0064 0.0542 1
Plasmodium falciparum glutathione reductase 0.0178 0.2158 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0331 0.0911
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0062 0.0505 0.2137
Loa Loa (eye worm) hypothetical protein 0.0032 0.0086 0.0237
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0045 0.0273 0.075
Schistosoma mansoni jumonji domain containing protein 0.007 0.0626 0.1169
Mycobacterium tuberculosis Conserved protein Acg 0.0064 0.0542 0.0115
Schistosoma mansoni lamin 0.0032 0.0086 0.0161
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0505 0.0452
Schistosoma mansoni coup transcription factor 0.005 0.0331 0.0619
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0239 0.0446
Loa Loa (eye worm) hypothetical protein 0.0074 0.0678 0.1865
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0062 0.0505 0.2137
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0141 0.1631 0.3045
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0911
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0856 0.2355
Brugia malayi Ets-domain containing protein 0.0087 0.0856 0.2355
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0287 0.3703 1
Echinococcus multilocularis lamin dm0 0.0032 0.0086 0.0161
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0062 0.0505 0.2137
Plasmodium falciparum thioredoxin reductase 0.0062 0.0505 0.2137
Onchocerca volvulus 0.005 0.0331 0.5375
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0062 0.0505 0.139
Echinococcus multilocularis musashi 0.0032 0.0086 0.0161
Schistosoma mansoni survival motor neuron protein 0.0058 0.0447 0.0834
Trypanosoma cruzi nitroreductase 0.0731 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0447 0.1228
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0088 0.0877 0.1638
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0242 0.3059 0.7986
Mycobacterium tuberculosis Probable reductase 0.0242 0.3059 0.7986
Leishmania major trypanothione reductase 0.0178 0.2158 0.2114
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0505 0.0452
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0911
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0626 0.1168
Echinococcus granulosus thioredoxin glutathione reductase 0.0178 0.2158 0.4029
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0331 0.0911
Schistosoma mansoni gabp alpha 0.0087 0.0856 0.1599
Brugia malayi hypothetical protein 0.0043 0.0239 0.0656
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0242 0.3059 0.7963
Loa Loa (eye worm) hypothetical protein 0.0059 0.0467 0.1285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0331 0.0911
Schistosoma mansoni retinoic acid receptor RXR 0.0167 0.2002 0.3739
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0911
Brugia malayi jmjC domain containing protein 0.007 0.0626 0.1721
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0242 0.3059 0.7986
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0167 0.2002 0.3738
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0062 0.0505 0.0452
Leishmania major hypothetical protein, conserved 0.0064 0.0542 0.0489
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0911
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0542 1
Mycobacterium ulcerans nitroreductase 0.0064 0.0542 1
Plasmodium vivax thioredoxin reductase, putative 0.0178 0.2158 1
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0331 0.0911
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.007 0.0626 0.1168
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0062 0.0505 0.5
Brugia malayi nitroreductase family protein 0.0064 0.0542 0.1491
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0505 0.0452
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0331 0.0911
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0331 0.0911
Mycobacterium ulcerans oxidoreductase 0.0064 0.0542 1
Loa Loa (eye worm) thioredoxin reductase 0.0178 0.2158 0.5934
Schistosoma mansoni lamin 0.0032 0.0086 0.0161
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0505 0.0452
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0331 0.0619
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0086 0.0237
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0151 0.1763 0.3291
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0331 0.0619
Echinococcus granulosus muscleblind protein 0.0147 0.1711 0.3195
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0626 0.1169
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0287 0.3703 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0911
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0542 1
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0542 1
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0331 0.0619
Schistosoma mansoni hypothetical protein 0.0043 0.0239 0.0446
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0242 0.3059 0.7986
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0331 0.0911
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0062 0.0505 0.0452
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0331 0.5375
Loa Loa (eye worm) hypothetical protein 0.0147 0.1711 0.4705
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0239 0.0446
Brugia malayi Fli-1 protein 0.0263 0.3356 0.9226
Schistosoma mansoni hypothetical protein 0.0062 0.0506 0.0944
