Detailed information for compound 840109

Basic information

Technical information
  • TDR Targets ID: 840109
  • Name: 3-[(3-chloro-4-methoxyphenyl)amino]-2-(4-chlo rophenyl)-3H-isoindol-1-one
  • MW: 399.27 | Formula: C21H16Cl2N2O2
  • H donors: 1 H acceptors: 1 LogP: 5.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Cl)NC1c2ccccc2C(=O)N1c1ccc(cc1)Cl
  • InChi: 1S/C21H16Cl2N2O2/c1-27-19-11-8-14(12-18(19)23)24-20-16-4-2-3-5-17(16)21(26)25(20)15-9-6-13(22)7-10-15/h2-12,20,24H,1H3
  • InChiKey: ABYHDCWRDIETMW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(3-chloro-4-methoxy-phenyl)amino]-2-(4-chlorophenyl)isoindolin-1-one
  • 3-[(3-chloro-4-methoxyphenyl)amino]-2-(4-chlorophenyl)-1-isoindolinone
  • 3-[(3-chloro-4-methoxy-phenyl)amino]-2-(4-chlorophenyl)-3H-isoindol-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.005 0.0327 0.0315
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0414 0.8703
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.0222 0.4631
Echinococcus multilocularis tyrosine protein kinase Abl 0.0039 0.0203 0.0191
Schistosoma mansoni tyrosine kinase 0.0039 0.0203 0.0201
Plasmodium falciparum calcium-dependent protein kinase 4 0.0041 0.0223 0.4225
Loa Loa (eye worm) hypothetical protein 0.0117 0.1083 0.1072
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0033 0.0134 0.0123
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0024 0.0039 0.0037
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0028 0.0079 0.1658
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.0203 0.0191
Loa Loa (eye worm) hypothetical protein 0.0141 0.1357 0.1347
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0184 0.1847 0.1837
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0041 0.0227 0.0465
Schistosoma mansoni tyrosine kinase 0.0114 0.1053 0.1052
Schistosoma mansoni tyrosine kinase 0.0039 0.0203 0.0201
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0117 0.1091 0.2619
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0041 0.0223 0.4689
Schistosoma mansoni protein kinase 0.0025 0.004 0.0038
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0904 1 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0114 0.1053 0.1043
Brugia malayi hypothetical protein 0.0033 0.0134 0.0122
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0327 0.0315
Echinococcus granulosus tyrosine protein kinase Btk29A 0.017 0.1684 0.1674
Echinococcus multilocularis cyclin dependent kinase 0.005 0.0327 0.0315
Echinococcus multilocularis calcium dependent protein kinase 0.0033 0.0135 0.0123
Echinococcus granulosus growth factor receptor bound protein 2 0.0022 0.0013 0.0001
Echinococcus multilocularis tyrosine protein kinase Blk 0.0033 0.0134 0.0123
Trypanosoma cruzi aurora B kinase, putative 0.0063 0.0475 0.1083
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0027
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0327 0.0315
Schistosoma mansoni protein kinase 0.0041 0.0222 0.0221
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0234 0.4871
Echinococcus granulosus tyrosine protein kinase Src64B 0.0039 0.0203 0.0191
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0039 0.0203 0.0191
Entamoeba histolytica protein kinase, putative 0.0063 0.0475 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0414 0.0931
Echinococcus multilocularis tyrosine protein kinase shark 0.0242 0.2506 0.2497
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0475 1
Brugia malayi ephrin receptor 1 precursor 0.0072 0.0575 0.0563
Echinococcus multilocularis mitogen activated protein kinase 11 0.0379 0.4054 0.4047
Onchocerca volvulus 0.0033 0.0134 0.039
Schistosoma mansoni protein kinase 0.0041 0.0222 0.0221
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0234 0.4871
Brugia malayi Protein kinase domain containing protein 0.0365 0.39 0.3892
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0031 0.0115 0.0104
Brugia malayi cell division control protein 2 homolog 0.005 0.0327 0.0314
Loa Loa (eye worm) TK/ALK protein kinase 0.0249 0.2579 0.257
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0041 0.0227 0.0465
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0414 0.8598
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0222 0.0221
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0475 0.0463
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0063 0.0475 0.0463
Loa Loa (eye worm) hypothetical protein 0.0041 0.0222 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0235 0.2419 0.2418
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.002 0.0019
