TDR Targets

Basic information

Technical information

TDR Targets ID: 847831
Name: N-(4-methoxyphenyl)-2-[2-[(4-methoxyphenyl)am ino]-2-oxoethyl]sulfanyl-4,6-dimethylpyridine -3-carboxamide
MW: 451.538 | Formula: C24H25N3O4S
H donors: 2 H acceptors: 3 LogP: 4.14 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)NC(=O)CSc1nc(C)cc(c1C(=O)Nc1ccc(cc1)OC)C
InChi: 1S/C24H25N3O4S/c1-15-13-16(2)25-24(22(15)23(29)27-18-7-11-20(31-4)12-8-18)32-14-21(28)26-17-5-9-19(30-3)10-6-17/h5-13H,14H2,1-4H3,(H,26,28)(H,27,29)
InChiKey: NPWUIJSPOABVBL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-methoxyphenyl)-2-[2-[(4-methoxyphenyl)amino]-2-oxo-ethyl]sulfanyl-4,6-dimethyl-pyridine-3-carboxamide
N-(4-methoxyphenyl)-2-[[2-[(4-methoxyphenyl)amino]-2-oxoethyl]thio]-4,6-dimethyl-3-pyridinecarboxamide
2-[[2-keto-2-[(4-methoxyphenyl)amino]ethyl]thio]-N-(4-methoxyphenyl)-4,6-dimethyl-nicotinamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Schistosoma mansoni	glucose transport protein	0.0103	0.2151	0.6011
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0549	0.1534
Brugia malayi	Sugar transporter family protein	0.0014	0.0072	0.0334
Trypanosoma cruzi	heat shock protein 85, putative	0.0031	0.0469	0.801
Onchocerca volvulus		0.0022	0.024	0.3994
Loa Loa (eye worm)	sugar transporter	0.0103	0.2151	1
Giardia lamblia	Grp94/Hsp90	0.0025	0.0319	0.6221
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0025	0.0319	0.5246
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Plasmodium vivax	endoplasmin, putative	0.0031	0.0469	0.0437
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0072	0.0334
Schistosoma mansoni	glucose transport protein	0.0103	0.2151	0.6011
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0437	1	1
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.0469	0.2057
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Brugia malayi	hypothetical protein	0.0014	0.0072	0.0334
Brugia malayi	Hsp90 protein	0.0013	0.0034	0.0158
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0472	0.8064
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0482	0.8238
Loa Loa (eye worm)	hypothetical protein	0.0022	0.024	0.1114
Toxoplasma gondii	sugar transporter ST2	0.0014	0.0072	0.0058
Echinococcus multilocularis	geminin	0.0164	0.3578	1
Schistosoma mansoni	sugar transporter	0.0014	0.0072	0.0201
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0272	0.4188
Brugia malayi	hypothetical protein	0.0016	0.0101	0.047
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0025	0.0319	0.6221
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0304	0.1413
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0272	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Schistosoma mansoni	glucose transporter	0.0014	0.0072	0.0201
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0427	0.1192
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0166	0.3641	0.3619
Echinococcus granulosus	solute carrier family 22	0.0014	0.0072	0.0201
Echinococcus granulosus	solute carrier family 22	0.0014	0.0072	0.0201
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0482	0.8238
Brugia malayi	hypothetical protein	0.0014	0.0072	0.0334
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0025	0.0319	0.0507
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0014	0.0072	0.0696
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.024	0.067
Onchocerca volvulus		0.0014	0.0072	0.0735
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0457	0.1278
Echinococcus granulosus	heat shock protein 90	0.0031	0.0469	0.1312
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0482	0.8238
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.024	0.1114
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Trypanosoma cruzi	heat shock protein 90, putative	0.0031	0.0469	0.801
Trypanosoma brucei	heat shock protein, putative	0.0031	0.0469	0.801
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.024	0.1114
Brugia malayi	nuclear receptor NHR-88	0.0022	0.024	0.1114
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2151	0.6011
Echinococcus multilocularis	heat shock protein 90	0.0025	0.0319	0.0892
Echinococcus multilocularis	heat shock protein 90	0.0031	0.0469	0.1312
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.024	0.067
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0549	0.9471
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.024	0.1114
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0205	0.0808
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0549	0.0977
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.024	0.1114
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0549	0.9471
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0549	0.2552
Toxoplasma gondii	transporter, major facilitator family protein	0.0014	0.0072	0.0058
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0072	0.0201
Echinococcus granulosus	heat shock protein 90	0.0025	0.0319	0.0892
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0482	0.2116
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0549	0.2433
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0549	0.9471
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.024	0.067
Trypanosoma brucei	heat shock protein 90, putative	0.0031	0.0469	0.801
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0549	0.2433
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0457	0.2127
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2151	0.6011
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0072	0.0179
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0472	0.132
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0457	0.2127
