Detailed information for compound 832466

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.437 | Formula: C19H18N4O2S
  • H donors: 1 H acceptors: 2 LogP: 3.11 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)CNC(=O)Cn1ncn2c(c1=O)cc1c2cc(s1)C
  • InChi: 1S/C19H18N4O2S/c1-12-3-5-14(6-4-12)9-20-18(24)10-23-19(25)16-8-17-15(7-13(2)26-17)22(16)11-21-23/h3-8,11H,9-10H2,1-2H3,(H,20,24)
  • InChiKey: WBUCFSBTDFTCDZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0227 0.0702 0.0702
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0115 0.0299 0.0738
Onchocerca volvulus Cathepsin L homolog 0.0227 0.0702 0.3186
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0227 0.0702 0.0667
Plasmodium vivax vivapain-1 0.0253 0.0798 0.3513
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Echinococcus granulosus calpain A 0.0056 0.0082 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0613 0.2106 0.4884
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.0798 0.0763
Entamoeba histolytica cysteine proteinase 1, putative 0.0253 0.0798 0.0641
Giardia lamblia Cathepsin B precursor 0.1019 0.3577 1
Onchocerca volvulus 0.0613 0.2106 0.9563
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Brugia malayi Papain family cysteine protease containing protein 0.0227 0.0702 0.0667
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0343 0.1126 0.1093
Loa Loa (eye worm) hypothetical protein 0.0227 0.0702 0.0702
Trypanosoma cruzi cruzipain precursor, putative 0.0737 0.2553 0.2525
Loa Loa (eye worm) histone deacetylase 0.0043 0.0037 0.0037
Echinococcus granulosus Dipeptidyl peptidase 9 0.0115 0.0299 0.0262
Brugia malayi Papain family cysteine protease containing protein 0.0253 0.0798 0.0763
Plasmodium falciparum serine repeat antigen 3 0.0227 0.0702 0.3068
Giardia lamblia Cathepsin B precursor 0.1019 0.3577 1
Echinococcus multilocularis cysteine protease 0.064 0.2203 0.2185
Echinococcus multilocularis caspase 2 0.009 0.0208 0.0187
Brugia malayi Cathepsin L-like cysteine proteinase 0.0613 0.2106 0.2077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Schistosoma mansoni inhibitor of apoptosis protein 0.0172 0.0503 0.0467
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Plasmodium vivax vivapain-2 0.064 0.2203 1
Plasmodium vivax vivapain-2 0.064 0.2203 1
Leishmania major cathepsin L-like protease 0.064 0.2203 0.6116
Entamoeba histolytica cysteine proteinase, putative 0.064 0.2203 1
Brugia malayi Papain family cysteine protease containing protein 0.0227 0.0702 0.0667
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.0798 0.0641
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0172 0.0503 0.0467
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Plasmodium falciparum cysteine proteinase falcipain 3 0.064 0.2203 1
Echinococcus granulosus cathepsin b 0.2788 1 1
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0172 0.0503 0.0467
Loa Loa (eye worm) calpain family protein 1 0.0053 0.0073 0.0073
Brugia malayi Cathepsin L-like precursor 0.064 0.2203 0.2173
Brugia malayi Cell death protein 3 precursor 0.009 0.0208 0.0171
Loa Loa (eye worm) histone deacetylase 7A 0.0043 0.0037 0.0037
Schistosoma mansoni caspase-7 (C14 family) 0.009 0.0208 0.0171
Plasmodium falciparum serine repeat antigen 2 0.0227 0.0702 0.3068
Toxoplasma gondii cathepsin CPC2 0.0227 0.0702 0.1877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Loa Loa (eye worm) ctsf protein 0.064 0.2203 0.2203
Echinococcus multilocularis cathepsin L cysteine protease 0.064 0.2203 0.2185
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0037 0.0016
Loa Loa (eye worm) hypothetical protein 0.064 0.2203 0.2203
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0227 0.0702 0.3068
Onchocerca volvulus Deterin homolog 0.0172 0.0503 0.2283
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0227 0.0702 0.0667
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0115 0.0299 0.0738
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0115 0.0299 0.0262
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0172 0.0503 0.0467
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0082 0.0044
Plasmodium falciparum serine repeat antigen 5 0.0227 0.0702 0.3068
Plasmodium vivax serine-repeat antigen (SERA) 0.0227 0.0702 0.3068
Loa Loa (eye worm) hypothetical protein 0.0613 0.2106 0.2106
Leishmania major cathepsin L-like protease 0.0737 0.2553 0.7106
Brugia malayi cathepsin Z-like cysteine proteinase 0.0227 0.0702 0.0667
Loa Loa (eye worm) prolyl oligopeptidase 0.0343 0.1126 0.1126
