Detailed information for compound 832813

Basic information

Technical information
  • TDR Targets ID: 832813
  • Name: 8-Methyl-1,2,3a,4,5,6-hexahydro-3H-pyrazino[3 ,2,1-jk]carbazole-3-carboxamide
  • MW: 269.342 | Formula: C16H19N3O
  • H donors: 1 H acceptors: 1 LogP: 1.61 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)c1CCCC3c1n2CCN3C(=O)N
  • InChi: 1S/C16H19N3O/c1-10-5-6-13-12(9-10)11-3-2-4-14-15(11)18(13)7-8-19(14)16(17)20/h5-6,9,14H,2-4,7-8H2,1H3,(H2,17,20)
  • InChiKey: DGUSFMGFVIXVRR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole-3-carboxamide
  • STOCK2S-15039
  • BAS 00454713
  • Oprea1_266885
  • Oprea1_708550

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax unspecified product 0.031 0.0889 0.3717
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0259 0.0721 0.0721
Onchocerca volvulus 0.0259 0.0721 0.3028
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0069 0.0069
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.006 0.006
Plasmodium falciparum cysteine proteinase falcipain 1 0.031 0.0889 0.3717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.031 0.0889 0.0585
Echinococcus granulosus histone deacetylase 6 0.0042 0.0006 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.031 0.0889 0.1011
Schistosoma mansoni cathepsin F (C01 family) 0.0711 0.2214 0.2214
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0343 0.0997 0.0997
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1129 0.3591 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2381 0.5785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0711 0.2214 0.5201
Echinococcus multilocularis geminin 0.0494 0.1495 0.1495
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0259 0.0721 0.3011
Trypanosoma cruzi cysteine peptidase, putative 0.031 0.0889 0.0884
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0014 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0948 0.2993 0.2989
Echinococcus granulosus histone deacetylase 6 0.0042 0.0006 0.0006
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0034 0.0034
Entamoeba histolytica cysteine protease, putative 0.031 0.0889 0.1011
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0115 0.0246 0.0241
Brugia malayi Papain family cysteine protease containing protein 0.0259 0.0721 0.0721
Giardia lamblia Cathepsin B precursor 0.1129 0.3591 1
Leishmania major cysteine peptidase A (CPA) 0.0762 0.2381 0.6626
Leishmania major cathepsin L-like protease 0.0948 0.2993 0.8331
Schistosoma mansoni cathepsin S (C01 family) 0.0259 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.0711 0.2214 0.2214
Loa Loa (eye worm) RNA binding protein 0.0061 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0762 0.2381 0.2381
Onchocerca volvulus 0.0762 0.2381 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2381 0.5785
Leishmania major cathepsin L-like protease 0.0762 0.2381 0.6626
Echinococcus granulosus histone deacetylase 6 0.0042 0.0006 0.0006
Plasmodium vivax serine-repeat antigen (SERA) 0.0259 0.0721 0.3011
Echinococcus granulosus cathepsin l1 0.0762 0.2381 0.2381
Brugia malayi prolyl oligopeptidase family protein 0.0343 0.0997 0.0997
Entamoeba histolytica cysteine proteinase, putative 0.031 0.0889 0.1011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0184 0.0474 0.0474
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2993 0.8331
Entamoeba histolytica cysteine protease, putative 0.031 0.0889 0.1011
Loa Loa (eye worm) hypothetical protein 0.0042 0.0006 0.0006
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0762 0.2381 0.2381
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3071 1 1
Echinococcus multilocularis histone deacetylase 7 0.0042 0.0006 0.0006
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0115 0.0246 0.0671
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0069 0.0069
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0051 0.0034 0.0034
Brugia malayi Cathepsin L-like precursor 0.0762 0.2381 0.2381
Loa Loa (eye worm) hypothetical protein 0.0055 0.0046 0.0046
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.006 0.5
Echinococcus multilocularis cathepsin L 0.0259 0.0721 0.0721
Echinococcus multilocularis cysteine protease 0.0762 0.2381 0.2381
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2381 0.5785
Loa Loa (eye worm) hypothetical protein 0.0259 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.0051 0.0034 0.0034
Plasmodium falciparum cysteine proteinase falcipain 3 0.0762 0.2381 1
