TDR Targets

Basic information

Technical information

TDR Targets ID: 863775
Name: EU-0063620
MW: 607.095 | Formula: C31H28ClFN4O4S
H donors: 2 H acceptors: 4 LogP: 4.45 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: Fc1ccc(cc1)S(=O)(=O)Nc1cc(ccc1N1CC2CC(C1)c1n(C2)c(=O)ccc1)C(=O)NCc1ccc(cc1)Cl
InChi: 1S/C31H28ClFN4O4S/c32-24-7-4-20(5-8-24)16-34-31(39)22-6-13-29(27(15-22)35-42(40,41)26-11-9-25(33)10-12-26)36-17-21-14-23(19-36)28-2-1-3-30(38)37(28)18-21/h1-13,15,21,23,35H,14,16-19H2,(H,34,39)
InChiKey: ANOZOWBHKSMJEE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.2494	0.5608	0.5635
Brugia malayi	cathepsin L-like cysteine proteinase	0.052	0.1079	0.1074
Plasmodium falciparum	cysteine proteinase falcipain 1	0.1098	0.2405	0.533
Brugia malayi	Cathepsin L-like precursor	0.1946	0.435	0.4347
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4409	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1946	0.435	0.768
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0131	0.0185	0.0185
Entamoeba histolytica	cysteine protease, putative	0.052	0.1079	0.2145
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.052	0.1079	0.1079
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0131	0.0185	0.0185
Brugia malayi	Cathepsin L-like precursor	0.1946	0.435	0.4347
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.052	0.1079	0.1074
Brugia malayi	Cathepsin L-like precursor	0.1946	0.435	0.4347
Onchocerca volvulus		0.1946	0.435	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.1098	0.2405	0.533
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1946	0.435	0.768
Loa Loa (eye worm)	hypothetical protein	0.052	0.1079	0.1079
Brugia malayi	cathepsin Z-like cysteine proteinase	0.052	0.1079	0.1074
Echinococcus granulosus	cathepsin L	0.052	0.1079	0.1074
Plasmodium vivax	unspecified product	0.052	0.1079	0.2145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.052	0.1079	0.1647
Trypanosoma cruzi	major cysteine proteinase, putative	0.052	0.1079	0.091
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.052	0.1079	0.1647
Loa Loa (eye worm)	hypothetical protein	0.052	0.1079	0.1079
Loa Loa (eye worm)	hypothetical protein	0.052	0.1079	0.1079
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1098	0.2405	0.2401
Schistosoma mansoni	cathepsin s	0.0578	0.1212	0.1207
Loa Loa (eye worm)	carboxylesterase	0.0052	0.0005	0.0005
Entamoeba histolytica	cysteine proteinase, putative	0.1368	0.3024	0.6816
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1098	0.2405	0.4093
Leishmania major	cathepsin L-like protease	0.4325	0.9809	1
Entamoeba histolytica	cysteine proteinase, putative	0.1098	0.2405	0.533
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.052	0.1079	0.2145
Entamoeba histolytica	cysteine protease, putative	0.1098	0.2405	0.533
Leishmania major	cysteine peptidase A (CPA)	0.1946	0.435	0.4328
Loa Loa (eye worm)	fibroinase	0.1946	0.435	0.435
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0578	0.1212	0.1207
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4325	0.9809	1
Plasmodium falciparum	serine repeat antigen 1	0.052	0.1079	0.2145
Toxoplasma gondii	cathepsin CPC2	0.052	0.1079	0.1647
Entamoeba histolytica	cysteine protease, putative	0.1098	0.2405	0.533
Loa Loa (eye worm)	hypothetical protein	0.1368	0.3024	0.3024
Entamoeba histolytica	cysteine protease, putative	0.052	0.1079	0.2145
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4325	0.9809	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.052	0.1079	0.1647
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1946	0.435	0.768
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4325	0.9809	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1946	0.435	0.768
Brugia malayi	Papain family cysteine protease containing protein	0.1946	0.435	0.4347
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1946	0.435	0.768
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1946	0.435	0.768
Plasmodium falciparum	serine repeat antigen 2	0.052	0.1079	0.2145
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1946	0.435	0.4347
Trypanosoma cruzi	cysteine proteinase, putative	0.1098	0.2405	0.2262
Entamoeba histolytica	cysteine protease, putative	0.1098	0.2405	0.533
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.052	0.1079	0.1079
Entamoeba histolytica	cysteine protease, putative	0.1098	0.2405	0.533
Plasmodium vivax	serine-repeat antigen (SERA)	0.052	0.1079	0.2145
Plasmodium falciparum	serine repeat antigen 3	0.052	0.1079	0.2145
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4325	0.9809	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4325	0.9809	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.052	0.1079	0.2145
Onchocerca volvulus		0.1368	0.3024	0.5946
Schistosoma mansoni	cathepsin F (C01 family)	0.1368	0.3024	0.302
