TDR Targets

Basic information

Technical information

TDR Targets ID: 842073
Name: N-(4-chloro-2-methylphenyl)-4-methoxybenzamid e
MW: 275.73 | Formula: C15H14ClNO2
H donors: 1 H acceptors: 1 LogP: 3.72 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C(=O)Nc1ccc(cc1C)Cl
InChi: 1S/C15H14ClNO2/c1-10-9-12(16)5-8-14(10)17-15(18)11-3-6-13(19-2)7-4-11/h3-9H,1-2H3,(H,17,18)
InChiKey: SLSPVEMEGSKNRK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-chloro-2-methyl-phenyl)-4-methoxy-benzamide
BIM-0018686.P001
Oprea1_509248
CBMicro_018778
ZINC00215108

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0232	0.7984	0.7608
Schistosoma mansoni	calcium-transporting atpase 2 (atpase 2)	0.007	0.1607	0.004
Giardia lamblia	Potassium-transporting ATPase alpha chain 1	0.0184	0.6066	1
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0069	0.1573	0.8418
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.007	0.1607	1
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.0284	1	1
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0075	0.1826	0.1643
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0069	0.1573	0.9707
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0075	0.1826	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0069	0.1573	0.1348
Brugia malayi	Protein kinase domain containing protein	0.0036	0.0272	0.0047
Echinococcus granulosus	nervana 2	0.0192	0.6409	0.5739
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0036	0.0272	0.0047
Echinococcus multilocularis	m phase inducer phosphatase(cdc25)	0.0284	1	1
Onchocerca volvulus		0.0192	0.6409	0.095
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0075	0.1826	0.1608
Leishmania major	calcium-transporting ATPase, putative	0.007	0.1607	1
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0189	0.6285	0.6199
Trypanosoma cruzi	P-type H+-ATPase, putative	0.004	0.0445	0.2772
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0284	1	1
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0069	0.1573	0.1384
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0284	1	1
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0164	0.5291	0.5182
Leishmania major	calcium-translocating P-type ATPase	0.0069	0.1573	0.9707
Brugia malayi	Rhodanese-like domain containing protein	0.0284	1	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0069	0.1573	0.1348
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0232	0.7984	0.7608
Loa Loa (eye worm)	hypothetical protein	0.0262	0.9131	0.9111
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0035	0.0226	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0114	0.3332	0.3178
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0164	0.5291	0.5182
Trypanosoma cruzi	P-type H+-ATPase, putative	0.004	0.0445	0.2772
Trichomonas vaginalis	cdc25c, putative	0.0284	1	1
Echinococcus multilocularis	nervana 2	0.0232	0.7984	0.7608
Echinococcus multilocularis	sodium:potassium transporting ATPase subunit	0.0232	0.7984	0.7608
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0272	0.0013
Entamoeba histolytica	rodhanase-like domain containing protein	0.0284	1	1
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.0157	0.5038	0.5
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.007	0.1607	0.004
Schistosoma mansoni	sodium / potassium ATPase beta chain	0.0192	0.6409	0.5739
Echinococcus multilocularis	calcium transporting atpase	0.007	0.1607	0.004
Leishmania major	calcium motive p-type ATPase, putative	0.007	0.1607	1
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0069	0.1573	0.9707
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0075	0.1826	0.03
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0232	0.7984	0.7608
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0069	0.1573	0.1348
Mycobacterium tuberculosis	Possible metal cation transporting P-type ATPase CtpH	0.0044	0.0578	0.5
Echinococcus granulosus	plasma membrane calcium transporting ATPase	0.007	0.1607	0.004
Entamoeba histolytica	rodhanase-like domain containing protein	0.0284	1	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.6285	0.6199
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0069	0.1573	0.1348
Echinococcus multilocularis	nervana 2	0.0192	0.6409	0.5739
Loa Loa (eye worm)	hypothetical protein	0.0129	0.3911	0.377
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0041	0.0479	0.0266
Onchocerca volvulus		0.0284	1	1
Loa Loa (eye worm)	hypothetical protein	0.0262	0.9131	0.9111
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1573	0.1378
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0075	0.1826	0.03
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.0284	1	1
Toxoplasma gondii	P-type ATPase PMA1	0.004	0.0445	0.1369
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0069	0.1573	0.9707
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0272	0.0013
Toxoplasma gondii	P-type ATPase4, putative	0.0075	0.1826	1
Loa Loa (eye worm)	calcium ATPase	0.0041	0.0472	0.0251
Leishmania major	P-type ATPase, putative	0.007	0.1607	1
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0069	0.1573	0.9788
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0189	0.6285	0.5592
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0069	0.1573	0.9788
Echinococcus granulosus	Ca2 transporting ATPase plasma membrane	0.007	0.1607	0.004