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.0798 0.0763
Brugia malayi Cathepsin L-like precursor 0.064 0.2203 0.2173
Loa Loa (eye worm) hypothetical protein 0.0172 0.0503 0.0503
Trypanosoma cruzi cysteine proteinase, putative 0.0253 0.0798 0.0763
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0227 0.0702 0.3068
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0227 0.0702 0.3068
Echinococcus granulosus cathepsin l1 0.0613 0.2106 0.2077
Toxoplasma gondii preprocathepsin c precursor, putative 0.0227 0.0702 0.1877
Loa Loa (eye worm) cysteine protease 0.064 0.2203 0.2203
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1019 0.3577 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0227 0.0702 0.3068
Brugia malayi cathepsin L-like cysteine proteinase 0.0227 0.0702 0.0667
Plasmodium vivax unspecified product 0.0253 0.0798 0.3513
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0037 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Brugia malayi prolyl oligopeptidase family protein 0.0115 0.0299 0.0262
Onchocerca volvulus 0.064 0.2203 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Plasmodium falciparum serine repeat antigen 7 0.0227 0.0702 0.3068
Brugia malayi hypothetical protein 0.0088 0.02 0.0163
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0227 0.0702 0.3068
Trypanosoma cruzi cysteine peptidase, putative 0.0737 0.2553 0.2525
Plasmodium falciparum serine repeat antigen 9 0.0227 0.0702 0.3068
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1019 0.3577 0.3553
Brugia malayi cathepsin Z-like cysteine proteinase 0.0227 0.0702 0.0667
Brugia malayi Cathepsin L-like precursor 0.0613 0.2106 0.2077
Leishmania major cathepsin L-like protease 0.0737 0.2553 0.7106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Loa Loa (eye worm) hypothetical protein 0.009 0.0208 0.0208
Brugia malayi Cathepsin L-like precursor 0.064 0.2203 0.2173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Echinococcus multilocularis cathepsin L 0.0227 0.0702 0.0681
Entamoeba histolytica cysteine proteinase, putative 0.0613 0.2106 0.9359
Loa Loa (eye worm) hypothetical protein 0.0043 0.0037 0.0037
Giardia lamblia Cathepsin B precursor 0.1019 0.3577 1
Onchocerca volvulus Cathepsin F homolog 0.064 0.2203 1
Echinococcus multilocularis geminin 0.0165 0.048 0.0459
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2788 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0253 0.0798 0.3513
Echinococcus multilocularis cathepsin b 0.2788 1 1
Leishmania major cathepsin L-like protease 0.064 0.2203 0.6116
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Schistosoma mansoni cathepsin F (C01 family) 0.0613 0.2106 0.2077
Loa Loa (eye worm) hypothetical protein 0.009 0.0208 0.0208
Echinococcus multilocularis cysteine protease 0.064 0.2203 0.2185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Loa Loa (eye worm) hypothetical protein 0.0227 0.0702 0.0702
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Onchocerca volvulus 0.0227 0.0702 0.3186
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.0798 0.0763
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.0798 0.0334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Echinococcus multilocularis apoptotic protease activating factor 1 0.009 0.0208 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.0798 0.0334
Onchocerca volvulus 0.064 0.2203 1
Echinococcus multilocularis histone deacetylase 7 0.0043 0.0037 0.0016
Schistosoma mansoni hypothetical protein 0.0165 0.048 0.0444
Leishmania major cathepsin L-like protease 0.064 0.2203 0.6116
Trypanosoma cruzi cysteine protease, putative 0.0253 0.0798 0.0763
Loa Loa (eye worm) cathepsin B 0.1019 0.3577 0.3577
Onchocerca volvulus 0.064 0.2203 1
Leishmania major cathepsin L-like protease 0.064 0.2203 0.6116
Brugia malayi Papain family cysteine protease containing protein 0.0227 0.0702 0.0667
Trypanosoma cruzi cysteine peptidase, putative 0.0737 0.2553 0.2525
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0056 0.0082 0.0044
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0227 0.0702 0.3068
Toxoplasma gondii cathepsin CPL 0.064 0.2203 0.6116
Schistosoma mansoni hypothetical protein 0.0165 0.048 0.0444
Onchocerca volvulus 0.064 0.2203 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0323 0.1052 0.1019
Echinococcus granulosus caspase 2 0.009 0.0208 0.0171
Loa Loa (eye worm) hypothetical protein 0.0047 0.0051 0.0051
