TDR Targets

Basic information

Technical information

TDR Targets ID: 825800
Name: N-(2-ethylphenyl)-5-(4-methoxyphenyl)-2-methy l-1,1-dioxo-1,2,6-thiadiazine-3-carboxamide
MW: 399.463 | Formula: C20H21N3O4S
H donors: 1 H acceptors: 3 LogP: 2.94 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccccc1NC(=O)C1=CC(=NS(=O)(=O)N1C)c1ccc(cc1)OC
InChi: 1S/C20H21N3O4S/c1-4-14-7-5-6-8-17(14)21-20(24)19-13-18(22-28(25,26)23(19)2)15-9-11-16(27-3)12-10-15/h5-13H,4H2,1-3H3,(H,21,24)
InChiKey: MUNWMQGKSFXDKU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-ethylphenyl)-1,1-diketo-5-(4-methoxyphenyl)-2-methyl-1,2,6-thiadiazine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0401	0.1563	0.5
Brugia malayi	hypothetical protein	0.0048	0.0043	0.0034
Echinococcus multilocularis	serotonin transporter	0.2364	1	1
Brugia malayi	RE15519p	0.0048	0.0043	0.0034
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0401	0.1563	0.1556
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0043	0.0024	0.0024
Echinococcus granulosus	sodium and chloride dependent glycine	0.0401	0.1563	0.1527
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	opsin-like receptor	0.0048	0.0043	0.0043
Brugia malayi	neuropeptide F receptor	0.0048	0.0043	0.0034
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0401	0.1563	0.1527
Schistosoma mansoni	biogenic amine receptor	0.0048	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0401	0.1563	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0401	0.1563	0.1563
Loa Loa (eye worm)	hypothetical protein	0.2364	1	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0048	0.0043	0.0043
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0048	0.0043	0.0034
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0048	0.0043	0.0034
Plasmodium vivax	amine transporter, putative	0.0401	0.1563	0.5
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0401	0.1563	0.1563
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0048	0.0043	0.0034
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0048	0.0043	0.0043
Schistosoma mansoni	neuropeptide F-like receptor	0.0048	0.0043	0.0043
Brugia malayi	Melatonin receptor type 1A	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Brugia malayi	putative neuropeptide receptor NPR1	0.0048	0.0043	0.0034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0043	0.0043
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.0043	0.0043
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0048	0.0043	0.0034
Loa Loa (eye worm)	TYRA-2 protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	solute carrier family 6 member 4	0.2364	1	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Onchocerca volvulus		0.0401	0.1563	0.1527
Brugia malayi	ORL1-like opioid receptor	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0401	0.1563	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Brugia malayi	Dopamine receptor protein 2	0.0048	0.0043	0.0034
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0043	0.0043
Schistosoma mansoni	histamine h1 receptor	0.0048	0.0043	0.0043
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0048	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	sodium/chloride dependent transporter	0.0401	0.1563	0.1563
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0401	0.1563	0.1563
Brugia malayi	neuropeptide F receptor	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0043	0.0043
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0401	0.1563	0.1527
Schistosoma mansoni	adenoreceptor	0.0048	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0401	0.1563	0.1556
Toxoplasma gondii	hypothetical protein	0.0401	0.1563	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.0043	0.0043
Schistosoma mansoni	hypothetical protein	0.0048	0.0043	0.0043
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0043	0.0043
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0043	0.0043
Treponema pallidum	sodium- and chloride- dependent transporter	0.2364	1	0.5
Echinococcus granulosus	sodium and chloride dependent glycine	0.0401	0.1563	0.1527
Brugia malayi	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0043	0.0043
Onchocerca volvulus		0.2364	1	1
Brugia malayi	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	hypothetical protein	0.0048	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0401	0.1563	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Brugia malayi	Dopamine receptor	0.0048	0.0043	0.0034
Brugia malayi	follicle stimulating hormone receptor	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0401	0.1563	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0043	0.0043
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0086	0.0207	0.0207
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0401	0.1563	0.1527
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Brugia malayi	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Brugia malayi	AKH receptor	0.0048	0.0043	0.0034
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.0043	0.0043
Brugia malayi	putative neuropeptide receptor	0.0048	0.0043	0.0034
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0401	0.1563	0.5
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0401	0.1563	0.1527
Schistosoma mansoni	sodium/chloride dependent transporter	0.0401	0.1563	0.1563
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	biogenic amine receptor	0.0048	0.0043	0.0043
Brugia malayi	Serotonin receptor	0.0048	0.0043	0.0034
Brugia malayi	larval opioid receptor	0.0048	0.0043	0.0034
Loa Loa (eye worm)	melatonin receptor type 1A	0.0048	0.0043	0.0034
Schistosoma mansoni	growth hormone secretagogue receptor	0.0048	0.0043	0.0043
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0401	0.1563	0.1563