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0549	0.0977
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0457	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0272	0.4371
Mycobacterium ulcerans	heat shock protein 90	0.0025	0.0319	0.5185
Loa Loa (eye worm)	hypothetical protein	0.0022	0.024	0.1114
Toxoplasma gondii	heat shock protein 90, putative	0.0031	0.0469	0.0667
Plasmodium falciparum	hexose transporter	0.0103	0.2151	0.2124
Trichomonas vaginalis	esterase, putative	0.0035	0.0549	0.2433
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0072	0.0201
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.024	0.1114
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0321	0.1494
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.024	0.1114
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0473	0.044
Leishmania major	hypothetical protein, conserved	0.0014	0.0072	0.0696
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0472	0.2196
Trichomonas vaginalis	heat shock protein, putative	0.0019	0.0184	0.071
Schistosoma mansoni	sugar transporter	0.0014	0.0072	0.0201
Schistosoma mansoni	sugar transporter	0.0014	0.0072	0.0201
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.024	0.067
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0578	1
Trypanosoma brucei	heat shock protein, putative	0.0031	0.0469	0.801
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0549	0.2552
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0549	1
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0472	0.132
Onchocerca volvulus		0.0014	0.0072	0.0735
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.024	0.067
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0457	0.2127
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0473	0.044
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0549	0.2552
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0457	0.7449
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0457	0.9658
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0072	0.0179
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0427	0.1192
Onchocerca volvulus		0.0014	0.0072	0.0735
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.024	0.067
Schistosoma mansoni	protein kinase	0.0032	0.0472	0.132
Onchocerca volvulus		0.0035	0.0549	1
Onchocerca volvulus		0.0014	0.0072	0.0735
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.024	0.067
Schistosoma mansoni	sugar transporter	0.0014	0.0072	0.0201
Plasmodium falciparum	heat shock protein 90	0.0031	0.0469	0.0437
Onchocerca volvulus		0.0014	0.0072	0.0735
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0482	0.8238
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Plasmodium vivax	sugar transporter, putative	0.0014	0.0072	0.0038
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2151	0.6011
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.024	0.067
Trypanosoma cruzi	hexose transporter, putative	0.0014	0.0072	0.0696
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Trypanosoma cruzi	heat shock protein 85, putative	0.0031	0.0469	0.801
Schistosoma mansoni	protein kinase	0.0032	0.0472	0.132
Echinococcus granulosus	solute carrier family 22	0.0014	0.0072	0.0201
Entamoeba histolytica	protein kinase, putative	0.0032	0.0472	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0482	0.8238
Schistosoma mansoni	hypothetical protein	0.0164	0.3578	1
Trypanosoma brucei	heat shock protein, putative	0.0031	0.0469	0.801
Loa Loa (eye worm)	heat shock protein 90	0.0031	0.0469	0.2183
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.024	0.1114
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0482	0.8238
Schistosoma mansoni	glucose transport protein	0.0103	0.2151	0.6011
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0272	0.4188
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.024	0.067
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0166	0.3641	0.5521
Echinococcus multilocularis	General substrate transporter	0.0088	0.1811	0.506
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0549	0.2552
Onchocerca volvulus		0.0035	0.0549	1
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0072	0.0201
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.024	0.1114
Toxoplasma gondii	protein kinase, putative	0.0291	0.6567	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0549	0.2433
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.024	0.067
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0472	0.132
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0013	0.0034	0.0095
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0304	0.4963
Echinococcus multilocularis	heat shock protein	0.0031	0.0469	0.1312
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.077	0.2152
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0072	0.0334
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.024	0.1114
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0549	1
Echinococcus granulosus	solute carrier family 22	0.0014	0.0072	0.0201
Brugia malayi	major facilitator superfamily protein	0.0014	0.0072	0.0334
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0031	0.0469	1
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0272	0.2269
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.019	0.0243
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.024	0.067
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Brugia malayi	beta-lactamase	0.0035	0.0549	0.2552
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.077	0.2152
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0549	0.0977
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.024	0.067
