TDR Targets

Basic information

Technical information

TDR Targets ID: 863679
Name: 1-[(4-ethyl-5-methylthiophen-3-yl)methyl]-4-( 4-methoxyphenyl)piperazine
MW: 330.488 | Formula: C19H26N2OS
H donors: 0 H acceptors: 0 LogP: 4.2 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCc1c(csc1C)CN1CCN(CC1)c1ccc(cc1)OC
InChi: 1S/C19H26N2OS/c1-4-19-15(2)23-14-16(19)13-20-9-11-21(12-10-20)17-5-7-18(22-3)8-6-17/h5-8,14H,4,9-13H2,1-3H3
InChiKey: SVIXWAPBNZFZBT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[(4-ethyl-5-methyl-3-thienyl)methyl]-4-(4-methoxyphenyl)piperazine
1-[(4-ethyl-5-methyl-thiophen-3-yl)methyl]-4-(4-methoxyphenyl)piperazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0118	0.0752	0.1423
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0056	0.0239	0.0452
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0118	0.0752	0.1423
Loa Loa (eye worm)	steroid hormone receptor	0.0118	0.0752	0.0752
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0115	0.0724	0.1371
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0178	0.0178
Brugia malayi	hypothetical protein	0.0115	0.0724	0.0724
Entamoeba histolytica	protein kinase domain containing protein	0.0087	0.0492	0.6432
Brugia malayi	hypothetical protein	0.0056	0.0239	0.0239
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0173	0.0173
Echinococcus multilocularis	dual specificity	0.0087	0.0492	0.0932
Echinococcus granulosus	dual specificity	0.0087	0.0492	0.0932
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0273	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.0118	0.0752	0.1423
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0153	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0752	0.0752
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0239	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0752	0.0752
Brugia malayi	orphan nuclear receptor NR2E1	0.0056	0.0239	0.0239
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0273	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0489	0.0489
Schistosoma mansoni	serine/threonine protein kinase	0.0087	0.0492	0.0932
Echinococcus multilocularis	jun protein	0.0181	0.1266	0.2396
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0239	0.0239
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0273	0.5
Loa Loa (eye worm)	hypothetical protein	0.1242	1	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0074	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0118	0.0752	0.1423
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0181	0.1266	0.2396
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0752	0.0752
Onchocerca volvulus		0.0048	0.0173	0.1828
Echinococcus multilocularis	survival motor neuron protein 1	0.0234	0.1706	0.3228
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0153	0.0289
Schistosoma mansoni	hypothetical protein	0.0332	0.2512	0.4753
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0294	0.0294
Echinococcus granulosus	thyroid hormone receptor alpha	0.0056	0.0239	0.0452
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0118	0.0752	0.1423
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0087	0.0492	0.0492
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0229	0.1666	0.1666
Onchocerca volvulus		0.0056	0.0239	0.2522
Schistosoma mansoni	zinc finger protein	0.0056	0.0239	0.0452
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0056	0.0239	0.0239
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0118	0.0752	0.0752
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0056	0.0239	0.0452
Echinococcus granulosus	jun protein	0.0181	0.1266	0.2396
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0239	0.0239
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0118	0.0752	0.1423
Echinococcus multilocularis	lysine specific demethylase 5A	0.0058	0.0258	0.0488
Brugia malayi	jmjC domain containing protein	0.0058	0.0258	0.0258
Brugia malayi	ecdysone receptor	0.0056	0.0239	0.0239
Onchocerca volvulus		0.0093	0.0545	0.5755
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0273	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0115	0.0724	0.1371
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0056	0.0239	0.0452
Echinococcus granulosus	lysine specific demethylase 5A	0.0058	0.0258	0.0488
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0074	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0118	0.0752	0.0752
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0056	0.0239	0.0452
Brugia malayi	steroid hormone receptor	0.0118	0.0752	0.0752
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0118	0.0752	0.1423
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0118	0.0752	0.0752
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0118	0.0752	0.1423
Onchocerca volvulus		0.0056	0.0239	0.2522
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0118	0.0752	0.7942
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0056	0.0239	0.0239
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0056	0.0239	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0239	0.0239
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.0074	0.5
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0056	0.0239	0.2522
Entamoeba histolytica	hypothetical protein	0.0115	0.0724	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0052	0.0099
Schistosoma mansoni	retinoic acid receptor RXR	0.0118	0.0752	0.1423
Schistosoma mansoni	hypothetical protein	0.0332	0.2512	0.4753
Echinococcus granulosus	nuclear receptor nhr 48	0.0056	0.0239	0.0452
Brugia malayi	Nuclear hormone receptor E75	0.0056	0.0239	0.0239
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0118	0.0752	0.0752
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0118	0.0752	0.0752
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0243	0.1777	0.3363
Brugia malayi	bZIP transcription factor family protein	0.0181	0.1266	0.1266
Echinococcus granulosus	lysosomal alpha glucosidase	0.0161	0.1102	0.2086
