Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.034 | 0.1331 | 0.1276 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0769 | 0.3324 | 0.5 |
Onchocerca volvulus | 0.2206 | 1 | 1 | |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0374 | 0.1491 | 0.1436 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0374 | 0.1491 | 0.1436 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0769 | 0.3324 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0371 | 0.1476 | 0.1476 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.1491 | 0.1436 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0374 | 0.1491 | 0.1491 |
Echinococcus multilocularis | serotonin transporter | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.2206 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.2206 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0374 | 0.1491 | 0.1491 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0374 | 0.1491 | 0.1436 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0374 | 0.1491 | 0.1491 |
Loa Loa (eye worm) | hypothetical protein | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0374 | 0.1491 | 0.1436 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.1491 | 0.1436 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.034 | 0.1331 | 0.1276 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.2206 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0099 | 0.0209 | 0.0146 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0374 | 0.1491 | 0.1436 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0318 | 0.1227 | 0.3568 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.1491 | 0.1436 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0769 | 0.3324 | 0.5 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0374 | 0.1491 | 0.1436 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0067 | 0.0064 | 0.0064 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0374 | 0.1491 | 0.1491 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0769 | 0.3324 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0769 | 0.3324 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0374 | 0.1491 | 0.1436 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0374 | 0.1491 | 0.1436 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0374 | 0.1491 | 0.1436 |
Echinococcus granulosus | serotonin transporter | 0.2206 | 1 | 1 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0374 | 0.1491 | 0.1436 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0099 | 0.0209 | 0.0209 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0374 | 0.1491 | 0.1491 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0318 | 0.1227 | 0.3568 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0374 | 0.1491 | 0.1491 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0374 | 0.1491 | 0.1436 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0374 | 0.1491 | 0.1436 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0099 | 0.0209 | 0.0146 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.2206 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0099 | 0.0209 | 0.0146 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0099 | 0.0209 | 0.0146 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0374 | 0.1491 | 0.1491 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0769 | 0.3324 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.2206 | 1 | 1 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0374 | 0.1491 | 0.1436 |
Loa Loa (eye worm) | hypothetical protein | 0.2206 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0371 | 0.1476 | 0.1476 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0067 | 0.0064 | 0.0064 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.2206 | 1 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0769 | 0.3324 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0099 | 0.0209 | 0.0146 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0067 | 0.0064 | 0.0064 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0099 | 0.0209 | 0.0209 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0374 | 0.1491 | 0.1436 |
Brugia malayi | hypothetical protein | 0.0374 | 0.1491 | 0.1436 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0067 | 0.0064 | 0.0064 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0067 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.1491 | 0.1436 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0209 | 0.0146 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0374 | 0.1491 | 0.1436 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.034 | 0.1331 | 0.1276 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0067 | 0.0064 | 0.0064 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0374 | 0.1491 | 0.1436 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.1491 | 0.1436 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0769 | 0.3324 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0374 | 0.1491 | 0.1491 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.1122 | 0.1066 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.1491 | 0.1436 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0374 | 0.1491 | 0.1491 |
Loa Loa (eye worm) | hypothetical protein | 0.2206 | 1 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0374 | 0.1491 | 0.1491 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0374 | 0.1491 | 0.1436 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.034 | 0.1331 | 0.1276 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.1491 | 0.1436 |
Trichomonas vaginalis | hypothetical protein | 0.0769 | 0.3324 | 1 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0374 | 0.1491 | 0.1491 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.