TDR Targets

Basic information

Technical information

TDR Targets ID: 862518
Name: 4-[[3-[(3-methylphenyl)methyl]imidazo[5,4-c]p yridin-2-yl]sulfanylmethyl]-N-(3-piperidin-1- ylpropyl)benzamide
MW: 513.697 | Formula: C30H35N5OS
H donors: 1 H acceptors: 3 LogP: 5.18 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: Cc1cccc(c1)Cn1c(SCc2ccc(cc2)C(=O)NCCCN2CCCCC2)nc2c1cncc2
InChi: 1S/C30H35N5OS/c1-23-7-5-8-25(19-23)21-35-28-20-31-15-13-27(28)33-30(35)37-22-24-9-11-26(12-10-24)29(36)32-14-6-18-34-16-3-2-4-17-34/h5,7-13,15,19-20H,2-4,6,14,16-18,21-22H2,1H3,(H,32,36)
InChiKey: SJSGERPYGWURAG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[[3-[(3-methylphenyl)methyl]imidazo[5,4-c]pyridin-2-yl]sulfanylmethyl]-N-[3-(1-piperidyl)propyl]benzamide
4-[[[3-[(3-methylphenyl)methyl]-2-imidazo[5,4-c]pyridinyl]thio]methyl]-N-[3-(1-piperidyl)propyl]benzamide
4-[[[3-(3-methylbenzyl)imidazo[5,4-c]pyridin-2-yl]thio]methyl]-N-(3-piperidinopropyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0029	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Onchocerca volvulus		0.0029	0.0234	0.0222
Loa Loa (eye worm)	glycogen phosphorylase	0.0348	0.4551	0.4551
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0234	0.01
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0029	0.0234	0.01
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0029	0.0234	0.01
Onchocerca volvulus		0.0029	0.0234	0.0222
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0348	0.4551	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0029	0.0234	0.01
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Onchocerca volvulus		0.0029	0.0234	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Schistosoma mansoni	protein tyrosine phosphatase	0.0029	0.0234	0.01
Echinococcus granulosus	glycogen phosphorylase	0.0348	0.4551	0.4475
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0029	0.0234	0.01
Onchocerca volvulus		0.0029	0.0234	0.0222
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0029	0.0234	0.01
Onchocerca volvulus		0.0029	0.0234	0.0222
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0029	0.0234	0.01
Brugia malayi	Protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.015	0.1878	0.5
Schistosoma mansoni	glycogen phosphorylase	0.0348	0.4551	0.4475
Onchocerca volvulus		0.0029	0.0234	0.0222
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0029	0.0234	0.0234
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0029	0.0234	0.01
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0029	0.0234	0.01
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Brugia malayi	hypothetical protein	0.0029	0.0234	0.0234
Entamoeba histolytica	glycogenphosphorylase, putative	0.015	0.1878	0.3809
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0348	0.4551	0.4475
Brugia malayi	hypothetical protein	0.0029	0.0234	0.0234
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0037	0.034	0.0207
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.034	0.0207
Brugia malayi	hypothetical protein	0.0029	0.0234	0.0234
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Brugia malayi	carbohydrate phosphorylase	0.0348	0.4551	0.4551
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0029	0.0234	0.01
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0234	0.01
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Onchocerca volvulus		0.0029	0.0234	0.0222
Onchocerca volvulus		0.0029	0.0234	0.0222
Brugia malayi	Intermediate filament tail domain containing protein	0.0022	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0029	0.0234	0.01
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0131	0.0131
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Entamoeba histolytica	glycogen phosphorylase, putative	0.015	0.1878	0.3809
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.034	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0029	0.0234	0.01
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Echinococcus granulosus	Glycosyl transferase family 35	0.0348	0.4551	0.4475
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0029	0.0234	0.01
Entamoeba histolytica	glycogen phosphorylase, putative	0.0348	0.4551	1
Brugia malayi	hypothetical protein	0.0029	0.0234	0.0234
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0751	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0029	0.0234	0.01
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0029	0.0234	0.01
Echinococcus multilocularis	hypothetical protein	0.0029	0.0234	0.01
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Entamoeba histolytica	glycogen phosphorylase, putative	0.0348	0.4551	1
Echinococcus multilocularis		0.0029	0.0234	0.01
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0029	0.0234	0.01
Onchocerca volvulus		0.0029	0.0234	0.0222
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0029	0.0234	0.01
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0029	0.0234	0.01
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Brugia malayi	intermediate filament protein	0.0022	0.0136	0.0136
Schistosoma mansoni	glycogen phosphorylase	0.0348	0.4551	0.4475
Onchocerca volvulus		0.0029	0.0234	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Onchocerca volvulus		0.0029	0.0234	0.0222
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0029	0.0234	0.01
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0029	0.0234	0.01
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0234	0.01
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0037	0.034	0.034
Brugia malayi	Protein-tyrosine phosphatase 1	0.0029	0.0234	0.0234
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0029	0.0234	0.01
