Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.1241 | 0.1241 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0135 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0135 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0023 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0064 | 0.3653 | 0.3653 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0135 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0064 | 0.3653 | 0.3653 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0071 | 0.4332 | 0.4332 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0064 | 0.3653 | 0.3653 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Mycobacterium leprae | putative cytochrome p450 | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0064 | 0.3653 | 0.3653 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0135 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0135 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0071 | 0.4332 | 0.4332 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0135 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0135 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0135 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0135 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0064 | 0.3653 | 0.3653 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0135 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0135 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0064 | 0.3653 | 0.3653 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0135 | 1 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0064 | 0.3653 | 0.3653 |
Brugia malayi | Cytochrome P450 family protein | 0.0078 | 0.4988 | 0.4988 |
Brugia malayi | nuclear receptor RXR | 0.0071 | 0.4332 | 0.4332 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0064 | 0.3653 | 0.3653 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.1241 | 0.1241 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.4332 | 0.4332 |
Loa Loa (eye worm) | DR-78 | 0.0064 | 0.3653 | 0.3653 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.4332 | 0.4332 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0071 | 0.4332 | 0.4332 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0064 | 0.3653 | 0.3653 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0064 | 0.3653 | 0.3653 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0071 | 0.4332 | 0.4332 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0135 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0064 | 0.3653 | 0.3653 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Brugia malayi | nuclear receptor NHR-88 | 0.0135 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0135 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0135 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0064 | 0.3653 | 0.3653 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0023 | 0 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0078 | 0.4988 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0064 | 0.3653 | 0.3653 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0023 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0078 | 0.4988 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0135 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0064 | 0.3653 | 0.3653 |
Schistosoma mansoni | nuclear hormone receptor | 0.0135 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0064 | 0.3653 | 0.3653 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0064 | 0.3653 | 0.3653 |
Schistosoma mansoni | thyroid hormone receptor | 0.0135 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0135 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0135 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0064 | 0.3653 | 0.3653 |
Brugia malayi | hypothetical protein | 0.0071 | 0.4332 | 0.4332 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.1026 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0064 | 0.3653 | 0.3653 |
Schistosoma mansoni | nuclear receptor | 0.0064 | 0.3653 | 0.3653 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0135 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0064 | 0.3653 | 0.3653 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0135 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0064 | 0.3653 | 0.3653 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0135 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0135 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0135 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0064 | 0.3653 | 0.3653 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0064 | 0.3653 | 0.3653 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0064 | 0.3653 | 0.3653 |
Brugia malayi | nuclear hormone receptor | 0.0064 | 0.3653 | 0.3653 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0064 | 0.3653 | 0.3653 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0078 | 0.4988 | 0.4988 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0071 | 0.4332 | 0.4332 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0135 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0135 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0023 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0078 | 0.4988 | 0.4988 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.4332 | 0.4332 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.154 | 0.154 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0078 | 0.4988 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0078 | 0.4988 | 0.4988 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0064 | 0.3653 | 0.3653 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0064 | 0.3653 | 0.3653 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0135 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.1241 | 0.1241 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0064 | 0.3653 | 0.3653 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0135 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0135 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0135 | 1 | 1 |
Brugia malayi | tailless protein | 0.0064 | 0.3653 | 0.3653 |
Brugia malayi | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0064 | 0.3653 | 0.3653 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0135 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.1241 | 0.1241 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.4332 | 0.4332 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0064 | 0.3653 | 0.3653 |
Schistosoma mansoni | coup transcription factor | 0.0135 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0135 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0064 | 0.3653 | 0.3653 |
Brugia malayi | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0135 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0135 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0135 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0064 | 0.3653 | 0.3653 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0135 | 1 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0064 | 0.3653 | 0.3653 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0135 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.4332 | 0.4332 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0135 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0071 | 0.4332 | 0.4332 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.154 | 0.154 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0135 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0135 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0135 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0071 | 0.4332 | 0.4332 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0078 | 0.4988 | 0.4988 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0135 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0023 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0135 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0078 | 0.4988 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3653 | 0.3653 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0135 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0135 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0135 | 1 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.1026 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0135 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0811 | 0.0811 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0071 | 0.4332 | 0.4332 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0135 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.2973 | 0.2973 |
Brugia malayi | ecdysone receptor | 0.0064 | 0.3653 | 0.3653 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0078 | 0.4988 | 1 |
Onchocerca volvulus | 0.0135 | 1 | 1 | |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0023 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.