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.052	0.1079	0.2145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1946	0.435	0.768
Schistosoma mansoni	ubiquitin conjugating enzyme 13	0.0131	0.0185	0.018
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4325	0.9809	1
Loa Loa (eye worm)	cysteine protease	0.1946	0.435	0.435
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.2494	0.5608	1
Trypanosoma cruzi	cysteine peptidase, putative	0.4325	0.9809	0.9806
Toxoplasma gondii	cathepsin CPL	0.1946	0.435	0.768
Trichomonas vaginalis	conserved hypothetical protein	0.052	0.1079	0.1647
Echinococcus granulosus	cathepsin b	0.4409	1	1
Entamoeba histolytica	cysteine protease, putative	0.1098	0.2405	0.533
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.4409	1	1
Echinococcus multilocularis	cathepsin L	0.1098	0.2405	0.2401
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1946	0.435	0.768
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1368	0.3024	0.5234
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1946	0.435	0.768
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1946	0.435	0.768
Echinococcus granulosus	ubiquitin conjugating enzyme E2 N	0.0131	0.0185	0.018
Plasmodium vivax	vivapain-2	0.1946	0.435	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.052	0.1079	0.1074
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.052	0.1079	0.2145
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1098	0.2405	0.2306
Plasmodium vivax	vivapain-3	0.1098	0.2405	0.533
Echinococcus granulosus	cathepsin L cysteine protease	0.1098	0.2405	0.2401
Toxoplasma gondii	cathepsin B	0.2494	0.5608	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.052	0.1079	0.1647
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1946	0.435	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.052	0.1079	0.2145
Onchocerca volvulus		0.1946	0.435	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.052	0.1079	0.1647
Giardia lamblia	Cathepsin B precursor	0.2494	0.5608	1
Entamoeba histolytica	hypothetical protein	0.052	0.1079	0.2145
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.052	0.1079	0.1647
Brugia malayi	cathepsin L-like precursor	0.1368	0.3024	0.302
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4325	0.9809	1
Entamoeba histolytica	cysteine proteinase, putative	0.1098	0.2405	0.533
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.052	0.1079	0.2145
Brugia malayi	Cathepsin L-like precursor	0.1946	0.435	0.4347
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.1098	0.2405	0.2262
Plasmodium vivax	vivapain-1	0.1098	0.2405	0.533
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.052	0.1079	0.1647
Toxoplasma gondii	preprocathepsin c precursor, putative	0.052	0.1079	0.1647
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.052	0.1079	0.1074
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1946	0.435	0.4347
Schistosoma mansoni	cathepsin S (C01 family)	0.052	0.1079	0.1074
Trypanosoma cruzi	cysteine peptidase, putative	0.4325	0.9809	0.9806
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.052	0.1079	0.1074
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1368	0.3024	0.302
Entamoeba histolytica	cysteine proteinase, putative	0.1946	0.435	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.052	0.1079	0.1647
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0578	0.1212	0.1212
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.052	0.1079	0.2145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1946	0.435	0.768
Echinococcus multilocularis	cathepsin L cysteine protease	0.1946	0.435	0.4347
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2494	0.5608	0.5606
Trypanosoma cruzi	cysteine proteinase, putative	0.1098	0.2405	0.2262
Entamoeba histolytica	cysteine proteinase, putative	0.1098	0.2405	0.533
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1946	0.435	0.768
Entamoeba histolytica	cysteine protease, putative	0.052	0.1079	0.2145
Trypanosoma cruzi	cruzipain precursor, putative	0.0578	0.1212	0.1046
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.4409	1	1
Brugia malayi	Cathepsin L-like precursor	0.1368	0.3024	0.302
Brugia malayi	Papain family cysteine protease containing protein	0.052	0.1079	0.1074
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4325	0.9809	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1946	0.435	0.768
Entamoeba histolytica	cysteine protease, putative	0.1098	0.2405	0.533
Trichomonas vaginalis	conserved hypothetical protein	0.052	0.1079	0.1647
Schistosoma mansoni	cathepsin F (C01 family)	0.1946	0.435	0.4347
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.052	0.1079	0.1074
Trypanosoma cruzi	cysteine protease, putative	0.1098	0.2405	0.2262
Loa Loa (eye worm)	hypothetical protein	0.052	0.1079	0.1079
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.052	0.1079	0.2145