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0227 0.0702 0.3068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Brugia malayi cathepsin F-like cysteine proteinase 0.0227 0.0702 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0227 0.0702 0.0667
Loa Loa (eye worm) fibroinase 0.064 0.2203 0.2203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.0798 0.2148
Echinococcus multilocularis histone deacetylase 0.0043 0.0037 0.0016
Schistosoma mansoni cathepsin S (C01 family) 0.0227 0.0702 0.0667
Entamoeba histolytica cysteine proteinase 2 0.0253 0.0798 0.0641
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1019 0.3577 0.3553
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0343 0.1126 0.1107
Echinococcus granulosus cathepsin l1 0.064 0.2203 0.2173
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0227 0.0702 0.3068
Brugia malayi Cathepsin L-like precursor 0.064 0.2203 0.2173
Loa Loa (eye worm) hypothetical protein 0.0053 0.0073 0.0073
Echinococcus granulosus inhibitor of apoptosis protein 0.0172 0.0503 0.0467
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.0798 0.0641
Leishmania major cathepsin L-like protease 0.064 0.2203 0.6116
Loa Loa (eye worm) papain family cysteine protease containing protein 0.064 0.2203 0.2203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.0798 0.2148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0227 0.0702 0.0667
Brugia malayi Cathepsin L-like precursor 0.064 0.2203 0.2173
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0115 0.0299 0.0262
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0227 0.0702 0.3068
Plasmodium falciparum cysteine proteinase falcipain 2a 0.064 0.2203 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Echinococcus multilocularis calpain A 0.0056 0.0082 0.006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2788 1 1
Onchocerca volvulus 0.009 0.0208 0.0944
Brugia malayi prolyl oligopeptidase family protein 0.0343 0.1126 0.1093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.0798 0.0641
Echinococcus granulosus cysteine protease 0.0253 0.0798 0.0763
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0227 0.0702 0.3068
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2788 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0227 0.0702 0.0667
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0037 0.0016
Loa Loa (eye worm) hypothetical protein 0.0613 0.2106 0.2106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Schistosoma mansoni hypothetical protein 0.0172 0.0503 0.0467
Echinococcus granulosus cathepsin L 0.0253 0.0798 0.0763
Leishmania major cathepsin L-like protease 0.0737 0.2553 0.7106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Plasmodium falciparum serine repeat antigen 4 0.0227 0.0702 0.3068
Plasmodium falciparum serine repeat antigen 6 0.0227 0.0702 0.3068
Loa Loa (eye worm) hypothetical protein 0.2788 1 1
Plasmodium falciparum serine repeat antigen 8 0.0227 0.0702 0.3068
Loa Loa (eye worm) hypothetical protein 0.0172 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0227 0.0702 0.0702
Plasmodium vivax vivapain-3 0.0253 0.0798 0.3513
Onchocerca volvulus 0.064 0.2203 1
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2788 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0253 0.0798 0.0763
Loa Loa (eye worm) hypothetical protein 0.0088 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0039 0.0022 0.0022
Entamoeba histolytica cysteine proteinase, putative 0.064 0.2203 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0172 0.0503 0.0482
Echinococcus multilocularis cathepsin L cysteine protease 0.064 0.2203 0.2185
Trypanosoma cruzi cysteine peptidase, putative 0.0253 0.0798 0.0763
Brugia malayi fibroinase precursor 0.0227 0.0702 0.0667
Echinococcus granulosus geminin 0.0165 0.048 0.0444
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Echinococcus granulosus cathepsin L cysteine proteinase 0.064 0.2203 0.2173
Loa Loa (eye worm) calpain family protein 1 0.0039 0.0022 0.0022
Brugia malayi cathepsin L precursor 0.0227 0.0702 0.0667
Trypanosoma brucei cysteine peptidase C (CPC) 0.1019 0.3577 1
Loa Loa (eye worm) hypothetical protein 0.0227 0.0702 0.0702
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0227 0.0702 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2788 1 1
Brugia malayi calpain family protein 1 0.0053 0.0073 0.0036
Onchocerca volvulus 0.064 0.2203 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.0798 0.0641
Plasmodium falciparum serine repeat antigen 1 0.0227 0.0702 0.3068
Onchocerca volvulus 0.064 0.2203 1
Onchocerca volvulus Cathepsin L homolog 0.064 0.2203 1
