TDR Targets

Basic information

Technical information

TDR Targets ID: 847336
Name: 2-[[4-hydroxy-6-oxo-5-(phenylmethyl)-1H-pyrim idin-2-yl]sulfanyl]-N-naphthalen-1-ylacetamid e
MW: 417.48 | Formula: C23H19N3O3S
H donors: 3 H acceptors: 5 LogP: 5.08 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cccc2c1cccc2)CSc1nc(O)c(c(n1)O)Cc1ccccc1
InChi: 1S/C23H19N3O3S/c27-20(24-19-12-6-10-16-9-4-5-11-17(16)19)14-30-23-25-21(28)18(22(29)26-23)13-15-7-2-1-3-8-15/h1-12H,13-14H2,(H,24,27)(H2,25,26,28,29)
InChiKey: WSYMXDKHGQNWSB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[[4-hydroxy-6-oxo-5-(phenylmethyl)-1H-pyrimidin-2-yl]sulfanyl]-N-(1-naphthyl)acetamide
2-[[4-hydroxy-6-oxo-5-(phenylmethyl)-1H-pyrimidin-2-yl]thio]-N-(1-naphthyl)acetamide
2-[[5-(benzyl)-4-hydroxy-6-keto-1H-pyrimidin-2-yl]thio]-N-(1-naphthyl)acetamide
2-[[4-hydroxy-6-oxo-5-(phenylmethyl)-1H-pyrimidin-2-yl]sulfanyl]-N-naphthalen-1-yl-ethanamide
5373-37-5
BIM-0019479.P001
Oprea1_110089
STK216011
CBMicro_019392