Loa Loa (eye worm) histone deacetylase 7A 0.0042 0.0006 0.0006
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0361 0.1056 0.1051
Brugia malayi Papain family cysteine protease containing protein 0.0762 0.2381 0.2381
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0259 0.0721 0.3011
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.0599 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0115 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0259 0.0721 0.0721
Echinococcus granulosus tar DNA binding protein 0.0061 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0048 0.0026 0.0026
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2993 0.8331
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0259 0.0721 0.3011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.006 0.5
Plasmodium falciparum serine repeat antigen 2 0.0259 0.0721 0.3011
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0259 0.0721 0.3011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0014 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0948 0.2993 0.2989
Echinococcus granulosus cathepsin l1 0.0711 0.2214 0.2214
Schistosoma mansoni cathepsin s 0.0051 0.0034 0.0034
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0259 0.0721 0.3011
Schistosoma mansoni hypothetical protein 0.0494 0.1495 0.1495
Entamoeba histolytica cysteine protease, putative 0.031 0.0889 0.1011
Onchocerca volvulus Cathepsin F homolog 0.0762 0.2381 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0259 0.0721 0.0721
Entamoeba histolytica cysteine proteinase, putative 0.031 0.0889 0.1011
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0259 0.0721 0.0721
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0259 0.0721 0.0721
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0711 0.2214 0.5201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0014 0.0014
Brugia malayi fibroinase precursor 0.0259 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.0259 0.0721 0.0721
Giardia lamblia Cathepsin B precursor 0.1129 0.3591 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2381 0.5785
Brugia malayi calpain family protein 1 0.0055 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.031 0.0889 0.2463
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0259 0.0721 0.0721
Plasmodium vivax vivapain-2 0.0762 0.2381 1
Brugia malayi Histone deacetylase family protein 0.0042 0.0006 0.0006
Brugia malayi Cathepsin L-like precursor 0.0762 0.2381 0.2381
Loa Loa (eye worm) hypothetical protein 0.0088 0.0157 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2993 0.8331
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2381 0.5785
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0259 0.0721 0.3011
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0343 0.0997 0.0997
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0259 0.0721 0.0721
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.006 0.006
Leishmania major cathepsin L-like protease 0.0948 0.2993 0.8331
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0259 0.0721 0.3011
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1129 0.3591 0.3587
Brugia malayi Cathepsin L-like precursor 0.0711 0.2214 0.2214
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0259 0.0721 0.3011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2993 0.8331
Trypanosoma cruzi cysteine peptidase, putative 0.0948 0.2993 0.2989
Loa Loa (eye worm) cysteine protease 0.0762 0.2381 0.2381
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0069 0.0069
Leishmania major cathepsin L-like protease 0.0762 0.2381 0.6626
Loa Loa (eye worm) hypothetical protein 0.0051 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0711 0.2214 0.2214
Trypanosoma cruzi cysteine proteinase, putative 0.031 0.0889 0.0884
Loa Loa (eye worm) ctsf protein 0.0762 0.2381 0.2381
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1129 0.3591 0.3591
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0014 0.0014
Echinococcus granulosus Dipeptidyl peptidase 9 0.0115 0.0246 0.0246
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0361 0.1056 0.1056
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.3071 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0014 0.0014
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3071 1 1
Leishmania major cathepsin L-like protease 0.0762 0.2381 0.6626
Entamoeba histolytica cysteine protease, putative 0.031 0.0889 0.1011
