Detailed information for compound 825644

Basic information

Technical information
  • TDR Targets ID: 825644
  • Name: 5-(4-methoxyphenyl)-2-methyl-1,1-dioxo-N-prop an-2-yl-1,2,6-thiadiazine-3-carboxamide
  • MW: 337.394 | Formula: C15H19N3O4S
  • H donors: 1 H acceptors: 3 LogP: 1.39 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1=NS(=O)(=O)N(C(=C1)C(=O)NC(C)C)C
  • InChi: 1S/C15H19N3O4S/c1-10(2)16-15(19)14-9-13(17-23(20,21)18(14)3)11-5-7-12(22-4)8-6-11/h5-10H,1-4H3,(H,16,19)
  • InChiKey: WMBWYDPYJDSQAU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-isopropyl-5-(4-methoxyphenyl)-2-methyl-1,1-dioxo-1,2,6-thiadiazine-3-carboxamide
  • N-isopropyl-1,1-diketo-5-(4-methoxyphenyl)-2-methyl-1,2,6-thiadiazine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0094 0.1107 0.1107
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0094 0.1107 1
Echinococcus granulosus Zinc finger RanBP2 type 0.0094 0.1107 0.1107
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0077 0.0077
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0077 0.023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0077 0.0077
Echinococcus multilocularis SWI:SNF matrix associated 0.0265 0.3353 0.3353
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0094 0.1107 0.3145
Schistosoma mansoni hypothetical protein 0.0138 0.1674 0.4993
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0077 0.0077
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0138 0.1674 0.4993
Echinococcus multilocularis ring and YY1 binding protein 0.0094 0.1107 0.1107
Loa Loa (eye worm) hypothetical protein 0.0094 0.1107 0.3303
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0077 0.0229
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0265 0.3353 1
Schistosoma mansoni loxhd1 0.0039 0.0375 0.1119
Echinococcus granulosus tyrosine protein kinase Src64B 0.0038 0.036 0.036
Echinococcus multilocularis tumor protein p63 0.0682 0.8818 0.8818
Brugia malayi SWIB/MDM2 domain containing protein 0.0265 0.3353 1
Echinococcus granulosus zinc finger protein Ran binding 0.0094 0.1107 0.1107
Loa Loa (eye worm) hypothetical protein 0.0094 0.1107 0.3303
Chlamydia trachomatis DNA topoisomerase I 0.0265 0.3353 0.5
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0265 0.3353 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0077 0.0077
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0375 0.0375
Onchocerca volvulus 0.0094 0.1107 0.3303
Schistosoma mansoni hypothetical protein 0.0039 0.0375 0.1119
Schistosoma mansoni hypothetical protein 0.0265 0.3353 1
Schistosoma mansoni lipoxygenase 0.017 0.2096 0.6252
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0375 0.0375
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0094 0.1107 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.0265 0.3353 0.5
Echinococcus granulosus SWI:SNF matrix associated 0.0265 0.3353 0.3353
Schistosoma mansoni lipoxygenase 0.01 0.1183 0.3528
Loa Loa (eye worm) hypothetical protein 0.0094 0.1107 0.3303
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0094 0.1107 1
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0094 0.1107 0.3303
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0528 0.1576
Echinococcus granulosus ring and YY1 binding protein 0.0094 0.1107 0.1107
Entamoeba histolytica protein kinase, putative 0.003 0.0263 0.5
Brugia malayi SRC-1 0.0038 0.036 0.1075
Leishmania major hypothetical protein, conserved 0.0094 0.1107 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0077 0.0229
Brugia malayi Doublecortin family protein 0.0039 0.0375 0.1119
Schistosoma mansoni hypothetical protein 0.0265 0.3353 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.036 0.036
Onchocerca volvulus 0.01 0.1178 0.3513
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0077 0.0077
Plasmodium vivax hypothetical protein, conserved 0.0265 0.3353 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0528 0.1576
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0094 0.1107 0.3303
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase Blk 0.0034 0.0312 0.0312
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0138 0.1674 0.4993
Brugia malayi hypothetical protein 0.0039 0.0375 0.1119
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0375 0.0375