Entamoeba histolytica	hypothetical protein	0.0115	0.0724	1
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0125	0.0805	0.1524
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.0258	0.0488
Entamoeba histolytica	hypothetical protein	0.0087	0.0492	0.6432
Schistosoma mansoni	thyroid hormone receptor	0.0243	0.1777	0.3363
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0239	0.0239
Schistosoma mansoni	nuclear receptor	0.0056	0.0239	0.0452
Entamoeba histolytica	hypothetical protein	0.0115	0.0724	1
Schistosoma mansoni	jumonji domain containing protein	0.0058	0.0258	0.0488
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0062	0.0294	0.0556
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0087	0.0492	0.0515
Echinococcus multilocularis	ecdysone induced protein 78C	0.0118	0.0752	0.1423
Schistosoma mansoni	alpha-glucosidase	0.0138	0.0918	0.1738
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0153	0.0289
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0273	0.0517
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0087	0.0492	0.0515
Echinococcus multilocularis	geminin	0.0332	0.2512	0.4753
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0056	0.0239	0.0452
Entamoeba histolytica	hypothetical protein	0.0115	0.0724	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0058	0.0258	0.0488
Brugia malayi	nuclear receptor RXR	0.0062	0.0294	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0752	0.0752
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0056	0.0239	0.2522
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0239	0.0239
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0056	0.0239	0.0452
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0118	0.0752	0.1423
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0273	0.0517
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0056	0.0239	0.0452
Brugia malayi	Nuclear hormone receptor E75	0.0056	0.0239	0.0239
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0118	0.0752	0.1423
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0062	0.0294	0.0556
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0118	0.0752	0.0752
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0178	0.0178
Brugia malayi	ecdysteroid receptor	0.0118	0.0752	0.0752
Echinococcus multilocularis	nuclear receptor nhr 48	0.0056	0.0239	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0239	0.0239
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0161	0.1102	0.1102
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0118	0.0752	0.1423
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0115	0.0724	0.1371
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0118	0.0752	0.1423
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0118	0.0752	0.0752
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0074	0.5
Brugia malayi	tailless protein	0.0056	0.0239	0.0239
Onchocerca volvulus	Protein ultraspiracle homolog	0.0118	0.0752	0.7942
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0752	0.0752
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0074	0.014
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0118	0.0752	0.0752
Loa Loa (eye worm)	nuclear hormone receptor	0.0056	0.0239	0.0239
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0062	0.0294	0.0556
Brugia malayi	hypothetical protein	0.0056	0.0239	0.0239
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.0258	0.0258
Schistosoma mansoni	nuclear receptor	0.0056	0.0239	0.0452
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0118	0.0752	0.0752
Loa Loa (eye worm)	DR-78	0.0056	0.0239	0.0239
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0161	0.1102	0.1102
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0239	0.0239
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0052	0.0052
Schistosoma mansoni	hypothetical protein	0.0147	0.0988	0.1869
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0118	0.0752	0.1423
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0074	0.5
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0239	0.0239
Onchocerca volvulus		0.0118	0.0752	0.7942
Echinococcus multilocularis	FTZ F1 alpha	0.0118	0.0752	0.1423
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0118	0.0752	0.0752
Entamoeba histolytica	protein kinase, putative	0.0087	0.0492	0.6432
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0294	0.0294
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0074	0.0074
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0153	0.0289
Echinococcus multilocularis	microtubule associated protein 2	0.0669	0.5285	1
Brugia malayi	follicle stimulating hormone receptor	0.0229	0.1666	0.1666
Brugia malayi	nuclear hormone receptor	0.0056	0.0239	0.0239
Schistosoma mansoni	RAR-like nuclear receptor	0.0118	0.0752	0.1423
Brugia malayi	hypothetical protein	0.0062	0.0294	0.0294
Schistosoma mansoni	hypothetical protein	0.0125	0.0805	0.1524
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0118	0.0752	0.0752
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0118	0.0752	0.1423
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0058	0.0258	0.0488
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0118	0.0752	0.1423
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0239	0.0239
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0273	0.0517
Brugia malayi	hypothetical protein	0.0234	0.1706	0.1706
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0118	0.0752	0.1423
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.0258	0.0488
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0153	0.0289
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0161	0.1102	0.2086
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0752	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0052	0.0052
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0273	0.0245
Brugia malayi	nuclear receptor NHR-88	0.0118	0.0752	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0239	0.0239