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0222	0.4954	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0549	0.2552
Onchocerca volvulus		0.0014	0.0072	0.0735
Trypanosoma brucei	heat shock protein, putative	0.0031	0.0469	0.801
Leishmania major	glucose transporter, lmgt3	0.0032	0.0482	0.8238
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0272	0.1123
Toxoplasma gondii	heat shock protein HSP90	0.0031	0.0469	0.0667
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0549	0.1534
Loa Loa (eye worm)	heat shock protein 75	0.0013	0.0034	0.0158
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.024	0.067
Loa Loa (eye worm)	hypothetical protein	0.0022	0.024	0.1114
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0072	0.0179
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0013	0.0034	0.0095
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.024	0.3994
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0482	0.8238
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.019	0.0243
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2151	0.6011
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.024	0.1114
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0014	0.0072	0.0038
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.024	0.1114
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.077	0.2152
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0472	0.2196
Toxoplasma gondii	ABC1 family protein	0.0035	0.0549	0.0788
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.077	0.358
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.024	0.067
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Onchocerca volvulus		0.0014	0.0072	0.0735
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0482	0.8238
Trypanosoma cruzi	hexose transporter	0.0032	0.0482	0.8238
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0272	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0022	0.024	0.1114
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.077	0.2152
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0549	0.2433
Onchocerca volvulus		0.0014	0.0072	0.0735
Brugia malayi	major facilitator superfamily protein	0.0014	0.0072	0.0334
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0457	0.2
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Toxoplasma gondii	sugar transporter ST3	0.0014	0.0072	0.0058
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Schistosoma mansoni	heat shock protein	0.0031	0.0469	0.1312
Trichomonas vaginalis	heat shock protein, putative	0.0025	0.0319	0.1347
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.024	0.067
Onchocerca volvulus		0.0014	0.0072	0.0735
Trichomonas vaginalis	myo-inositol transporter, putative	0.0014	0.0072	0.0179
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0304	0.0271
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.024	0.067
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0457	0.1278
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0473	0.044
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0578	1
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0549	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0549	0.2552
Brugia malayi	heat shock protein 90	0.0031	0.0469	0.2183
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0473	0.044
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0272	0.1263
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.024	0.1114
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0473	0.044
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.024	0.067
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Toxoplasma gondii	sugar transporter ST1	0.0014	0.0072	0.0058
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.024	0.067
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0472	0.2196
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0272	0.0364
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.077	0.2152
Trypanosoma brucei	Heat shock protein 83, putative	0.0031	0.0469	0.801
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.024	0.1114
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.024	0.3994
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Loa Loa (eye worm)	hypothetical protein	0.0022	0.024	0.1114
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0549	0.1534
Trichomonas vaginalis	heat shock protein, putative	0.0025	0.0319	0.1347
Trypanosoma brucei	heat shock protein, putative	0.0031	0.0469	0.801
Entamoeba histolytica	hypothetical protein	0.0023	0.0272	0.542
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0304	0.0271
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0549	0.0977
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0472	0.132
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0304	0.4963
Schistosoma mansoni	heat shock protein	0.0013	0.0034	0.0095
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0272	0.0759
Trypanosoma brucei	heat shock protein, putative	0.0031	0.0469	0.801
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0272	0.4371
Entamoeba histolytica	heat shock protein 90, putative	0.0031	0.0469	0.9933
Trypanosoma brucei	sugar transporter, putative	0.0014	0.0072	0.0696
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.024	0.1114
Schistosoma mansoni	endoplasmin	0.0031	0.0469	0.1312
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0549	0.0977
Trypanosoma cruzi	heat shock protein 90, putative	0.0025	0.0319	0.5246
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0472	0.2196
Entamoeba histolytica	protein kinase, putative	0.0032	0.0472	1
Brugia malayi	Endoplasmin precursor	0.0031	0.0469	0.2183
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0549	0.0977