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0038 0.036 0.036
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.036 0.036
Echinococcus multilocularis RUN 0.0039 0.0375 0.0375
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0094 0.1107 0.3145
Loa Loa (eye worm) hypothetical protein 0.0039 0.0375 0.1119
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0094 0.1107 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0094 0.1107 1
Chlamydia trachomatis SWIB complex protein 0.0265 0.3353 0.5
Schistosoma mansoni rab6-interacting 0.0039 0.0375 0.1119
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0034 0.0312 0.0312
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0038 0.036 0.036
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0772 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.036 0.036
Schistosoma mansoni polycystin 1-related 0.0039 0.0375 0.1119
Loa Loa (eye worm) hypothetical protein 0.0138 0.1674 0.4993
Echinococcus granulosus GPCR family 2 0.0016 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0094 0.1107 0.3303
Echinococcus granulosus tyrosine protein kinase HCK 0.003 0.0263 0.0263
Leishmania major hypothetical protein, conserved 0.0094 0.1107 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0038 0.036 0.036
Schistosoma mansoni hypothetical protein 0.0016 0.0077 0.0229
Brugia malayi protein-tyrosine kinase 0.0034 0.0312 0.0932
Schistosoma mansoni tyrosine kinase 0.0038 0.036 0.1075
Leishmania major hypothetical protein, conserved 0.0094 0.1107 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0094 0.1107 0.3303
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0265 0.3353 0.3353
Loa Loa (eye worm) brahma associated protein 0.0265 0.3353 1
Trypanosoma cruzi hypothetical protein, conserved 0.0094 0.1107 1
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0138 0.1674 0.1674
Echinococcus multilocularis tyrosine protein kinase HCK 0.003 0.0263 0.0263
Trypanosoma cruzi WLM domain containing protein, putative 0.0094 0.1107 1
Schistosoma mansoni hypothetical protein 0.0138 0.1674 0.4993
Brugia malayi MH2 domain containing protein 0.0121 0.145 0.4324
Trypanosoma brucei hypothetical protein, conserved 0.0094 0.1107 1
Schistosoma mansoni rab6-interacting 0.0039 0.0375 0.1119
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0265 0.3353 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.017 0.2096 0.2096
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0038 0.036 0.036
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0077 0.023
Echinococcus multilocularis GPCR, family 2 0.0016 0.0077 0.0077
Onchocerca volvulus 0.0094 0.1107 0.3303
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0375 0.0375
Trypanosoma cruzi WLM domain containing protein, putative 0.0094 0.1107 1
Echinococcus granulosus RUN 0.0039 0.0375 0.0375
Echinococcus granulosus tumor protein p63 0.0682 0.8818 0.8818
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0077 0.0229
Trypanosoma brucei hypothetical protein, conserved 0.0094 0.1107 1
Leishmania major hypothetical protein, conserved 0.0094 0.1107 1
Schistosoma mansoni hypothetical protein 0.0094 0.1107 0.3303
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0375 0.091
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.145 0.4324
Echinococcus granulosus tyrosine protein kinase Src42A 0.0033 0.0299 0.0299
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0094 0.1107 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0265 0.3353 0.3353
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0094 0.1107 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0077 0.023
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0265 0.3353 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0375 0.0375
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0077 0.0077
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0265 0.3353 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.036 0.036
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0038 0.036 0.036
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0033 0.0299 0.0299
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.036 0.036
Echinococcus granulosus tyrosine kinase 0.0034 0.0312 0.0312
