Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0045 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.2535 | 0.5 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0.8362 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0045 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.2535 | 0.2535 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 1 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0045 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0045 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 1 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.2535 | 0.2535 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0.8362 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.2535 | 0.2535 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0045 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2535 | 0.2535 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 1 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 53 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | > 47.1 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.2589 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.