TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 437.511 | Formula: C23H23N3O4S
H donors: 2 H acceptors: 4 LogP: 3.76 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1OC)C1CC(=O)Nc2c1c(O)nc(n2)SCc1ccccc1
InChi: 1S/C23H23N3O4S/c1-3-30-17-10-9-15(11-18(17)29-2)16-12-19(27)24-21-20(16)22(28)26-23(25-21)31-13-14-7-5-4-6-8-14/h4-11,16H,3,12-13H2,1-2H3,(H2,24,25,26,27,28)
InChiKey: NFVJKFMNFCIXAJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	serine repeat antigen 2	0.0154	0.0544	0.2343
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0154	0.0544	0.0544
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0544	0.0544
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0409	0.1865	0.1865
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.0544	0.041
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0409	0.1865	0.1865
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0154	0.0544	0.2343
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0409	0.1865	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0154	0.0544	0.041
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.0544	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0544	0.0544
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0409	0.1865	1
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.0544	0.0544
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Giardia lamblia	Cathepsin B precursor	0.0719	0.3469	1
Plasmodium vivax	vivapain-2	0.0409	0.1865	1
Onchocerca volvulus	Cathepsin L homolog	0.0409	0.1865	1
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0154	0.0544	0.2343
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0409	0.1865	0.4515
Onchocerca volvulus	Cathepsin L homolog	0.0154	0.0544	0.0461
Leishmania major	cysteine peptidase A (CPA)	0.0409	0.1865	0.5322
Echinococcus multilocularis	cathepsin L	0.0154	0.0544	0.0539
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.0544	0.0544
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0409	0.1865	0.4515
Onchocerca volvulus		0.0409	0.1865	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Trypanosoma cruzi	cysteine protease, putative	0.0154	0.0544	0.0506
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0154	0.0544	0.0544
Giardia lamblia	Cathepsin B precursor	0.0719	0.3469	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.014	0.014
Trypanosoma cruzi	cruzipain precursor, putative	0.0409	0.1865	0.1832
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Echinococcus multilocularis	cathepsin b	0.1981	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1981	1	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0154	0.0544	0.0544
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0409	0.1865	0.186
Plasmodium falciparum	serine repeat antigen 8	0.0154	0.0544	0.2343
Echinococcus granulosus	cathepsin b	0.1981	1	1
Trypanosoma cruzi	prolyl endopeptidase	0.0141	0.0481	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0544	0.0544
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0154	0.0544	0.041
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1981	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0719	0.3469	0.3376
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0126	0.0404	0.4425
Trypanosoma cruzi	major cysteine proteinase, putative	0.0154	0.0544	0.0506
Plasmodium falciparum	serine repeat antigen 7	0.0154	0.0544	0.2343
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0154	0.0544	0.2343
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0409	0.1865	0.1832
Brugia malayi	prolyl oligopeptidase family protein	0.0141	0.0481	0.0481
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0154	0.0544	0.2343
Echinococcus granulosus	cathepsin L	0.0154	0.0544	0.0539
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0409	0.1865	0.186
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.1219	0.5106
Trypanosoma cruzi	cysteine proteinase, putative	0.0154	0.0544	0.0506
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0154	0.0544	0.2343
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0719	0.3469	1
Onchocerca volvulus	Cathepsin F homolog	0.0409	0.1865	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Schistosoma mansoni	cathepsin F (C01 family)	0.0409	0.1865	0.1749
Trypanosoma cruzi	cysteine peptidase, putative	0.0409	0.1865	0.1832
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.0544	0.1471
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.014	0.2347
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0154	0.0544	0.041
Plasmodium falciparum	serine repeat antigen 3	0.0154	0.0544	0.2343
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.0544	0.1471
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0154	0.0544	0.2343
Onchocerca volvulus		0.0409	0.1865	1
Toxoplasma gondii	cathepsin CPC1	0.0154	0.0544	0.1214
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0154	0.0544	0.2343
Schistosoma mansoni	cathepsin F (C01 family)	0.0409	0.1865	0.1749
Giardia lamblia	Cathepsin B precursor	0.0719	0.3469	1
Schistosoma mansoni	cathepsin C	0.0154	0.0544	0.041
Brugia malayi	cathepsin L-like precursor	0.0409	0.1865	0.1865
Plasmodium vivax	serine-repeat antigen (SERA)	0.0154	0.0544	0.2343
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0154	0.0544	0.2343
Loa Loa (eye worm)	ctsf protein	0.0409	0.1865	0.1865
Brugia malayi	Papain family cysteine protease containing protein	0.0409	0.1865	0.1865
Onchocerca volvulus		0.0409	0.1865	1
Echinococcus granulosus	cathepsin L	0.0154	0.0544	0.0539
Treponema pallidum	fructose-bisphosphate aldolase	0.0284	0.1219	1
Loa Loa (eye worm)	hypothetical protein	0.0409	0.1865	0.1865
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Plasmodium vivax	unspecified product	0.0154	0.0544	0.2343
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.0544	0.041
Toxoplasma gondii	cathepsin CPL	0.0409	0.1865	0.5181
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Onchocerca volvulus		0.0409	0.1865	1
Onchocerca volvulus		0.0409	0.1865	1
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.0544	0.0544
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.014	0.5
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0481	0.0481
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Brugia malayi	Probable ClpP-like protease	0.0076	0.014	0.014
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0139	0.0467	1
Plasmodium vivax	vivapain-1	0.0154	0.0544	0.2343
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Echinococcus granulosus	cathepsin L cysteine protease	0.0154	0.0544	0.0539
Echinococcus multilocularis	cathepsin L	0.0154	0.0544	0.0539
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0154	0.0544	0.2343
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.014	0.5
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0154	0.0544	0.1214
Entamoeba histolytica	cysteine proteinase, putative	0.0409	0.1865	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Trypanosoma cruzi	cysteine peptidase, putative	0.0409	0.1865	0.1832