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0549	0.2552
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.024	0.067
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0473	0.044
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0578	1
Plasmodium vivax	hexose transporter	0.0103	0.2151	0.2124
Leishmania major	myo-inositol/proton symporter (MIT)	0.0014	0.0072	0.0696
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0482	0.8238
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0482	0.2116
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0473	0.0672
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.024	0.067
Brugia malayi	hypothetical protein	0.0014	0.0072	0.0334
Trypanosoma brucei	heat shock protein, putative	0.0031	0.0469	0.801
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0482	0.8238
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Onchocerca volvulus		0.0014	0.0072	0.0735
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0482	0.2116
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0472	0.132
Trypanosoma cruzi	sugar transporter, putative	0.0014	0.0072	0.0696
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.024	0.067
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0304	0.4963
Trypanosoma brucei	heat shock protein 90, putative	0.0031	0.0469	0.801
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0482	0.8238
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.024	0.1114
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0472	0.132
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.024	0.067
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Brugia malayi	hypothetical protein	0.0024	0.0304	0.1413
Loa Loa (eye worm)	endoplasmin	0.0031	0.0469	0.2183
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0578	0.0546
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0549	0.2552
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0272	0.0238
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0472	0.2071
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.024	0.1114
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.024	0.1114
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0473	0.0672
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0272	0.0759
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0072	0.0334
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0072	0.0179
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Brugia malayi	Cam kinase protein 1	0.0032	0.0472	0.2196
Leishmania major	glucose transporter, lmgt2	0.0032	0.0482	0.8238
Trichomonas vaginalis	heat shock protein, putative	0.0025	0.0319	0.1347
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.003	0.0137
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0482	0.8238
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.024	0.1114
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.024	0.1114
Onchocerca volvulus		0.0014	0.0072	0.0735
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0457	0.1278
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0025	0.0319	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0549	0.0977
Onchocerca volvulus		0.0035	0.0549	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0103	0.2151	0.324
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Trypanosoma cruzi	heat shock protein 90, putative	0.0019	0.0167	0.2449
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0549	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2151	0.6011
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0482	0.8238
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0072	0.0201
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0304	0.0271
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.077	0.358
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0072	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Leishmania major	glucose transporter, lmgt1	0.0032	0.0482	0.8238
Loa Loa (eye worm)	hypothetical protein	0.0022	0.024	0.1114
Echinococcus granulosus	endoplasmin	0.0025	0.0319	0.0892
Schistosoma mansoni	endoplasmin	0.0031	0.0469	0.1312
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.024	0.067
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0272	0.0759
Schistosoma mansoni	hypothetical protein	0.0164	0.3578	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2151	0.6011
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0549	0.1534
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0578	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.024	0.1114
Leishmania major	heat shock protein 83-1	0.0031	0.0469	0.801
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.077	0.2152
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0272	0.5
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0072	0.0334
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.024	0.1114
Plasmodium falciparum	endoplasmin, putative	0.0019	0.0184	0.0151
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0272	0.5025
Brugia malayi	steroid hormone receptor	0.0022	0.024	0.1114
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0072	0.0201
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0578	1
Echinococcus granulosus	geminin	0.0164	0.3578	1
Plasmodium falciparum	protein kinase 7	0.0291	0.6567	0.6555
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0578	0.0832
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.024	0.067
Loa Loa (eye worm)	sugar transporter	0.0014	0.0072	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0549	0.2552
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Trypanosoma cruzi	Heat shock protein 83, putative	0.0031	0.0469	0.801