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0381 0.037
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0063 0.0475 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0024 0.0039 0.0027
Schistosoma mansoni tyrosine kinase 0.0272 0.284 0.2839
Echinococcus granulosus aurora kinase A 0.0063 0.0475 0.0463
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0475 0.0463
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0025 0.004 0.0028
Brugia malayi SH2 domain containing protein 0.0033 0.0134 0.0122
Echinococcus multilocularis neuroglian 0.003 0.0099 0.0087
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0414 0.0931
Onchocerca volvulus Tyrosine kinase homolog 0.0158 0.1553 1
Echinococcus multilocularis protein kinase shaggy 0.0055 0.0381 0.037
Brugia malayi Furin-like cysteine rich region family protein 0.0425 0.4572 0.4565
Onchocerca volvulus 0.0055 0.0381 0.2063
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0055 0.0381 0.037
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0041 0.0222 0.0211
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0028 0.0079 0.0929
Echinococcus granulosus cyclin dependent kinase 5 0.005 0.0327 0.0315
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0379 0.4054 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0055 0.0381 0.038
Loa Loa (eye worm) hypothetical protein 0.0033 0.0134 0.0123
Trypanosoma brucei cdc2-related kinase 1 0.005 0.0327 0.0714
Entamoeba histolytica protein kinase domain containing protein 0.0063 0.0475 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0033 0.0134 0.0123
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0117 0.1091 0.1081
Schistosoma mansoni tyrosine kinase 0.0242 0.2506 0.2505
Echinococcus multilocularis insulin receptor 0.0365 0.39 0.3893
Trypanosoma brucei aurora B kinase 0.0063 0.0475 0.1083
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0077
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0234 0.4871
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0379 0.4054 1
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0381 0.7891
Echinococcus granulosus defective proboscis extension response 0.0024 0.0039 0.0027
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0063 0.0475 0.0463
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0077
Brugia malayi Protein kinase domain containing protein 0.0249 0.258 0.2571
Echinococcus granulosus Immunoglobulin 0.0024 0.0039 0.0027
Loa Loa (eye worm) TK protein kinase 0.0119 0.1113 0.1102
Brugia malayi Protein kinase domain containing protein 0.0033 0.0134 0.0122
Onchocerca volvulus 0.0032 0.0126 0.0337
Brugia malayi p70 ribosomal S6 kinase beta 0.0038 0.0196 0.0183
Leishmania major protein kinase, putative 0.0041 0.0222 0.0455
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0475 1
Brugia malayi serine/threonine-protein kinase 6 0.0063 0.0475 0.0463
Onchocerca volvulus 0.0117 0.1083 0.6812
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0203 0.0191
Toxoplasma gondii aurora kinase 0.0063 0.0475 1
Brugia malayi Protein kinase domain containing protein 0.0033 0.0134 0.0122
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0041 0.0222 0.0211
Plasmodium vivax tyrosine kinase-like protein, putative 0.0024 0.0038 0.0804
Brugia malayi protein-tyrosine kinase 0.0033 0.0134 0.0122
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0134 0.0123
Trypanosoma brucei developmentally regulated phosphoprotein 0.0117 0.1091 0.2619
Schistosoma mansoni nephrin 0.0034 0.0149 0.0147
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0414 0.0931
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0134 0.0123
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.004 0.0179
Schistosoma mansoni hypothetical protein 0.0028 0.0077 0.0075
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0022 0.0013 0.0001
Schistosoma mansoni tyrosine kinase 0.0226 0.2324 0.2322
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0327 0.0714
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0039 0.0203 0.0191
Giardia lamblia Kinase, CMGC GSK 0.0055 0.0381 0.7642
Onchocerca volvulus 0.0136 0.1304 0.8308
Trypanosoma brucei protein kinase, putative 0.0058 0.0414 0.0931
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0022 0.0013 0.0001
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0203 0.0191
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0381 0.7891
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0904 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0175 0.0163