Echinococcus granulosus	serotonin transporter	0.2364	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.2364	1	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0048	0.0043	0.0043
Loa Loa (eye worm)	serotonin transporter b	0.2364	1	1
Schistosoma mansoni	hypothetical protein	0.0046	0.0037	0.0037
Brugia malayi	hypothetical protein	0.0048	0.0043	0.0034
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0401	0.1563	0.1563
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0401	0.1563	0.5
Schistosoma mansoni	amine GPCR	0.0048	0.0043	0.0043
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0401	0.1563	0.1563
Schistosoma mansoni	amine GPCR	0.0048	0.0043	0.0043
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0048	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0401	0.1563	0.1527
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0401	0.1563	0.1527
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.009	0.0223	0.0181
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0048	0.0043	0.0043
Schistosoma mansoni	sodium/chloride dependent transporter	0.2364	1	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0048	0.0043	0.0043
Brugia malayi	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	amine GPCR	0.0048	0.0043	0.0043
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0401	0.1563	0.1527
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0197	0.0685	0.0645
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0401	0.1563	0.1563
Loa Loa (eye worm)	hypothetical protein	0.0401	0.1563	0.1556
Brugia malayi	Serotonin receptor	0.0575	0.2309	0.2302
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.2364	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0048	0.0043	0.0043
Trypanosoma brucei	RNA helicase, putative	0.0038	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0043	0.0043
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0401	0.1563	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0048	0.0043	0.0043
Plasmodium vivax	hypothetical protein, conserved	0.0401	0.1563	0.5
Plasmodium falciparum	amino acid transporter, putative	0.0401	0.1563	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0401	0.1563	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Brugia malayi	G protein-coupled receptor F59B2.13	0.0048	0.0043	0.0034
Brugia malayi	hypothetical protein	0.0048	0.0043	0.0034
Brugia malayi	GnHR receptor homolog	0.0048	0.0043	0.0034
Toxoplasma gondii	hypothetical protein	0.0401	0.1563	0.5
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0401	0.1563	0.1563
Schistosoma mansoni	neuropeptide f receptor 76f	0.0048	0.0043	0.0043
Brugia malayi	hypothetical protein	0.0401	0.1563	0.1556
Brugia malayi	Dopamine receptor protein 1	0.0048	0.0043	0.0034
Loa Loa (eye worm)	norepinephrine transporter	0.2364	1	1
Brugia malayi	G-protein coupled receptor	0.0048	0.0043	0.0034
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0401	0.1563	0.1556
Schistosoma mansoni	opsin-like receptor	0.0048	0.0043	0.0043
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0048	0.0043	0.0043
Schistosoma mansoni	neuropeptide F-like receptor	0.0048	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Brugia malayi	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0043	0.0043
Schistosoma mansoni	opsin-like receptor	0.0048	0.0043	0.0043
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0401	0.1563	0.1563
Loa Loa (eye worm)	neuropeptide F receptor	0.0048	0.0043	0.0034
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0401	0.1563	0.1527
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0401	0.1563	0.1556
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0197	0.0685	0.0645
Schistosoma mansoni	hypothetical protein	0.0048	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	hypothetical protein	0.0048	0.0043	0.0043
Schistosoma mansoni	biogenic amine receptor	0.0048	0.0043	0.0043
Brugia malayi	sulfakinin receptor protein	0.0048	0.0043	0.0034
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0401	0.1563	0.1527
Brugia malayi	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0048	0.0043	0.0034
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0401	0.1563	0.1556
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0048	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Echinococcus granulosus	voltage dependent calcium channel subunit	0.009	0.0223	0.0181
Schistosoma mansoni	serine-rich repeat protein	0.0046	0.0037	0.0037
Schistosoma mansoni	myosin xvIII	0.0048	0.0043	0.0043
Schistosoma mansoni	amine GPCR	0.0048	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.2364	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0048	0.0043	0.0034
Plasmodium falciparum	transporter, putative	0.0401	0.1563	0.5
Brugia malayi	G protein-coupled receptor	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0048	0.0043	0.0043
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0043	0.0043
Loa Loa (eye worm)	G-protein coupled receptor	0.0048	0.0043	0.0034
Onchocerca volvulus		0.0401	0.1563	0.1527
Brugia malayi	hypothetical protein	0.0048	0.0043	0.0034
Onchocerca volvulus		0.0401	0.1563	0.1527
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0043	0.0043
Schistosoma mansoni	amine GPCR	0.0868	0.357	0.357
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Brugia malayi	G-protein coupled receptor	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0401	0.1563	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0043	0.0034
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0048	0.0043	0.0043
Loa Loa (eye worm)	G-protein coupled receptor	0.0048	0.0043	0.0034
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0401	0.1563	0.1556

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 825800