Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0154 | 0.039 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0132 | 0.1877 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0592 | 0.194 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0154 | 0.0257 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0323 | 0.0172 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0054 | 0.0694 | 0.0549 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0075 | 0.1014 | 0.2696 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.001 | 0.0019 | 0.0002 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0054 | 0.0694 | 0.0549 |
Echinococcus multilocularis | protein patched | 0.0054 | 0.0694 | 0.0549 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0154 | 0.0504 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.1392 | 0.7256 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0323 | 0.1965 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0154 | 0.1578 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0108 | 0.0355 |
Trichomonas vaginalis | set domain proteins, putative | 0.0238 | 0.3493 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0062 | 0.0809 | 0.2277 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0062 | 0.0809 | 0.2277 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.0877 | 0.4343 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0154 | 0.1704 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0054 | 0.0694 | 0.2273 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0132 | 0.1877 | 0.175 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0075 | 0.1014 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0054 | 0.0694 | 0.0549 |
Loa Loa (eye worm) | acetyltransferase | 0.0146 | 0.2085 | 0.6831 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0075 | 0.1014 | 1 |
Brugia malayi | CHE-14 protein | 0.0054 | 0.0694 | 0.1989 |
Echinococcus multilocularis | protein dispatched 1 | 0.0054 | 0.0694 | 0.0549 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0075 | 0.1014 | 0.2799 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0142 | 0.2023 | 0.1898 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0146 | 0.2085 | 0.6714 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0075 | 0.1014 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.0877 | 0.4343 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0666 | 1 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0049 | 0.0619 | 0.0472 |
Brugia malayi | Probable ClpP-like protease | 0.0075 | 0.1014 | 0.3077 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0146 | 0.2085 | 0.1961 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0043 | 0.0518 | 0.1439 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0146 | 0.2085 | 0.1961 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0132 | 0.1877 | 0.6008 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0229 | 0.3345 | 0.3241 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.0464 | 0.563 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.0877 | 0.0734 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0132 | 0.1877 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0108 | 0.0355 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0154 | 0.0257 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0154 | 0.0257 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0666 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) | 0.0229 | 0.3345 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0062 | 0.0809 | 0.2277 |
Echinococcus multilocularis | tumor protein p63 | 0.0326 | 0.4828 | 0.4747 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.246 | 0.2343 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0154 | 0.014 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0229 | 0.3345 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0323 | 0.0172 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0062 | 0.0809 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0323 | 0.0172 |
Onchocerca volvulus | 0.0238 | 0.3493 | 1 | |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0075 | 0.1014 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0075 | 0.1014 | 0.0874 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.0518 | 0.037 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0132 | 0.1877 | 0.5465 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0043 | 0.0518 | 0.5018 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1014 | 0.3323 |
Echinococcus granulosus | tumor protein p63 | 0.0326 | 0.4828 | 0.4747 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0075 | 0.1014 | 0.2441 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.0877 | 0.0734 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.0518 | 0.4238 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0132 | 0.1877 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0026 | 0.0262 | 0.1252 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0066 | 0.0877 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0694 | 0.2273 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0132 | 0.1877 | 0.175 |
Echinococcus multilocularis | geminin | 0.0171 | 0.246 | 0.2343 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.0451 | 0.0302 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0016 | 0.0108 | 0.0355 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0323 | 0.0172 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0132 | 0.1877 | 0.175 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0026 | 0.0262 | 0.1252 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.0877 | 0.4343 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0049 | 0.0619 | 0.1158 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0209 | 0.3052 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.0464 | 0.5193 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0043 | 0.0518 | 0.1439 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0026 | 0.0262 | 0.1252 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0592 | 0.0445 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.0451 | 0.0302 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0075 | 0.1014 | 0.2799 |
Brugia malayi | Pre-SET motif family protein | 0.0209 | 0.3052 | 1 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.001 | 0.0019 | 0.0002 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0323 | 0.0172 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0229 | 0.3345 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0154 | 0.0257 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0154 | 0.039 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0066 | 0.0877 | 0.2609 |
Onchocerca volvulus | 0.0048 | 0.0592 | 0.0849 | |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1877 | 0.615 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0049 | 0.0619 | 0.1457 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0075 | 0.1014 | 0.0874 |
Toxoplasma gondii | hypothetical protein | 0.0026 | 0.0262 | 0.2436 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0154 | 0.1353 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0054 | 0.0694 | 0.0549 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0075 | 0.1014 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0049 | 0.0619 | 0.1457 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0323 | 0.0729 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.0464 | 0.3606 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.0877 | 0.2872 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0323 | 0.0172 |
Echinococcus granulosus | geminin | 0.0171 | 0.246 | 0.2343 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0229 | 0.3345 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0323 | 0.0172 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0075 | 0.1014 | 0.0874 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.0877 | 0.0734 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0054 | 0.0694 | 0.0549 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0049 | 0.0619 | 0.0472 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.1392 | 0.1257 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0323 | 0.1058 |
Schistosoma mansoni | patched 1 | 0.0054 | 0.0694 | 0.0549 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0066 | 0.0877 | 0.4343 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0306 | 0.0155 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0132 | 0.1877 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.246 | 0.2343 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0075 | 0.1014 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0154 | 0.0154 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0075 | 0.1014 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0043 | 0.0518 | 0.5018 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0323 | 0.3053 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0054 | 0.0694 | 0.0549 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0054 | 0.0694 | 0.1944 |
Trichomonas vaginalis | MYB, putative | 0.001 | 0.0019 | 0.0002 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.