Detailed information for compound 831313

Basic information

Technical information
  • TDR Targets ID: 831313
  • Name: 6-fluoro-1-[(4-methoxyphenyl)methyl]-3-phenyl sulfonylquinolin-4-one
  • MW: 423.457 | Formula: C23H18FNO4S
  • H donors: 0 H acceptors: 3 LogP: 4.27 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Cn1cc(c(=O)c2c1ccc(c2)F)S(=O)(=O)c1ccccc1
  • InChi: 1S/C23H18FNO4S/c1-29-18-10-7-16(8-11-18)14-25-15-22(30(27,28)19-5-3-2-4-6-19)23(26)20-13-17(24)9-12-21(20)25/h2-13,15H,14H2,1H3
  • InChiKey: PBURWTORAQYFKJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-fluoro-1-[(4-methoxyphenyl)methyl]-3-phenylsulfonyl-quinolin-4-one
  • 6-fluoro-1-[(4-methoxyphenyl)methyl]-3-phenylsulfonyl-4-quinolinone
  • 6-fluoro-1-(4-methoxybenzyl)-3-phenylsulfonyl-4-quinolone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Plasmodium falciparum serine repeat antigen 4 0.0211 0.0724 0.2817
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0639 0.2548 0.6356
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0211 0.0724 0.0724
Trypanosoma cruzi cysteine peptidase, putative 0.0262 0.0943 0.0935
Echinococcus granulosus cathepsin L cysteine proteinase 0.0639 0.2548 0.2546
Brugia malayi hypothetical protein 0.0089 0.0206 0.0205
Onchocerca volvulus 0.0639 0.2548 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0639 0.2548 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0062 0.0062
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2388 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Loa Loa (eye worm) hypothetical protein 0.0049 0.0035 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Plasmodium falciparum serine repeat antigen 2 0.0211 0.0724 0.2817
Echinococcus granulosus cathepsin l1 0.0639 0.2548 0.2546
Trypanosoma cruzi major cysteine proteinase, putative 0.0398 0.1522 0.1514
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Toxoplasma gondii cathepsin B 0.0884 0.3593 1
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0117 0.0323 0.0877
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0015 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0015 0.0013
Schistosoma mansoni cathepsin S (C01 family) 0.0211 0.0724 0.0723
Echinococcus multilocularis cathepsin L cysteine protease 0.0639 0.2548 0.2548
Loa Loa (eye worm) hypothetical protein 0.0051 0.0046 0.0046
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0347 0.1304 0.5117
Echinococcus multilocularis cathepsin L cysteine protease 0.0639 0.2548 0.2548
Plasmodium vivax unspecified product 0.0211 0.0724 0.2817
Echinococcus granulosus histone deacetylase 6 0.0043 0.0009 0.0008
Loa Loa (eye worm) ctsf protein 0.0639 0.2548 0.2548
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0262 0.0943 0.0942
Plasmodium falciparum serine repeat antigen 1 0.0211 0.0724 0.2817
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0211 0.0724 0.2817
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.0046 0.0044
Brugia malayi Cathepsin L-like precursor 0.0639 0.2548 0.2546
Schistosoma mansoni cathepsin B (C01 family) 0.0211 0.0724 0.0723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Giardia lamblia Cathepsin B precursor 0.0884 0.3593 1
Onchocerca volvulus Cathepsin L homolog 0.0639 0.2548 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0262 0.0943 0.2606
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0117 0.0323 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Schistosoma mansoni gamma-secretase subunit aph-1 0.0237 0.0835 0.0834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Leishmania major cysteine peptidase A (CPA) 0.0639 0.2548 0.7083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0015 0.0013
Echinococcus multilocularis cathepsin b 0.2388 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Echinococcus multilocularis cysteine protease 0.0639 0.2548 0.2548
Brugia malayi cathepsin Z-like cysteine proteinase 0.0211 0.0724 0.0723
Trypanosoma cruzi cysteine peptidase, putative 0.0826 0.3345 0.3339
Entamoeba histolytica cysteine proteinase, putative 0.0262 0.0943 0.1201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0262 0.0943 0.2606
Plasmodium falciparum cysteine proteinase falcipain 3 0.0639 0.2548 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0211 0.0724 0.2817
Leishmania major cathepsin L-like protease 0.0639 0.2548 0.7083
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0211 0.0724 0.0724
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0211 0.0724 0.2817
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0211 0.0724 0.0723
Trypanosoma brucei cysteine peptidase C (CPC) 0.0884 0.3593 1
Brugia malayi Histone deacetylase family protein 0.0043 0.0009 0.0008
Brugia malayi Cathepsin L-like precursor 0.0639 0.2548 0.2546
Plasmodium vivax vivapain-1 0.0262 0.0943 0.368
Echinococcus multilocularis cathepsin L 0.0211 0.0724 0.0724