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0375 0.091
Toxoplasma gondii ran binding protein 0.0094 0.1107 0.3145
Schistosoma mansoni zinc finger protein 0.0094 0.1107 0.3303
Echinococcus granulosus tyrosine protein kinase Blk 0.0034 0.0312 0.0312
Echinococcus multilocularis SWI:SNF matrix associated 0.0265 0.3353 0.3353
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.145 0.4324
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0319 0.0952
Leishmania major hypothetical protein, conserved 0.0094 0.1107 1
Brugia malayi YY1-associated factor 2 0.0094 0.1107 0.3303
Brugia malayi brahma associated protein 60 kDa 0.0265 0.3353 1
Schistosoma mansoni brg-1 associated factor 0.0265 0.3353 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0034 0.0312 0.0312
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0077 0.0077
Loa Loa (eye worm) TK protein kinase 0.003 0.0263 0.0785
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0077 0.0077
Loa Loa (eye worm) TK protein kinase 0.0034 0.0312 0.0932
Loa Loa (eye worm) hypothetical protein 0.0016 0.0077 0.0229
Schistosoma mansoni hypothetical protein 0.0034 0.0319 0.0952
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0094 0.1107 0.3303
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0038 0.036 0.036
Brugia malayi brahma associated protein 60 kDa 0.0265 0.3353 1
Schistosoma mansoni hypothetical protein 0.0016 0.0077 0.0229
Onchocerca volvulus 0.0094 0.1107 0.3303
Schistosoma mansoni hypothetical protein 0.0016 0.0077 0.0229
Loa Loa (eye worm) hypothetical protein 0.0034 0.0319 0.0952
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.036 0.036
Schistosoma mansoni hypothetical protein 0.0265 0.3353 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0138 0.1674 0.1674
Loa Loa (eye worm) hypothetical protein 0.005 0.0528 0.1576
Schistosoma mansoni hypothetical protein 0.0016 0.0077 0.0229
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0265 0.3353 0.3353
Schistosoma mansoni RNA binding protein 0.0094 0.1107 0.3303
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0312 0.0312
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0077 0.5
Onchocerca volvulus 0.0265 0.3353 1
Trypanosoma cruzi hypothetical protein, conserved 0.0094 0.1107 1
Loa Loa (eye worm) apoptosis regulator protein 0.0138 0.1674 0.4993
Loa Loa (eye worm) hypothetical protein 0.0094 0.1107 0.3303
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0265 0.3353 1
Schistosoma mansoni fusion 0.0094 0.1107 0.3303
Onchocerca volvulus 0.0039 0.0375 0.1119
Brugia malayi hypothetical protein 0.0039 0.0375 0.1119
Schistosoma mansoni tyrosine kinase 0.0038 0.036 0.1075
Schistosoma mansoni apoptosis regulator bax 0.0138 0.1674 0.4993
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0038 0.036 0.036
Onchocerca volvulus 0.0039 0.0375 0.1119
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0077 0.023
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.01 0.1178 0.3513
Echinococcus granulosus tyrosine protein kinase Lyn 0.0038 0.036 0.036
Trypanosoma cruzi hypothetical protein, conserved 0.0094 0.1107 1
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0094 0.1107 0.1107
Echinococcus multilocularis zinc finger protein Ran binding 0.0094 0.1107 0.1107
Schistosoma mansoni cellular tumor antigen P53 0.01 0.1178 0.3513
Loa Loa (eye worm) SRC-1 0.0038 0.036 0.1075
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0528 0.1576
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0094 0.1107 0.3303
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0077 0.0077
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0375 0.1119
Loa Loa (eye worm) hypothetical protein 0.0039 0.0375 0.1119
Schistosoma mansoni hypothetical protein 0.0138 0.1674 0.4993
Onchocerca volvulus 0.0094 0.1107 0.3303
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.017 0.2096 0.2096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0077 0.0077
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0094 0.1107 1
Schistosoma mansoni TRABID protein (C64 family) 0.0094 0.1107 0.3303
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.036 0.036

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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