Entamoeba histolytica nitroreductase family protein 0.0064 0.0542 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0151 0.1763 0.3291
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0331 0.0619
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0331 0.0911
Schistosoma mansoni thyroid hormone receptor 0.02 0.2465 0.4603
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0542 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0331 0.0911
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0062 0.0505 0.0452
Echinococcus multilocularis muscleblind protein 1 0.0147 0.1711 0.3195
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0626 0.1169
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0331 0.0619
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0062 0.0505 0.0452
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.0505 0.0452
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.007 0.0626 0.1168
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0542 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0062 0.0505 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0331 0.0619
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0626 0.1168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0331 0.0911
Trypanosoma brucei Nitroreductase family, putative 0.0064 0.0542 0.0489
Brugia malayi Thioredoxin reductase 0.0178 0.2158 0.5934
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0331 0.0911
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0331 0.0619
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0626 0.1721
Brugia malayi Muscleblind-like protein 0.0147 0.1711 0.4705
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0062 0.0505 0.0944
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0331 0.5375
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0331 0.0619
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0331 0.0619
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0331 0.0619
Schistosoma mansoni nuclear hormone receptor 0.005 0.0331 0.0619
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0062 0.0505 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0542 1
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0331 0.5375
Echinococcus granulosus lamin dm0 0.0032 0.0086 0.0161
Onchocerca volvulus Iodotyrosine dehalogenase 1 homolog 0.0064 0.0542 1
Loa Loa (eye worm) hypothetical protein 0.0283 0.3637 1
Brugia malayi hypothetical protein 0.003 0.0056 0.0155
Mycobacterium tuberculosis Conserved protein 0.0064 0.0542 0.0115
Mycobacterium ulcerans hypothetical protein 0.0064 0.0542 1
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0331 0.0911
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0331 0.0619
Brugia malayi Ets-domain containing protein 0.0087 0.0856 0.2355
Brugia malayi steroid hormone receptor 0.005 0.0331 0.0911
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0542 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0178 0.2158 0.5169
Toxoplasma gondii NADPH-glutathione reductase 0.0062 0.0505 0.2137
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0542 1
Echinococcus multilocularis geminin 0.0203 0.2501 0.467
Schistosoma mansoni ets-related 0.0263 0.3356 0.6265
Entamoeba histolytica hypothetical protein 0.0064 0.0542 1
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0331 0.0619
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0062 0.0505 0.0452
Brugia malayi hypothetical protein 0.0283 0.3637 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0078 0.0214
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0331 0.0619
Mycobacterium ulcerans nitroreductase 0.0064 0.0542 1
Toxoplasma gondii thioredoxin reductase 0.0178 0.2158 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0331 0.0911
Entamoeba histolytica nitroreductase family protein 0.0064 0.0542 1
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0542 1
Loa Loa (eye worm) glutathione reductase 0.0178 0.2158 0.5934
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0542 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0505 0.0452
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0062 0.0505 0.0452
Schistosoma mansoni cellular tumor antigen P53 0.0059 0.0467 0.0872
Schistosoma mansoni hypothetical protein 0.0203 0.2501 0.467
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0331 0.0619
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0062 0.0505 0.0452
Mycobacterium ulcerans F420-0--gamma-glutamyl ligase 0.0064 0.0542 1
Giardia lamblia Nitroreductase Fd-NR2 0.0064 0.0542 1
Echinococcus multilocularis muscleblind protein 0.0147 0.1711 0.3195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0331 0.0911
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0331 0.0619
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0911
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0542 1
Onchocerca volvulus 0.0058 0.0447 0.79
Plasmodium falciparum glutathione reductase 0.0062 0.0505 0.2137
Echinococcus multilocularis lamin 0.0032 0.0086 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0542 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0062 0.0505 0.2137
Echinococcus multilocularis survival motor neuron protein 1 0.0283 0.3637 0.679

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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