Entamoeba histolytica protein kinase , putative 0.0063 0.0475 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0031 0.0117 0.0192
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0414 0.0931
Echinococcus multilocularis mitogen activated protein kinase 11 0.0379 0.4054 0.4047
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0041 0.0223 0.4689
Schistosoma mansoni ephrin receptor 0.0133 0.1273 0.1271
Echinococcus multilocularis tyrosine protein kinase Srms 0.0033 0.0134 0.0123
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0033 0.0134 0.0123
Schistosoma mansoni vesicular amine transporter 0.0024 0.0039 0.0037
Onchocerca volvulus 0.0033 0.0134 0.039
Loa Loa (eye worm) hypothetical protein 0.0031 0.0115 0.0104
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0134 0.0123
Trypanosoma brucei cdc2-related kinase 3 0.005 0.0327 0.0714
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0041 0.0222 0.0455
Echinococcus multilocularis tyrosine kinase 0.0033 0.0134 0.0123
Echinococcus multilocularis NCK adaptor protein 0.0022 0.0013 0.0001
Echinococcus granulosus NCK adaptor protein 0.0022 0.0013 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0065
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0041 0.0222 0.0211
Entamoeba histolytica protein kinase, putative 0.0063 0.0475 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0042 0.0234 0.0222
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0041 0.0227 0.4296
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0041 0.0222 0.0211
Brugia malayi Protein kinase domain containing protein 0.0033 0.0134 0.0122
Loa Loa (eye worm) hypothetical protein 0.0036 0.0175 0.0163
Plasmodium falciparum glycogen synthase kinase 3 0.0055 0.0381 0.7861
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0134 0.0123
Brugia malayi Immunoglobulin I-set domain containing protein 0.0119 0.1113 0.1102
Onchocerca volvulus 0.0033 0.0134 0.039
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0327 0.6847
Schistosoma mansoni nck2/grb4 0.0022 0.0013 0.0011
Plasmodium falciparum protein kinase 5 0.005 0.0327 0.6606
Trypanosoma brucei rac serine-threonine kinase, putative 0.0042 0.0234 0.0483
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0114 0.1053 0.1043
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0327 0.0714
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0033 0.0134 0.0123
Echinococcus multilocularis epidermal growth factor receptor 0.0425 0.4572 0.4566
Schistosoma mansoni hypothetical protein 0.0028 0.0077 0.0075
Echinococcus granulosus serine/threonine protein kinase 0.0031 0.0117 0.0105
Echinococcus granulosus twitchin 0.0037 0.0187 0.0175
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0063 0.0475 1
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0134 0.0123
Loa Loa (eye worm) TK/EGFR protein kinase 0.0425 0.4572 0.4566
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0041 0.0222 0.0211
Entamoeba histolytica protein kinase 2, putative 0.0028 0.0079 0.1056
Brugia malayi hypothetical protein 0.0029 0.0089 0.0076
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0024 0.0035 0.0024
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0033 0.0134 0.0123
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0414 0.0402
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0077
Plasmodium vivax glycogen synthase kinase 3, putative 0.0055 0.0381 0.8033
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0414 0.8703
Brugia malayi Tyrosine-protein kinase abl-1 0.0039 0.0203 0.019
Echinococcus granulosus cyclin dependent kinase 1 0.005 0.0327 0.0315
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0134 0.0123
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0379 0.4054 1
Schistosoma mansoni tyrosine kinase 0.0365 0.39 0.3899
Schistosoma mansoni adapter molecule crk 0.0022 0.0013 0.0011
Brugia malayi hypothetical protein 0.0028 0.0077 0.0064
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0234 0.4871
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0327 0.0315
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0379 0.4054 0.4047
Echinococcus granulosus roundabout 2 0.0041 0.0225 0.0213
Brugia malayi serine/threonine protein kinase 6 0.0063 0.0475 0.0463
Entamoeba histolytica PH domain containing protein kinase, putative 0.0031 0.0117 0.1919
Echinococcus granulosus c src tyrosine kinase 0.0039 0.0203 0.0191
Echinococcus multilocularis c src tyrosine kinase 0.0039 0.0203 0.0191
Plasmodium falciparum protein kinase, putative 0.0025 0.004 0.0039