Echinococcus granulosus	m phase inducer phosphatasecdc25	0.0284	1	1
Loa Loa (eye worm)	hypothetical protein	0.0284	1	1
Trypanosoma brucei	calcium motive p-type ATPase, putative	0.007	0.1607	1
Schistosoma mansoni	na+/k+ atpase alpha subunit	0.0184	0.6066	0.5332
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0069	0.1573	0.1348
Trypanosoma brucei	calcium-translocating P-type ATPase	0.007	0.1607	1
Echinococcus multilocularis	Ca2+ transporting ATPase plasma membrane	0.007	0.1607	0.004
Schistosoma mansoni	transmemberane protein	0.0232	0.7984	0.7608
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0232	0.7984	0.7608
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0192	0.6409	0.5739
Brugia malayi	Membrane calcium atpase protein 3	0.007	0.1607	0.1412
Trypanosoma cruzi	calcium-transporting ATPase, putative	0.0044	0.0612	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0143	0.446	0.4331
Brugia malayi	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.007	0.1607	0.1412
Trypanosoma cruzi	plasma-membrane proton-efflux P-type ATPase, putative	0.0035	0.0226	0.1409
Brugia malayi	E1-E2 ATPase family protein	0.0047	0.0698	0.0483
Onchocerca volvulus		0.0284	1	1
Trichomonas vaginalis	cation-transporting ATPase, putative	0.004	0.0445	0.0191
Entamoeba histolytica	rodhanase-like domain containing protein	0.0284	1	1
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0284	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0272	0.0013
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0069	0.1573	0.1348
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.0041	0.0472	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0232	0.7984	0.7937
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.007	0.1607	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0232	0.7984	0.7937
Echinococcus granulosus	nervana 2	0.0192	0.6409	0.5739
Brugia malayi	calcium ATPase	0.0035	0.0253	0.0027
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0069	0.1573	0.9788
Onchocerca volvulus		0.0284	1	1
Trichomonas vaginalis	cdc25b, putative	0.0284	1	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0612	0.0395
Echinococcus multilocularis	plasma membrane calcium transporting ATPase	0.007	0.1607	0.004
Onchocerca volvulus		0.0284	1	1
Trypanosoma cruzi	calcium-translocating P-type ATPase, putative	0.0035	0.0226	0.1409
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.007	0.1607	1
Trichomonas vaginalis	cdc25b, putative	0.0284	1	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0232	0.7984	0.7608
Schistosoma mansoni	m-phase inducer phosphatase(cdc25)	0.0284	1	1
Echinococcus granulosus	calcium transporting atpase	0.007	0.1607	0.004
Echinococcus multilocularis	nervana 2	0.0232	0.7984	0.7608
Echinococcus granulosus	Na:K ATPase alpha subunit	0.0184	0.6066	0.5332
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0075	0.1826	0.03
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0069	0.1573	0.9707
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.0075	0.1826	1
Echinococcus granulosus	nervana 2	0.0232	0.7984	0.7608
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0192	0.6409	0.5739
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0069	0.1573	0.1348
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0183	0.6032	1
Brugia malayi	Probable calcium-transporting ATPase KIAA0703	0.0044	0.0612	0.0395
Loa Loa (eye worm)	E1-E2 ATPase	0.004	0.0445	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0284	1	1
Brugia malayi	Na,K-ATPase alpha subunit	0.0189	0.6285	0.6199
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0069	0.1573	0.1348
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.007	0.1607	0.004
Plasmodium vivax	calcium-transporting ATPase, putative	0.0075	0.1826	0.5
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0069	0.1573	0.1384
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0041	0.0472	0.0259
Plasmodium vivax	P-type ATPase4, putative	0.0075	0.1826	0.5
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.007	0.1607	0.004
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0192	0.6409	0.5739
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0069	0.1573	0.9707
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0075	0.1826	0.03
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0232	0.7984	0.7608
Echinococcus multilocularis	Na+:K+ ATPase alpha subunit	0.0184	0.6066	0.5332
Echinococcus multilocularis	nervana 2	0.0192	0.6409	0.5739
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.007	0.1607	0.004
Echinococcus granulosus	nervana 2	0.0232	0.7984	0.7608
Onchocerca volvulus		0.0232	0.7984	0.4919
Loa Loa (eye worm)	calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0044	0.0612	0.0395
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.0075	0.1826	0.2287
Toxoplasma gondii	plasma membrane-type Ca(2+)-ATPase A1 PMCAA1	0.007	0.1607	0.8631
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0069	0.1573	0.1384
Echinococcus granulosus	sodium:potassium transporting ATPase subunit	0.0232	0.7984	0.7608
Trypanosoma brucei	calcium-transporting ATPase, putative	0.0044	0.0612	0.1439
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0069	0.1573	0.0465

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 842073