TDR Targets

Basic information

Technical information

TDR Targets ID: 831393
Name: 6-fluoro-1-[(4-methoxyphenyl)methyl]-3-(4-pro pan-2-ylphenyl)sulfonylquinolin-4-one
MW: 465.536 | Formula: C26H24FNO4S
H donors: 0 H acceptors: 3 LogP: 5.39 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)Cn1cc(c(=O)c2c1ccc(c2)F)S(=O)(=O)c1ccc(cc1)C(C)C
InChi: 1S/C26H24FNO4S/c1-17(2)19-6-11-22(12-7-19)33(30,31)25-16-28(15-18-4-9-21(32-3)10-5-18)24-13-8-20(27)14-23(24)26(25)29/h4-14,16-17H,15H2,1-3H3
InChiKey: BTHCBKABWZVRSE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-fluoro-3-(4-isopropylphenyl)sulfonyl-1-[(4-methoxyphenyl)methyl]quinolin-4-one
6-fluoro-3-(4-isopropylphenyl)sulfonyl-1-[(4-methoxyphenyl)methyl]-4-quinolinone
6-fluoro-3-(4-isopropylphenyl)sulfonyl-1-(4-methoxybenzyl)-4-quinolone
6-fluoro-1-[(4-methoxyphenyl)methyl]-3-(4-propan-2-ylphenyl)sulfonyl-quinolin-4-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0419	0.2378	0.6045
Echinococcus multilocularis	nmda type glutamate receptor	0.0096	0.0339	0.0339
Plasmodium vivax	vivapain-2	0.0419	0.2378	1
Onchocerca volvulus		0.0419	0.2378	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0419	0.2378	0.6045
Entamoeba histolytica	cysteine protease, putative	0.0168	0.0789	0.0938
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0625	0.0625
Leishmania major	cathepsin L-like protease	0.0514	0.2976	0.8197
Entamoeba histolytica	cysteine protease, putative	0.0168	0.0789	0.0938
Leishmania major	cathepsin L-like protease	0.0514	0.2976	0.8197
Trypanosoma cruzi	cysteine proteinase, putative	0.0168	0.0789	0.0318
Brugia malayi	cathepsin L-like precursor	0.0393	0.2213	0.218
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0625	0.0584
Echinococcus multilocularis	cathepsin L	0.0142	0.0625	0.0625
Onchocerca volvulus		0.0419	0.2378	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0419	0.2378	0.6045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0419	0.2378	0.6045
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0393	0.2213	0.218
Giardia lamblia	Cathepsin B precursor	0.0601	0.3524	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0168	0.0789	0.0318
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0625	0.0625
Entamoeba histolytica	cysteine protease, putative	0.0168	0.0789	0.0938
Brugia malayi	Papain family cysteine protease containing protein	0.0168	0.0789	0.075
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0419	0.2378	0.6045
Echinococcus granulosus	cathepsin b	0.1627	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0168	0.0789	0.0938
Echinococcus multilocularis	cathepsin b	0.1627	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0168	0.0789	0.0318
Entamoeba histolytica	cysteine protease, putative	0.0168	0.0789	0.0938
Entamoeba histolytica	cysteine protease, putative	0.0168	0.0789	0.0938
Brugia malayi	Cathepsin L-like precursor	0.0419	0.2378	0.2345
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0601	0.3524	0.3524
Brugia malayi	Papain family cysteine protease containing protein	0.0142	0.0625	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0393	0.2213	0.218
Leishmania major	cathepsin L-like protease	0.0514	0.2976	0.8197
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0356	0.198	0.773
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0419	0.2378	0.6045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0168	0.0789	0.0567
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0514	0.2976	0.8197
Leishmania major	cysteine peptidase A (CPA)	0.0419	0.2378	0.6225
Schistosoma mansoni	cathepsin C	0.0142	0.0625	0.0625
Brugia malayi	prolyl oligopeptidase family protein	0.012	0.0486	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0393	0.2213	0.218
Brugia malayi	Papain family cysteine protease containing protein	0.0168	0.0789	0.075
Loa Loa (eye worm)	cathepsin B	0.0601	0.3524	0.3496
Echinococcus granulosus	glutamate receptor 2	0.0053	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.1627	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0142	0.0625	0.0584
Trypanosoma cruzi	cysteine peptidase, putative	0.0514	0.2976	0.2617
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0168	0.0789	0.0996
Toxoplasma gondii	cathepsin CPC2	0.0142	0.0625	0.0455