Onchocerca volvulus 0.0172 0.0503 0.2283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0227 0.0702 0.0667
Brugia malayi calpain family protein 1 0.0053 0.0073 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0613 0.2106 0.4884
Brugia malayi cathepsin L-like precursor 0.0613 0.2106 0.2077
Plasmodium vivax unspecified product 0.0227 0.0702 0.3068
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0115 0.0299 0.0262
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0227 0.0702 0.0667
Brugia malayi hypothetical protein 0.009 0.0208 0.0171
Loa Loa (eye worm) hypothetical protein 0.0227 0.0702 0.0702
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0172 0.0503 0.0467
Schistosoma mansoni cathepsin F (C01 family) 0.064 0.2203 0.2173
Loa Loa (eye worm) hypothetical protein 0.0043 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.071 0.2457 0.2428
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0115 0.0299 0.0277
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0227 0.0702 0.3068
Plasmodium falciparum cysteine proteinase falcipain 2b 0.064 0.2203 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0227 0.0702 0.0667
Echinococcus granulosus cathepsin l cysteine peptidase 0.064 0.2203 0.2173
Schistosoma mansoni hypothetical protein 0.009 0.0208 0.0171
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0227 0.0702 0.3068
Brugia malayi Papain family cysteine protease containing protein 0.064 0.2203 0.2173
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.064 0.2203 0.5219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.064 0.2203 0.2203
Echinococcus multilocularis cathepsin l cysteine peptidase 0.064 0.2203 0.2185
Trypanosoma cruzi cysteine peptidase, putative 0.064 0.2203 0.2173
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0253 0.0798 0.0763
Brugia malayi Papain family cysteine protease containing protein 0.0253 0.0798 0.0763
Echinococcus granulosus cathepsin L 0.0227 0.0702 0.0667
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0227 0.0702 0.0667
Onchocerca volvulus Cell death protein 3 homolog 0.009 0.0208 0.0944
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0115 0.0299 0.0738
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0227 0.0702 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.064 0.2203 0.5219
Onchocerca volvulus Cathepsin L homolog 0.064 0.2203 1
Loa Loa (eye worm) hypothetical protein 0.0227 0.0702 0.0702
Schistosoma mansoni cathepsin C 0.0227 0.0702 0.0667
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0056 0.0082 0.006
Brugia malayi Cathepsin L-like precursor 0.0613 0.2106 0.2077
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0343 0.1126 0.1093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1019 0.3577 1
Entamoeba histolytica cysteine protease, putative 0.064 0.2203 1
Brugia malayi Cathepsin L-like precursor 0.064 0.2203 0.2173
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0227 0.0702 0.3068
Schistosoma mansoni cathepsin F (C01 family) 0.064 0.2203 0.2173
Echinococcus multilocularis cathepsin b 0.2788 1 1
Leishmania major cysteine peptidase A (CPA) 0.064 0.2203 0.6116
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0053 0.0073 0.0036
Echinococcus granulosus cathepsin b 0.2788 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0227 0.0702 0.0667
Echinococcus granulosus cathepsin L cysteine protease 0.0253 0.0798 0.0763
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0227 0.0702 0.0702
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0343 0.1126 0.5113
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0082 0.0044
Echinococcus multilocularis inhibitor of apoptosis protein 0.0172 0.0503 0.0482
Echinococcus granulosus apoptotic protease activating factor 1 0.009 0.0208 0.0171
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Echinococcus multilocularis cathepsin L 0.0253 0.0798 0.0778
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0115 0.0299 0.0738
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Plasmodium vivax serine-repeat antigen (SERA) 0.0227 0.0702 0.3068
Toxoplasma gondii cathepsin B 0.1019 0.3577 1
Loa Loa (eye worm) hypothetical protein 0.0613 0.2106 0.2106
Trypanosoma cruzi cysteine peptidase, putative 0.0737 0.2553 0.2525
Toxoplasma gondii cathepsin CPC1 0.0227 0.0702 0.1877
Echinococcus multilocularis cathepsin l cysteine peptidase 0.064 0.2203 0.2185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0227 0.0702 0.0702

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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