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0235 0.2419 0.241
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0327 0.6653
Schistosoma mansoni tyrosine kinase 0.0272 0.284 0.2839
Brugia malayi Protein kinase domain containing protein 0.0033 0.0134 0.0122
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0134 0.0123
Loa Loa (eye worm) hypothetical protein 0.0204 0.2074 0.2065
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0414 0.0931
Schistosoma mansoni protein kinase 0.0063 0.0475 0.0473
Onchocerca volvulus 0.0033 0.0134 0.039
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0379 0.4054 1
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0414 0.0412
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.005 0.0327 0.0714
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0065
Brugia malayi kinase, mitochondrial precursor 0.0117 0.1091 0.108
Echinococcus multilocularis cyclin dependent kinase 5 0.005 0.0327 0.0315
Schistosoma mansoni tyrosine kinase 0.0029 0.0088 0.0086
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0475 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0041 0.0223 0.4689
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0041 0.0222 0.021
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0134 0.0123
Echinococcus multilocularis mitogen activated protein kinase 14 0.0379 0.4054 0.4047
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0025 0.004 0.0028
Onchocerca volvulus 0.0033 0.0134 0.039
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0414 0.8703
Schistosoma mansoni serine/threonine protein kinase 0.0904 1 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0033 0.0134 0.2311
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0234 0.4871
Brugia malayi Cam kinase protein 1 0.0041 0.0222 0.021
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0203 0.0191
Echinococcus granulosus MAM 0.0028 0.0077 0.0065
Loa Loa (eye worm) TK/EPH protein kinase 0.0165 0.1635 0.1625
Schistosoma mansoni tyrosine kinase 0.0272 0.284 0.2839
Echinococcus multilocularis roundabout 2 0.0041 0.0225 0.0213
Brugia malayi P38 map kinase family protein 2 0.0379 0.4054 0.4047
Brugia malayi MAP kinase sur-1 0.0058 0.0414 0.0402
Echinococcus granulosus serine threonine protein kinase nrc 0.0028 0.0079 0.0067
Echinococcus multilocularis growth factor receptor bound protein 2 0.0022 0.0013 0.0001
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0414 0.0931
Schistosoma mansoni tyrosine kinase 0.0365 0.39 0.3899
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0055 0.0381 0.7853
Echinococcus multilocularis 0.0125 0.1175 0.1165
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.017 0.1684 0.1674
Entamoeba histolytica protein kinase, putative 0.0041 0.0222 0.4301
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0414 0.8703
Schistosoma mansoni tyrosine kinase 0.0039 0.0203 0.0201
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0055 0.0381 0.0851
Entamoeba histolytica protein kinase, putative 0.0038 0.0196 0.3694
Brugia malayi Immunoglobulin I-set domain containing protein 0.0184 0.1847 0.1837
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0327 0.6847
Schistosoma mansoni pyruvate dehydrogenase 0.0111 0.1017 0.1016
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.005 0.0327 0.6592
Echinococcus granulosus mitogen activated protein kinase 14 0.0379 0.4054 0.4047
Giardia lamblia Aurora kinase 0.0063 0.0475 1
Entamoeba histolytica protein kinase, putative 0.0042 0.0234 0.4556
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0039 0.0203 0.0191
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0063 0.0475 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0041 0.0223 0.4225
Giardia lamblia Kinase, CMGC GSK 0.0055 0.0381 0.7642
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0048 0.0301 0.5996
Plasmodium falciparum calcium-dependent protein kinase 2 0.0041 0.0223 0.4225
Toxoplasma gondii AGC kinase 0.0038 0.0196 0.3579
Echinococcus granulosus tyrosine kinase 0.0033 0.0134 0.0123
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0039 0.0203 0.0191
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0055 0.0381 0.037
Echinococcus multilocularis mitogen activated protein kinase 14 0.0379 0.4054 0.4047
Schistosoma mansoni serine/threonine-protein kinase 0.0031 0.0117 0.0115
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0028 0.0079 0.0097
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0028 0.0079 0.0067
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0203 0.0191