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1981	1	1
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.014	0.0135
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0154	0.0544	0.041
Entamoeba histolytica	cysteine proteinase, putative	0.0409	0.1865	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0154	0.0544	0.0506
Onchocerca volvulus		0.0409	0.1865	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0154	0.0544	0.2343
Echinococcus multilocularis	cysteine protease	0.0409	0.1865	0.186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.014	0.0135
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Mycobacterium tuberculosis	Probable peptidase	0.0056	0.004	0.0384
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0154	0.0544	0.041
Plasmodium falciparum	serine repeat antigen 9	0.0154	0.0544	0.2343
Trypanosoma cruzi	cysteine peptidase, putative	0.0409	0.1865	0.1832
Schistosoma mansoni	cathepsin F (C01 family)	0.0409	0.1865	0.1749
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0154	0.0544	0.041
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0141	0.0481	0.0345
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0544	0.0544
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Entamoeba histolytica	cysteine protease, putative	0.0409	0.1865	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Echinococcus granulosus	cysteine protease	0.0154	0.0544	0.0539
Echinococcus multilocularis	prolyl endopeptidase	0.0141	0.0481	0.0475
Schistosoma mansoni	cathepsin S (C01 family)	0.0154	0.0544	0.041
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0719	0.3469	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0139	0.0467	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0154	0.0544	0.0544
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.014	0.2919
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.0544	0.041
Plasmodium falciparum	serine repeat antigen 4	0.0154	0.0544	0.2343
Trypanosoma cruzi	cysteine peptidase, putative	0.0409	0.1865	0.1832
Toxoplasma gondii	cathepsin CPC2	0.0154	0.0544	0.1214
Loa Loa (eye worm)	hypothetical protein	0.1981	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0154	0.0544	0.0506
Echinococcus multilocularis	cysteine protease	0.0409	0.1865	0.186
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1981	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1981	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0154	0.0544	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0544	0.0544
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Onchocerca volvulus		0.0154	0.0544	0.0461
Echinococcus granulosus	prolyl endopeptidase	0.0141	0.0481	0.0475
Echinococcus multilocularis	cathepsin b	0.1981	1	1
Loa Loa (eye worm)	hypothetical protein	0.0409	0.1865	0.1865
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0141	0.0481	0.1285
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0056	0.004	0.0384
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0154	0.0544	0.0544
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.014	0.2347
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Plasmodium falciparum	serine repeat antigen 5	0.0154	0.0544	0.2343
Plasmodium vivax	vivapain-2	0.0409	0.1865	1
Onchocerca volvulus	Cathepsin L homolog	0.0409	0.1865	1
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0141	0.0481	0.0345
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Echinococcus multilocularis	cathepsin L cysteine protease	0.0409	0.1865	0.186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0154	0.0544	0.041
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0409	0.1865	0.1865
Plasmodium vivax	unspecified product	0.0154	0.0544	0.2343
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0409	0.1865	0.186
Echinococcus granulosus	cathepsin l1	0.0409	0.1865	0.186
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0154	0.0544	0.0544
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.0906	1
Echinococcus granulosus	cathepsin b	0.1981	1	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Entamoeba histolytica	cysteine proteinase, putative	0.0409	0.1865	1
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Brugia malayi	cathepsin L precursor	0.0154	0.0544	0.0544
Toxoplasma gondii	cathepsin B	0.0719	0.3469	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0154	0.0544	0.2343
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0154	0.0544	0.2343
Brugia malayi	fibroinase precursor	0.0154	0.0544	0.0544
Echinococcus multilocularis	cathepsin L cysteine protease	0.0409	0.1865	0.186
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.014	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Loa Loa (eye worm)	fibroinase	0.0409	0.1865	0.1865
Onchocerca volvulus		0.0409	0.1865	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0719	0.3469	1
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0056	0.004	0.0748
Brugia malayi	cathepsin L-like cysteine proteinase	0.0154	0.0544	0.0544
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0409	0.1865	0.186
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0719	0.3469	0.3442
Giardia lamblia	Fructose-bisphosphate aldolase	0.0284	0.1219	0.2305
Loa Loa (eye worm)	cysteine protease	0.0409	0.1865	0.1865
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.1219	0.5106
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0154	0.0544	0.2343
Trypanosoma brucei	prolyl endopeptidase	0.0141	0.0481	0.1285
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Loa Loa (eye worm)	hypothetical protein	0.0409	0.1865	0.1865
Loa Loa (eye worm)	hypothetical protein	0.0409	0.1865	0.1865
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0154	0.0544	0.2343
Plasmodium vivax	vivapain-3	0.0154	0.0544	0.2343
Toxoplasma gondii	prolyl endopeptidase	0.0141	0.0481	0.1022
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0409	0.1865	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0139	0.0467	0.5127
Schistosoma mansoni	cathepsin B (C01 family)	0.0154	0.0544	0.041
Trypanosoma cruzi	major cysteine proteinase, putative	0.0154	0.0544	0.0506
Loa Loa (eye worm)	cathepsin B	0.0719	0.3469	0.3469
Onchocerca volvulus		0.0409	0.1865	1
Plasmodium falciparum	serine repeat antigen 1	0.0154	0.0544	0.2343
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.0544	0.041
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.0544	0.041
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Plasmodium vivax	serine-repeat antigen (SERA)	0.0154	0.0544	0.2343
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Echinococcus granulosus	cathepsin l1	0.0409	0.1865	0.186
Plasmodium falciparum	serine repeat antigen 6	0.0154	0.0544	0.2343
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.0544	0.0544
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0154	0.0544	0.0506
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0544	0.0544

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 830958