Brugia malayi prolyl oligopeptidase family protein 0.0117 0.0323 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0262 0.0943 0.0763
Onchocerca volvulus 0.0211 0.0724 0.2838
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0211 0.0724 0.0724
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0211 0.0724 0.2817
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2388 1 1
Echinococcus granulosus gamma secretase subunit aph 1 0.0237 0.0835 0.0834
Toxoplasma gondii cathepsin CPL 0.0639 0.2548 0.7083
Trypanosoma cruzi major cysteine proteinase, putative 0.0211 0.0724 0.0716
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0009 0.0008
Entamoeba histolytica cysteine proteinase 2 0.0262 0.0943 0.1201
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0051 0.0046 0.0044
Brugia malayi Cathepsin L-like precursor 0.0639 0.2548 0.2546
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2388 1 1
Echinococcus granulosus cathepsin L cysteine protease 0.0262 0.0943 0.0942
Echinococcus granulosus histone deacetylase 0.0043 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.2388 1 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0211 0.0724 0.2817
Brugia malayi Papain family cysteine protease containing protein 0.0262 0.0943 0.0942
Entamoeba histolytica cysteine proteinase, putative 0.0262 0.0943 0.1201
Loa Loa (eye worm) prolyl oligopeptidase 0.0347 0.1304 0.1304
Entamoeba histolytica cysteine proteinase, putative 0.0639 0.2548 1
Leishmania major cathepsin L-like protease 0.0826 0.3345 0.9309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Echinococcus multilocularis cathepsin L 0.0262 0.0943 0.0943
Schistosoma mansoni hypothetical protein 0.0164 0.0524 0.0523
Loa Loa (eye worm) hypothetical protein 0.0587 0.2329 0.2329
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0015 0.0015
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0211 0.0724 0.2817
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0046 0.0046
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0347 0.1304 0.1303
Brugia malayi Cathepsin L-like precursor 0.0587 0.2329 0.2327
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0211 0.0724 0.0723
Loa Loa (eye worm) hypothetical protein 0.0211 0.0724 0.0724
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0639 0.2548 0.2548
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0211 0.0724 0.0723
Loa Loa (eye worm) hypothetical protein 0.0089 0.0206 0.0206
Plasmodium vivax vivapain-2 0.0639 0.2548 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0884 0.3593 1
Schistosoma mansoni cathepsin F (C01 family) 0.0639 0.2548 0.2546
Brugia malayi Papain family cysteine protease containing protein 0.0262 0.0943 0.0942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0262 0.0943 0.0763
Onchocerca volvulus 0.0639 0.2548 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0073 0.0071
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0211 0.0724 0.0723
Plasmodium falciparum serine repeat antigen 6 0.0211 0.0724 0.2817
Onchocerca volvulus 0.0639 0.2548 1
Brugia malayi Papain family cysteine protease containing protein 0.0211 0.0724 0.0723
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0774 0.3126 0.312
Trypanosoma cruzi Aph-1 protein, putative 0.0092 0.022 0.0211
Toxoplasma gondii cathepsin CPC2 0.0211 0.0724 0.1995
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Entamoeba histolytica cysteine protease, putative 0.0639 0.2548 1
Schistosoma mansoni cathepsin F (C01 family) 0.0639 0.2548 0.2546
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0639 0.2548 0.2548
Leishmania major cathepsin L-like protease 0.0639 0.2548 0.7083
Brugia malayi Cathepsin L-like precursor 0.0639 0.2548 0.2546
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Brugia malayi calpain family protein 1 0.0055 0.0062 0.0061
Plasmodium falciparum serine repeat antigen 3 0.0211 0.0724 0.2817
Plasmodium falciparum serine repeat antigen 7 0.0211 0.0724 0.2817
Schistosoma mansoni cathepsin F (C01 family) 0.0587 0.2329 0.2327
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0015 0.0013
Entamoeba histolytica cysteine proteinase, putative 0.0587 0.2329 0.8799
Leishmania major cathepsin L-like protease 0.0639 0.2548 0.7083
Plasmodium vivax serine-repeat antigen (SERA) 0.0211 0.0724 0.2817
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Toxoplasma gondii preprocathepsin c precursor, putative 0.0211 0.0724 0.1995
Echinococcus granulosus geminin 0.0164 0.0524 0.0523
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0009 0.0009
Loa Loa (eye worm) calpain family protein 1 0.0055 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Echinococcus multilocularis gamma secretase subunit aph 1 0.0237 0.0835 0.0835
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0211 0.0724 0.0723
Echinococcus granulosus calpain A 0.0058 0.0073 0.0071
Brugia malayi cathepsin L precursor 0.0211 0.0724 0.0723