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.052	0.1079	0.1074
Loa Loa (eye worm)	hypothetical protein	0.4409	1	1
Brugia malayi	Cathepsin L-like precursor	0.0578	0.1212	0.1207
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1946	0.435	1
Entamoeba histolytica	cysteine protease, putative	0.1098	0.2405	0.533
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4409	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1098	0.2405	0.2306
Loa Loa (eye worm)	acetylcholinesterase 1	0.0052	0.0005	0.0005
Onchocerca volvulus		0.1946	0.435	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.052	0.1079	0.1647
Loa Loa (eye worm)	hypothetical protein	0.1946	0.435	0.435
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1946	0.435	0.768
Echinococcus granulosus	cysteine protease	0.1098	0.2405	0.2401
Echinococcus multilocularis	cathepsin L cysteine protease	0.1946	0.435	0.4347
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.052	0.1079	0.2145
Entamoeba histolytica	cysteine protease, putative	0.1098	0.2405	0.533
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.052	0.1079	0.1647
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.052	0.1079	0.1074
Plasmodium falciparum	serine repeat antigen 8	0.052	0.1079	0.2145
Plasmodium falciparum	serine repeat antigen 4	0.052	0.1079	0.2145
Trypanosoma cruzi	cruzipain precursor, putative	0.4325	0.9809	0.9806
Entamoeba histolytica	cysteine proteinase, putative	0.1946	0.435	1
Brugia malayi	Cathepsin L-like precursor	0.1946	0.435	0.4347
Onchocerca volvulus	Cathepsin L homolog	0.1946	0.435	1
Echinococcus multilocularis	cathepsin b	0.4409	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.3747	0.8483	0.8454
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1098	0.2405	0.2401
Onchocerca volvulus	Cathepsin F homolog	0.1946	0.435	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.052	0.1079	0.2145
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4325	0.9809	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1946	0.435	0.768
Trypanosoma cruzi	cysteine peptidase, putative	0.1098	0.2405	0.2262
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.052	0.1079	0.2145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1946	0.435	0.768
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4325	0.9809	1
Toxoplasma gondii	cathepsin CPC1	0.052	0.1079	0.1647
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1946	0.435	0.768
Brugia malayi	cathepsin F-like cysteine proteinase	0.0578	0.1212	0.1207
Entamoeba histolytica	cysteine protease, putative	0.1098	0.2405	0.533
Brugia malayi	Amyloid A4 extracellular domain containing protein	0.0118	0.0156	0.0151
Leishmania major	cathepsin L-like protease	0.1946	0.435	0.4328
Onchocerca volvulus		0.1946	0.435	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.052	0.1079	0.2145
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1946	0.435	1
Loa Loa (eye worm)	hypothetical protein	0.0578	0.1212	0.1212
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.052	0.1079	0.1074
Brugia malayi	cathepsin F-like cysteine proteinase	0.052	0.1079	0.1074
Echinococcus multilocularis	cysteine protease	0.1946	0.435	0.4347
Brugia malayi	fibroinase precursor	0.052	0.1079	0.1074
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1946	0.435	0.4347
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1368	0.3024	0.5234
Entamoeba histolytica	cysteine protease, putative	0.1098	0.2405	0.533
Leishmania major	cathepsin L-like protease	0.4325	0.9809	1
Plasmodium falciparum	serine repeat antigen 7	0.052	0.1079	0.2145
Leishmania major	cathepsin L-like protease	0.1946	0.435	0.4328
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1098	0.2405	0.2401
Brugia malayi	Papain family cysteine protease containing protein	0.052	0.1079	0.1074
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1946	0.435	0.768
Entamoeba histolytica	cysteine protease, putative	0.052	0.1079	0.2145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1946	0.435	0.768
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1946	0.435	0.435
Trypanosoma cruzi	cysteine peptidase, putative	0.0578	0.1212	0.1046
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.052	0.1079	0.1647
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1946	0.435	0.768
Leishmania major	cathepsin L-like protease	0.1946	0.435	0.4328
Plasmodium falciparum	serine repeat antigen 5	0.052	0.1079	0.2145
Loa Loa (eye worm)	cathepsin B	0.2494	0.5608	0.5608
Giardia lamblia	Cathepsin B precursor	0.2494	0.5608	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.052	0.1079	0.1074
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4409	1	1
Onchocerca volvulus		0.1946	0.435	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1946	0.435	0.768