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.037 0.3949 0.3942
Echinococcus granulosus c-Jun N-terminal kinases 0.0235 0.2419 0.241
Echinococcus granulosus protein kinase shaggy 0.0055 0.0381 0.037
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0414 0.0402
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0039 0.0203 0.0191
Plasmodium falciparum calcium-dependent protein kinase 5 0.0041 0.0223 0.4225
Leishmania major developmentally regulated phosphoprotein-like protein 0.0117 0.1091 0.2619
Entamoeba histolytica protein kinase, putative 0.0055 0.0381 0.7891
Plasmodium vivax protein kinase Crk2 0.005 0.0327 0.6879
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0561 0.6119 0.6114
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0414 0.0931
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.005 0.0327 0.0714
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0055 0.0381 0.0851
Brugia malayi Fibronectin type III domain containing protein 0.0029 0.0089 0.0076
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0134 0.0123
Echinococcus granulosus tyrosine protein kinase Lyn 0.0047 0.029 0.0279
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0114 0.1053 0.1043
Echinococcus granulosus ephrin type A receptor 4 A 0.0146 0.1418 0.1408
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.0203 0.0191
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0414 0.0402
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0235 0.2419 0.241
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0234 0.4871
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0381 0.8013
Schistosoma mansoni growth factor receptor-bound protein 0.0022 0.0013 0.0011
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0289 0.303 0.3022
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0033 0.0134 0.0123
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0041 0.0222 0.0211
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0381 0.037
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0041 0.0222 0.0211
Giardia lamblia Kinase, CMGC CDK 0.005 0.0327 0.6258
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0203 0.0191
Echinococcus multilocularis rac serine:threonine kinase 0.0031 0.0117 0.0105
Echinococcus multilocularis ephrin type A receptor 4 A 0.0146 0.1418 0.1408
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0041 0.0223 0.4202
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0414 0.0402
Schistosoma mansoni tyrosine kinase 0.0164 0.1616 0.1614
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0039 0.0203 0.0191
Schistosoma mansoni tyrosine kinase 0.0425 0.4572 0.4571
Brugia malayi SRC-1 0.0039 0.0203 0.019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0065
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0904 1 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0024 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.0059 0.0434 0.0423
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0041 0.0227 0.0465
Schistosoma mansoni protein kinase 0.0025 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0001
Trypanosoma cruzi Protein kinase B 0.0031 0.0117 0.0192
Leishmania major protein kinase, putative 0.0063 0.0475 0.1083
Echinococcus granulosus activin receptor type 0.0025 0.004 0.0028
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0022 0.0013 0.0011
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0117 0.1091 0.1081
Echinococcus granulosus tyrosine protein kinase Blk 0.0033 0.0134 0.0123
Giardia lamblia Kinase, CMGC CDK 0.005 0.0327 0.6258
Loa Loa (eye worm) SRC-1 0.0039 0.0203 0.0191
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0327 0.0714
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0203 0.0191
Brugia malayi Protein kinase domain containing protein 0.0033 0.0134 0.0122
Schistosoma mansoni protein kinase 0.0041 0.0222 0.0221
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0038 0.0196 0.0184
Schistosoma mansoni serine/threonine-protein kinase 0.0031 0.0117 0.0115
Echinococcus granulosus fibroblast growth factor receptor 4 0.0114 0.1053 0.1043
Echinococcus multilocularis Immunoglobulin 0.0024 0.0039 0.0027
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0041 0.0223 0.4202
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0414 0.0402
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0041 0.0222 0.0211
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0414 0.846
Echinococcus granulosus insulin receptor 0.0365 0.39 0.3893
Plasmodium falciparum serine/threonine protein kinase, putative 0.0063 0.0475 1