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0276	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0011	0.01	0.01
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0011	0.01	0.01
Schistosoma mansoni	protein tyrosine phosphatase	0.0017	0.0276	0.0178
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0182	0.5095	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0276	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0017	0.0276	0.0276
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0276	0.0276
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0126	0.3453	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0276	0.0276
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0276	0.0276
Leishmania major	tyrosine specific protein phosphatase, putative	0.0017	0.0276	0.1341
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0017	0.0276	0.0276
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0276	0.0276
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0011	0.01	0.01
Trichomonas vaginalis	ABC transporter, putative	0.0011	0.01	0.0196
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Onchocerca volvulus		0.0017	0.0276	0.0352
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0276	0.0181
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0276	0.0276
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0276	0.0178
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0276	0.0276
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0349	1	1
Onchocerca volvulus		0.0017	0.0276	0.0352
Brugia malayi	hypothetical protein	0.0017	0.0276	0.0178
Leishmania major	hypothetical protein, conserved	0.0056	0.1411	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Loa Loa (eye worm)	multidrug resistance protein 3	0.0011	0.01	0.0004
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0276	0.0276
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0011	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Onchocerca volvulus		0.0017	0.0276	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Onchocerca volvulus		0.0017	0.0276	0.0352
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0276	0.0181
Onchocerca volvulus		0.0017	0.0276	0.0352
Onchocerca volvulus		0.0017	0.0276	0.0352
Onchocerca volvulus		0.0017	0.0276	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0017	0.0276	0.0181
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0182	0.5095	1
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0017	0.0276	0.0178
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0182	0.5095	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0276	0.0276
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0011	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0011	0.01	0.0004
Brugia malayi	hypothetical protein	0.0017	0.0276	0.0178
Onchocerca volvulus		0.0017	0.0276	0.0352
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0276	0.0276
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0011	0.01	0.01
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0017	0.0276	0.0181
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0017	0.0276	0.0178
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0011	0.01	0.0196
Plasmodium falciparum	multidrug resistance protein 1	0.0011	0.01	0.5
Echinococcus multilocularis		0.0017	0.0276	0.0276
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0017	0.0276	0.0178
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0011	0.01	0.0196
Onchocerca volvulus		0.0017	0.0276	0.0352
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0182	0.5095	1
Onchocerca volvulus		0.0017	0.0276	0.0352
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0276	0.0181
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0276	0.0181
Schistosoma mansoni	pcd6 interacting protein-related	0.0017	0.0276	0.0178
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0017	0.0276	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0182	0.5095	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0.01	0.0196
Onchocerca volvulus		0.0017	0.0276	0.0352
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0276	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0017	0.0276	0.0276
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0276	0.0276
Brugia malayi	hypothetical protein	0.0017	0.0276	0.0178
Onchocerca volvulus		0.0017	0.0276	0.0352
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0011	0.01	0.0196
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0017	0.0276	0.0276
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0017	0.0276	0.0276
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0.01	0.0196
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Schistosoma mansoni	protein tyrosine phosphatase	0.0017	0.0276	0.0178
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0276	0.0276
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0011	0.01	0.5
Echinococcus granulosus	multidrug resistance protein 1	0.0011	0.01	0.01
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0017	0.0276	0.0276
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0.01	0.0196
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0017	0.0276	0.0276
Onchocerca volvulus		0.0017	0.0276	0.0352
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0182	0.5095	0.5047
Echinococcus granulosus	multidrug resistance protein 1	0.0011	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Brugia malayi	Protein-tyrosine phosphatase	0.0017	0.0276	0.0178
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0017	0.0276	0.0178
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0011	0.01	0.0004
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0276	0.0276
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0182	0.5095	1
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0017	0.0276	0.0181
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0017	0.0276	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0349	1	1
Trichomonas vaginalis	ABC transporter, putative	0.0011	0.01	0.0196
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0011	0.01	0.0196
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0011	0.01	0.01
Plasmodium vivax	multidrug resistance protein 1, putative	0.0011	0.01	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0276	0.0181
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0276	0.0181
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0.01	0.0196
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0276	0.0276
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0017	0.0276	0.0276
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0056	0.1411	1
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0011	0.01	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0.01	0.0196
Onchocerca volvulus	4.1 G protein, putative homolog	0.0017	0.0276	0.0352
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0017	0.0276	0.1341
Trichomonas vaginalis	ABC transporter, putative	0.0011	0.01	0.0196
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0017	0.0276	0.0178
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0276	0.0276
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0276	0.0181
Trichomonas vaginalis	abcb9, putative	0.0011	0.01	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Brugia malayi	Protein-tyrosine phosphatase	0.0017	0.0276	0.0178
Trichomonas vaginalis	abcb9, putative	0.0011	0.01	0.0196
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.1411	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0276	0.0181
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0276	0.0181
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0017	0.0276	0.0276
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0.01	0.0196
Onchocerca volvulus		0.0017	0.0276	0.0352
Onchocerca volvulus		0.0182	0.5095	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0017	0.0276	0.0181
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0276	0.0276
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0011	0.01	0.01
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0182	0.5095	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0276	0.0181
Echinococcus granulosus	multidrug resistance protein 1	0.0011	0.01	0.01
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0349	1	1
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0011	0.01	0.0196
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Echinococcus multilocularis	multidrug resistance protein 1	0.0011	0.01	0.01
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0349	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Trichomonas vaginalis	ABC transporter, putative	0.0011	0.01	0.0196
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0182	0.5095	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0276	0.0276
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0276	0.0178
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0276	0.0276
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0276	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0276	0.0276
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0017	0.0276	0.0178
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0276	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0011	0.01	0.0004
Trichomonas vaginalis	taga, putative	0.0011	0.01	0.0196
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0011	0.01	0.0196
Brugia malayi	Protein-tyrosine phosphatase 1	0.0017	0.0276	0.0178
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0276	0.0276
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0276	0.0181
Schistosoma mansoni	protein tyrosine phosphatase	0.0017	0.0276	0.0178
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0056	0.1411	0.277
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0017	0.0276	0.0276
Onchocerca volvulus		0.0017	0.0276	0.0352
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0017	0.0276	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0276	0.0181
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0011	0.01	0.0196
Trichomonas vaginalis	pten, drome, putative	0.0017	0.0276	0.0541
Echinococcus multilocularis	hypothetical protein	0.0017	0.0276	0.0276
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0182	0.5095	0.5045
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0182	0.5095	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Onchocerca volvulus		0.0017	0.0276	0.0352
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0276	0.0276
Brugia malayi	hypothetical protein	0.0017	0.0276	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0276	0.0276
Onchocerca volvulus		0.0017	0.0276	0.0352
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.1411	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0017	0.0276	0.0276
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0017	0.0276	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0.01	0.0196
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0276	0.0276
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0011	0.01	0.0196
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0011	0.01	0.0196
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0276	0.0276
Onchocerca volvulus		0.0017	0.0276	0.0352
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0276	0.0178
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0017	0.0276	0.0352
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0011	0.01	0.0196
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0.01	0.0196
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0011	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0276	0.0276
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0011	0.01	0.0196
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0011	0.01	0.0196
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0182	0.5095	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0011	0.01	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0017	0.0276	0.0352
Onchocerca volvulus		0.0017	0.0276	0.0352
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0276	0.0276
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Echinococcus multilocularis	multidrug resistance protein 1	0.0011	0.01	0.01
Trichomonas vaginalis	abcb9, putative	0.0011	0.01	0.0196
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0011	0.01	0.0196
Onchocerca volvulus		0.0017	0.0276	0.0352
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0017	0.0276	0.0276
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0011	0.01	0.0196
Brugia malayi	hypothetical protein	0.0017	0.0276	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0276	0.0178
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0056	0.1411	0.277
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0017	0.0276	0.0352
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0017	0.0276	0.0178
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0011	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0017	0.0276	0.0178
Onchocerca volvulus		0.0017	0.0276	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0181
Onchocerca volvulus		0.0017	0.0276	0.0352
Echinococcus multilocularis	ATP binding cassette sub family B	0.0011	0.0096	0.0096
Onchocerca volvulus		0.0017	0.0276	0.0352
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0276	0.0181

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 847336