Brugia malayi Histone deacetylase family protein 0.0042 0.0006 0.0006
Brugia malayi cathepsin L-like precursor 0.0711 0.2214 0.2214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0014 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0069 0.0069
Onchocerca volvulus 0.0762 0.2381 1
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0006 0.0006
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0762 0.2381 0.2381
Trypanosoma cruzi cysteine proteinase, putative 0.031 0.0889 0.0884
Schistosoma mansoni cathepsin F (C01 family) 0.0762 0.2381 0.2381
Loa Loa (eye worm) hypothetical protein 0.0259 0.0721 0.0721
Entamoeba histolytica cysteine protease, putative 0.031 0.0889 0.1011
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.031 0.0889 0.0889
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0069 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2993 0.8331
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0014 0.0014
Entamoeba histolytica cysteine proteinase 1, putative 0.031 0.0889 0.1011
Loa Loa (eye worm) fibroinase 0.0762 0.2381 0.2381
Brugia malayi calpain family protein 1 0.0055 0.0046 0.0046
Leishmania major cathepsin L-like protease 0.0762 0.2381 0.6626
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0115 0.0246 0.0671
Brugia malayi Papain family cysteine protease containing protein 0.031 0.0889 0.0889
Leishmania major cathepsin L-like protease 0.0762 0.2381 0.6626
Loa Loa (eye worm) cathepsin B 0.1129 0.3591 0.3591
Trypanosoma cruzi cruzipain precursor, putative 0.0948 0.2993 0.2989
Schistosoma mansoni cathepsin C 0.0259 0.0721 0.0721
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2381 0.5785
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.006 0.006
Trypanosoma cruzi cysteine protease, putative 0.031 0.0889 0.0884
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0115 0.0246 0.0241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2381 0.5785
Onchocerca volvulus 0.0762 0.2381 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.0361 0.1056 0.293
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.006 0.5
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0259 0.0721 0.0721
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2381 0.5785
Loa Loa (eye worm) calpain family protein 1 0.0055 0.0046 0.0046
Entamoeba histolytica cysteine protease, putative 0.0762 0.2381 1
Plasmodium falciparum serine repeat antigen 5 0.0259 0.0721 0.3011
Brugia malayi Papain family cysteine protease containing protein 0.0259 0.0721 0.0721
Brugia malayi Papain family cysteine protease containing protein 0.031 0.0889 0.0889
Loa Loa (eye worm) hypothetical protein 0.0042 0.0006 0.0006
Onchocerca volvulus Cathepsin L homolog 0.0762 0.2381 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0034 0.0034
Plasmodium falciparum serine repeat antigen 3 0.0259 0.0721 0.3011
Trypanosoma brucei cysteine peptidase C (CPC) 0.1129 0.3591 1
Echinococcus granulosus cysteine protease 0.031 0.0889 0.0889
Schistosoma mansoni hypothetical protein 0.0494 0.1495 0.1495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2381 0.5785
Trypanosoma cruzi major cysteine proteinase, putative 0.0259 0.0721 0.0716
Echinococcus multilocularis cathepsin L cysteine protease 0.0762 0.2381 0.2381
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0054 0.0054
Entamoeba histolytica cysteine proteinase, putative 0.031 0.0889 0.1011
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0115 0.0246 0.0671
Entamoeba histolytica cysteine proteinase, putative 0.0762 0.2381 1
Brugia malayi Cathepsin L-like precursor 0.0762 0.2381 0.2381
Plasmodium vivax vivapain-1 0.031 0.0889 0.3717
Brugia malayi hypothetical protein 0.0088 0.0157 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2381 0.5785
Plasmodium falciparum serine repeat antigen 1 0.0259 0.0721 0.3011
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0762 0.2381 0.5785
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0259 0.0721 0.3011
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0762 0.2381 0.2381
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2993 0.8331
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0057 0.0054 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2993 0.8331
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3071 1 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2381 0.5785
Leishmania major C-8 sterol isomerase-like protein 0.0361 0.1056 0.293