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0419	0.2378	0.6045
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1627	1	1
Loa Loa (eye worm)	hypothetical protein	0.0419	0.2378	0.2345
Schistosoma mansoni	glutamate receptor NMDA	0.0098	0.035	0.035
Echinococcus multilocularis	glutamate receptor NMDA	0.0081	0.0243	0.0243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0419	0.2378	0.6045
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0419	0.2378	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0514	0.2976	0.8197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0419	0.2378	0.6045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0419	0.2378	0.6045
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0601	0.3524	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0514	0.2976	0.8197
Entamoeba histolytica	cysteine proteinase, putative	0.0419	0.2378	1
Brugia malayi	prolyl oligopeptidase family protein	0.0356	0.198	0.1945
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0393	0.2213	0.5478
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.012	0.0486	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0625	0.0584
Leishmania major	cathepsin L-like protease	0.0419	0.2378	0.6225
Echinococcus multilocularis	cathepsin L cysteine protease	0.0419	0.2378	0.2378
Onchocerca volvulus	Cathepsin F homolog	0.0419	0.2378	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0625	0.0625
Entamoeba histolytica	cysteine proteinase, putative	0.0168	0.0789	0.0938
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0059	0.0104	0.0104
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0625	0.0625
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0601	0.3524	1
Entamoeba histolytica	cysteine proteinase, putative	0.0419	0.2378	1
Entamoeba histolytica	cysteine proteinase, putative	0.0393	0.2213	0.9062
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0098	0.035	0.035
Echinococcus granulosus	nmda type glutamate receptor	0.0093	0.0317	0.0317
Echinococcus granulosus	nmda type glutamate receptor	0.0096	0.0339	0.0339
Entamoeba histolytica	cysteine proteinase, putative	0.0168	0.0789	0.0938
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0168	0.0789	0.0938
Toxoplasma gondii	cathepsin CPC1	0.0142	0.0625	0.0455
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0142	0.0625	0.0625
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0419	0.2378	0.6045
Plasmodium vivax	unspecified product	0.0168	0.0789	0.0938
Brugia malayi	Cathepsin L-like precursor	0.0419	0.2378	0.2345
Brugia malayi	Cathepsin L-like precursor	0.0419	0.2378	0.2345
Echinococcus multilocularis	cysteine protease	0.0419	0.2378	0.2378
Onchocerca volvulus	Cathepsin L homolog	0.0419	0.2378	1
Echinococcus granulosus	cysteine protease	0.0168	0.0789	0.0789
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0419	0.2378	0.2345
Brugia malayi	Cathepsin L-like precursor	0.0419	0.2378	0.2345
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0356	0.198	0.198
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0142	0.0625	0.0584
Schistosoma mansoni	cathepsin S (C01 family)	0.0142	0.0625	0.0625
Onchocerca volvulus		0.0419	0.2378	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0142	0.0625	0.0584
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0419	0.2378	0.6045
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0488	0.2812	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0625	0.0584
Entamoeba histolytica	cysteine protease, putative	0.0419	0.2378	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0419	0.2378	0.2378
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0514	0.2976	0.8197
Onchocerca volvulus		0.0393	0.2213	0.9062
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0419	0.2378	0.6045
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0514	0.2976	0.8197
Brugia malayi	fibroinase precursor	0.0142	0.0625	0.0584
Brugia malayi	cathepsin F-like cysteine proteinase	0.0142	0.0625	0.0584
Echinococcus granulosus	Dipeptidyl peptidase 9	0.012	0.0486	0.0486
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0053	0.0065	0.0065
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0098	0.035	0.035
Echinococcus granulosus	cathepsin l1	0.0393	0.2213	0.2213
