TDR Targets

Basic information

Technical information

TDR Targets ID: 869459
Name: N-[(4-ethoxyphenyl)methyl]-2-(3-methoxyphenyl )imidazo[2,1-b][1,3]benzothiazole-6-carboxami de
MW: 457.544 | Formula: C26H23N3O3S
H donors: 1 H acceptors: 2 LogP: 6.03 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)CNC(=O)c1ccc2c(c1)sc1n2cc(n1)c1cccc(c1)OC
InChi: 1S/C26H23N3O3S/c1-3-32-20-10-7-17(8-11-20)15-27-25(30)19-9-12-23-24(14-19)33-26-28-22(16-29(23)26)18-5-4-6-21(13-18)31-2/h4-14,16H,3,15H2,1-2H3,(H,27,30)
InChiKey: BWQGQYDRXJADBU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(4-ethoxyphenyl)methyl]-2-(3-methoxyphenyl)-6-imidazo[2,1-b][1,3]benzothiazolecarboxamide
N-(4-ethoxybenzyl)-2-(3-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazole-6-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.1162	0.1162
Echinococcus multilocularis	Protein son of sevenless	0.0006	0.006	0.006
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0123	0.0282
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0565	0.3099
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0077	0.1823	0.1823
Trichomonas vaginalis	guanine nucleotide exchange factor, putative	0.0006	0.006	0.1635
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0123	0.0123
Brugia malayi	TAR-binding protein	0.013	0.3118	0.7151
Trichomonas vaginalis	ras GTP exchange factor, putative	0.0006	0.006	0.1635
Trichomonas vaginalis	ras GTP exchange factor, son of sevenless, putative	0.0006	0.006	0.1635
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.1162	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.006	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0006	0.006	0.0138
Brugia malayi	N-terminal motif family protein	0.0006	0.006	0.0138
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0027	0.0565	0.3099
Toxoplasma gondii	exonuclease III APE	0.0019	0.0368	0.2019
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0123	0.0282
Echinococcus multilocularis	geminin	0.0346	0.8477	0.8477
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.1162	0.6373
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0064	0.175
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0123	0.0282
Schistosoma mansoni	hypothetical protein	0.0407	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0064	0.175
Brugia malayi	RNA binding protein	0.013	0.3118	0.7151
Trichomonas vaginalis	ras GTP exchange factor, putative	0.0006	0.006	0.1635
Echinococcus granulosus	son of sevenless 1	0.0006	0.006	0.006
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.1823	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0368	0.2019
Loa Loa (eye worm)	hypothetical protein	0.018	0.436	1
Echinococcus granulosus	rap guanine nucleotide exchange factor 6	0.0006	0.006	0.006
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0368	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0064	0.175
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0064	0.175
Schistosoma mansoni	tar DNA-binding protein	0.013	0.3118	0.3118
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.006	0.0138
Echinococcus multilocularis	tar DNA binding protein	0.013	0.3118	0.3118
Schistosoma mansoni	ap endonuclease	0.0019	0.0368	0.0368
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.2136	0.2136
Echinococcus granulosus	ras GTP exchange factor	0.0006	0.006	0.006
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0123	0.0123
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0368	0.2019
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0368	1
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0123	0.0123
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.1162	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1823	0.4181
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0123	0.0123
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1823	1
Echinococcus granulosus	tar DNA binding protein	0.013	0.3118	0.3118
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0123	0.0123
Brugia malayi	RasGEF domain containing protein	0.0006	0.006	0.0138
Toxoplasma gondii	hypothetical protein	0.0009	0.0123	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0123	0.0282
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.013	0.3118	0.7151
Brugia malayi	RNA recognition motif domain containing protein	0.013	0.3118	0.7151
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0123	0.0123
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2136	0.2136
Schistosoma mansoni	hypothetical protein	0.0346	0.8477	0.8477
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2136	0.2136
Brugia malayi	RasGEF domain containing protein	0.0006	0.006	0.0138
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.008	0.008
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.1247	0.6839
Toxoplasma gondii	hypothetical protein	0.0027	0.0565	0.3099
Trypanosoma cruzi	guanine nucleotide releasing protein, putative	0.0006	0.006	0.1635
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0064	0.175
Echinococcus multilocularis	son of sevenless 1	0.0006	0.006	0.006
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0565	0.3099
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0027	0.0565	0.3099
Onchocerca volvulus		0.0009	0.0123	0.0282
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0077	0.1823	1
Onchocerca volvulus		0.0029	0.0613	0.1405
Schistosoma mansoni	tar DNA-binding protein	0.013	0.3118	0.3118
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0004	0.0005	0.0005
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0064	0.175
Schistosoma mansoni	tar DNA-binding protein	0.013	0.3118	0.3118
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.006	0.0138
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0123	0.0282
Schistosoma mansoni	cpg binding protein	0.003	0.0653	0.0653
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0123	0.0282
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0368	0.2019
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.008	0.008
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0064	0.175
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.2136	0.4898
Echinococcus granulosus	rap guanine nucleotide exchange factor 1	0.0006	0.006	0.006