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0056	0.0239	0.0452
Schistosoma mansoni	hypothetical protein	0.0115	0.0724	0.1371
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0087	0.0492	0.0515
Schistosoma mansoni	nuclear hormone receptor	0.0056	0.0239	0.0452
Schistosoma mansoni	alpha glucosidase	0.0036	0.0074	0.014
Schistosoma mansoni	nuclear receptor nhr-48	0.0056	0.0239	0.0452
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0178	0.0178
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0074	0.0074
Brugia malayi	jmjC domain containing protein	0.0058	0.0258	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0234	0.1706	0.1706
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0074	0.5
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0074	0.014
Echinococcus granulosus	geminin	0.0332	0.2512	0.4753
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0118	0.0752	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0489	0.0489
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0056	0.0239	0.0239
Echinococcus granulosus	FTZ F1 alpha	0.0118	0.0752	0.1423
Leishmania major	squalene monooxygenase-like protein	0.1023	0.8197	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.0074	0.5
Schistosoma mansoni	microtubule-associated protein tau	0.0669	0.5285	1
Trypanosoma cruzi	squalene monooxygenase, putative	0.1023	0.8197	1
Schistosoma mansoni	coup transcription factor	0.0118	0.0752	0.1423
Trypanosoma brucei	squalene monooxygenase, putative	0.1023	0.8197	1
Onchocerca volvulus		0.0142	0.0947	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0181	0.1266	0.2396
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0161	0.1102	0.2086
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0273	0.5
Schistosoma mansoni	hypothetical protein	0.0048	0.0173	0.0328
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0118	0.0752	0.1423
Trypanosoma cruzi	squalene monooxygenase, putative	0.1023	0.8197	1
Brugia malayi	hypothetical protein	0.0142	0.0947	0.0947
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0118	0.0752	0.1423
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0294	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0752	0.0752
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0022	0.0022
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0153	0.0153
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0056	0.0239	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0239	0.0239
Brugia malayi	Nuclear hormone receptor-like 1	0.0062	0.0294	0.0294
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0118	0.0752	0.0752
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0074	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0118	0.0752	0.0752
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0118	0.0752	0.0752
Brugia malayi	Protein kinase domain containing protein	0.0087	0.0492	0.0492
Brugia malayi	conserved hypotetical protein	0.0056	0.0239	0.0239
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0118	0.0752	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0178	0.0178
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0118	0.0752	0.0752
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0118	0.0752	0.1423
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1226	0.1226
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0118	0.0752	0.1423
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0118	0.0752	0.0752
Brugia malayi	nuclear receptor RXR	0.0056	0.0239	0.0239
Brugia malayi	Nuclear hormone receptor-like 1	0.0062	0.0294	0.0294
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0273	1
Entamoeba histolytica	protein kinase, putative	0.0087	0.0492	0.6432
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0118	0.0752	0.0752
Brugia malayi	nuclear hormone receptor family member odr-7	0.0056	0.0239	0.0239
Brugia malayi	nuclear hormone receptor	0.0118	0.0752	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0294	0.0294
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0118	0.0752	0.0752
Brugia malayi	Steroid receptor seven-up type 2	0.0118	0.0752	0.0752
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0125	0.0805	0.1524
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0153	0.0289
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0118	0.0752	0.0752
Onchocerca volvulus	Bile acid receptor homolog	0.0118	0.0752	0.7942
Brugia malayi	hypothetical protein	0.0062	0.0294	0.0294
Brugia malayi	photoreceptor-specific nuclear receptor	0.0118	0.0752	0.0752
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0153	0.0289
Schistosoma mansoni	jun-related protein	0.0147	0.0988	0.1869
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0118	0.0752	0.1423
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0056	0.0239	0.0239
Brugia malayi	nuclear receptor NHR-67	0.0056	0.0239	0.0239
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0173	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0239	0.0239
Echinococcus granulosus	microtubule associated protein 2	0.0669	0.5285	1
Echinococcus granulosus	survival motor neuron protein 1	0.0234	0.1706	0.3228
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0056	0.0239	0.0452
Schistosoma mansoni	nuclear hormone receptor	0.0056	0.0239	0.0452
Schistosoma mansoni	thyroid hormone receptor	0.0243	0.1777	0.3363
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0294	0.0294
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0062	0.0294	0.0556
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0062	0.0294	0.0294
Brugia malayi	nuclear receptor NHR-88	0.0056	0.0239	0.0239
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0074	0.5
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0087	0.0492	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0752	0.0752
Schistosoma mansoni	alpha-glucosidase	0.0138	0.0918	0.1738
Schistosoma mansoni	nuclear hormone receptor	0.0118	0.0752	0.1423

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 863679