Entamoeba histolytica cysteine protease, putative 0.031 0.0889 0.1011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3071 1 1
Plasmodium vivax unspecified product 0.0259 0.0721 0.3011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.031 0.0889 0.2463
Plasmodium falciparum serine repeat antigen 9 0.0259 0.0721 0.3011
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0046 0.0046
Brugia malayi Cathepsin L-like cysteine proteinase 0.0711 0.2214 0.2214
Schistosoma mansoni histone deacetylase 4 5 0.0042 0.0006 0.0006
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0343 0.0997 0.0997
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0259 0.0721 0.3011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2381 0.5785
Leishmania major cathepsin L-like protease 0.0948 0.2993 0.8331
Toxoplasma gondii cathepsin CPL 0.0762 0.2381 0.6626
Toxoplasma gondii preprocathepsin c precursor, putative 0.0259 0.0721 0.1995
Echinococcus granulosus cathepsin b 0.3071 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.031 0.0889 0.0884
Toxoplasma gondii cathepsin CPC2 0.0259 0.0721 0.1995
Schistosoma mansoni histone deacetylase 4 5 0.0042 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0259 0.0721 0.0721
Plasmodium falciparum serine repeat antigen 7 0.0259 0.0721 0.3011
Echinococcus multilocularis cathepsin L 0.031 0.0889 0.0889
Trypanosoma cruzi cruzipain precursor, putative 0.0051 0.0034 0.0028
Loa Loa (eye worm) hypothetical protein 0.0361 0.1056 0.1056
Loa Loa (eye worm) hypothetical protein 0.3071 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0762 0.2381 0.2377
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.006 0.006
Entamoeba histolytica cysteine protease, putative 0.031 0.0889 0.1011
Echinococcus multilocularis histone deacetylase 0.0042 0.0006 0.0006
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.0034 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2381 0.5785
Echinococcus granulosus cathepsin L 0.0259 0.0721 0.0721
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2381 0.5785
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.031 0.0889 0.0889
Plasmodium vivax vivapain-2 0.0762 0.2381 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0343 0.0997 0.0997
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0115 0.0246 0.0246
Onchocerca volvulus Cathepsin L homolog 0.0259 0.0721 0.3028
Entamoeba histolytica cysteine proteinase, putative 0.0762 0.2381 1
Brugia malayi Cathepsin L-like precursor 0.0051 0.0034 0.0034
Giardia lamblia Cathepsin B precursor 0.1129 0.3591 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0259 0.0721 0.0721
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0259 0.0721 0.0721
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0259 0.0721 0.3011
Echinococcus granulosus histone deacetylase 7 0.0042 0.0006 0.0006
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0762 0.2381 1
Echinococcus granulosus calpain A 0.0057 0.0054 0.0054
Echinococcus multilocularis cathepsin b 0.3071 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0762 0.2381 0.5785
Onchocerca volvulus 0.0762 0.2381 1
Echinococcus granulosus histone deacetylase 0.0042 0.0006 0.0006
Entamoeba histolytica cysteine protease, putative 0.031 0.0889 0.1011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2993 0.8331
Plasmodium vivax serine-repeat antigen (SERA) 0.0259 0.0721 0.3011
Echinococcus multilocularis cysteine protease 0.0762 0.2381 0.2381
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0006 0.0006
Onchocerca volvulus 0.0762 0.2381 1
Plasmodium falciparum serine repeat antigen 6 0.0259 0.0721 0.3011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2381 0.5785
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0259 0.0721 0.0721
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0057 0.0054 0.0054
Brugia malayi Cathepsin L-like precursor 0.0711 0.2214 0.2214
Onchocerca volvulus 0.0711 0.2214 0.9295
Brugia malayi cathepsin F-like cysteine proteinase 0.0259 0.0721 0.0721
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0069 0.0069
Brugia malayi cathepsin L-like cysteine proteinase 0.0259 0.0721 0.0721
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2993 0.8331
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.031 0.0889 0.0889
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0034 0.0028
Brugia malayi RNA binding protein 0.0061 0.0069 0.0069
Plasmodium vivax unspecified product 0.0051 0.0034 0.0118