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0064	0.175
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0368	0.0844
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.2136	0.4898
Echinococcus granulosus	geminin	0.0346	0.8477	0.8477
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1823	1
Schistosoma mansoni	tar DNA-binding protein	0.013	0.3118	0.3118
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1823	1
Brugia malayi	DIX domain containing protein	0.0009	0.0123	0.0282
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0064	0.175
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.1162	1
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0123	0.0123
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0123	0.0123
Echinococcus multilocularis	rap guanine nucleotide exchange factor 6	0.0006	0.006	0.006
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.1823	1
Brugia malayi	N-terminal motif family protein	0.0006	0.006	0.0138
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.006	0.006
Brugia malayi	RasGEF domain containing protein	0.0006	0.006	0.0138
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1823	1
Schistosoma mansoni	hypothetical protein	0.0346	0.8477	0.8477
Schistosoma mansoni	cpg binding protein	0.0029	0.0613	0.0613
Schistosoma mansoni	ras GTP exchange factor	0.0006	0.006	0.006
Trypanosoma cruzi	hypothetical protein	0.0006	0.006	0.1635
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0077	0.1823	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0123	0.0123
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.2136	0.2136
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0064	0.175
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.006	0.0138
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1823	1
Echinococcus multilocularis	ras GTP exchange factor	0.0006	0.006	0.006
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0368	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0368	1
Schistosoma mansoni	tar DNA-binding protein	0.013	0.3118	0.3118
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0368	0.0844
Brugia malayi	hypothetical protein	0.0009	0.0123	0.0282
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0123	0.0123
Echinococcus multilocularis	cpg binding protein	0.003	0.0653	0.0653
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0368	1
Trypanosoma cruzi	hypothetical protein	0.0006	0.006	0.1635
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0123	0.0123
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0613	0.1405
Schistosoma mansoni	cpg binding protein	0.003	0.0653	0.0653
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0368	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0368	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0123	0.0282
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0123	0.0123
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1823	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.008	0.008
Echinococcus granulosus	cpg binding protein	0.003	0.0653	0.0653
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0009	0.0123	0.0282
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0064	0.175
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0064	0.175
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0613	0.1405
Schistosoma mansoni	dishevelled	0.0009	0.0123	0.0123
Schistosoma mansoni	peptidase Clp (S14 family)	0.0077	0.1823	0.1823
Trichomonas vaginalis	helicase, putative	0.0006	0.0064	0.175
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0006	0.006	0.0138
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0123	0.0282
Loa Loa (eye worm)	RNA binding protein	0.013	0.3118	0.7151
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0006	0.006	0.006
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.018	0.436	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0064	0.175
Echinococcus multilocularis	rap guanine nucleotide exchange factor 1	0.0006	0.006	0.006
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0368	0.0368
Brugia malayi	Probable ClpP-like protease	0.0077	0.1823	0.4181
Echinococcus granulosus	Protein son of sevenless	0.0006	0.006	0.006
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0368	0.2019
Brugia malayi	N-terminal motif family protein	0.018	0.436	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.2136	0.2136
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.012	0.0276
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.006	0.006
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0368	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0064	0.175
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.008	0.008
Schistosoma mansoni	ap endonuclease	0.0019	0.0368	0.0368
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.2136	0.2136
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0006	0.0053	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0064	0.175
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0064	0.175
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0064	0.175
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0123	0.0123
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0123	0.0123
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.008	0.008
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.1407	0.1407
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0368	0.3168
Onchocerca volvulus		0.0006	0.006	0.0138
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0077	0.1823	0.1823
Brugia malayi	hypothetical protein	0.0009	0.0123	0.0282
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0123	0.0123
Schistosoma mansoni	dishevelled	0.0009	0.0123	0.0123
Schistosoma mansoni	dep domain containing protein	0.0009	0.0123	0.0123
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.006	0.006
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.0123	0.0282
Echinococcus multilocularis	dnaJ subfamily B	0.0407	1	1
Loa Loa (eye worm)	TAR-binding protein	0.013	0.3118	0.7151
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0368	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2136	0.2136
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1823	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 869459