Trypanosoma cruzi cruzipain precursor, putative 0.0826 0.3345 0.3339
Echinococcus multilocularis histone deacetylase 0.0043 0.0009 0.0009
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0211 0.0724 0.0723
Entamoeba histolytica cysteine proteinase, putative 0.0639 0.2548 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0639 0.2548 0.2548
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0884 0.3593 0.3587
Loa Loa (eye worm) hypothetical protein 0.0211 0.0724 0.0724
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Brugia malayi cathepsin L-like precursor 0.0587 0.2329 0.2327
Trypanosoma cruzi cysteine protease, putative 0.0262 0.0943 0.0935
Entamoeba histolytica cysteine proteinase 1, putative 0.0262 0.0943 0.1201
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0211 0.0724 0.2817
Plasmodium vivax unspecified product 0.0051 0.0046 0.0144
Loa Loa (eye worm) hypothetical protein 0.0051 0.0046 0.0046
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Brugia malayi prolyl oligopeptidase family protein 0.0347 0.1304 0.1303
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0117 0.0323 0.0877
Trypanosoma cruzi cysteine proteinase, putative 0.0262 0.0943 0.0935
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0015 0.0013
Echinococcus granulosus cathepsin b 0.2388 1 1
Leishmania major cathepsin L-like protease 0.0639 0.2548 0.7083
Onchocerca volvulus 0.0639 0.2548 1
Echinococcus multilocularis cathepsin b 0.2388 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0211 0.0724 0.0723
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0237 0.0835 0.0835
Plasmodium vivax unspecified product 0.0262 0.0943 0.368
Plasmodium falciparum serine repeat antigen 9 0.0211 0.0724 0.2817
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0211 0.0724 0.2817
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Onchocerca volvulus 0.0639 0.2548 1
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0211 0.0724 0.0723
Trypanosoma brucei Aph-1 protein, putative 0.0092 0.022 0.0587
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Brugia malayi Cathepsin L-like precursor 0.0639 0.2548 0.2546
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0058 0.0073 0.0073
Brugia malayi Cathepsin L-like cysteine proteinase 0.0587 0.2329 0.2327
Echinococcus multilocularis geminin 0.0164 0.0524 0.0524
Trypanosoma cruzi cysteine peptidase, putative 0.0826 0.3345 0.3339
Giardia lamblia Cathepsin B precursor 0.0884 0.3593 1
Onchocerca volvulus Cathepsin F homolog 0.0639 0.2548 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0211 0.0724 0.0723
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0347 0.1304 0.1303
Onchocerca volvulus 0.0587 0.2329 0.914
Leishmania major cathepsin L-like protease 0.0639 0.2548 0.7083
Giardia lamblia Cathepsin B precursor 0.0884 0.3593 1
Echinococcus granulosus cathepsin L 0.0262 0.0943 0.0942
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0009 0.0009
Brugia malayi gamma-secretase subunit aph-1 0.0237 0.0835 0.0834
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0073 0.0071
Toxoplasma gondii cathepsin CPC1 0.0211 0.0724 0.1995
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0211 0.0724 0.2817
Brugia malayi fibroinase precursor 0.0211 0.0724 0.0723
Loa Loa (eye worm) hypothetical protein 0.0587 0.2329 0.2329
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0262 0.0943 0.0942
Echinococcus multilocularis inhibitor of apoptosis protein 0.0041 0.0002 0.0002
Plasmodium falciparum cysteine proteinase falcipain 1 0.0262 0.0943 0.368
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Trypanosoma cruzi cruzipain precursor, putative 0.0051 0.0046 0.0037
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0117 0.0323 0.0877
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0211 0.0724 0.2817
Echinococcus granulosus histone deacetylase 7 0.0043 0.0009 0.0008
Echinococcus multilocularis calpain A 0.0058 0.0073 0.0073
Brugia malayi cathepsin Z-like cysteine proteinase 0.0211 0.0724 0.0723
Echinococcus granulosus Dipeptidyl peptidase 9 0.0117 0.0323 0.0322
Loa Loa (eye worm) hypothetical protein 0.0211 0.0724 0.0724
Schistosoma mansoni cathepsin s 0.0051 0.0046 0.0044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0015 0.0015
Loa Loa (eye worm) histone deacetylase 0.0043 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0046 0.0037
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0117 0.0323 0.0315
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0639 0.2548 0.2548
Brugia malayi Histone deacetylase family protein 0.0043 0.0009 0.0008
Onchocerca volvulus Cathepsin L homolog 0.0211 0.0724 0.2838
Brugia malayi Papain family cysteine protease containing protein 0.0639 0.2548 0.2546
Loa Loa (eye worm) hypothetical protein 0.0639 0.2548 0.2548
Brugia malayi Cathepsin L-like precursor 0.0639 0.2548 0.2546