Echinococcus granulosus cathepsin L cysteine proteinase 0.0762 0.2381 0.2381
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0259 0.0721 0.0721
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0762 0.2381 0.2381
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0897 0.2825 0.2821
Loa Loa (eye worm) hypothetical protein 0.0259 0.0721 0.0721
Brugia malayi prolyl oligopeptidase family protein 0.0115 0.0246 0.0246
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2381 0.5785
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0259 0.0721 0.3011
Onchocerca volvulus Cathepsin L homolog 0.0762 0.2381 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0259 0.0721 0.0721
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0069 0.0069
Schistosoma mansoni cathepsin F (C01 family) 0.0762 0.2381 0.2381
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0762 0.2381 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2381 0.5785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2381 0.5785
Onchocerca volvulus 0.0762 0.2381 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2381 0.5785
Loa Loa (eye worm) histone deacetylase 0.0042 0.0006 0.0006
Brugia malayi Cathepsin L-like precursor 0.0762 0.2381 0.2381
Plasmodium vivax vivapain-3 0.031 0.0889 0.3717
Echinococcus granulosus cathepsin L 0.031 0.0889 0.0889
Brugia malayi Papain family cysteine protease containing protein 0.0259 0.0721 0.0721
Toxoplasma gondii cathepsin CPC1 0.0259 0.0721 0.1995
Brugia malayi TAR-binding protein 0.0061 0.0069 0.0069
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0259 0.0721 0.0721
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0069 0.0069
Brugia malayi Cathepsin L-like precursor 0.0762 0.2381 0.2381
Brugia malayi Cathepsin L-like precursor 0.0762 0.2381 0.2381
Entamoeba histolytica cysteine protease, putative 0.031 0.0889 0.1011
Brugia malayi cathepsin Z-like cysteine proteinase 0.0259 0.0721 0.0721
Entamoeba histolytica cysteine proteinase, putative 0.0711 0.2214 0.8989
Trypanosoma cruzi major cysteine proteinase, putative 0.0444 0.1332 0.1327
Echinococcus multilocularis calpain A 0.0057 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2381 0.5785
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1129 0.3591 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2993 0.8331
Onchocerca volvulus 0.0762 0.2381 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0762 0.2381 0.2381
Brugia malayi cathepsin L precursor 0.0259 0.0721 0.0721
Echinococcus granulosus cathepsin b 0.3071 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0762 0.2381 0.2381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2381 0.5785
Echinococcus multilocularis cathepsin b 0.3071 1 1
Schistosoma mansoni histone deacetylase hda2 0.0042 0.0006 0.0006
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0054 0.0054
Plasmodium falciparum serine repeat antigen 4 0.0259 0.0721 0.3011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.031 0.0889 0.0585
Entamoeba histolytica cysteine protease, putative 0.031 0.0889 0.1011
Echinococcus granulosus geminin 0.0494 0.1495 0.1495
Entamoeba histolytica cysteine protease, putative 0.031 0.0889 0.1011
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.006 0.015
Schistosoma mansoni cathepsin B (C01 family) 0.0259 0.0721 0.0721
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.006 0.015
Entamoeba histolytica cysteine proteinase 2 0.031 0.0889 0.1011
Entamoeba histolytica cysteine protease, putative 0.031 0.0889 0.1011
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0343 0.0997 0.4187
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0115 0.0246 0.0671
Entamoeba histolytica cysteine protease, putative 0.031 0.0889 0.1011
Echinococcus granulosus cathepsin L cysteine protease 0.031 0.0889 0.0889
Plasmodium falciparum serine repeat antigen 8 0.0259 0.0721 0.3011
Toxoplasma gondii cathepsin B 0.1129 0.3591 1
Loa Loa (eye worm) hypothetical protein 0.0711 0.2214 0.2214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2993 0.8331
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0014 0.0014
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0259 0.0721 0.3011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2381 0.5785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2381 0.5785
Brugia malayi cathepsin Z-like cysteine proteinase 0.0259 0.0721 0.0721

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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