Loa Loa (eye worm)	hypothetical protein	0.0393	0.2213	0.218
Loa Loa (eye worm)	ctsf protein	0.0419	0.2378	0.2345
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0053	0.0065	0.0065
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0047	0.0029	0.0029
Leishmania major	cathepsin L-like protease	0.0419	0.2378	0.6225
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0053	0.0065	0.0065
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0514	0.2976	0.8197
Toxoplasma gondii	cathepsin CPL	0.0419	0.2378	0.6225
Schistosoma mansoni	glutamate receptor NMDA	0.0134	0.0578	0.0578
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0142	0.0625	0.0455
Entamoeba histolytica	cysteine proteinase 1, putative	0.0168	0.0789	0.0938
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0514	0.2976	0.8197
Loa Loa (eye worm)	fibroinase	0.0419	0.2378	0.2345
Leishmania major	cathepsin L-like protease	0.0419	0.2378	0.6225
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1627	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0142	0.0625	0.0584
Schistosoma mansoni	cathepsin F (C01 family)	0.0419	0.2378	0.2378
Echinococcus granulosus	glutamate receptor NMDA	0.0081	0.0243	0.0243
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0168	0.0789	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0625	0.0584
Echinococcus multilocularis	cysteine protease	0.0419	0.2378	0.2378
Giardia lamblia	Cathepsin B precursor	0.0601	0.3524	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0142	0.0625	0.0584
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0419	0.2378	0.2378
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0419	0.2378	1
Onchocerca volvulus		0.0419	0.2378	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0053	0.0065	0.0065
Plasmodium vivax	vivapain-1	0.0168	0.0789	0.0938
Leishmania major	cathepsin L-like protease	0.0419	0.2378	0.6225
Echinococcus granulosus	cathepsin L	0.0142	0.0625	0.0625
Entamoeba histolytica	cysteine protease, putative	0.0168	0.0789	0.0938
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0142	0.0625	0.0625
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0419	0.2378	0.6045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0419	0.2378	0.6045
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0419	0.2378	0.2345
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0419	0.2378	0.6045
Entamoeba histolytica	cysteine proteinase 2	0.0168	0.0789	0.0938
Entamoeba histolytica	cysteine protease, putative	0.0168	0.0789	0.0938
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1627	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0419	0.2378	0.2345
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1627	1	1
Leishmania major	cathepsin L-like protease	0.0419	0.2378	0.6225
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0142	0.0625	0.0584
Entamoeba histolytica	cysteine protease, putative	0.0168	0.0789	0.0938
Echinococcus multilocularis	glutamate receptor 2	0.0053	0.0065	0.0065
Echinococcus multilocularis	cathepsin b	0.1627	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0142	0.0625	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0308	0.0267
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0053	0.0065	0.0065
Onchocerca volvulus		0.0419	0.2378	1
Echinococcus granulosus	cathepsin L	0.0168	0.0789	0.0789
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0514	0.2976	0.8197
Trypanosoma cruzi	cruzipain precursor, putative	0.0514	0.2976	0.2617
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0168	0.0789	0.0996
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0419	0.2378	0.2378
Brugia malayi	Cathepsin L-like precursor	0.0393	0.2213	0.218
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0059	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0104	0.0061
Echinococcus granulosus	cathepsin b	0.1627	1	1
Entamoeba histolytica	cysteine protease, putative	0.0168	0.0789	0.0938
Entamoeba histolytica	cysteine protease, putative	0.0168	0.0789	0.0938
Onchocerca volvulus	Cathepsin L homolog	0.0419	0.2378	1
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0356	0.198	0.198
Echinococcus granulosus	cathepsin L cysteine protease	0.0168	0.0789	0.0789
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1627	1	1
Plasmodium vivax	vivapain-3	0.0168	0.0789	0.0938