Entamoeba histolytica cysteine proteinase, putative 0.0262 0.0943 0.1201
Echinococcus granulosus cathepsin b 0.2388 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0117 0.0323 0.0315
Loa Loa (eye worm) hypothetical protein 0.0041 0.0002 0.0002
Plasmodium vivax vivapain-2 0.0639 0.2548 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0211 0.0724 0.2817
Plasmodium vivax vivapain-3 0.0262 0.0943 0.368
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0015 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Onchocerca volvulus 0.0639 0.2548 1
Trypanosoma cruzi Aph-1 protein, putative 0.0092 0.022 0.0211
Loa Loa (eye worm) hypothetical protein 0.0211 0.0724 0.0724
Brugia malayi Papain family cysteine protease containing protein 0.0211 0.0724 0.0723
Echinococcus granulosus cysteine protease 0.0262 0.0943 0.0942
Schistosoma mansoni hypothetical protein 0.0164 0.0524 0.0523
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0639 0.2548 0.6356
Loa Loa (eye worm) cathepsin B 0.0884 0.3593 0.3593
Brugia malayi cathepsin L-like cysteine proteinase 0.0211 0.0724 0.0723
Echinococcus multilocularis histone deacetylase 7 0.0043 0.0009 0.0009
Echinococcus granulosus cathepsin l1 0.0587 0.2329 0.2327
Schistosoma mansoni cathepsin C 0.0211 0.0724 0.0723
Loa Loa (eye worm) histone deacetylase 7A 0.0043 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0639 0.2548 0.2541
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0347 0.1304 0.1304
Loa Loa (eye worm) hypothetical protein 0.0211 0.0724 0.0724
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0211 0.0724 0.0723
Loa Loa (eye worm) hypothetical protein 0.0051 0.0046 0.0046
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0211 0.0724 0.2817
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Brugia malayi Cathepsin L-like precursor 0.0587 0.2329 0.2327
Trypanosoma cruzi cysteine peptidase, putative 0.0826 0.3345 0.3339
Brugia malayi cathepsin F-like cysteine proteinase 0.0211 0.0724 0.0723
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0009 0.0008
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0262 0.0943 0.0942
Echinococcus granulosus histone deacetylase 6 0.0043 0.0009 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0058 0.0073 0.0071
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Entamoeba histolytica cysteine proteinase, putative 0.0262 0.0943 0.1201
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0117 0.0323 0.0877
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0639 0.2548 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0015 0.0015
Loa Loa (eye worm) fibroinase 0.0639 0.2548 0.2548
Echinococcus granulosus histone deacetylase 6 0.0043 0.0009 0.0008
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0041 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0587 0.2329 0.2329
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Onchocerca volvulus 0.0639 0.2548 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0639 0.2548 0.2546
Plasmodium falciparum serine repeat antigen 8 0.0211 0.0724 0.2817
Brugia malayi Papain family cysteine protease containing protein 0.0211 0.0724 0.0723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0062 0.0061
Onchocerca volvulus Cathepsin L homolog 0.0639 0.2548 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0002 0.0002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0884 0.3593 0.3592
Loa Loa (eye worm) cysteine protease 0.0639 0.2548 0.2548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0587 0.2329 0.5592
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0211 0.0724 0.2817
Schistosoma mansoni histone deacetylase hda2 0.0043 0.0009 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Echinococcus multilocularis cysteine protease 0.0639 0.2548 0.2548
Brugia malayi calpain family protein 1 0.0055 0.0062 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Leishmania major cathepsin L-like protease 0.0826 0.3345 0.9309
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2388 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0117 0.0323 0.0322
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2388 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0262 0.0943 0.0935
Plasmodium falciparum serine repeat antigen 5 0.0211 0.0724 0.2817
Leishmania major cathepsin L-like protease 0.0826 0.3345 0.9309
Trypanosoma cruzi cysteine proteinase, putative 0.0262 0.0943 0.0935
Brugia malayi Cathepsin L-like precursor 0.0051 0.0046 0.0044
Loa Loa (eye worm) hypothetical protein 0.0211 0.0724 0.0724
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0211 0.0724 0.2817
Echinococcus granulosus cathepsin L 0.0211 0.0724 0.0723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0587 0.2329 0.5592
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0884 0.3593 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.