Brugia malayi intracellular kinase 0.0055 0.0381 0.0369
Entamoeba histolytica PH domain containing protein kinase, putative 0.0031 0.0117 0.1919
Brugia malayi serine/threonine kinase 12 0.0063 0.0475 0.0463
Loa Loa (eye worm) TK protein kinase 0.0033 0.0134 0.0123
Brugia malayi SH2 domain containing protein 0.0033 0.0134 0.0122
Brugia malayi Protein kinase domain containing protein 0.0158 0.1547 0.1536
Echinococcus granulosus tyrosine protein kinase Srms 0.0033 0.0134 0.0123
Schistosoma mansoni pyruvate dehydrogenase 0.0111 0.1017 0.1016
Brugia malayi Protein kinase domain containing protein 0.005 0.0327 0.0314
Brugia malayi Stress-activated protein kinase jnk-1 0.0235 0.2419 0.241
Echinococcus granulosus tyrosine kinase 0.0033 0.0134 0.0123
Echinococcus granulosus tyrosine protein kinase shark 0.0242 0.2506 0.2497
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0327 0.6847
Echinococcus granulosus insulin growth factor 1 receptor beta 0.037 0.3949 0.3942
Onchocerca volvulus 0.0033 0.0134 0.039
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0041 0.0222 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0327 0.0325
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0475 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.005 0.0327 0.0315
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0117 0.1091 0.1081
Echinococcus granulosus calcium dependent protein kinase 0.0033 0.0135 0.0123
Schistosoma mansoni cell adhesion molecule 0.0036 0.0165 0.0163
Schistosoma mansoni pyruvate dehydrogenase 0.0117 0.1091 0.109
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0327 0.0325
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0327 0.6653
Echinococcus multilocularis aurora kinase A 0.0063 0.0475 0.0463
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0041 0.0223 0.4689
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0028 0.0079 0.0067
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0089 0.0076
Echinococcus multilocularis activin receptor type 0.0025 0.004 0.0028
Echinococcus granulosus epidermal growth factor receptor 0.0425 0.4572 0.4566
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0027
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0227
Echinococcus multilocularis Immunoglobulin 0.0024 0.0039 0.0027
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0475 0.0463
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0041 0.0222 0.0211
Echinococcus multilocularis MAM 0.0028 0.0077 0.0065
Schistosoma mansoni tyrosine kinase 0.0289 0.303 0.3029
Brugia malayi Protein kinase domain containing protein 0.0042 0.0234 0.0221
Echinococcus multilocularis epidermal growth factor receptor 0.0289 0.303 0.3022
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0039 0.0203 0.0191
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0234 0.4871
Echinococcus granulosus epidermal growth factor receptor 0.0289 0.303 0.3022
Schistosoma mansoni tyrosine kinase 0.0289 0.303 0.3029
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0327 0.0315
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0027
Loa Loa (eye worm) TK/ABL protein kinase 0.0033 0.0134 0.0123
Echinococcus granulosus cyclin dependent kinase 0.005 0.0327 0.0315
Echinococcus granulosus neuroglian 0.003 0.0099 0.0087
Trypanosoma brucei protein kinase, putative 0.0055 0.0381 0.0851
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0381 0.8013
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0327 0.0714
Loa Loa (eye worm) TK/INSR protein kinase 0.0365 0.39 0.3893
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0039 0.0203 0.0201
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0063 0.0475 1
Entamoeba histolytica protein kinase, putative 0.0042 0.0234 0.4556
Schistosoma mansoni tyrosine kinase 0.0039 0.0203 0.0201
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0134 0.0123
Plasmodium falciparum calcium-dependent protein kinase 3 0.0041 0.0223 0.4225
Entamoeba histolytica protein kinase, putative 0.0041 0.0222 0.4301
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0475 0.0473
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0041 0.0223 0.4202
Schistosoma mansoni growth factor receptor-bound protein 0.0022 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0117 0.1091 0.1081
Schistosoma mansoni protein kinase 0.0025 0.004 0.0038
Echinococcus granulosus mitogen activated protein kinase 11 0.0379 0.4054 0.4047

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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