Echinococcus multilocularis	cathepsin b	0.4409	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.052	0.1079	0.2145
Echinococcus granulosus	cathepsin b	0.4409	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.052	0.1079	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0578	0.1212	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0578	0.1212	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0005	0.0005
Entamoeba histolytica	cysteine protease, putative	0.1098	0.2405	0.533
Brugia malayi	Papain family cysteine protease containing protein	0.1098	0.2405	0.2401
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1098	0.2405	0.4093
Brugia malayi	Papain family cysteine protease containing protein	0.1098	0.2405	0.2401
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.052	0.1079	0.1647
Echinococcus multilocularis	ubiquitin conjugating enzyme E2 N	0.0131	0.0185	0.018
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.052	0.1079	0.1647
Entamoeba histolytica	cysteine proteinase, putative	0.1098	0.2405	0.533
Schistosoma mansoni	cathepsin B (C01 family)	0.052	0.1079	0.1074
Entamoeba histolytica	cysteine protease, putative	0.1098	0.2405	0.533
Entamoeba histolytica	cysteine protease, putative	0.1098	0.2405	0.533
Trypanosoma cruzi	cysteine peptidase, putative	0.4325	0.9809	0.9806
Brugia malayi	Cathepsin L-like precursor	0.1368	0.3024	0.302
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4325	0.9809	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.052	0.1079	0.1079
Entamoeba histolytica	cysteine protease, putative	0.1946	0.435	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1946	0.435	0.768
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.052	0.1079	0.1074
Onchocerca volvulus		0.1946	0.435	1
Entamoeba histolytica	cysteine protease, putative	0.052	0.1079	0.2145
Entamoeba histolytica	cysteine protease, putative	0.052	0.1079	0.2145
Brugia malayi	Cathepsin L-like precursor	0.1946	0.435	0.4347
Schistosoma mansoni	cathepsin C	0.052	0.1079	0.1074
Loa Loa (eye worm)	hypothetical protein	0.1368	0.3024	0.3024
Loa Loa (eye worm)	hypothetical protein	0.1368	0.3024	0.3024
Brugia malayi	ubiquitin conjugating enzyme protein 13	0.0131	0.0185	0.018
Plasmodium vivax	unspecified product	0.0578	0.1212	0.2464
Trypanosoma cruzi	major cysteine proteinase, putative	0.29	0.6538	0.6472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.052	0.1079	0.1647
Plasmodium falciparum	serine repeat antigen 9	0.052	0.1079	0.2145
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1946	0.435	0.4347
Brugia malayi	cathepsin L precursor	0.052	0.1079	0.1074
Schistosoma mansoni	cathepsin F (C01 family)	0.1946	0.435	0.4347
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.052	0.1079	0.1647
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.2494	0.5608	0.5526
Loa Loa (eye worm)	hypothetical protein	0.052	0.1079	0.1079
Trypanosoma brucei	cysteine peptidase C (CPC)	0.2494	0.5608	0.5635
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1946	0.435	0.435
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.052	0.1079	0.1074
Onchocerca volvulus	Cathepsin L homolog	0.1946	0.435	1
Plasmodium vivax	vivapain-2	0.1946	0.435	1
Loa Loa (eye worm)	ctsf protein	0.1946	0.435	0.435
Brugia malayi	Ubiquitin conjugating enzyme protein 13	0.0131	0.0185	0.018
Plasmodium falciparum	serine repeat antigen 6	0.052	0.1079	0.2145
Leishmania major	cathepsin L-like protease	0.1946	0.435	0.4328
Onchocerca volvulus		0.1946	0.435	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1946	0.435	0.768
Echinococcus granulosus	cathepsin L	0.1098	0.2405	0.2401
Plasmodium vivax	unspecified product	0.1098	0.2405	0.533
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1946	0.435	0.768
Echinococcus multilocularis	cathepsin L	0.052	0.1079	0.1074
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.052	0.1079	0.2145
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.052	0.1079	0.1647
Leishmania major	cathepsin L-like protease	0.1946	0.435	0.4328
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1946	0.435	0.768
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.052	0.1079	0.2145
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.052	0.1079	0.1079
Echinococcus granulosus	cathepsin l1	0.1368	0.3024	0.302
Entamoeba histolytica	cysteine proteinase 2	0.1098	0.2405	0.533
Plasmodium vivax	serine-repeat antigen (SERA)	0.052	0.1079	0.2145
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.052	0.1079	0.1647
Giardia lamblia	Cathepsin B precursor	0.2494	0.5608	1
Leishmania major	cathepsin L-like protease	0.4325	0.9809	1
Echinococcus granulosus	cathepsin l1	0.1946	0.435	0.4347
Echinococcus multilocularis	cysteine protease	0.1946	0.435	0.4347
Trypanosoma cruzi	cysteine peptidase, putative	0.1946	0.435	0.4244

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 863775