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0514	0.2976	0.8197
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0514	0.2976	0.8197
Trypanosoma cruzi	cysteine peptidase, putative	0.0419	0.2378	0.1988
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0419	0.2378	0.6045
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0625	0.0625
Brugia malayi	cathepsin L-like cysteine proteinase	0.0142	0.0625	0.0584
Entamoeba histolytica	cysteine proteinase, putative	0.0168	0.0789	0.0938
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0053	0.0065	0.0065
Echinococcus granulosus	cathepsin l1	0.0419	0.2378	0.2378
Onchocerca volvulus		0.0419	0.2378	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0419	0.2378	0.6045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0419	0.2378	0.6045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0419	0.2378	0.6045
Plasmodium vivax	vivapain-2	0.0419	0.2378	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0419	0.2378	0.2378
Echinococcus multilocularis	cathepsin L	0.0168	0.0789	0.0789
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0419	0.2378	0.2378
Brugia malayi	Cathepsin L-like precursor	0.0419	0.2378	0.2345
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0514	0.2976	0.8197
Brugia malayi	Cathepsin L-like precursor	0.0393	0.2213	0.218
Echinococcus multilocularis	cathepsin L cysteine protease	0.0419	0.2378	0.2378
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0601	0.3524	1
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.012	0.0486	0.0486
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0142	0.0625	0.0625
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0168	0.0789	0.0567
Loa Loa (eye worm)	prolyl oligopeptidase	0.0356	0.198	0.1945
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0419	0.2378	0.6045
Toxoplasma gondii	cathepsin B	0.0601	0.3524	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0514	0.2976	0.2617
Trypanosoma cruzi	cysteine peptidase, putative	0.0168	0.0789	0.0318
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0053	0.0065	0.0065
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0142	0.0625	0.0584
Entamoeba histolytica	cysteine protease, putative	0.0168	0.0789	0.0938
Brugia malayi	Cathepsin L-like precursor	0.0419	0.2378	0.2345
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0419	0.2378	0.6045
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0053	0.0065	0.0065
Echinococcus multilocularis	nmda type glutamate receptor	0.0093	0.0317	0.0317
Loa Loa (eye worm)	cysteine protease	0.0419	0.2378	0.2345
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0356	0.198	0.198
Brugia malayi	hypothetical protein	0.0092	0.0308	0.0267
Brugia malayi	cathepsin L precursor	0.0142	0.0625	0.0584
Schistosoma mansoni	cathepsin F (C01 family)	0.0393	0.2213	0.2213
Onchocerca volvulus		0.0419	0.2378	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0601	0.3524	0.3193
Trypanosoma cruzi	major cysteine proteinase, putative	0.0237	0.1224	0.0775
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0419	0.2378	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0168	0.0789	0.0789
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0168	0.0789	0.0789
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0393	0.2213	0.5478
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0419	0.2378	0.6045
Entamoeba histolytica	cysteine protease, putative	0.0168	0.0789	0.0938
Trypanosoma cruzi	cysteine protease, putative	0.0168	0.0789	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0625	0.0584
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0142	0.0625	0.0625
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0142	0.0625	0.0584
Trypanosoma cruzi	cysteine peptidase, putative	0.0514	0.2976	0.2617
Schistosoma mansoni	cathepsin B (C01 family)	0.0142	0.0625	0.0625
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0419	0.2378	0.6045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0419	0.2378	0.6045
Giardia lamblia	Cathepsin B precursor	0.0601	0.3524	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0625	0.0584
Entamoeba histolytica	cysteine protease, putative	0.0168	0.0789	0.0938

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 831393