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0234	0.01
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0029	0.0234	0.01
Onchocerca volvulus		0.0029	0.0234	0.0222
Echinococcus granulosus	glycogen phosphorylase	0.0348	0.4551	0.4475
Loa Loa (eye worm)	intermediate filament protein	0.0022	0.0136	0.0136
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0037	0.034	0.0207
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Onchocerca volvulus		0.0029	0.0234	0.0222
Entamoeba histolytica	glycogen phosphorylase, putative	0.015	0.1878	0.3809
Onchocerca volvulus		0.0029	0.0234	0.0222
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.034	0.0207
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0029	0.0234	0.01
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0029	0.0234	0.01
Onchocerca volvulus		0.0029	0.0234	0.0222
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0029	0.0234	0.01
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0029	0.0234	0.0234
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0029	0.0234	0.01
Onchocerca volvulus		0.0029	0.0234	0.0222
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0029	0.0234	0.01
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0029	0.0234	0.01
Brugia malayi	hypothetical protein	0.0029	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0029	0.0234	0.01
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0029	0.0234	0.01
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0029	0.0234	0.01
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0029	0.0234	0.0234
Schistosoma mansoni	protein tyrosine phosphatase	0.0029	0.0234	0.01
Giardia lamblia	Glycogen phosphorylase	0.0348	0.4551	1
Brugia malayi	Protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0029	0.0234	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0029	0.0234	0.01
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0029	0.0234	0.0234
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0029	0.0234	0.01
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0234	0.01
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0029	0.0234	0.01
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0037	0.034	0.0207
Echinococcus multilocularis	glycogen phosphorylase	0.0348	0.4551	0.4475
Onchocerca volvulus		0.0029	0.0234	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Onchocerca volvulus	4.1 G protein, putative homolog	0.0029	0.0234	0.0222
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0037	0.034	0.034
Onchocerca volvulus		0.0029	0.0234	0.0222
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0029	0.0234	0.01
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0029	0.0234	0.01
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0029	0.0234	0.01
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0029	0.0234	0.01
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Echinococcus multilocularis	glycogen phosphorylase	0.0348	0.4551	0.4475
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0029	0.0234	0.0234
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Onchocerca volvulus		0.0029	0.0234	0.0222
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0029	0.0234	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0751	1	1
Onchocerca volvulus		0.0029	0.0234	0.0222
Schistosoma mansoni	pcd6 interacting protein-related	0.0029	0.0234	0.01
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0751	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0136	0.0136
Schistosoma mansoni	glycogen phosphorylase	0.015	0.1878	0.1766
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0751	1	1
Chlamydia trachomatis	glycogen phosphorylase	0.0348	0.4551	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0234	0.01
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0029	0.0234	0.01
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0029	0.0234	0.5
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.015	0.1878	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0029	0.0234	0.01
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0029	0.0234	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0029	0.0234	0.01
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0348	0.4551	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0029	0.0234	0.01
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0029	0.0234	0.0234
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0029	0.0234	0.01
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Schistosoma mansoni	protein tyrosine phosphatase	0.0029	0.0234	0.01
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0234	0.01
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0029	0.0234	0.01
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Onchocerca volvulus		0.0029	0.0234	0.0222
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0029	0.0234	0.5
Leishmania major	tyrosine specific protein phosphatase, putative	0.0029	0.0234	0.5
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0348	0.4551	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0029	0.0234	0.01
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0234	0.0234
Onchocerca volvulus		0.0029	0.0234	0.0222
Onchocerca volvulus		0.0029	0.0234	0.0222
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0029	0.0234	0.01
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0234	0.0234
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0037	0.034	0.0207
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0234	0.01
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0234	0.0234
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0022	0.0136	0.0136

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 862518