Trypanosoma cruzi	heat shock protein 85, putative	0.0031	0.0469	0.801
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.024	0.1114
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0072	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.024	0.067
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0549	1
Schistosoma mansoni	hypothetical protein	0.0103	0.2151	0.6011
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0549	1
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0025	0.0319	0.0892
Trypanosoma cruzi	heat shock protein 85, putative	0.0025	0.0319	0.5246
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0482	0.8238
Schistosoma mansoni	protein kinase	0.0032	0.0472	0.132
Loa Loa (eye worm)	hypothetical protein	0.0022	0.024	0.1114
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0549	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0473	0.044
Plasmodium vivax	heat shock protein 86, putative	0.0031	0.0469	0.0437
Onchocerca volvulus		0.0014	0.0072	0.0735
Brugia malayi	beta-lactamase family protein	0.0035	0.0549	0.2552
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0457	0.2127
Treponema pallidum	heat shock protein 90	0.0025	0.0319	0.5
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0472	0.132
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.2151	1
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0482	0.8238
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Leishmania major	hypothetical protein, conserved	0.0024	0.0304	0.4963
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0072	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0482	0.2116
Onchocerca volvulus		0.0014	0.0072	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0549	0.2552
Brugia malayi	Sugar transporter family protein	0.0014	0.0072	0.0334
Trichomonas vaginalis	glucose transporter, putative	0.0014	0.0072	0.0179
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0473	0.0672
Brugia malayi	nuclear hormone receptor	0.0022	0.024	0.1114
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0472	0.132
Trypanosoma brucei	heat shock protein, putative	0.0031	0.0469	0.801
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0549	0.0977
Brugia malayi	Sugar transporter family protein	0.0103	0.2151	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.024	0.067
Loa Loa (eye worm)	hypothetical protein	0.0022	0.024	0.1114
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0103	0.2151	0.6011
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.024	0.067
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.024	0.067
Schistosoma mansoni	coup transcription factor	0.0022	0.024	0.067
Onchocerca volvulus		0.0014	0.0072	0.0735
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0457	0.9697
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0272	0.1263
Trypanosoma cruzi	glucose transporter, putative	0.0014	0.0072	0.0696
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0025	0.0319	0.3595
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0482	0.2116
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0473	0.044
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.024	0.1114
Trichomonas vaginalis	sugar transport protein, putative	0.0014	0.0072	0.0179
Entamoeba histolytica	heat shock protein 90, putative	0.0031	0.0469	0.9933
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0304	0.0413
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0272	0.4371
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0578	0.0546
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0166	0.3641	0.3619
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0142	0.1982
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0482	0.2116
Trichomonas vaginalis	endoplasmin, putative	0.0019	0.0184	0.071
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0482	0.8238
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0482	0.2116
Leishmania major	protein kinase, putative	0.0032	0.0472	0.8064
Onchocerca volvulus		0.0014	0.0072	0.0735
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.024	0.1114
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0549	0.0977
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0482	0.8238
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0473	0.044
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0072	0.0334
Echinococcus granulosus	General substrate transporter	0.0088	0.1811	0.506
Mycobacterium ulcerans	lipase LipD	0.0035	0.0549	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0072	0.0179
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0072	0.0334
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0472	0.132
Echinococcus granulosus	heat shock protein	0.0031	0.0469	0.1312
Echinococcus multilocularis	endoplasmin	0.0025	0.0319	0.0892
Schistosoma mansoni	heat shock protein	0.0031	0.0469	0.1312
Brugia malayi	ecdysteroid receptor	0.0022	0.024	0.1114
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.077	0.2152
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.024	0.3994
Leishmania major	hypothetical protein, conserved	0.0035	0.0549	0.9471
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0072	0.0201
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.024	0.067
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0549	0.0977
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0072	0.0179
Onchocerca volvulus		0.0014	0.0072	0.0735
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2151	0.6011
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0549	0.2433
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.024	0.067
Onchocerca volvulus	Putative transporter	0.0014	0.0072	0.0735

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 847831